MXPA96005407A

MXPA96005407A - Movie extruded from a mix eco decopolimeros

Info

Publication number: MXPA96005407A
Application number: MXPA/A/1996/005407A
Authority: MX
Inventors: James Michie William Jr; H Moy Francis
Original assignee: Union Carbide Chemicals & Plastics Technology Corporation
Priority date: 1995-11-07
Filing date: 1996-11-06
Publication date: 1998-07-03

Abstract

The present invention relates to a film, which has been extruded to a caliber within the range of about .0127 mm (0.5 mils) to about .1524 mm (6 mils) comprising a mixture of (i) a linear low density polyethylene having a melt index within the range of about 0.3 to about 3 grams per 10 minutes and a density within the range of 0.900 to about 0.940 gram per cubic centimeter, and (ii) a multimodal resin that consists of an in situ blend of polymers of ethylene and one or more alpha-olefins having from 3 to 8 carbon atoms, the resin having a flow index in the range of about 40 to about 150 grams per 10 minutes; of melting on the scale from about 50 to about 150, a ratio of Mw / Mn from about 8 to about 22, and a density within the range of 0.908 to 0.930 grams per cent. cubic meter, where (a) the weight ratio of component (i) to component (ii) is within the range of approximately 1: 1 to approximately 3: 1; (b) the mixture has been extruded, under conditions of extrusion, at a matrix regime within the range of about 1.4 to about 2.7 kilograms per hour per centimeter of matrix circumference and a matrix space within the range of about 0.889 to 1.27 millimeters (0.035 to 0.050 inches); (c) the film essentially exhibits no melt fracture, component (ii) has been produced without situ contacting ethylene and one or more alpha-olefins with a magnesium / titanium based catalyst system in each of two reactors connected in series, under polymerization conditions, wherein the relatively high molecular weight polymer formed in a reactor has a flow index within the range of about 0.2 to about 6 grams per 10 minutes and a density within the range of about 0.900 to about 0.940 grams per cubic centimeter, and the relatively low molecular weight polymer formed in the other reactor has a melt index within the range of about 100 to about 1500 grams per 10 minutes, and a density within the range of about 0.905 to about 0.970 grams per cubic centimeter, the weight ratio of the high molecular weight polymer to the low molecular weight polymer is within the range of about 0.67: 1 to about 1.5

Description

MIXTURES OF ABSORBABLE POLIOXAESTERES CONTAINING AMINO AND / OR AMIDO GROUPS FIELD OF THE INVENTION The present invention is a contiguous part of serial number 08 / 554,011, filed on November, 1955, which is an on + inuation in part of serial number 08 / 199,308, filed by Man: o of 1095 , now US No. 5,464,929 (all incorporated herein by reference) and refers to poloxaesters containing amines and / or arnide groups and mixtures thereof with other polymers and more particularly to surgical products made from polyoxaesters containing amines and / or filler groups and mixtures thereof with other polymers.

BACKGROUND OF THE INVENTION Since the first work of Carothers in the decade of the 20s and 30s, the aromatic polyester, especially polyethylene terephthalate, has become the most important polyesters as well. The usefulness of these polymers is intimately linked to the hardening action of the polyethylene. μ-phenylene group in the polymer chain. The presence of the p-temleno group in the base structure of the polymer chain leads to high melting points and good mechanical properties especially for fibers, films and some molded products. In fact, polyethylene terephthalate has become the polymer of choice for many common consumer products, such as one or two two-liter soda containers. Different related polyester reams have been described in US Pat. Nos. 4,440.92 ?, 4,552,948 and 4,963,641, which seek to improve the properties of filled polyethylene terephthalate by replenishing the erephthalic acid with other related dicarboxylic acids containing phenylene groups. These polymers are generally designed to reduce the gas permeability of aromatic polyesters. Other aromatic poly esters have also been developed for special applications such as stable bioabsorbable radiation materials. The bonds are North American,, 5 0,295, 4,546,15? and 4,689,424 describe stable aromatic radiation polyesters that can be used to make sutures and the like. These polymers, such as polyethylene terephthalate, have phenylene groups in the base structure of the polymers. However, less research has been recorded in alkylated polyesters. After Carother's first work on polyesters, aliphatic polyesters were generally ignored because these materials were believed to have low melting points and high solubilities. The only aliphatic polyesters that have been esively studied are polylactones, such as polylactide, polyol, poly (p-dioxanone), and polycaprolactone. These polylactones have been used primarily for bioabsorbable surgical sutures and surgical devices such as staples, despite the fact that polylactones have proven useful in many applications, do not meet all the needs of the medical community. For example, polylactone films do not transmit water vapor, therefore, they are not ideally suited for use as bandages in which the transmission of water vapor should be desired.It has only recently been renewed in aliphatic polyesters without lactone. US Pat. No. 5,349,028 discloses the formation of very simple aliphatic polyesters based on the reaction of a diol with a di-carboxylic acid to form prepolymer chains which are then coupled in. These polyesters have been promoted for use in fibers and molded articles since that these poly est are biodegradable after they are buried as on land. These materials are not described as being suitable for use in surgical devices. Thus, an object of the present invention is to provide a new class of aliphatic polyesters and mixtures thereof which may be used in surgical devices such as sutures, molded devices, drug surgeries, reversals, lubricants and the like. .

BRIEF DESCRIPTION OF THE INVENTION A new class of synthetic polymer materials and mixtures thereof have been discovered which can be used to produce surgical devices such as sutures, sutures with added needles, molded devices, drug assortment matrices, coatings, lubricants and the like. The invention also contemplates a process for producing the polymers and mixtures thereof. The polyoxaesters to the facists of the present invention are a polyester comprising a first bivalent repeating unit of the formula T: r? -C (0) -C (R?) (R2) -0- (F3) -0- (R?) (R2) -C (0) -1 E and a second repeating unit selected from the group of formulas consisting of: and optionally a third repeat unit with a formula selected from the group consisting of: ro-Rs -c (o) -] B r? t (CO-RI3-C (O? PO) LG XT and com taminations thereof, wherein Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms, R3 is an alkylene unit containing from 2 to 12 carbon atoms or is an oxyalkylene group of the following formula: -r (CH2) C-0-1D- (CH2) E - rv where C is an integer on the scale of 2 to about b, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero in which case E will be an integer from 0 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and contains an internal amine (-N (R? O) -) or amide (-N (Rn) -); Rio and R11 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; A and U are independently integers on the scale of 1 to about 2,000 and preferably independently on the scale of 1 to about 1000; R12 is an alkylene unit containing of? to 8 carbon atoms; R5 and R13 are independently selected from the group consisting of -C (Rβ) (R7) -, - (CH2 > 3-0-, -CH2-CH2-O-CH2-, CRβH-CH2-, - (CH2 -, - (CH2) F -0-C (0) - and - (CH2)? ~ C (0) -CH2-; Re V R7 are independently hydrogen or an alkyl containing from 1 to 8 volumes of carbon, Rs is hydrogen or me + ilo, F- "and K are integers on the scale of 2 to ñ; B is an integer on the scale of 1 an so that the average number molecular weight of the formula TTT is lower - about 200,000; P is an integer on the 1 am scale so that the molecular weight of the formula XT is less than about 1,000,000; G represents the residue minus 1 to L hydrogen atoms of the hydroxyl group of a alcohol that previously contains from 1 to about 200 hydroxyl groups, and L is an integer from about 1 to about 200.

DETAILED DESCRIPTION OF THE INVENTION The aliphatic polyoxaesters of the present invention are the reaction product of an aliphatic polyalkylcarboxylic acid IOX and at least one of the following compounds: a diol (or polydiol), a lactone (or lactone buffer), a coupling agent or combination of the aliphatic alpha-oxycarboxylic acids suitable for use in the present invention generally have the following formula: HO -C (0) -C (R?) (R2) -0- (R3) -0-C, (R?) (R2) -C (0) ~ 0H V wherein Ri and R2 are independently selected from the group consisting of hydrogen or an alkyl group that co t Lene of 1 to 8 carbon atoms and R3 is a lqullene containing from 2 to 12 carbon atoms or is a group of oxyalkylene of the following formula: [(CH2) c-0 -] - D (CH2) E- IV where C is an integer in the scale of about 2 to about 5, D is an integer on the scale of about 0 to about 2,000 and preferably about 0 to about 12, and E is an integer in the scale of about 2 to about 5. These alpha-oxycarboxylic acids may be formed by reacting a diol or polydiol containing an internal amine or internal knot with an ac to the halocarboxylic acid such as anhydride. or acid brornoaoet 1 co or chloroacetic acid under suitable conditions. Suitable amine and amide containing diols or poly-diols to be used in the present invention are diol ion or diol repeat units with up to 8 carbon atoms having the formula: wherein R12 is an alkylene unit containing from 2 to 8 ethylene units and containing an internal amine (-N (R? o) -) or amide (-N (Rn) -); R or V Ri 1 are independently hydrogen or an alkyl group containing from 1 to 0 carbon atoms; U is an integer in the scale from 1 to approximately 2,000 and preferably from 1 to 1000. Suitable arm and knot examples containing diols include diethanol amine and acetarnide from? -h? DROXY-N- (2-Hydroxyethyl) »The poloxaester may additionally contain * diols or poly diols for use in 1A present invention are diol or diol repeating units with up to 8 carbon atoms having the formulas: HC - (0-R4 ~) A] 0II, VT where R4 is an alkylene unit containing from? to 8 full met units; A is an integer in the range of about 2,000 and preferably from 1 to about 1000. Examples of suitable diols include diols selected from the group consisting of (ethylene glycol) of 1, 2, etaned? Ol, (polypropylene glycol) of 1,2-propanediol, 1, -propanediol, 1,4-butanediol, 1,5-pentanedione, 1-cyclopentanediol, 1,6-hexanediol, 1,4-cyclohexanediol, 1, 8-octanediol and combinations thereof. Examples of preferred polyols include polycides selected from the group consisting of (HC-0-CH2-OH2-) AOH,) of polyethylene glycol and (HC-0-CH2-CH- (OH3) -IAOH,) g polypropylene cabbage. The polymer produced by reacting the aliphatic dioxycarboxylic acid with the diols described above must provide a polymer which generally has the formula: [-O-C (O) -CÍRI) (R2) -0- (R3) -0-C (R?) (R2) -C (0) - (0 -R12) u - ^ M Vfl wherein Ri, R2, R3, R12 V are as described above; and N is an integer in the range of about 1 to about 10,000 and preferably is in the range of about 10 to about 1,000 and most preferred in the range of 50 to about 200. Suitable Lactone Monomers that can be used herein invention usually have the formula.

