MXPA97004663A - Ora compositions - Google Patents

Abstract

An oral composition in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum or candy comprising one or more of the components of the oral composition selected from abrasives, binders, humectants , surfactants, fluoride ion sources, anti-calculus agents and sweeteners and further comprising an aminoalkyl silicone having an aminoalkylsiloxane content of about 0.1% to 2% on a repeating unit base; the composition provides activity anti-plate and anti-bacterial improved together with excellent performance of clean

Description

ORAL COMPOSITIONS TECHNICAL CUSTOMS The present invention relates to oral compositions such as toothpastes, tooth powders, liquid dentifrices, mouthwashes, denture cleansers, chewing gums, candies and the like. In particular, the invention relates to oral compositions having improved anti-lacquer activity in June with excellent cleaning performance, physical characteristics, and operating characteristics in use.

BACKGROUND The plaque starts when the bacilli adhered to the cuticle form a proteinaceous film on the surface of the teeth. The attached bacteria bolize me the food constituents and they reproduce and add to form the sticky deposit known as plaque. The plaque usually consists of bacteria, bacterial end products such as polysaccharides, inorganic salts and salivary proteins. The bacteria in the plate ferment food carbohydrates in organic acids that demineralize the enamel that results in tooth decay.

F: The calculation is essentially plate that has been mineralized with calcium phosphate salts. As the calculation matures and hardens, it tends to be noticeably stained due to the adsorption of the food chromases. Other than its unattractive appearance, the deposits of calculus in the gum are a source that contributes to gingivitis and periodontal disease. 0 part of the health and hygiene problems that arise from the plaque, research has shown that the main source of bad breath is the retention and subsequent degradation of the dead cellular material thrown continuously by the normal, healthy mouth. Modern dental hygiene and denture preparations typically contain anti-plaque and anti-tartar agents, as well as antimicrobial agents and sabotagers. The non-microbial action can affect plaque formation either by reducing the number of bacteria in the mouth / dentures or by killing such bacteria trapped in the film to prevent further growth and metabolism. The flavorings can alleviate the problem of bad breath by means of a desodopzante action. Some antimicrobial agents, for example, menthol, can serve as breath deodorants. However, the effectiveness of anti-microbial agents depends largely on their intraoral / denture retention, particularly their retention on the surface of the teeth or dentures where the plaque is formed.

A typical disadvantage of known dental preparations is that only a relatively short time during which the teeth are being cleaned or the mouth is being rinsed is available to the antimicrobial agents in the preparations to take effect. The problem is compounded by the fact that toothpaste preparations are used without frequency: most are used once, or perhaps twice a day. Therefore, the long period between brushing for a majority of the population provides optimal plaque formation conditions. Therefore, there has been a need to develop an oral formulation that has a prolonged impact effect, residual antimicrohial and / or taste. It is known to include silicones in dentifrice compositions, presumably to coat the teeth and prevent cavities and stains. For example, British Patent Application 689,679 discloses a mouth rinse containing an organopolysiloxane to prevent adhesion of, or to restore tar, stains, tartar and food particles from the teeth. Mouthwash may include antiseptic compounds, such as thymol, and flavoring or perfuming agents. The patent application of E.U.ñ. 2,805,814 describes dental preparations including, in combination, a higher aliphatic acyl amide of an aminocarboxylic acid compound as an active and a silicone compound. The patent states that silicone compounds have been proposed for the prevention of adhesion or to facilitate the removal of tar, stains, tartar and similar teeth. The ilicon compound is said to act as a smergistico to improve the antimicrobial and acid inhibitory activity of the active ingredient. It is said that dimethyl polysiloxanes are effective in particular. Saponifying and / or rnentol oils may be included. The patent application of E.U.ft. No. 3624120 discloses quaternary ammonium salts of cyclic siloxane polymers for use as cationic surfactants, bactericides and as anti-clogging agents. Accordingly, the present invention provides oral compositions having improved efficacy in plaque, mucilage and bacterial deposits. and that at the same time provides excellent cleaning performance, physical characteristics, and operating characteristics in use. The invention further provides oral compositions containing a lipophilic compound such as a sabotagent, physiological or antimicrobial freshener, and which has improved substantivity, impact and / or efficacy in teeth and dentures.

