MXPA06008976A - Tooth coating compositions and methods - Google Patents

Abstract

A tooth coating comprising at least 10%by weight of a natural resin system comprising at least two natural resins;a colorant;and pearlescent particles. Methods of coloring a tooth and methods of preventing or treating oral care conditions are also provided.

Description

COMPOSITIONS FOR COATING TEETH AND METHODS RELATED REQUEST This application claims the priority of the patent application of the United States of America series number 10 / 775,706 filed on February 10, 2004, the contents of which are incorporated herein by reference.

INTRODUCTION This invention relates to compositions and methods for whitening or coloring the teeth. The invention also relates to compositions and methods for applying orally or pharmaceutically active care agents, such as anti-caries agents or breath fresheners for teeth.

Consumers who want to whiten or color their teeth have a limited variety of products to choose from. The successful application of some products such as varnishes, crowns and lids, involves the destruction of the enamel of the teeth, and requires the service of a dental professional such as a dentist. In addition, teeth whitening or coloring products have not been used as carriers for active materials such as pharmaceutically active compounds, anti-cavity agents or breath fresheners.

Therefore, there is a continued need for new compositions and methods for whitening teeth, in particular compositions and methods for whitening teeth without the destruction of tooth enamel, as well as compositions and methods for delivering active materials to the oral cavity.

SYNTHESIS The present invention provides compositions and methods for imparting whiteness or color to teeth, using natural or synthetic resins and at least one colorant. In several embodiments, the present invention provides a coating for teeth comprising at least 10% by weight of a natural resin system comprising at least two natural resins, a dye, and talking particles. In several embodiments, the coating of the teeth comprises a natural resin system comprising at least two different resins, a dye, talking particles, and an active material. In one embodiment, the present invention provides a tooth coating composition comprising at least 10% of a natural resin system comprising rosin, mastic and shellac; the titanium dioxide dye and the titanium mica pearl particle.

The present invention also provides methods for coloring a tooth in a human or other animal subject which comprises applying to a tooth a coating comprising: at least 10% by weight of a natural resin system comprising at least two natural resins, a dye, and pearled particles. The present invention also provides a method for preventing or treating a condition for oral care in a human or other animal subject which comprises applying to a tooth of said subject a coating composition comprising at least 10% by weight of a system of natural resin comprising at least two natural resins, a dye and a pearled particle and an active for oral care.

It has been discovered that the compositions and methods of this invention provide advantages over temporary bleaching compositions among those known in the art including one or more of aesthetics and improved coloring efficacy, improved stability in the oral cavity including, improved adhesion of the coating of teeth to the surface of the tooth in the presence of saliva, and the delivery of benefits for oral care. Additional uses, benefits, and modifications of the present invention are apparent from the description set forth herein.

DETAILED DESCRIPTION The following description of the preferred incorporation or incorporations is merely exemplary in nature and it is not intended to limit the invention in any way, nor in its application or uses.

The following non-limiting definitions and guidelines should be considered in the review of the description of this invention as set forth herein. The headings (such as "introduction" and "summary") used herein are intended only for a general organization of the topics within the description of the invention and are not intended to limit the description of the invention or any aspect thereof. In particular, the subject matter described in the "introduction" may include aspects of technology within the scope of the invention and may not constitute a recitation of prior art. The subject matter described in the "synthesis" is not an exhaustive or complete description of the full scope of the invention or any incorporations thereof. The classification or discussion of a material within this section of this description as having a particular utility (for example as being a "system") is done for convenience and no inference should be drawn that the material must necessarily or only function in accordance with its classification given here when it is used in any given composition.

The citation references given herein do not constitute an admission that those references are prior art or that they have any relevance to the patentability of the invention described herein. All references cited in the description section of this specification are incorporated herein by reference in their entirety.

The description and specific examples, even when indicating embodiments of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention. In addition, the recitation of multiple incorporations having the declared characteristics is not intended to exclude other incorporations that have additional characteristics or other incorporations that incorporate different combinations of the declared characteristics. The specific examples are provided for illustrative purposes of how to make and use the compositions and methods of this invention and, unless explicitly stated otherwise, they are not intended to be a representation that given the embodiments of the invention are made or not done or tested.