-O-Rs-C (O) - VTII These lactone monomers (or equivalent acids, if any) can be polypeptized to provide polymers of the following general structures: HC-0-R3-C (0) -] BOH IX (H [-0-Ri3-C (0)] p-0 -) - | _G X wherein R5 and R13 are independently selected from the group consisting of -C (Rβ) (R7) -, - (CH2) 3 ~ 0--, -CH2-CII2-O-CH2-, -CR8H-CH2 -, - (CH2 -, -ÍCH2) F-0-C (0) ~ and - (CH2)? -C (0) -CH2-; Re and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; Re is hydrogen or methyl; F and K are integers of? ñ; B one integer on the scale of L an so that the average number molecular weight of formula IX is less * than about * 200,000, preferably about 100,000, much preferred less than 40,000 and less * than 20,000, P is an integer in the 1 am scale so that the average number molecular weight of formula X is less than about 1,000,000, preferably less than 200,000, most preferred less than 40,000 and most preferred less than 20,000; G represents the minimum residue of 1 to L hydrogen atoms of the hydroxyl groups of an alcohol that previously contains from 1 to about 200 hydroxy groups; and L is an integer from 1 to about 200. Preferably G will be the residue of a dihydroxy alcohol minus both hydroxyl groups. Suitable repeating units derived from lactone can be generated from the following monomers which include but are not limited to lactone monomers selected from the group consisting of glycolide, d-lactide, 1-lactide, that-1 cf i da, S-caprolacton, p-dioxanone, full t rirnet carbonate, 1,4-d? oxepan-? -one, 1,5-d? oxe? an-2-one, and combinations of the rni sinos. The polymer formed by reacting the aforementioned amine and amide containing diols (or polydiol) XIV and the polyoxycarboxylic acid Varyl can also be copolymerized in a condensation polymerization with the lactone polymers IX and X described above for form a general polymer of fonnuLa: l "CC (0) -C (R?) (R2) O-R3 -0-C (R?) (R2) -0 (0) - (O-R12) or" 0) s XTT (0 (0 ) RS -0) B3W or rC-0 (0) -C (R?) (R2) -O-R3 -0-0 (R?) (R2) -0 (0) - (0-Ri2) u - 0) s (ro - Ri3-c) o)] po-) L6] -w xnr or where S is an integer in the scale of about 1 to 10,000 and preferably from 1 to 1,000 and W is an integer on the scale of about 1 to about 1,000. These polymers can be made in the form of different slug copolymers or block copolymers. For the diols, the polyoxy carboxylic acids to the lactic acid and lactone species described above, a coupling agent selected from the group consisting of polyols t r * can be added. functional or tetra functional, oxycarboxylic acids, and polybasic carboxylic acids (or acid anhydrides thereof). 01 adding coupling agents results in the production of long chains, which can impart desirable properties in the molten state of the μoliester prepolinder. Examples of suitable polyfunctional coupling agents include trirnethylol propane, glycepna, pentaep tptol, alic acid, citric acid, tartaric acid, trunic acid, propacarboxylic acid 1-prodrug, anhydro tetracarboxylic acid cyclopentane and combinations thereof.

The amount of coupling agent to be added before the gelation occurs is a function of the coupling agent type used and the polymerization conditions of the polyoxyester or molecular weight of the polymer to which it is added. Generally on the scale of about .l to about 10% molar of a coupling agent < Functional Ri or Rafunctional Tet can be added based on the moles of aliphatic polyoxaester polymers present or anticipated from the sm "s The preparation of the aliphatic polyoxaester is preferably a polymerization performed under molten polycondensation conditions in the presence of an organometallic catalyst * at elevated temperatures. . The organometallic catalyst * is preferably a brass base catalyst for example octoate is anosene. The catalyst * pre fer *? The mixture will be present in the mixture at a molar ratio * of diol, poloxic acid, and aliphatic acid, and the monomer option of lactone to catalyst will be on the scale of about 5,000 to approximately 80,000 / 1. The reaction is preferably carried out at a temperature which is not less than about * 120 ° 0 under reduced pressure. Higher polymerization temperatures can lead to further increases in the molecular weight of the copolymer, which may be desirable for numerous applications. The exact reaction conditions chosen will depend on numerous factor-s, which include the properties of the desired polymer, the viscosity of the reaction mixture, and the temperature of the glass tianssion and softening temperature of the polymer, the preferred reaction conditions. of temperature, time and pressure can be determined by ensuring these and other factors. Generally, the reaction mixture will be maintained at approximately 220 ° O. The polymerization reaction can be allowed to proceed at this temperature until the desired molecular weight and percent conversion is achieved for the copolymer, which typically will take approximately 15 minutes to fully LO 20 hours. Increasing the reaction temperature generally decreases the reaction time required to achieve a particular molecular weight, but also increases the degree of side reactions. It has been found that the reaction at around 220 ° C is generally adequate. In another embodiment, aliphatic polyoxester copolymers can be prepared by forming a prepolymerized aliphatic polyoxester prepoly under molten polycondensation conditions, then adding at least one lactone buffer or lactone prepolymer. The mixture should then be subjected to the desired temperature and time conditions for copolyzing the prepolymer with the lactone monomers in a polycondensation polymerization. The molecular weight of the prepolymer as well as its composition can be varied depending on the desired characteristic that the prepolymer will impart to the copolymer. NeverthelessIt is preferred that the polyoxaester prepolymers to which the copolymer is prepared have a molecular weight that provides an inherent viscosity of approximately 0.2 to about 2.0 deciliters per gram (di / g) as measured in a hex fluoroLSO ropanol solution of 0.1 g / dl at 25 ° C. It will be appreciated by those skilled in the art that the polyaxester prepolymers to the fatics described herein may also be made from mixtures of more than one diol and dioxycarboxylic acid. One of the beneficial properties of poloxaester * ai fatLco made by the process of this invention, is that the ester linkages are hydrolytically unstable, and therefore the polymer is bioabsorbable because it is divided into small segments at Be exposed to wet body tissue. In this ret, while it is seen that the reactable co-reactants can be incorporated into the reaction mixture of the aliphatic dioxycarboxylic acid and the diol for the formation of the polyoxaester aliphatic prepolymer, it is preferable that the The reaction mixture does not include a concentration of any reactable co-material that the non-absorbable prepared polymer can give. Preferably, the reaction mixture is substantially free of any reactable co-matepal if the resulting polymer is not absorbable. These aliphatic polyoxesters described herein and those described in serial number 08 / 399,308, filed on (March 5, 1995) and assigned to Ethicon, now US Pat. No. 5,464,929 can be mixed with other homo polyesters, copolymers and Graft copolymers to impart new properties to the material foamed by the blend. The other polymers that the aliphatic polyoxaesters can mix include, but are not limited to, a polyethylene copolymer and lactone with the units of repeatability described by the formula VIIT, polyurethanes, polyether polyurethanes, polyurethanes, polyester polymers, full copolymers (such as copolymers of ethyl acetate and copolymers of aluminum acyl acetate). ethylene), pol lamides, polyvinyl alcohol 1 LCOS, full polyethylene oxide, polypropylene acid, polyethylene glycol no, polypropylene glycol, full poly tetrarnet oxide, pyrrolidone polyvinyl, polyacrylamide, polyhydroxyethyl acrylate, polyhydroxymethyl methacrylate. Copolymers (ie containing two or more repeating units) include several block copolymers and segmented copolymers. Suitable repeating units derived from lactone can be generated from the following monomers including, but not limited to, lactone rnonomers selected from the group consisting of licolide, d-Lactide, 1-lactide, mesolate, α-lac. ? rolactone, p-dioxanone, t-methylene carbonate, 1,4-dioxe? an-2-one, 1, 5-d? oxe? an-? -one and combinations of the same. The mixtures may contain about 1% by weight to about 99% by weight of the aliphatic loxaesters containing amines and / or amido groups.