BRIEF DESCRIPTION OF THE INVENTION According to a first aspect of the invention, an oral composition is provided in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum or candy comprising one or more components of the composition orally selected from LVOS abrasives, agglutinants, humectants, surfactants, fluoride ion sources, anti-calculus agents and sweeteners and also comprising an ammoalkyl silicone having an ontf-nido of a about 0.1% to 2% in a repeating unit base. In accordance with another aspect of the invention, an oral composition is provided in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum or candy comprising a lipophilic compound selected from sabopzantes, physiological refreshing agents and antirnicrobial compounds and an ammoalkyl silicone having a moalkylsi loxane content of 0.1% to 2% on a repeating unit basis. All percentages and ratios herein are by weight of the total composition, unless otherwise indicated. The oral compositions of the invention, in this way, comprise an anti-alkyl aryl silicone anti-pial agent while the preferred compositions further comprise a lipophilic compound and / or one or more components of the oral composition selected from abrasives, binders, humectants, surfactants, fluoride ion sources, anti-calculus agents and sweeteners. Each of these will be discussed in turn. In general terms, the aminoalkyl sil ik is selected from non-cyclic hydrophobic amyl noalkyl silicones having a formula comprising two basic units: 1) (Ri) m (R) n? O (4-mn) / 2 where rrp n is 1, 2 or 3; n is 1, 2 or 3; m is 0, 1,; and 2) (Ri) a (R2) 0S? O (_i-ab) / 2 where a * -b is 1, 2 or 3, and a and b are integers, where * and R2 are independently selected from H , alkyl or alkylene of from about 1 to about 10 carbons optionally substituted with fluorine or cyano, hydroxy, alkoxy, and acetoxy groups, for example, wherein R * and R2 are independently selected from methyl, ethyl, phenyl , vimlo, tpfluoropropyl and cyanopropyl, and R is R * R * - R3-N-RS or --R3-N-RS X ". wherein R3 is a divalent alkylene of about 20, preferably of about 3 to 5 carbon atoms optionally substituted with or interrupted by 0 atoms, R *, R5 and R6 which may be the same or different are selected starting from H, alkyl of from about 1 to 20, preferably from about 10, most preferred from about 4 carbons optionally substituted or interrupted by N and / or 0 atoms, and X- is a monovalent anion such as haiuro, hydroxide, and tosylate, said aminoalkyl silicone including from 0.1% to 2%, preferably from about 0.5% to 2% unit (1) in a repeating unit base. In a preferred embodiment, the arninoalkyl silons comprise amodimethicones. The amodimethicones are polymers of pol i di and ilsi loxane containing aminoalkyl groups. The arninoalkyl groups may be present either as pendent or at one or more ends of the polydimethylsiloxane chain. Preferred are ammoalkyl silicones wherein the R-moiety of aminoalkyl is selected from (CH2) 3H2, (CH2) 3NHCH2CH2H2, (CH2) 3N (CH2CH20H) 2, (CH2) 3NH3 + X ", and (CH2) ) 3 (CH3) 2 (C? 8H37) + X ", and especially from (CH2) 3NH2 and (CH2) 3NHCH2CH2 H2. Preferred are also the molar alkyl silicones having an average molecular weight of about 5,000 and more, preferably from about 5,000 to about 100,000, most preferred from about 5,000 to about 30,000. The ammoalkyl silicone compounds suitable for use herein are well known. The methods for preparing silicones of a moalkyl are given in, for example, the patent application of E.U.fl. 2,930,809. Examples of anodirneticones include Magnasoft fluid from OSI. These polymers comprise aminoalkyl groups attached to a predominantly polydirnethylsiloxane structure. The typical structure of the units containing the arninoalkyl group of tlagnasoft is -ÜSl (Me) C3H6NHCH2CH2NH2. The ammoalkyl silicone is generally present at a level of about 0.01% to about 25%, preferably about 0.1% to about 5%, most preferably about 0.5% to about 1.5% by weight. The oral compositions of the invention also preferably include a lipophilic compound. In general terms, the lipophilic compounds suitable for use herein are oil-like materials that are soluble or can be soluble in the aminoalkyl moiety, preferably at a level of at least about 1%, more preferably at least about 5% by weight at 25 ° C. Preferred lipophilic compounds are selected from flavorings, physiological cooling agents and antimicrobial compounds. Ammoalkyl silicon acts to improve the substantivity of the lipophilic compound for teeth and / or dentures, thus providing improved and / or sustained flavor impact and antimicrobial efficacy. The lipophilic flavors suitable for use herein comprise one or more flavor components selected from pyrogenic oil, oregano oil, bay oil, peppermint oil, spearmint oil, spice clove oil, sage oil, Saffron oil, lemon oil, orange oil, anise oil, benzaldehyde oil, bitter almond oil, camphor, cedar oil, arnaraco oil, citronella oil, lavender oil, mustard oil, oil of pine, pine needles oil, rosemary oil, screw oil, cinnamon oil, and mixtures thereof. Suitable lipophilic antimicrobial compounds for use herein include thymol, rnentol, triclosan, 4-hexylresorcinol, phenol, eucalyptol, benzoic acid, benzoyl peroxide, butyl paraben, metii paraben, propyl paraben, salicylamides, and mixtures of the same. The physiological cooling agent suitable for use herein includes carbo amides, enanti esters and rnentane ethers, and mixtures thereof. Mental ethers suitable for use herein are selected from those with the formula: wherein RS is an aliphatic radical substituted by hydroxy optionally containing up to 25 carbon atoms, preferably up to 5 carbon atoms, and wherein X is hydrogen or hydroxy, such as those commercially available under the trademark Takasago, from Takasayo International Corporation . A preferred cooling agent particularly for use in the compositions of the present invention is Takasago 10 [3-1-rnentoxy propan-1,2-diol (flPT))]. MPT) is a monoglicepna derivative of 1-rnentol and has ex < The most useful carboxarnides are those described in the patent application of E.U.fl. 4,136,163, January 23, 1979 to fason et al., And the patent application of E.U.A. 4,230,688, October 28, 1980 to Rawsell et al. The level of lipophilic compound in the compositions of the invention is generally in the range of from about 0.01% to about 