For some applications it may be desirable to add additional ingredients such as stabilizers, 10x1 ant radiopacifiers, fillers or the like. The aliphatic polyoxaesters and other polymers can be mixed using conventional mixing procedures known in the art. For example a mixture can be prepared by using a two-roll mill, an intena mixer (such as a Brabender or Banbury mixer), an extruder * (such as a twin-nut extruder) or the like. The polymer blends of this invention can be melted by different methods to prepare a wide array of useful devices. These polymers can be injection molded or compressed to make medical surgical devices, especially devices for closing wounds. The devices for closing * preferred wounds are fasteners, staples and surgical sutures. Alternatively, the polymer blends can be squeezed to prepare fibers. The filaments thus produced can be fabricated into sutures or ligatures, added to surgical needles, packaged, and sterilized by known techniques. The polymer blends of the present invention can be spun as yarn and filament yarn and woven or spun to form sponges or gauzes, (or non-woven sheets can be prepared) or used together with other compression structures as prosthetic devices within the body of 1 ? a human or animal where it is desirable for the structure to stress high tension and desirable levels docility and / or ductility. Useful modalities include tubes, which include branched tubes, for artery, vein, or intestinal repair, nerve joint, tendon joint, savanna to classify and support damaged surface abrasions, particularly major abrasions, or areas where The skin and fundamental tissues are damaged or removed surgically. Irnent is added, or blends of Lunero can be molded to form films that, when used, are useful as adhesion prevention barriers. Another alternative processing technique for the polymer blends of this invention includes solvent molding, particularly for those applications wherein a drug assortment matrix is desired. In detail, the surgical and medical uses of the filaments, elicers, and molded articles of the present invention are limited, but are not necessarily limited to. spun, woven or non-woven products, and molded products that include: a. bandage for burns b. patches pa r-a hern i a c. prescription bandages d. sust i tut os fac i a l es e. gauze, cloth, sheet, felt or sponge for liver hemosis. gauze g "arterial graft or substitutes h. bandages for skin surfaces i. suture knot bra j. pins, fasteners, screws and orthopedic plates k. clips (for example, for vena cava) L. staples. hooks, buttons, and fasteners n. bone substitutes (for example, mandible prostheses) or. intrauterine devices (eg, sporadicidal devices) p. Drainage or test tubes or capillaries q. surgical instruments r. implants or vascular supports s. vertebral discs t. ext. tube for eoe for kidney and heart-lung machines u. artificial skin and others v. catheters (including but not limited to, the catheters described in US Pat. No. 4,883,699 which is incorporated herein by reference) w. frameworks for tissue engineering applications. In another embodiment, the polymer blends can be used to coat a surface of a surgical article to improve the lubricity of the coated surface. The polymer blends can be applied as a coating using conventional techniques. For example, polymer blends can be solubilized in a dilute solution of a volatile organic solvent for example., acetone, methanol, ethyl acetate or toluene, and then the article can be submerged in the solution to coat its surface. Once the surface is coated, the surgical article can be removed from the solution where it can be dried at room temperature or elevated until the solvent and any residual reactable material are removed. For use in coating applications polymer blends must exhibit an inherent viscosity, as measured in 0.1 gram per deciliter (g / dl) of hexafl uoroisopropanol (HFIP), between about 0.5 at approximately 2.0 dl / g, preferably from about 10 to about 0.80 dl / g. If the inherent viscosity is less than about 0.05 dl / g, then the polymer blends can not have the integrity necessary for the preparation of films or coatings for the surfaces of various surgical and medical articles. By ot I? However, even if it is possible to use polymer mixtures with an inherent viscosity greater than about 2.0 dl / g, it can be extremely difficult to do so. Although it is contemplated that numerous surgical articles (including but not limited to endoscopic instruments) may be coated with the polymer blends of this invention to improve the surface properties (1), preferred surgical articles are sutures and surgical needles. The most preferred surgical article is a highly preferred suture attached to a needle Preferably, the suture is a synthetic absorbable suture This sutures are derived, for example, from furnace polymers and copolymers of lactone monomers such as glycolide, lactide, etc. £ - caprolactone, 1, -dioxanone, and full-strength carbonate.The preferred suture is a suture of multi-strand intertwined filament composed of polyglycolic or ida-colacid polyol). The amount of coating to be applied on the surface of an intertwined suture can be determined indistinctly, and will depend on the particular copolymer and suture chosen. Ideally, the amount of coating applied on the surface of the suture may vary from about 0.5 to about 30% of the weight of the coated suture, most preferably from about 1.0 to about 20% by weight, most preferred from 1. around 5% by weight. If the amount of coating on the suture is greater than about 30% by weight, then the risk of the coating flaking when the suture passes through the tissue can increase. The sutures coated with the polymer blends of this invention are desirable as they have a slippery feeling, thus making it easier for the surgeon to slip a knot under the suture to the site of surgical trauma. In addition, the suture can pass through the body tissue more easily, thus reducing tissue trauma. These advantages are exhibited in comparison with sutures that do not have their surfaces coated with the polymer blends of this invention. In another embodiment of the present invention, when the article is a surgical needle, the amount of coating applied to the surface of the article is an amount that creates a layer with a thickness that ranges preferably from about 2 to about * 20 microns. the needle, most preferably from 4 to about 8 microns if the amount of coating on the needle was such that the thickness of the coating layer was greater than about 20 microns, or if the thickness was less than about 2 microns, then the desired performance of the needle while passing through the tissue can not be achieved. In another embodiment of the present invention, polymer blends can be used as a pharmaceutical carrier in a drug assortment matrix. To form this mixture the mixture can be mixed? with a therapeutic agent to form the matrix. The variety is wide of different therapeutic agents that can be used in conjunction with the polymer blends of the present invention. In general, the therapeutic agents that can be administered by means of pharmaceutical compositions?; c of the invention include, without limitation: An i i f f e c t IOSOS such as antibiotics and agents ait i v i r a 1 es; ana1gesi eo y co bi naci ones of -ina 1 ges i co; anorexic; an ihelmínticos; antiartj rieos; antiarrhythmic agents; an i cornvul sivos; anti depressants; antidiuret agents cos; antidiarrhea; anti-istamines; anti-inflammatory agents; antirrigana preparations; antimause; anti-meoplastic; antiparkinism drugs; anti-pruritic; antis cotieos; anti-r * et icos; antispasmodi eos; anti coliner-gicos; sirnpatornimetica; xanthine derivatives; cardiovascular preparations that include calcium channel blockers and beta blockers such as pmdolol and antiarrhythmics; antihypertensive; diuretics; vasodilators that include general coronary, fetal and cerebral pep; stimulants of the central nervous system; preparations for cough and flu, which include descongestors; hormones such as estradiol. and other steroids, which include cor * t i co-steroids; hypnotics; immunosuppressive; muscle relaxants; parasitpatol itic; psicoestimulant.es; sedatives; and ranks; and naturally derived or genetically formulated proteins, polysaccharides, gl coprot eins or liprotins. The drug assortment matrix can be administered in any suitable dosage form such as orally, parenterally, subcutaneously as an implant, vaginally or as a suppository. Are matrix formulations containing polyei-e ezcLas can be formulated? Mix one or more therapeutic agents with the polyoxaester. The therapeutic agent may be present as a liquid, a finely divided liquid, or any other appropriate physical form. Typically, but optionally, the matrix will include one or more additives, for example, non-toxic auxiliary substances such as diluents, vehicles, excipients, stabilizers or the like. Other suitable additives can be formulated with the mixture of polyuneum and pharmaceutically active agent or compound, however, if the water is to be used it should be added immediately before administration. The amount of therapeutic agent will depend on the particular drug employed and medical condition that will be treated. Typically, the amount of drug represents about 0.001% at about f0%, more typically about * 0.001% to about 50%, very typical of about 0.001% to about 20% by weight of the matrix. The amount and type of polyoxaester incorporated in the parenteral type will vary depending on the desired release and the amount of drug employed. The product may contain mixtures of polymers having different molecular weights to provide the desired release profile or consistency of a given formulation. Polymer blends, upon contact with body fluids including blood or the like, undergo gradual degradation (primarily through hydrolysis) with concomitant release of the dispersed drug over an extended or sustained period (as compared to the release of the drug). an isotope saline solution). This may result in a prolonged assortment (eg, for more than 2,000 hours, preferably 2 to 800 hours) of effective amounts (eg, 0.0001 g / kg / hour to 10 mg / hour). kg / hours) of the drug. This dosage form can be administered as necessary depending on the subject to be treated, the severity of the affliction, the judgment of the prescribing physician, and the like. Individual drug and polyoxaester formulations can be tested in appropriate models in vitro and m vivo to achieve the desired drug release profiles. For example, a drug can be formulated with a polyoxaester and orally administered to an animal. The drug release profile can then be controlled by appropriate means such as by taking blood samples at specific times and testing the samples for drug concentration. After this procedure or similar, those skilled in the art will be able to formulate a variety of formulations. The polymers, copolymers and blends of the present invention can be entangled to affect the mechanical properties. Interlacing can be achieved by adding interlaced and / or irradiating enhancers (such as gamma-irradiation). In particular, the interleaving can be used to control the agitation of the water of said invention. In a further embodiment of the present invention, K Polymers containing amines and / or amido groups and polymer blends of the present invention can be used in tissue engineering applications or brackets cells. Suitable tissue frame structures are known in the art such such as the prostatic articular cartilage described in the Nortemaepcana patent 5,106,311, the porous biodegradable scaffold described in WO 94/25079, and the pre-vascularized cartilages described in UO 93/08850 (all incorporated herein by reference). Methods for seeding and / or culturing cells in tissue frames are also known in the art as those methods described in EPO 422 209 I, WO 88/03785, WO 90/12604 and WO 95/33821 (all incorporated herein by reference). ). The examples set forth below are for purposes of illustration, and are not intended to limit the scope of said invention in any way. Numerous additional embodiments within the scope and spirit of the invention will be apparent to those skilled in the art.

EXAMPLE 1 Preparation of 3,6-dioxaoctanedioic acid dimethyl ester H O. -O H0 HNOa JL OH OH triethylene glycol 3,6-dioxaoctanedioic acid dimethyl ester of 3,6-dioxaoctanedioic acid The diacid, 3,6-d-oxaoctanedioic acid, was synthesized by means of oxidation of triethyl glycol. The oxidation was carried out in a three-necked flask of 500 milliliters with a thermometer, an additional funnel, a gas absorption tube and a magnetic spinning bar. The reaction bottle was immersed in an oil bath that rests on a magnetic stirrer *. For the reaction bottle, 157.3 rnl of a 60% nitric acid solution were added; 37.0 g of triethylene glycol was added to the additional funnel. The contents of the bottle were heated to 78-80 ° C. A test tube containing 0.5 g of glycol and 1 rnl of concentrated nitric acid was heated in a water bath until brown gases appeared to appear. The contents were then added to the reaction bottle. The mixture was stirred for a few minutes; the glycol was then carefully added. Adhesion speed had to be rolled with extreme care to maintain the reaction or control. The adhesion rate was low enough so that the temperature of the exothermic reaction mixture was maintained at rO-82ßC. After the addition was complete * (80 minutes), the temperature of the reaction mixture was maintained at 78 ° -0 ° for an additional hour. By continuing to maintain this temperature scale, the excess of nitric acid and water was then distilled under reduced pressure (water suction). The syrup type residue was cooled; some sounds appeared. The product had the expected IR and NMR spectrum for the dicarboxylic acid; the crude product was used as such to be f icated. The presence of the 1, 6-di-oxo-octane-di-o-or 5-crude acid was achieved in the following manner. For the reaction flask containing 36 g of the crude diacid, 100 ml of methanol was added. This was stirred for 3 days at room temperature then 15 g of sodium bicarbonate were added and stirred overnight. The mixture was filtered to re-over Lf) solid. For the liquid, an additional 10 g of sodium bicarbonate was added; This mixture was stirred during the night. The mixture was filtered once more; the liquid was fractioned! disillusioned. The NMR analysis of the stepped product showed a mixture of dirnethyl triglycollate (78.4% molar) and ethyl pyl olatolate ethylene (21.6 mole%). No significant condensation of di- cide was observed.

Example 2 Preparation of polyoxaester from methyl esters of 3,6-dioxaoctanedioic acid and ethylene glycol.