10%, preferably from about 0.05% to about 5%, most preferred from about 0.1% to about 3% in weigh. The compositions in the form of toothpastes, liquids and pastes for cleaning dentures and the like will generally comprise a binder or thickening agent. Suitable binders for use include polymers of carboxyvinyl, carrageenan, hydroxyethyl cellulose and water soluble salts of cellulose ethers such as carboxy ethyl cellulose sodium and carboxymethyl hydroxyethyl cellulose sodium. Natural gums such as karaya gum, xanthan gum, gum arabic and tragacanth gum can also be used. Alumina colloidal magnesium inosilicate or finely divided silica can be used as part of the thickening agent to further improve the texture .. Binders / thickening agents can be used in an amount of from about 0.1% to about 5.0%, preferably from about 0.1 to about 1% by weight of the total composition It is also desired to include some wetting material or toothpaste to prevent the composition from hardening upon exposure to air. Certain humectants may also have a desirable sweetness to the toothpaste compositions. The liquid dentifrice and mouth rinses may also contain a quantity of humectant. Suitable humectants include glycepna, sorbitol, xylitol, polyethylene glycols, propylene glycol, other edible polyhydric alcohols, and mixtures thereof. When present, humectants generally represent from about 10% to about 70% by weight of the compositions of the invention. Toothpastes, liquid dentifrices and denture cleaners in liquid or paste form will generally comprise an abrasive polishing material. The abrasive polishing material contemplated for use herein may be any material that does not excessively abrade dentin or denture acrylic. These include, for example, silicas including xerogels, idrogels, aerogels and precipitates, calcium and magnesium carbonates, ortho-, pyro-, meta- and calcium polyphosphates such as ortho- or dicalcium dihydrate, calcium pyrophosphate, phosphate calcium, calcium phosphate, sodium phosphate, soluble alumina, and hydrates thereof, such as alpha alumina hydroxide, aluminosilicates such as calcined aluminum silicate and aluminum silicate, magnesium silicates and zircomo such as tpsilicate of magnesium and polyacrypted reams tepnofi as talos as condensation products of urea particle and formal dehí or, pol-nililrnetacplato, polietiieno powder and others as described in the US patent application 3,070,510, December 25, 1962. Mixtures of abrasives can also be used. Abrasive polishing materials generally have an average particle size of about 0.1 to about 30 microns, preferably about 5 to 15 microns. Silica dental abrasives of various types offer outstanding dental performance cleaner and sm polish improperly scrape the enamel or dentin from the teeth. The silica abrasive can be silica or precipitated silica gels such as the silica xerogels described in Pader and others., patent application of E.U.A. 3,538,230, issued March 2, 1970 and DiGiulio, patent application of E.U.A. 3,862,307, June 21, 1975, for example, silica xerogels manufactured under the trademark "Syloid" by U. R. Grace 8 Company, Davison Chemical Division. Suitable precipitated silica materials include those manufactured by 1. 1 * 1. Huber Corporation under the registered trademark "Zeodent", in particular the silica bearing the designation "Zeodent 119". These silica abrasives are described in the patent application of E.U.A. 4,340,583, July 29, 1982. Calcium carbonate abrasives are particularly preferred herein from a viewpoint to provide good cleaning performance with excellent comp ability with the anti-piaca agent. The abrasive is generally present in the dentifrice formulations of the invention at a level of from about 10% to about 70%, preferably from about 15% to about 25% by weight. The present compositions may also contain surfactants. Suitable surfactants are those which are reasonably stable and foamed through a wide pH range, including organic synthetic detergents, ammonium, nonionic, cationic, zwitterionic and amphoteric without soap. Many of these suitable agents are described by Gieske et al. In the patent application of E.U.A. 4,051,234, September 27, 1977. Examples of suitable surfactants include alkyl sulfates; condensation products of ethylene oxide with fatty acids, fatty alcohols, fatty amides, polyhydric alcohols (for example, sorbitol monoetherate, sorbitan oleate), alkylphenols (for example, Tergitol) and polypropylene oxide or filled poly loxibu (for example , Pluronics); amine oxides such as dimethyl ammonium oxide, dimethyl L1 amine oxide, and cocoalkyldirne amine oxide (Ar * ornox); polysorbates such as T een 40 and Tween 80 (Hercules); sorbitan stearates, sorbitan monoalleate, etc; sarcosinates such as sodium cocoilsarcosmate, sodium roilsarcosinate (Hamposyl-95 ex L. R. Graee); cationic surfactants such as cetyl pyridinium chloride, priamyl or cetiium bromide, di-isobutyl phenoxy ethoxyethyl di-methanediyl chloride and coconut alkyl tpmeti nitrate lamomo. A suitable fluoride ion source can also be incorporated into the present compositions. The suitable fluoride ion source is used in sufficient amounts to provide from about 50 to about 3500 pprn of the fluoride ion. Preferred fluorides are sodium fluoride, stannous fluoride, indium fluoride, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride and sodium monofluorophosphate. Norps et al., Patent application of E.U.A. 2,946,735, issued July 26, 1960 and Uidder et al., Patent application of E.U.A. 3,678,154, issued July 18, 1972, describe such salts as well as others. The present compositions may also include an anti-calculus agent. Suitable anti-calculus agents include di- and tetra-alkali metal pyrophosphates as set forth in European patent application 097476. Specific salts include tetraalkali metal pyrophosphate, dialkali metal diacid pyrophosphate, talocalcium metal nonacid pyrophosphate. and nezcLas of the misinos, where the alkaline metals are sodium or potassium. The salts are useful both in their hydrated and non-hydrated forms. The amount of pyrophosphate salt useful in these compositions is any effective amount and is generally sufficient to provide in the composition at least 1.0% P2O7"" 4, preferably from about 1.5% to about 10%, most preferred of about 3% to about 6% by weight of the composition. Pyrophosphate salts are described in more detail in Kirk S Othrner, Encyclopedia of Chemical Technology, second edition, volume 15, Interscience Publishers (1968). Other anti-calculus agents suitable for use herein are the zinc salts. The zinc salts are described in the patent application of E.U.A. 4,100,269, patent application of E.U.A. 4,416,867, patent application of E.U.A. 4,425,325, and patent application of E.U.A. 4,339,432. A preferred agent of the zinc variety is zinc citrate. The zinc compounds may be present in amounts sufficient to provide from about 0.01% to about 4%, preferably from about 0.05% to about 1% by weight of zinc ion. Other suitable anti-calculus agents include synthetic ammonium polymers (including polyacrylates and copolymers of maleic anhydride or acid and methylvinyl ether (eg, Gantrez) as described in US patent application 4,627,977, polyarnide sulfo acid propane, polyphosphates (eg, tripoli phosphate, hexametaphosphate), di phosphonates (eg, EHDP, AHP), polypeptides (eg, polyaspartic and polyglutaric acids), and mixtures thereof. present include aspirin, acosulfarne, saccharin, dexose, levulose and sodium cyclamate.The sweetening agents are generally used at levels from about 0.005% to about 2% by weight of the composition.Other optional components to be used in present include water-soluble antibacterial agents, such as chlorhexidine co-digluconate, quaternary ammonium antibacterial compounds and soluble sources in of certain metal ions such as zinc, copper, silver and tin (for example, zinc chloride, copper and tin, and silver nitrate); pigments such as titanium dioxide; Tints / colors are orally acceptable such as FDSC blue #L, FDRC yellow # 10, FDSC red # 40; antioxidants, vitamins such as vitamin C and E, other anti-plaque agents such as stannous salts, copper salts, strontium salts and salts (eg magnesium, pH adjusting agents, anti-caries agents such as urea, calcium glycerophosphate, Sodium trinetaphosphate, plant extracts, desensitizing agents for sensitive teeth such as potassium nitrate and potassium citrate, and mixtures thereof Typically, mouth rinses comprise a water / alcohol solution, flavor, humectant, sweetener, foaming agent, and colorant as described above Mouthwashes may include ethanol at a level of 0 to 60%, preferably 5 to 30% by weight The denture cleaning compositions of the invention may also include one or more agents bleaches, organic peroxyacid precursors, effervescence generators, chelating agents, etc. The bleaching agent takes the form of an inorganic salt * and can be selected or from any well-known bleaching agent for use in cleaners (dentures such as persulfates, perborates, percarbonates and ammonium and alkali metal perfosphates, and alkaline metal peroxides and at calcareous. Examples of suitable bleaching agents include persulfates of potassium, ammonium, sodium and lithium and mono and tetrahydrates of perborate, sodium pyrophosphate peroxyhydrate and magnesium, calcium, strontium and zinc peroxides. However, of these, the persulfates, alkali metal perborates and mixtures thereof are preferred for use herein, with alkali metal perborates being highly preferred. In fact, a feature of the invention is that the tablet compositions herein will provide excellent antimicrobial activity even in the absence of IB persul ats of alkali metal. The amount of bleaching agent in the total composition is generally from about 5 to about 70%, preferably from about 10% to about 50%. In the compositions comprising a mixture of alkali metal persulphates and perborates, the total ratio of per-sulfate to perborate is suitably from about 5: 1 to about 1: 5, more especially about 2: 1. Approximately 1: 2. The compositions for cleaning dentures can also incorporate a effervescence generator, that is to say a material that in the presence of water releases carbon dioxide or oxygen with effervescence. The effervescence generator can be selected from generators that are effective under acid, neutral or alkaline pH conditions, but preferably consists of a combination of a generator that is effective or more effective under acidic or neutral pH conditions and a generator that is effective or more effective under alkaline pH conditions. Effervescence generators that are effective under acidic or neutral pH conditions include a combination of at least one alkali metal carbonate or bicarbonate, such as sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, potassium carbonate, sodium bicarbonate, potassium, or mixtures thereof, in admixture with at least one non-toxic, physiologically acceptable organic acid such as tartaric, fumaric, citric, rnálico, maleic, glucocortico, succimco, salicylic, Jidipico or its phallic, sodium fumarate , sodium or potassium acid phosphates, betaine hydrochloride or mixtures thereof. Of these, preferred is rnálico acid. Effervescence generators that are effective under alkaline pH conditions include persalts such as alkali metal peroxyborates and heat-exchange as well as perborates, persulfates, percarbonates, perfosphates and mixtures thereof as previously described, eg, a mixture of an alkali metal perborate (anhydrous, mono- or tetrahydrate) with a rnonopersulfato such as Caroat® manufactured by ET du Point de Nernours Co "and which is a mixture of 2: 1: 1 of onopersulfate, potassium sulfate and bisulfate of potassium and that have an active oxygen content of about 4.5%. In the preferred denture cleanser compositions in tablet form, the effervescence generator takes the form of a solid base material which in the presence of water releases carbon dioxide or oxygen with effervescence. Suitably, the solid base material incorporates an effervescent pair of (bi) carbonate / acid optionally in combination with a perborate / persulfato oxygen effervescence generator. The combination of generators is valuable to obtain optimal dissolution characteristics and pH conditions to obtain optimal cleaning and antirrnicrobial activity. The (bi) carbonate components generally comprise from about 5% to about 65%, preferably from about 25% to 55% of the total composition; the acid components generally comprise from about 5% to about 50%, preferably from about 10% to about 30% of the total composition. The denture cleaning compositions of the invention may be supplemented by other known components of said formulations. An additional component especially pronounced is an organic peroxyacid precursor, which in general terms can be defined as a compound having a titer of at least 1.5 ml of 0.1N sodium thiosulfate in the following peracid formation test. A test solution is prepared by dissolving the following materials in 1000 ml of distilled water. sodium pyrophosphate (Na4P2? 