East POl ["OXA" ESTERES A 50 ml, mechanically stirred, flame-dried glass reactor, suitable for reaction of the poly condensation, was charged with 20.62 g (about 0.1 mole) of the methyl esters of 3,6-d-oxo-octane-3-acetic acid. of Example 1, 18.62 g (0.3 moles) of distilled otylene glycol, and 0.0606 rnl of a 0.33M solution of stannous o tol in toluene. After purging the reactor and venting with nitrogen, the temperature was gradually increased over the course of 26 hours at 180 ° C. A temperature of 180 ° C was then maintained for another 20 hours; during all these periods of heating under nitrogen to an atmosphere, the methanol formed was collected. The reaction bottle was allowed to cool- at room temperature; then it was heated slowly under reduced pressure (0.015-1.0 nm) over the course of approximately 32 hours at 160 ° C, during which time additional distillates were collected. A temperature of 100 ° C was maintained for 4 hours after a sample, a few grams in size, of the polymer formed was rolled. It was found that the sample had an inherent viscosity (TV) of 0.28 dl / g, as determined in hexaf1 uoroi sopropanol (HFIP) at 25 ° C at a concentration of 0.1 g / dL The continuous polymerization under reduced pressure at increase the temperature, in the course of approximately 16 hours, from 160 ° C to 10 ° C, a temperature of 180 ° C was maintained for an additional 8 hours, at which time a sample of polymer was turned over and it was discovered that it had an IV of 0.34 of 1 / g The reaction continued under reduced pressure for another 8 hours at 180 ° C. The resulting polymer has an inherent viscosity of 0.40 dl / g, as determined in HFTP at 25 ° C and at a concentration of 0.1 g / dl.

Example 3 Preparation of polyoxaester with 3,6,9-trioxaundecanedioic acid and ethylene glycol. acid 3,6-9 -tpoxaundecanodi oieo 0 POLI "OXA" E TERES A 250 milliliter, mechanically stirred, flame-dried glass reactor, suitable for poly condensation reaction, was charged with 44.44 g (0.2 mole) of 3,6-9- 1 poxaundecanedioic acid, 62.07 g (1.0 mole) of distilled ethylene glycol, and 9.96 mg of dibutyltin oxide, After purging the reactor and venting * with nitrogen, the contents of the reaction flask were gradually heated under trógeno to an atmosphere, over the course of about 32 hours, to around 180 ° 0, during this time the water formed was collected. The reaction mass was allowed to cool to room temperature. The reaction mass was then heated under reduced pressure (0.015-1.0 nm), gradually increasing the temperature to 180 ° 0 in approximately 40 hours; during this time additional distillates were collected. Polymerization continued under reduced pressure while maintaining at 180 ° C for an additional 16 hours. The resulting polymer has an inherent viscosity of 0.63 dl / g as determined in HFIP at 25 ° C and a concentration of 0.1 g / dl.

Example 4 Preparation of polyoxaester with polyglycol diacid and glycol Polyglycol diacid P0LI "0XA" ESTERES A 500 milliliter glass reactor, mechanically stirred, flame-dried, (suitable for reaction of -15 polycondensation) was charged with 123.8 g (0.2 mole) of polyglycol dihydrogen (630 molar molecular weight), 62. 0 g (1.0 mole) of distilled ethylene glycol, and 9.96 g of oxidized dibutiltma After purging the reactor * and purging with nitrogen, the contents of the reaction vessel were heated under nitrogen to an atmosphere, gradually increasing the temperature to 200 ° C for about 32 hours; during this time the water formed was collected. The reaction flask was gradually heated under reduced pressure (0.015-1.0 rnl) from room temperature to 140 ° C during Approximately 24 hours, during this time additional distillates were introduced. A polymer sample of around 10 g was added at this stage, and it was discovered that it takes a T.D. of 0.14 dl / g in HFrP at 25 ° C, 0.1 g / dl. The polymerization continued under reduced pressure when heating from 140 ° C to 180 ° C for about 0 hours, and then maintained at 180 ° C for an additional 8 hours. A sample of polymer was once again layered and it was discovered that it had a T.V. of 0.17 dl / g., The reaction temperature was then increased to 190 ° 0 and maintained under reduced pressure for an additional 0 hours. The resulting polymer has an inherent viscosity of 0.70 dl / g as determined in HFIP at 25 ° C and at a concentration of 0.1 g / dl.

Example 5 Copolymer of polyoxaester / caprolactone / tri ethylene carbonate at 5/5/5 wt.

A single-neck round bottom flask *, 50 milliliter flame dried, was loaded with 5 grams of the polyoxaester aliquot of Example 4 which < ? an I.V. of 0.14 dl / g, 5.0 grams (0.0438 moles) of £ -caprolactone, 5.0 grams and 0.049 moles) of full tprnet carbonate, and 0.0094 ml of a 0.33 molar solution of stannous toluene octoate. The bottle was adjusted with a magnetic stirring bar. The reactor was purged with nitrogen three times before venting with nitrogen. The reaction mixture was heated to 160 ° O and maintained at this temperature for 6 hours. The copolunte was dried under vacuum (0.1 hr at 80 ° C) for about 16 hours to remove any monomer that was not reacted. The copolymer has an inherent viscosity of 0.34 dl / g as determined in HFIP at 25 ° 0 and at a concentration of 0.1 g / 1. Copolymer is a viscous liquid at room temperature. The molar ratio of poloxaester / PCL / Tt C was found by NMR analysis of 47.83 / 23.73 / 28.45.

Example 6 Polyoxaester / caprolactoma / glycolide copolymer at 6 / 8.1 / 0 / 0.9 by weight.

A single-neck bottle, d at the bottom, of 25 ml, flame-dried, was loaded with 6 grams of the sample. 4 that has a T.V. him 0.17 < IL / g., 8.1 grams (0.0731 moles) of £ -capr * olaet orna, 0.9 grams (U.Ü08) moles of glycol ida and 0.0080 i of a solution of stannous octoate of 0.33 in toluene. The bottle was adjusted with a magnetic stirring bar. The reactor was purged with nitrogen three times before venting with nitrogen. The reaction mixture was heated to 160 ° 0 and maintained at this temperature for about 18 hours. The first copolymer has an inherent viscosity of 0.26 dl / g in HF1P at 25 ° C and a concentration of 0.1 g / dl. The copolymer is solid at room temperature. The molar ratio of poloxates / PCL / PGA / capitulum was found by means of NMR analysis to be 56.54 / 37..73/3. (9 / 1.94 ..

Example 7 In vitro hydrolysis The polyoxaester of Example 3 was tested for in vitro hydrolysis at 50 ° C and at reflux temperature. A 100 mg sample of the poloxaester, placed in 100 ml of a phosphate buffer (0.2 m in phosphate, pH 7.27), was completely hydrolyzed for about 7 days at 50 ° C, where reflux was completely hydrolysed during ad 16 hours.

Example 8 In vitro hydrolysis The polyoester of Example 2 was tested for in vitro hydrolysis at 50 ° C and at reflux temperature. A rnuest r * a of 100 mg of the polyoxyester, placed in a buffer solution of 100 rnl (H of 7.27), was completely hydrolysed for about 25 days at 50 ° C, where reflux was completely hydrolysed during Appropriately? 16 hours.

Claims

NOVELTY OF THE INVENTION CLAIMS

1. - An aliphatic poloxester comprising a first bivalent repeating unit in the formula E: ro-c (o) -c (R?) (R2) -o- (R3) -oc (R?) (R2) ~ c (o) - 1 r and a second repeating unit selected from the group of the formulas consisting of: G -0 - RI 2 - 1U, XTV where Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: -r (CH2) C-0-1D - (CH-2) E ~ TV where C is an integer on the scale of 2 to approximately 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (-N (R? O) -) or amide (-N (Rp) -); R-10 and Rn are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; and U is an integer on the scale of 1 to approximately 2,000.

2. The aliphatic poloxester according to claim 1, further characterized in that the aliphatic poloxester a < J? C onally contains a third repeating unit selected from the group consisting of: GOR * 1A GT (C ~ 0-RI3-0 (0)] P-0-) LG and XI and combinations thereof; wherein R is a unit of the cyanole containing 2 to 8 carbon atoms; A is an integer in the scale from 1 to approximately 2000; Rs and Ri3 are i independently selected from the group consisting of -C (Rβ) (R?) -, - (CH2> 3-0-, -CH2 -CH2 -0 -CH2-, 0R8H-0H2-, - (CH2U ~, - (CH2) F-0-C (0) - and - (CH2)? -C (0) -CH2-; Re and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms. car-bond, Rs is hydrogen or methyl, F and K are integers in the scale from 2 to 6, B is an integer in the esc 1 an so that the average number molecular weight of the TTI formula is less than about 2,000,000, P is an integer on the 1-mil scale of the average molecular weight of the formula XI is less than about 1,000,000, G represents the residue less than 1 to L hydrogen atoms of the hydroxyl groups of an alcohol that previously contains from 1 to approximately 200 hydroxyl groups, and L is an integer from around the approximately 200 nm.

3. Polyoxaesters to 1 ("attics according to claim 1, further characterized in that the polymer has the formula: r? -C) 0) -C (R? (R2) -0- (R3) -0-C (R?) (R2) 0 (0) - (0-Ri2) u- ^ N where N is an integer on the scale ele around I a a p i? x a dame nt e 10,000 .. 4 ..- The aliphatic polyoxaesters of co nition with claim 2, characterized furthermore because the polymer 1 ene 1 af or rm u 1 a: r (~ C (0) -C (R (R2) ~ 0 -R3-0- (R?) (R2) -0 (0) - (O-R12) u -0) s (C (0) ~ R5-0) B 1W where S is an integer in the scale of about 1 to 10,000 and U is an integer in the scale of 1 to about 1,000 5. The aliphatic polyoxaesters according to claim 2, further characterized in that the polymer has the formula: [(- C (O) -C (R? (R2) -0-R3-0-C (R?) (R2) -C (O) - (O -R12) or -0) S (CO-R13 -0 ( 0)] P -0 ~) LG3W where S is an integer on the scale of about 1 to 10,000 and W is an integer on the scale of 1 to about 1,000.-A device made of an aliphatic polyoxaester that comprises a first bivalent repeating unit of the formula T: [0-0 (0) -C (R?) (R2) -0- (R3) -0-C (R?) (R2) -C (0) -] E and a second repeating unit selected from the group of fóos formulas consisting of: wherein Ri and R2 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms; R 3 is an alkylene unit or is an oxyalkylene group of the same form; - [(CH2) C- -] D - (CH - 2) E - IV on which C is an integer on the scale from 2 to approximately 5, D is an integer on the scale from about 0 to about 2,000 , and E is an integer in the scale of about 2 to about 5, except quack D is zero in which case E is an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (-N (R? O) -) or amide (-N (Rn) -); Rio and R 11 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; and U is an integer on the scale of L to approximately 2,000. 7. The device according to claim 6, further characterized in that the aliphatic polyoxaester additionally contains a third repeating unit selected from the group consisting of: CO-RA-IA, II ([-O-R13-C] (0) J -0-) LG and XI and combinations thereof; where R R is a unit of the cyanole containing 2 to 8 carbon atoms; A is an integer in the scale from 1 to approximately 2000; Rs and R13 are independently selected from the group consisting of -C (Rβ) (R7) -, - (CH2) a-0-, -CH2 -CH2 -0-CH2 -, -CRßH-0H2-, - ( CH2 -, - (CH2) F -OC (O) - and - (CH2)? - C (0) -CH2-; Re and R7 are independently hydrogen or an alkene containing from 1 to 8 carbon atoms; hydrogen or methyl, F and K are integers on the scale or 2 to 6, B is an integer on the scale of 1 an, so that the molecular weight of the average number of the ITT is less than about 2,000,000; P is an enter-o on the scale of 1 to rn so that the molecular weight of the priority number of formula XI is less than about 1,000,000; G represents the residue less than 1 to L atoms of hydrogen of the hydroxyl groups of a alcohol that previously contains from 1 to approximately 200 hydroxyl groups, and L is an integer from about 1 to about 200. 8. The device according to claim 6, further characterized in that the device is a device. Surgical surgical instrument. 9. The absorbable surgical device according to claim 6, further characterized in that the absorbable surgical device is selected from the group consisting of bandages for burns, hernia patches, prescription bandages, facial substitutes, gauzes, fabrics, sheets , felts, sponges, gauze, arterial graft, bandages for skin surfaces, suture bra, pins, fasteners, screws, plates, clips, staples, hooks, buttons, fasteners, bone substitutes, intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin 10.- The surgical device absorbable in accordance with claim 6, characterized further because the device is a filament. 11. The filament according to claim 10, further characterized in that the filament is added to a needle. 12. The device according to claim 6, further characterized in that the aliphatic polyoxaesters have the formula: r? -C) 0) -0 (R? (R2) -0- (R3) -0-C (R? ) (R2) C (0) - (0 - R12) u ~ 1N where N is an integer on the scale of about * 1 to about 10,000 13. The device according to claim 6, further characterized because the aliphatic polyoxaesters have the formula: r (-C (0) -C (R? (R2) -0 ~ R3-0- (R?) (R2) ~ 0 (0) - (0-R 2) u - 0) S (C (0) -R5-0) B] w where S is an integer on the scale of around <1 to 10,000 and U is an integer on the scale of 1 to approximately 1,000. - The device according to claim 6, further characterized in that the aliphatic polyoxaesters have E (-C (O) -C (R?) (R2) -0- (R3) -0- (R?) (R2) - C (0) ~ (0-Ri2) u "0) s ([-0-RI3-C (0) -] P -0-) LG] W where is an integer on the scale of about 1 to 10,000 and W is an integer on the scale of 1 to approximately 1,000. dressed with an absoibible backing comprising a fat poloxester having a first bivalent axis repeating unit the formula 1: r? -C (O) -C (R? ) (R2) ~ 0- (R3) ~ 0-C (R?) (R2) -C (0) -1 T and a second repeat unit selected from the group of formulas consisting of: G ~ O - RI 2? U, XIV where Ri and R2 are independently hydrogen or an alkyl group eg contains from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: -r (CH2) c -0-] D- (CH-2) E-TV where C eβ is an integer on the scale 2 a approximately 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale around? Approximately 5, except when D is zero in which case E will be an integer 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal ami (-N (R? O) -) or arnieja (-N (Rn) -); Rio and Ri 1 are independently hydrogen or an alkyl group < } e contains from L to 8 carbon atoms; and U is an integer in the scale of approximately 2,000; where the inherent viscosity of the polyoxaester is on the scale of about 0.5 to about 2.0 deciliters per gram (dl / g) as measured in a 0.1 g / dl solution of hexafluoroisopropane (HFIP) at 25 ° C. 16.- The device coated with an absorbable coating according to claim 1? cation 15, further characterized in that the alkaline polyester optionally contains a third repeating unit selected from the group consisting of: GO-RS ~ C (O) -1B, GTT (C-) 0-Ri3-C (0) 1p -0-) 6 and XI and eornLu nations of the same; wherein R 0 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer in the scale from 1 to approximately 2000; Rs V Ri3 are independently selected from the group rue consisting of -C (Rß> <R7> -, - (CH2) 3-0-, -CH2-CH2 -O-CH2 -, -CRBH-OH2 -, - (CH2) - »-, - (CH2) F-0-C (0) - and - (CH2? K- 0 (0) ~ CH2-; Re VR? Are independently hydrogen or an alkyl containing 1 to 8 carbon atoms, Re is hydrogen or methyl, F and K are integers on the scale from 2 to 6, B is an integer on the scale 1 to 1 so that the molecular weight of the average number axis IBD is less than about 2,000,000, P is an integer on the 1 am scale so that the average number molecular weight of formula XI is less than about 1,000,000, G represents the residue less than 1 to L atoms of hydrogen of the hydroxyl groups of an alcohol that previously contains from the approximately 200 hydroxyl axis groups, and L is an integer from about 1 to about