7-10H20) 2.5 g sodium perborate (NaBO2.H2O2.3H2O) having 10.4% available oxygen 0.615 g sodium dodecylbenzenesulfonate 0.5 g A quantity of activator is added to this solution at 60 ° C., so that a molar equivalent of activator is introduced for each available oxygen atom present. The mixture obtained by the addition of the activator is vigorously stirred and maintained at 60 ° C. After 5 minutes of the addition, a portion of 100 ml of the solution is removed and pipetted immediately into a mixture of 250 g of cracked ice and 15 ml of glacial acetic acid, then potassium iodide (0.4 g) is added and the liberated iodide is titrated immediately with 0.1N of sodium thiosulfate with starch as indicator until the first disappearance of the blue color.The amount of the sodium thiosulfate solution used in me is the title of the bleach activator. organic compounds are compounds that typically contain one or more acyl groups, which are susceptible to perhydrolylism.The preferred activators are those of the N-acyl or 0-acyl compound type containing an acyl radical R-CO wherein R is a hydrocarbon or a substituted hydrocarbon group preferably having from about 1 to about 20 carbon atoms Examples of suitable acid precursors include: RCONR1R2, wherein RCO is carboxylic acyl radical, Ri is an acyl radical and R2 is an organic radical, as described in the patent application of E.U.A. 3,117,148. Examples of compounds that fall within this group include: a) N, N-diaceti.aniline and N-acetyl phthalimide; b) N-acylhydantoins, such as N, N'-diacet.i l-5, 5-dimethylhydantoin; c) polyacrylated alkylene diarynins, such as N, N, N, N'-te raacetylethylenediamine (TAED) and the corresponding derivatives of hexamethylenediamine (TAHD), as described in Great Britain patent application 907,356, Great Britain patent application 907,357, and Gran patent application Brittany 907,358; d) gli colunia aci sides, such as tetraacet i lglicolup 1, as described in the application "the Great Britain Patent 1,246,338, Great Britain Patent Application 1,246,339 and Great Britain Patent Application 1,247,429. ) Sulfonamides to the Jas, such as sulfonamide of N-rnet-lN-benzoyl-methane and sulphonamide, which is described in the Gran patent application. Britain 3,183,266. ) Carboxylic esters as described in British patent application 836,988, application "He Great Britain patent 963,135 and Great Britain patent application 1,147,871. Examples of compounds of this type include phenylacetate, sodium acetoxybenzenesulfanate, t-chloroethiacetate, sorbitol hexaacetate, fructose pentaacetate, diacrylate, p-nitrobenzaldehyde, isopropemium acetate, acetylhydroxarnic acid acetyl, and acetyl salicylic acid. Other examples are esters of a phenol or phenol substituted with an aliphatic carboxylic acid lower than the chlorinated one, such as chloroacetyl phenol and chloracetic acid, as described in the patent application of E.U.A. 3,130,165. Carboxylic esters having the general formula Ac L wherein Ac is the acyl portion of an organic carboxylic acid comprising an optionally substituted straight or branched alkyl or alkenyl portion "Je Ce -C20" or a substituted aryl portion "Je alkyl" Je Cß ~ C20 and L is a leaving group, the conjugate acid of which has a pKa on a scale of 4 to 13, for example oxibenzenesulfonate or oxybenzoate. Preferred compounds of this type are those in which: a) Ac is R 3 -CO and R 3 is a linear or branched alkyl group "containing 6 to 20, preferably 6 to 12, most preferably 7 to 9 carbon atoms and wherein the longer linear alkyl chain extending from and including the carbonyl carbon contains from 5 to 18, preferably 5 to 10 carbon atoms, R3 is optionally substituted (preferably alpha to the carbonyl moiety) ) by Cl, Br, 0CH3 or OC2HS. Examples of this class of material include 3,5,5-tr? Methexano? Lox? Sodium benzenesulfonate, 3,5,5-tpmet? Lhexane? Lox? Sodium benzoate, 2-and ilehxanoi sodium loxibenzenesulfonate, nonanoyloxy sodium benzenesulfonate and octanol loxibencenesulfanate sodium, the acyloxy group in each case being p-substu bute preferably; b) Ac has the formula R3 (A0) mXA wherein R3 is a linear or branched alkyl or alkyl group containing from 6 to 20, preferably from 6 to 15 carbon atoms in the alkyl portion, R & being optionally substituted by Cl, Br, OCH3, or OC2H5, AO is oxyethylene or oxypropylene, rn is from 0 to 100, X is 0, NR «jo CO-NR4 and A is CO, CO-CO, Rfi ~ CO, C0 -R6-C0, or CO-NR4-R6-CO wherein R4 is alkyl "Je Ci -C" and is alkylene, alkenylene, arylene or alkylene containing from the 8 carbon atoms in the alkylene or alkenylene portion. Bleach activator compounds of this type include carbonic acid derivatives of the formula R3 (AO) m0C0L, "Succinate acid derivatives of the formula R3? CO (CH2) 2? OL, glycolic acid derivatives of the formula R3OCH2COL , derivatives of hydroxy propionic acid of the formula R3 OCH2 CH2 COL, oxalic acid derivatives of the formula R3OCOCOL, derivatives of rnaleic acid and fu of the formula R3? COCH = CHCOL, derivatives of acylaminocaproic acid R3CONR1 (CH2) ßC0L, acyl glycine derivatives of the formula R3CONR1CH2COL, and derivatives of animo-6-oxocaproic acid with the formula R3N (R?) C0 (CH2 UCOL.) In the foregoing, m is preferably 0 to 10, and R3 is preferably to the "C6-C12 jule, more preferably Ce-Cio when rn is zero and C-C15 when it is not zero.The leaving group I is co or defined before. ) Acyl-cyanurates, such as co-triacetii- or tp benzoylcyanurates, as described in The US Patent Specification No. 3,332,882. h) Optional anhydrides substitutes for benzoic or phthalic acid, for example, benzoic anhydride, m-chlorobenzoic anhydride and phthalic anhydride. Of all the above, preferred are the organic peracid precursors of types l (c) and 4 (a). When present, the level of peroxyacid bleach precursor by weight of the total composition is preferably from about 0.1% to about 10%, more preferably from about 0.5% to about 5% and is usually added in the form «Je un agglomera« Precursor Jo «He bleaching. Preferred bleach precursor agglomerates for use herein generally comprise a binder or agglomerating agent at a level of from about 5% to about 40%, more especially from about 10% to about 30%. % in weight of them. Suitable agglomerating agents include polyvinylpyrrolidone, polyol, molecular weight from 20,000 to 500,000, polyethylene glycols, molecular weight from about 1,000 to approximately 50,000, Carhowax having a molecular weight. from 4000 to 20,000, non-ionic surfactants, fatty acids, carboxypropylene cell, sodium, gelatin, fatty alcohols, phosphates and polyphosphates, clays, aluminosilicates and polycarboxylates. Of the above, polyethylene glycols are highly preferred, especially those having a molecular weight of from about 1,000 to about 30,000, preferably from 2,000 to about 10,000. The "precursor bleach agglomerates are preferred from a point". The view is given to dissolution and optimum ph characteristics, which comprise about 10% to about 75%, preferably from about 20% to about 60% by weight thereof of peroxyacid bleach precursor, from about 5% to about 60%, preferably from about "5% to about 50%, most preferably around" 10% to 10% by weight < It is often 40% of an effervescent pair of (bi) carbonate / acid, from about 0% to about 20% of a peroxoboroate, and from the "Jor" range from 5% to about 40%, preferably from about 10%. % to about 30% of an agglomerating agent. The final granules of the bleach precursor desirably have an average particle size of from about 500 to about 1500, preferably from about 500 to about 1,000 jj, this being valuable from an optimal dissolution, performance and aesthetics standpoint. ,. The level of bleach precursor agglomerates is also preferably from about 1% to about 20%, more preferably from about 5% to about 15% by weight of the composition. Denture cleaning compositions of the invention may be in the form of a paste, tablet, granule or powder, although tablet compositions are highly preferred herein. The compositions in tablet form can be single or multiple stratified tablets. The compositions for cleaning dentitions of the invention can be supplemented by other usual components of said formulations, especially surfactants, chelating agents, enzymes, sabopzantes, physiological refreshing agents, antirnicrobial.es compounds, coloring articles, sweeteners, binders and tablet fillers. , depressants "Such foams such as dimethylpolieiloxanes, foam stabilizers such as fatty acid sugar esters, preserves" Jores, lubricants such as talc, magnesium stearate, finely divided amorphous pyrogenic silicas, etc. The final moisture content of the final composition is desirably less than about 1% and especially less than about 0.5%. The binders and fillers suitable for use herein include polyvinylpyrrolidone, polydeoxyethylene, of molecular weight from 20,000 to 500,000, molecular polyethylene glycols ranging from about 1,000 to about 50,000, Carbowax having a weight molecular- from 4000 to 20,000, non-ionic surfactants, fatty acids, sodium carboxymethylcellulose, gelatin, fatty alcohols, clays, polycarboxylates, sodium carbonate, calcium carbonate, calcium hydroxide, magnesium oxide, carbonate magnesium hydroxide, sodium sulfate, proteins, cellulose ethers, cellulose esters, ivory alcohol, esters of algid acid, vegetable fatty materials of a pseudocolloidal character. Of the above, polyethylene glycols are highly preferred, especially those having a molecular weight of from about 1,000 to about 30,000, preferably from 12,000 to about 30,000. The surfactant used in the denture cleaning compositions of the invention can be selected from the many available which are compatible with other denture cleansing ingredients, both in the dry state and in solution. It is believed that said materials improve the efficacy of the other ingredients of the composition, and their penetration into the interdental surfaces. Also, these materials help in the removal of food waste fixed to the teeth. Between 0.1 and 5 weight percent of the dry composition of an ammonium surfactant in dried or granulated powder, such as sodium lauryl sulfate, N-lauroi 1 sarcosm or sodium, sodium lauryl sulphoacetate or sodium dioctyl sulfosuccinate or sulfosuccinate of sodium ricinoleyl, can, for example, be included in the composition and preferably the surfactant comprises between 0.5 and 4 percent of the composition. Suitable cationic, nonionic and ampholytic surfactants include, for example, quaternary ammonium compounds such as cetyl bromide prnet and larnome, condensation products of alkylene oxides such as ethylene or propylene oxide with fatty alcohols, phenols, fatty amines or fatty acid alkanolamides, the fatty acid alkanolanides themselves, fatty esters of long chain fatty acids (C8-C22) with polyalcohols or sugars, for example glycerophanone this time or saccharosamonolaur or sorbitolpolyoxietienienone or di-stearate , bet ai ñas, sulfobetaínas or long chain alkylaminocarboxylic acids. The chelating agents help in the cleaning and bleaching stability by keeping in solution metallic ions, such as calcium, magnesium and heavy metal cations. Examples of suitable chelating agents include sodium tppoli phosphate, sodium acid pyrophosphate, pyrophos or tetrasodium, arninopolicarboxylates such as nitrophacytic acid and tetracetic acid of eti lendiarnin and salts thereof, and polyphosphonates and aminopolyphosphonates such such as hydroxyethanediphosphate acid, rarnetilene phosphonic acid of eti lendiamma, acid rianinpentaphosphonic acid and salts thereof. The selected chelating agent is not critical except that "It must be compatible with other ingredients of the denture cleanser when it is in the dry state and in aqueous solution. Advantageously, the chelating agent comprises between 0.1 and 60 weight percent of the composition and preferably between 0.5 and 30 percent. However, the acid or phosphonic chelating agents comprise "Preference of around".Jedor from 0.1 to about 1 percent, preferably from about 0.1% to about 0.5% by weight of the composition. Examples suitable for use herein are exemplified by proteases, alkases, amylases, lipases, dextranaees, mutanases, glucanase, etc. The following examples describe "Jemas and" Show the preferred embodiments within the scope of the present invention.