200. 17. The device coated with a water-repellent coating according to claim 15, further characterized in that the device is a suture, 18. The device coated with an absorbable coating according to claim 17, further characterized in that the suture is added. to a needle. 19. The device coated with an absorbable coating according to the rei indication 15, further characterized in that the aliphatic poloxaesters have the formula: C0-O0) -0 (R? (R2) -0- (R3) -0- C (R?) (R2) C (0) - (0-Ri2) U-3N in dôle N is an integer on the scale of about 1 ap ro xi rna dame te 10,000 20"- Fl eiispositive coated with a absorbable coating of condensation with claim 15, further characterized by the fact that the polyoxaesthers have the formula: [(-O (O) -C (R? (R2) -0-R3 ~ 0-C (R?) ( R2) -C (0) - (O-R12) u -0) s (0 (0) -RS-0) B] W in which CJ is an integer on the scale around 10,000 and U is an integer in the scale from 1 to approximately 1,000 21. The device coated with an absorbable coating according to claim 15, further characterized in that the aliphatic polyoxaesters have the formula: pC (O) -C (R? (R2) -0 -R3 ~ 0-C (R?) (R2) -C (0) - (O-R12) u -0) s (r-0-Ri3-C (0) lp-0- ) LG1W on which is an integer on the scale of about 1 to 10,000 and U is an integer on the scale 1 to about 1, 000, 22.- A matrix of the left side of a drug that contains a drug and a polyoxaester aliphatic having a first bivalent repeat axis unit of formula I: r? -C (0) -C (R? ) (R2) -0-ÍR3) -0-C (R?) (R2? -C (O) -] T and a second repeating unit of the forrnuLa: wherein Ri and R2 are independently hydrogen or a group of alkyl containing 1 to 8 carbon atoms, R3 is an alkylane unit or is an oxyalkyl group of the following formula: -r (CH2) C-0-] D- (CH-2) E -in where C is an integer on the scale of 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to approximatively 5, except when D is zero in which case E will be an integer from 2 to 12, R12 is an alkylene unit containing from 2 to 8 carbon atoms and containing an internal amine (-N (R? o) -) or amide (- N (Rn) -); Rio and R11 are independently hydrogen or an alkyl group containing 1 to 8 carbon atoms, and an integer on a scale of 1 to about 2,000 .. 23.- The assortment matrix drug axis according to claim 22, characterized Furthermore, because the polyphasic aliphatic polyoxester additionally contains a third unit of r * epet? c? on selected from the group c | ue consisting of: C-0-RA-] A TT GO-RS -C (O) -] B , iti ([~ 0-Ri3-C (0) lp -0-) G and XI and combinations thereof; wherein RA is an axis unit to the cyanole containing 2 to 8 carbon atoms; To an integer in the scale from 1 to approximately 2000; Rs and R13 are independently selected from the group consisting of -C (Rβ) (R7) -, - (CH2? 3-O-, -CH2-CH2 -0-CH2 -, -CR8H-CH2-, - (CH2) -, - (CH2) F-0-C (0) - and - (CH2) --C (0) -CH2 ~; Re and R7 are independently hydrogen or an alkyl containing 1 to 8 carbon atoms carbon, Rs is hydrogen or methyl, F and K are integers on the scale of 2 to 6, B is an integer on the ele 1 an scale so that the average number molecular weight of the TTI formula is smaller * axis around 2,000,000; P is an integer in the scale from 1 to rn so that the average number molecular weight of formula XI is less than about L, 000, 000; G represents the residue less than 1 to L hydrogen atoms; hydroxyl groups of an alcohol that previously contains from 1 to about 200 hydroyl groups, and L is an integer from about * 1 to about 200. 24 - The drug assortment matrix in accordance with the Claim 22, characterized furthermore because oL pol loxaester ali fatico has the formula: p-C (0) -0 (R? (R2) -0-R3-0-0 (R?) (R2) -0 (0) - (0 -R12) u ") s (0 (0) -Rs -0) Blw where"? is an integer on the scale of about 1 to 10,000 and l is an integer on the scale of 1 to about 1,000. 25.- The matrix <The drug axis assortment according to claim 22, further characterized in that the aliphatic polyoxester has the formula [(-C (O) -O (R? (R2) -0-R3-0-C (R?)] R2) -C (0) - (0-Ri2) u ~ 0) s (C-0-Ri3-0 (0)] P -OJLGUW where is an integer on the scale of about 1 to 10,000 and U is an integer in the scale from 1 to approximately 1,000.26.- An aliphatic polyoxyester comprising a first bivalent repeating unit of the formula T: r? -C (0) -C (R?) (R2) -0- (R3) ~ 0-C (R?) (R2) ~ 0 (0) -1 and two second repeating units of the formula: r -0 ~ R5 -C (0) -3B, and III ([-0 -RR3-C (0)] P ~ 0-) LG XT wherein Ri and R2 are independently hydrogen or an alkyl radical which contains from 1 to 8 carbon atoms, R3 is an alkylene unit or is an oxyalk group filled with the following formula: -C (CH2) C ~ 0-] D - (0H-2) E-EV in which the C is an integer on the scale of 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale around 2 to apr-ox 5, except when D is zero in which case E is an integer 2 to 12; Rs and R13 are independently selected from the group consisting of -OÍRβ MR? ) -, (0H2) 3-0-, -CH2-CH2 -O-CH2-, -CR8H-OH2-, - INCH2 U-, - (CH2) F ~ 0-0 (0) and - (CH2)? ~ C (0) -CH2-; Re and R7 are indefinitely and hydrogen or an alkyl, preferably containing 1 to 8 carbon atoms; Re is hydrogen or methyl; F and K are integers on the scale of 2 to 6; I) is an integer on the scale ele 1 to n so that the molecular weight * of the average number of the IIT formula is less than about 2,000,000; P is an integer in the scale of 1 to m mode because the average molecular weight of the formula XE is less than about 1,000,000; G represents the residue less than 1 to L atoms of hydrogen of the hydroxyl groups of an alcohol that previously contains from 1 to about 200 hydroxyl groups; and L is an integer of about 1 aap ro x 1 rna dame te 200. 27.- Fl polioxaester all of conforrnidaej fatico with the reiv indication 26, also characterized ponjue additionally is a third unit of repetition of the formula: GOR -4 - IA, II where R "is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer on the scale of 1 to 1,000. 28.- A device made from a polyoxester * ali atic ejue comprises a first bivalent repeating unit of the formula I: r? -C (0) ~ C (R?) (R2) -0- (R3) -0-C (R?) (R2) -C (0) -1 1 and the second repeat units selected from the group of formulas ejue consist of: (r-0-Ri3-0 (0)] p -0-) LG XI wherein Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: -C (CH2) c-0-3D- (CH-2) -E- IV wherein C is an integer in the range from 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale from about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R5 and R13 are independently selected from the group consisting of ele -0 (R1) (R7) -, - (GH2) 3-0-, -CH2-OH2-O-CH2-, -CR8H-OH2-, ~ ( CH2) -. ~, - (GH2) F-0-0 (0) - and - (CH2)? - 0 (0) ~ CH2 ~; Re and R are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; Rs is hydrogen or methyl; F and K are integers on the scale 2 to 6; B is an integer on the scale of 1 to n so that the average number molecular weight of the IIT formula is less than about 2,000,000; P is an integer in the scale of 1 to the fact that the average number molecular weight of formula XI is smaller < approximately 1,000,000; G represents the residue less than 1 to L hydrogen atoms of the hydroxyl groups of an alcohol previously contains from 1 to about 200 hydroxyl groups; and L is an integer around 1 to a p r * o x i rna dame n te 200. 29.- The aliphatic polyoxyester in accordance with the r * e? v? nelí cation 26, further characterized because additionally a third repeating unit of the formula is found: [~ 0 ~ R.I -1A, TI where RA is an alkylene unit containing from 2 to 8 atoms of carbon; A is an integer on the scale of 1 to 1,000. 30. A device coated with an absorbent coating comprising a polyoxyester to the fatico having a first bivalent repeating unit of the formula I: ["0 ~ C (0) -C (R?) (R2) -O- ( R3) -0 ~ C (R?) (R2) -C (0) -] I and two second repeating units of the formula: [-O-RS-C (O) -IB, and ni (CO-RI3 -C (O? PO-) LG XI wherein Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms, R3 is an alkylene unit or is an oxyalkylene group of the following formula: - ["(Cite) c -0-1D- (CH-2) E- IV where C is an integer on the scale 2 to approximately 5, D is an integer on the scale of about 0 to about 2,000 , and E is an integer on the scale around axis 2 to about 5, except when D is zero in which case E will be an enter-o or 2 to 12; R5 and R13 are independently selected from the group ejue consisting of 0 (Rβ) (R7) -, (0H2) 3-0-, -CH2-CH2 -O-OH2-, -OR8H-CH2-, (CH2) « - / - (CH2JF-0-0 (0) - and - (CH2)? -C (0) -CH2-; Re and R7 are independently hydrogen or an alkyl containing 1 to 8 carbon atoms; Rs is hydrogen or methyl, F and K are integers on the scale of 2 to 6, B is an integer on the elena scale so that the average molecular weight of the formula EII is less than about 2,000,000, P is an integer in the 1-am scale, it is estimated that the average number molecular weight of formula XI is less than about 1,000,000, G represents the residue less than 1 to L hydrogen atoms of the hydroxy groups of an alcohol that previously contains 1 to about 200 wherein the inherent viscosity of polyoxyester is in the scale of about * 0.5 axis to about 2.0 deciliters per gram (dl / g) as measured in a 0.1 g / 1 solution of hexaf1 uoropropanol (l-IFTP) at 25 ° 0. 31.- The poloxester at 1 fatico in accordance with La rei indication 30, characterized adornas because it adds Úñente is a third unit of repetition of the formula: COR ^ -IA, II where R4 is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer on the scale of 1 to 1,000. 32. A matrix of the drug assortment comprising a drug and a polyoxyester * at the pentane has a first bivalent repeating unit of formula 1: [0-0 (0) -C (R?) (R) -0- (R3) -0-C (R?) (R2) "C (0) -] I and two second units in the repetition of the formula: r -0-R5-0 (0) -1B, V ET1 (C-0-RI3-C (0) 1P-0-) LG XT wherein Ri and R2 are independently hydrogen or a hydrocarbon alkyl group containing 1 to 8 carbon atom atoms; R3 is an alkyl unit; or is an oxyalkylene axis group of the following formula: -r (CH2) C-0-] D- (0H-2) E-TV where 0 is an integer in the scale from 2 to approximately 5, D is an whole on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R5 and R13 are independently selected from the group consisting of -C (Re) (R7) -, - (CH2) 3-0-, -CH2-CH2-O-CH2-, -CR8H-CH2-, - (CH2 -, - ( 0H2) F ~ 0-0 (0) - and - (CH2) - C (0) -0H2-; Re and R7 are independently hydrogen or an alkyl < : That contains from 1 to 8 carbon atoms; Rs os hydrogen or methyl; F and K are integers on the scale of 2 to 6; B is an integer on the scale of 1 to n so that the molecular weight * of the average number of the formula Til is less than about 2,000,000; P is an integer on the scale of 1 to m so < The average number molecular weight of the formula XT is less than about 1,000,000; G represents the residue less than 1 to L atoms of hydrogen of the hydroxyl groups of an alcohol that previously contains from 1 to about 200 wherein the inherent viscosity of polyoxaester is in the? scale from about 0.5 to about 2., 0 deciliters per gram (ell / g) as measured in a 0.1 g / 1 solution of hexaf luoropropanol (HFIP) at 25 ° C. 33. The drug assortment matrix according to claim 32, further characterized in that the aliphatic polyoxaester additionally has a third repeat unit of the formula: GOR «-] A / II in which R4 is an alkylene unit containing 2 to 8 carbon atoms; A is an integer on the scale axis 1 to 1,000. 34.- A polymer mixture comprising an aliphatic polyoxaester composed of a first bivalent repeating unit of the formula I: C0-C (0) -C (R?) (R2) ~ 0- (R3) -0-C (R?) (R2) -0 (0) -] I and a second repeating unit selected from the group of formulas consisting of: C-0-Ri2C1u, XIV wherein R and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: -CÍCH2) C-0-] D- (0H-2) E-TV wherein C is an integer on the scale of 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero in which case L ^ e? -a integer of 2 a 12; R12 is an alkylene unit containing 2 to 8 carbon atoms and containing an internal amide (-N (R? O) -) or amide (-N (Rn) -); Rio V Ri 1 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms *; and U is an integer in the scale from 1 to approximately 2,000; and a second polymer selected from the group consisting of homopolymer and lactone-type copolymer with repeating units described by formulas III, XI, polyurethanes to fatics, polyurethanes, polyester polyurethanes, polyethenes of polyester, polyethylene copolymers, polyamides, polyamide alcohols, polyethylene oxide, polypropylene oxide, polyethylene glycol, polypropylene glycol, polypropylene oxide 1 logs, polyvinyl pyrrolidone, polyacrylate, polyhydroxy ethoxide, polyhydroxy methacrylate drox? ot ? and combinations thereof. The polymer mixture according to claim 34, further characterized in that the aliphatic polyoxaeste additionally contains a third repeat unit selected from the group consisting of: GO-RA-IA TI l 0-R5 ~ G (0) -] B, III (C-0-Ri3-C (0)] p -0-LG and XI and combinations thereof, wherein R4 is an alkylene unit eμje contains 2 to 8 carbon atoms, A is an integer in the scale from ele 1 to approximately 2000, Rs and R13 are independently selected from the group < jue consisto ele C (R6) (R7) -, - (CH2) 3 ~ 0-, -CH2-CH2-O-CH2-, -CR8H-0H2 ~, - (CH2) 4-, - (0H2) F-0-C (0) - and - (CH2)? - 0 ( 0) -CH2-; Re and R7 are independently hydrogen or an alkyl that contains uncle 1 to 8 atoms carbon axis, Rs is hydrogen or methyl, F and K are integers on the scale axis 2 to 6, B is an integer on the scale of 1 an so that the molecular weight of the average number of the formula is not less than about 2,000,000; P os an integer on the scale of 1 to rn so that the number-average molecular weight of formula XI is less than approximately 1,000,000; G represents the residue less than 1 to L hydrogen atoms of the hydroxyl groups of an alcohol that previously contains < it to approximately 200 hydroxyl axis groups; and L is an integer from about 1 to about