EXAMPLES I TO V The following are tablets for cleaning representative dentures in accordance with the invention. The percentages are by weight of the total tablet. The tablets are made by compressing a mixture of the granulated components in a press to form a die tablet and given at a pressure of about 10 * * PA. II III TV Aci or ico 12 10 15 - 14 Citric acid - 10 - 15 - Sodium carbonate 10 8 10 6 10 Sulfamic acid 5 - - 3 3 PEG 20,000 - 3 7 8 5 PVP 40,000 6 3 - _ - Sodium bicarbonate 22 25.2 25 1 .9 23 Monohydrate «le perborato de sodio 1 155 12 16 30 15 Potassium monopiersulfate 15 18 13 - 14 Pyrogenic silica - 0.3 0.1 0.1.

Such co EDTA EDTMPl 1 - - 1 - Taste * 2 1 2 1 2 Magnasal Fluid t * 1 1.5 5 10 l Agglomerate «Jo of bleaching precursor 9 8 10 12 10 Agglomerate of precursor I II III IV IV bleaching TAED2 2.5 TMH0S3 2 3 - - - Sulfamic acid 2 2 2 2 3.5 Sodium bicarbonate 0.5 0.2 0.2 0.5 2 PEG 6000 2.5 2 2.4 2.5 1.5 Colorant - 0.8 1.4 2 0.5 L. Acid etiiendianintetrarnetiienofosfóco 2. Tetraacet i let ilendiarnina 3. 3, 5,5- tnmetilhexanoi loxi benzenesulon sodium 4. FIUKJO Magnasoft - provided by- OST 5. Mint based flavor In the examples I to V above, the total tablet weight is 3 g; diameter «Je 25 mm. The denture cleaning tablets of Examples E to V show improved anti-plaque, cleansing and antibacterial activity together with cohesion and other excellent physical and operational characteristics in use.

EXAMPLES VI TO VIII The following are toothpastes / pastes for cleaning representative dentures according to the invention. The percentages are by weight of the total composition.

VI VII VIII Calcium carbonate 20 25 15 Glicepna 10 12 8 Sodium CMC 3.5 3 4 Titanium dioxide 0.7 0.5 0.6 Metii / propyl parabens 0.1 0.1 0.1 Saccharin "Je sodium 0.3 0.4 0.2 Flavor * 1 Magnificent 4 1.5 0.5 Triclosan 0.5 Water ALO The denture toothpastes / toothpastes of Examples VI to VII show anti-plaque, taste impact and antibacterial activity together with excellent cleaning characteristics.

Claims (11)

NOVELTY OF THE INVENTION CLAIMS

1. An oral composition in the form of a toothpaste, powder, liquid dentifrice, mouthwash, denture cleanser, chewing gum or candy comprising one or more of the components of the oral composition selected from abrasives, binders, Moisturizers, surfactants, ions of fluoride ions, anti-scalp agents and sweeteners, and further comprises an amino-alkyl amino acid having an arninoalkylsiloxane content of about 0.1% to 2% on a repeat unit.

2. A composition according to claim 1, further characterized in that the aninoalkyl silicone is a hydrophobic, non-cyclic non-alkyl silicone having a formula comprising "the basic units: 1) (R1) (R ) n Si0 (4-mn) / 2 in don «Je rn + n is 1, 2 or 3; n is 1, 2 or 3; m is 0, 1, 2; and 2) (R1) »(2 h SiO (4-ab) / 2 in don« Je a + b is 1, 2 or 3, and a and b are integers, in which «Je Ri and R2 are independently selected from H , alkyl and alkenyl from about 1 to about 10 carbons optionally substituted with fluoro or cyano, hydroxy, alkoxy, and acetoxy groups, and R is R 4 R 4 -R 3 -N-R 5 or -R 3 -N-RS X ~ R « wherein R3 is a divalent alkylene of about 1 to 20 carbon atoms optionally substituted or interrupted by 0 atoms, R, R5 and R6 which may be the same or different are selected from H, alkyl of from about 1 to 20 optionally substituted carbons included or interrupted by N and / or 0 atoms, and X- is a monovalent anion, said sil.i with arninoalkyl include "Jo of about 0.1% to 2%" Je unit (1) on a base of unit «Je repetition.

3. A composition according to claim 2, further characterized in that the aminoalkyl silicone has a molecular weight of at least about 5,000.

4. A composition according to claim 3, further characterized in that the aminoalkyl silicone has a molecular weight of about 5000 to about 100,000.

5. A composition according to claim 1, further characterized in that it comprises from about 0.01% to about 25% by weight of the aminoalkyl silicone.

6. A composition according to claim 5, further characterized in that it comprises from about 0.1% to about 5% by weight of the arninoalkyl silicone.

7. A composition according to claim 1, further characterized in that it comprises from about 10% to about 70% by weight of a dental LVO opening selected from silica, alumina, alurninosilicates, magnesium silicates and zirconium , ortho-, pyro-, meta- and polyphos- phates of calcium, calcium and magnesium carbonates, insoluble meta- phosphates and thermophilic polymerized resins.

8. A composition according to claim 1, further characterized in that it comprises an amount of fluoride ion source sufficient to provide from 50 ppm to 3500 ppm of fluoride ions.

9. A composition according to claim 1, further characterized in that it comprises from about 0.1% to about 1% by weight of an agglutin.

10. Use of a silicone compound in the preparation of an oral anti-pineapple composition, wherein the aminoalkyl silicone has an aminoalkylsiloxane content between about 0.1% and 2% on a unit basis. of repetition.

11. Use according to claim 10, further characterized in that the oral copofunction obtained is a composition for cleaning dentures.