200. 36.- The mixture of the polymer axis according to claim 34, further characterized in that the aliphatic pol oxaest have the formula: l ~ 0-0) 0) -C (R? (R2) -0- (R3) -0 -C (R?) (R2) 0 (0) - (0 ~ Ri2) ü - ^ N where N is an integer in the scale from about 1 to about 10,000 37.- The polymer mixture in accordance with claim 35, further characterized in that the polymer has the formula: r (-0 (0) -C (R? (R2) - -R3 -0-CCR?) (R2) ~ C (0) - (O- R12) u -0) s (0 (()) - RS-0) B 1 where is an integer on the scale of about 1 to 10, 000 and W is an integer in the scale from axis 1 to approximately 1,000 .. 38. - The polymer mixture according to claim 35, further characterized in that the aliphatic pol 1 oxaesters have the formula: [(-C (O ) -C (R? (R2) -0-R3 ~ 0-C (R?) (R2) -C (0) - (O-R12) U -O) S (C-0-Ri3-0 (0 )] p-0-) LG3W where S is an integer on the scale of about 1 to 10,000 and W is an integer on the scale of 1 to about 1,000. 39.- A device made from a polymer axis mix comprising an aliphatic polyoxyester composed of a first bivalent repeating unit of formula I: r -C (O) -0 (R?) (R2) -0- (R3) ~ 0-0 (R?) (R2) -0 (0) -l T and a second repetition unit selected from the group of formulas ejue consist of: wherein Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is a unit of alejuylene or is an oxyalkylene group of the following formula: -r (CH2) C-0-] D- (CH-2) E-EV where 0 is an integer in the scale of 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of around * from 2 to approximately 5, except when T) is zero in whose case E will be an integer axis 2 to 12; R12 is an alkylene axis containing 2 to 0 carbon atoms and having an internal amine (-N (R? O -) or amide (N (n) -); R and Rn are independently hydrogen or a group alkyl containing from L to 8 carbon atoms, and U is an integer in the scale from 1 to about 2,000, and a second polymer selected from the group consisting of homopolymer and lactone-type copolymer with repeating axis units described by formulas III, XI, polyurethanes ali faticos, polurethane polyurethanes, polyester polyurethanes, full polyethylene copolymers, polyamides, polyvinyl alcohols, polyethylene oxide oxide, polypropylene oxide, polyethylene glycol, polypropylene glieol, poly tetrainet oxide 1 log, pyrrolidone, polyvinyl, polyacrylamide, polyhydroxyethyl acrylate, polyhydroxy ethyl metacrate and combinations thereof 40. The device according to claim 39, further characterized by The aliphatic Loxaester additionally contains a third repeating unit selected from the group consisting of: ["-O R4 - 1A ET GO-R5 -c (o) -? B, iti (C-0- Ri3-C (0)] p -O-LG and XE and combinations thereof; wherein R4 is an alkyl axle unit containing from 2 to 8 carbon atoms; A is an entity on the scale of 1 to approximately 2000; Rs and R13 are independently selected from the group e | uo consisting of -G (Re) (7) -, - (CH2) 3-0-, -CH2-CH2-O-CH2-, CRTH CH2-, - ( CH2U-, - (CH2) F ~ 0-C (0) - and - (CH2)? - C (0) -CH2-; Re and R7 are independently hydrogen or an alkyl containing 8 carbon atoms; is hydrogen or methyl, F and K are integers on the scale from axis 2 to 6, B is an integer on the scale of 1 an in which the average molecular weight of formula III is less than about 2,000,000; P an integer on the scale of 1 am so that the average number molecular weight of formula XI is less than about 1,000,000; G represents the residue minus ele 1 to I. Hydrogen atoms of the hydroxyl groups of a alcohol previously contains from the approximately 200 hydroxyl groups, and L is an integer of about 200. 41. The device according to claim 39, further characterized in that the device is a di surgical absorbable device. 42.- The absorbent surgical device according to claim 39, further characterized in that the absorbable surgical device is selected from the group consisting of bandages for burns, hernia patches, prescription bandages, facial substitutes, gauzes, fabrics, sheets , felts, sponges, gauze, arterial graft, bandages for skin surfaces, fastener * of suture knot, pins, fasteners, screws, plates, clips, staples, hooks, buttons, fasteners, replace ", of bones , intrauterine devices, tubes, surgical instruments, vascular implants, vascular supports, vertebral discs, and artificial skin 43.- The absorbable surgical device axis according to claim 39, further characterized because the device is a filament. The filament according to claim 43, further characterized in that the filament is added to a needle. ad with claim 39, further characterized in that the polyoxates aliphatic have the formula: C0-C) 0) -C (R? (R2) -0- (R3) -0-C (R?) (R2) C (0) - (O-R12) u-1N in clone N is an integer in the scale axis about axis 1 to about 10 , 000. 46.- The device according to claim 39, characterized in addition because the polxaesters to the isatics have the formula: pC (O) -C (R? (R2) -0-R3-0 -C (R?) (R2) -C (0) - (O-R12) u -o) s (0 (0) -Rs-0) Blw where S is an enter-o in the scale around the 10, 000 and U is an integer on the scale of 1 to about 1,000. 47.- The device according to claim 39, further characterized in that the aliphatic poloxesters have M -C (0) -0 (R? (R2) -0-R3-0-C (R?) (R2) -C (0) - (O-R12)? "0) s (r-0 -Ri3 -0 (0) 1 -0 -)? _ 01w where is an integer on the scale of anything from 1 to 10,000 and U is an integer in the scale from 1 to about 1. 0 - 48. A device coated with a polumeric mixture comprising an aliphatic polyoxaester having a first bivalent repeating unit of the formula?: r? -O (O ) -C (R?) (R2) -0- (R3) -0-C (R?) (R2) -0 (0) -l 1 and a second repeat unit of the formula: and combinations thereof , wherein Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: -r (CH2) c -0 ~ 3D ~ (CH-2) E-TV where 0 is an integer in the range from 2 to about 5 , D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R12 is an alkyl ene unit containing from 2 to 8 carbon atoms and containing an internal amine (-M (R? O) -) or amide (-N (Rp) -); Rio and R11 are independently hydrogen or an alkyl group, eg it contains from 1 to 8 carbon atoms; and U is an integer in the scale from 1 to approximately 2,000; and a second polymer selected from the group consisting of homopolymer and lactone-type copolymer with repeating units described by formulas III, XI, aliphatic polyurethanes, polyurethanes, polyester polyurethane, polyethylene copolymer, polyamides, polyvinyl alcohols, full polyamide oxide, polypropylene oxide, polyethylene glycol, polypropylene glycol, polypropylene oxide, polyvinyl pyrrolidone, lacplarnide pol, polyhydric acid acrylate, inetacpy Axis pol i hi droxiet i lo and combinations thereof where the inherent viscosity of the poloxaester axis is in the scale of about 0.5 to about 2.0 deciliters per gram (dl / g) as measured in a solution of 0.1 g / 1 hexafluoropropanol (HFEP) at 25 ° C. 49.- The device coated with the polymer mixture according to claim 48, further characterized in that the polyoxyester-to-the-attic additionally contains a third repeat unit selected from the group consisting of: GOR ^ - IA TT CO-Rs -0 (0) -1B, III (CO-R13 -C (0)] p -0-LG and XI and combinations thereof wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms: A is an integer in the range of 1 to about 2000; Rs and R13 are independently selected from the group consisting of -CÍRβ) (R7) -, - (CH2Í3-0-, -CH2 -CH2 -O-CH2-, -CR8H- bl 0H2-, - (Ol-b -, - (CH2) F -OO (O) - and ~ (CH2)? - C00? -CH2-; Re and R7 are independently hydrogen or an alkyl containing from L to 8 atoms carbon, hydrogen or methyl Rs, F and K are integers on the scale from 2 to 6, B is an integer on the scale of 1 an axis so that the average molecular weight of the formula TTT is less than about ele 2,000,000; P is an integer in the scale of 1 to rn of rnode e.} that the molecular weight of average number of formula XI is less - of approximately 1,000,000; G represents the residue less than 1 to I. atoms of hydrogen of the hydroxyl groups of an alcohol which previously contains from 1 to about 200 hydroxyl groups, and L is an integer from about 1 to about 200. 50.- The device coated with the polymer mixture in accordance with Claim 48, further characterized because the device is a suture 51. The device coated with the polymer blend according to claim 1. 50, further characterized in that the suture is added to a needle. 52. The device coated with the polymer mixture according to claim 48, further characterized in that the aliphatic polyoxaesters have the formula: C0-C) 0) -C (R? (R2) -0- (R3) -0 -C (R?) (R2) C (0) - (0-RI2) U "1N where N is an integer on the scale of about 1 to about 10,000. 53.- The device coated with the pol Element according to claim 48, further characterized in that the aliphatic polyoxesters have the formula: r (- (O) - (R? (R2) -0-R3-0-C (R?) (R2) -C (0 ) - (0-Ri2) u "0) s (C (0) -R5 -0) Blw where C is an integer on the scale ele around 1 to 10,000 and U is an integer on the scale of 1 to approve 1. The device coated with the polymer mixture according to claim 48, further characterized in that the polyoxesters ali faticos have the formula: p -C (0) -0 (R? (R2) -0-R3 -0-C (R?) (R2) -C (0) - (0-Ri2) or "0) S (CO-R13 -0 (0) lp -0-) LG1 where S is an integer in the esca that of about l to 10,000 and an integer in the scale of 1 to about 1, 000 55. - A drug-based matrix comprising a drug and a polymer mixture composed of an aliphatic polyoxaester < Which has a first bivalent repeating unit of the formula E: r? -C (0) -C (R?) (R2) -0- (R3) -0-CÍR? ) (R2) ~ C (0) -1 T and a second repeating unit of the formula: CO-R12-IU, XIV on joint Ri and R2 are independently hydrogen or an alkyl group which contains from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula. ~ C (CH2) c -0 ~] P- (CH-2), - where 0 is an integer on the scale ele 2 to about 5, D os an integer on the axis scale around 0 to about 2,000, / F Í », an integer on the oscala d-1 around < him? Approximately 5, except when T) is zero in which case F will be an integer from 2 to 12; R12 is an alkylene unit containing from 2 to 8 carbon atoms and it contains an internal amine (-N (R? O) -) or amide (-N (Rn) -); Rio and R 11 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; and U is an integer in the scale from 1 to approximately 2,000; and a second polymer selected from the group consisting of lactone-type copolymer and copolymer furnace with repeat units described by * formulas III, XI, aliphatic alkyl ethane, polyester polyurethanes, polyester polyurethanes, full polyether copolymers , polyamides, polyvinyl alcohols, polyethylene oxide, polypropylene oxide, polyethylene glycol, polypropylene glycol, polyether oxide, polypropylene oxide, polyacrylamide, polyhydroxyethyl acrylate, meta polyhydr-ox let 1 lo and combinations thereof. 56.- The drug assortment matrix according to claim 55, further characterized in that the additional polyster-aliphatic ol pol or ment contains a third repeating unit selected from <; I read group consisting of axis: G -0-R «-1A TI G ~ 0-RS -0 (O) -3B, III (C-0-RI3-C (0) 1P-0-LG and XT and axis combinations the same, where R4 is a unit of the cell containing axis 2 to 8 carbon atoms, A is an integer in the scale of 1 to approximately 2000, R5 and R13 are independently selected from the group ejue consists of -C (Re) (R7) -, - (CH2) 3-0-, -CH2-CH2-O-CH2-, -CR8H-0H2-, - (CH2) 4 ~, - (CH2) F -0- 0 (0) - and - (CH2) - 0 (0) -CH2-; R & and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms; Re is hydrogen or methyl; F and K are integers on the scale 2 to 6, B is an integer on the scale of 1 an so that the average molecular weight of the formula Til is less than about 2,000,000, P is an integer on the scale of 1 to rn so that the molecular weight of the average number of the formula XI is less than about 1,000,000, G represents the residue minus axis 1 to L atoms of the hydroxy group of the hydride groups oxyl of an alcohol that previously contains from 1 to about 200 hydroxyl groups; and L is an integer from about 1 to about 200. 57.- The matrix of the drug assortment according to claim 55, further characterized in that the aliphatic polyoxester has the formula: ["(-CÍO) -C ( R (R2) -O-R3 -0-C (R?) (R2) -C (0) - (O-R12) u -O> S (C (0) -F? 5--0) B1W where is an integer on the scale of about 1 to 10,000 and U is an integer on the scale of 1 to about 1,000.

58. - The drug assortment matrix according to claim 55, further characterized in that the fat-polyoxaesther has the formula: [(-C (O) -C (R? (R2) -0-R3-0-C (RI) (R2) -0 (0) - (0 ~ Ri2) U -0) S ([~ 0-Ri3-C (0)] p ~ 0-) LG1 where is an integer in the scale around from 1 to LO, 000 and U is an integer in the scale from 1 to approximately 1,000.59 - A polymer mixture comprising a polyoxaester to the attic comprising a first bivalent repeating unit of the formula I: [OC (0) -C (RI) (R2) -0- (R3) ~ 0 ~ C (R?) (R2) -C (0) -] I and two second repeating units of the formulas: GO-RS- C (O) -3B, and ni (C-0-RI3-C (0) 1P-0-) LG XI where Ri and R2 are independently hydrogen or an alkyl group ei? E contains from the 8 carbon atoms R3 is an alkylene unit or is an oxyalkylone group of the following formula: -CICCH2) c-0 ~ lD- (CH-2) E-TV where 0 is an integer in the range from 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero in which case E will be an integer from 2 to 12; R5 and R13 are independently selected from the group consisting of -C (Rβ) (R7) -, - (CH2) 3-0-, -CH2-CH2 -O-CH2-, -CR8H-OH2-, - ( CH2 -, - (CH2JF-0-0 (0) and - (CH2)? -C (0) -CH2-; Re and R7 are independently hydrogen or an alkyl which contains from 1 to 8 carbon atoms; Hydrogen or methyl, F and K are integers on the scale from 2 to 6, B is an integer on the L-axis scale so that the average number molecular weight of the Til formula is less than about 2,000,000; P is an integer on the scale of 1 am so that the molecular weight of the average number of the formula XT is less than about 1,000,000; G represents the residue less than 1 to L atoms of hydrogen in the hydroxyl groups of an alcohol which previously contains axis 1 to approximately 200 and second polymer selected from the group consisting of homopolymer and copolymer eg lactone type with repeat units described by the formulas Til, XI, aliphatic polyurethanes, p oliurethanes < polyester, polyester polyurethanes, polyethylene copolymers, polyamides, polyvinyl alcohols 11, polyethylene oxide, polypropylene 0x1, polyethylene glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl pyrrole donut, polyapralnide , polyhydroxyethyl acrylate, polyhydroxyethyl methacrylate and combinations thereof. 60.- The polymer mixture according to the r * e? VI ndication 59, also characterized because additionally a third unit of repetition of the formula is found: G ~ 0-R4-1A, II in which R4 is an alkylene unit containing 2 to 8 carbon atoms; A is an integer on the scale of 1 to 1,000.

61. - A device made from an inefficient polymer of an aliphatic polyoxaester comprising a first bivalent repeating unit of the formula I: T 0 -C (O) -0 (Ri) (R2) -O- (R3 ) -0-0 (Ri) (R2) -0 (0) -] I and two second repeat units select them from the group of formulas consisting of: r-0-Rs-C (0) -] B, and Til (C-0-Ri3-0 (0) lp-0-) LG XI wherein Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is an alkylene unit or is an oxyalkylene group of the following formula: - [(CH2) C-0-] D- (CH-2) E-TV where 0 is an integer in the range from 2 to about 5, D is an integer on the scale of about 0 to about 2,000, and F ones an on the scale of about 2 to about 5, except when D is zero in which case F will be an integer 2 to 12; R5 and R13 are independently selected from the group consisting of 0 (R1) (R7) -, - (CH2) 3-0-, -CH2-CH2 -O-CH2 -, -CR8H-CH2-, - (CH2 -, - (CH2) F ~ 0-0 (0) - and - (CH2)? - C (0) -CH2-; Re and R7 are independently hydrogen or an alkyl containing from 1 to 8 carbon atoms carbon; Rs is hydrogen or methyl; F and K are integers on the scale of 2 to 6; B is an integer on the scale of 1 to n so that the average number molecular weight of the Til formula is less than about 2,000,000; P is an integer on the 1-axis scale so that the molecular weight * of the average number of the formula XT is less than about 1,000,000; G represents the residue less than 1 to t hydrogen atoms of the hydroxyl groups of an alcohol that previously contains from 1 to approximately 200 hydroxyl groups; and L is an integer from about * 1 to approximately 200. 62.- The aliphatic polyoxaester according to claim 59, further characterized by additionally being a third repeat unit of the formula: wherein RA is a unit of alkylene containing from 2 to 8 carbon atoms; A is an integer on the scale of 1 to 1,000. 63.- A device coated with an absorbable coating that comprises an aliphatic polyoxaester having a first unißladle bivalent axis repeat formula 1: r? ~ 0 (0) -C (R?) (R2) -0- ( R3) -0-C (R?) (R2) -0 (0) -] 1 and two second repeating units of the formulas: GO-RS-CÍO) -] B / v ?? t ([-0- Ri3-C (0) 3p ~ 0-) | _G XI where Ri and R2 are independently hydrogen or an alkyl group containing from 1 to 8 carbon atoms; R3 is an aguilene unit or is a group < The oxyalkylene axis follows the formula: -C (CH2) c ~ 0-] D - (0H2) E ~ TV where 0 is an integer on the scale 2 to about 5, D is an integer on the axis scale around 0 to approximately 2,000, and E is an integer on the scale of about 2 to approximately 5, except when D is zero in which case I. "will be an integer 2 to 12 Rs and R13 are independently selected from the group consisting of -C (Rβ) (R7) -, - (0l2) 3-0-, -CH2 -OH2-O-H2-, -CR8H-CH2-, - (CH2) 4-, - (0H2) F 0 0 (0) - and ~ (CH2)? - C (0) -CH2-; Re and R7 are independently hydrogene-) or an alkyl containing 1 to 8 atoms The carbon, Rs is hydrogen or methyl, F and K are integers on the scale 2 to 6, B is an integer on the scale of 1 an, so the molecular weight of the average number of the formula III is less than around 2,000,000; P an integer on the scale of 1 to in order that the average molecular weight of the formula XI is less than about 1,000,000; G represents the residue less than 1 to L hydrogen atoms of the groups of hydroxyl of an alcohol < iue previously contains 1 aa Next is 200 where the inherent viscosity of polyoxester is in the reagent stage of 0.5 to about 2.0 deciliters / grams (eil / g) as measured in a 0.1 g / 1 solution of hexafl uoropropanol (HFTP) a 25 ° C "64.- The polymer mixture according to claim 30, further characterized in that a third repeating unit of the fopnuLa is also found: wherein R4 is an alkylene unit containing from 2 to 8 carbon atoms. carbon; A is an integer on the scale l to 1,000. 65.- A drug assortment matrix comprising a drug and a polymer mixture composed of an aliphatic poloxester having a first bivalent repeating unit of the formula T: r? -0 (0) -C (R? ) (R2) -0- (R3) -0-C (R?) (R2) -0 (0) -1 T r *. and two second repeating units of the formulas: ro-Rs-c (o) -] B, and? tt (L ~ -0-RI3-0 (0? P ~ 0-) LG XI in donel Ri and R2 are independently hydrogen or an alkyl group which contains from the 8 carbon atoms, R3 is a unit or alkylene axis or is an oxyalkylene group of the following formula: -G (OH2) C-0-] D- (0H2 JE- IV where O is an integer on the scale of 2 to about 5, D is an integer on the scale ele around 0 to about 5 2,000, and E is an integer on the scale of about 2 to about 5, except when D is zero, in which case E will be an integer axis 2 to 12, R5 and R13 are independently selected from the group consisting of -0 (Re) (R7) -, (H2 J3-O-, , -CH2-CH2-O-CH2-, -0R3H H2-, - (CH2 -, - (CH2 JF -O-0 0 (0) - and - (0H2)? ~ 0 (0) ~ 0H2 ~; Re and R7"independently of hydrogen or an alkyl containing 1 to 8 carbon atoms, hydrogen or methyl R, F and K are integers on the scale 2 to 6, B is an enter or on the scale, so that the molecular weight of the average number of the formula III is less than 5 per cent-2,000,000; P is an integer in the scale of 1 to m, because the average molecular weight of the formula XT p less than about 1,000,000; G represents the residue less than 1 to L hydrogen atoms, the hydroxyl group groups of an alcohol < It previously contains from 1 to about 200 wherein the inherent viscosity of the polysaccharide is in the range from about 0.5 to about 2.0 deciliters / grams (dl / g) as measured in a 0.1 g / 1 solution. of hexafluoropropanol (HFTP) at 25 ° 0. 66.- The ma ri of drug curing according to claim 65, also characterized because ol Lfi polioxaester alifatico adi cíona! It has a third repeating unit of the formula: C-O-RÜ -1A, II wherein R "is an alkylene unit containing from 2 to 8 carbon atoms; A is an integer on the scale of 1 to 1,000 ..