As used herein, the words "preferred" and "preferably" refer to embodiments of the invention that provide certain benefits, under certain circumstances. However, other additions may also be preferred, under the same or other circumstances. In addition, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, and is not intended to exclude other embodiments from the scope of the invention.

As used here, the word "includes", and its variants, is intended to be non-limiting, so that this recitation of items in a list is not for the exclusion of other similar items that may also be useful in the materials, compositions, devices and methods of this invention.

As mentioned herein, all percentages of composition are by weight of the total composition unless otherwise specified.

The articles "a" and "an" as used herein indicate "at least one" of the article that is present. As used herein, the term "around" when applied to the value for a parameter of a composition or method of this invention indicates that the calculation or measurement of the value allows some slight inaccuracy without having a substantial effect on the chemical or physical attributes of the composition or method. If, for some reason, the inaccuracy provided by "around" is not otherwise understood in the art with this, ordinary meaning, then "around" is used here to indicate a possible variation of up to 5% in value.

Teeth Coating Compositions According to several embodiments of the present invention, a tooth coating composition is provided to impart a color, preferably a natural white color, to a tooth surface. The surface of the tooth is generally composed of tooth enamel, and the bleaching composition makes contact and preferably adheres to the tooth enamel to impart an immediate discernible coloring effect, thereby rapidly altering the color of the tooth surface. As mentioned herein "tooth" or "teeth" refers to natural teeth, dentures, dental plates, fillings, caps, crowns, bridges, dental implants and the like, and any hard surface dental prosthesis either permanently or temporarily fixed within of the oral cavity.

As used herein, "blanched" refers to a change in visual appearance of a tooth, preferably so that the tooth has a brighter hue. The color change of a tooth surface can be observed visually, for example with the help of meters or color comparison charts or can be measured by colorimetry, using any suitable instrument such as a Minolta Chromameter, for example the CR-400 model (from Minolta Corporation, of Ramsey, New Jersey). The instrument can be programmed, for example, to measure the Hunter Lab values or the L * a * b * values according to the standard established by the International Lighting Committee (CIÉ). The system L * a * b * provides a numerical representation of three-dimensional color space where L * represents a brightness axis, a * represents a red-green axis and b * represents a yellow-blue axis. The axes L * and b * are typically of greater application to the measurement of whiteness of the tooth. The increase in whiteness can be computed from the differences in the values L *, a * and b * before and after the treatment, or between the untreated and treated surfaces. A useful parameter is? E *, calculated as the square root of the sum of the squares of the differences in the values L *, a * and b * using the formula: ? E * = [(? L *) 2 + (? A *) 2 + (? B *) 2] 1/2 A higher value of? E * indicates a greater increase in whiteness. In various embodiments, the method of the present invention can perform an "E *" of at least about 1, or at least about 3, or at least about, or at least about .

The present invention includes tooth coating compositions and methods for imparting whiteness or color to the teeth. Such compositions comprise at least 10% of a natural resin system, a colorant, and pearlescent particles. The dye and pearlescent particles can impart whiteness or a non-white color to the teeth. The application of the compositions to the teeth in a mammal such as, for example, a human, covers the teeth and imparts whiteness or a color to the teeth.

Natural Resin System The natural resin system of the embodiments of the present invention comprises at least two different natural resins different from one another. As used herein, "natural resins" includes plant resins (e.g., those derived from plant sources) and animal resins (e.g., those derived from animal sources). Such resins include plant resins such as from trees, shrubs and seed exudates of recent origin, fossil resins, mined resins such as asphaltite, and resins derived from animals, such as derived from shellac from lacquer insects. The selection of the natural resins used in the system can be based on factors such as: 1) desired hardness of the coating of the teeth, 2) desired level and longevity of adhesion of the tooth coating to the teeth, 3) attributes of film formation , 4) the type of dye and pearlescent particles used, and 5) inclusion of additional active ingredients.

Natural resins vary based on the number of acid, polarity, molecular weight, softening point or a geographical origin of the resin. The standard classifications of natural resins by the American Rubber Importers Association include dammars, oriental indians, copal, acroids, elemi, mastic, sandarac and colophonium, all of which are suitable for incorporations of the present invention. Natural resins can take the form of rosins, distillates, saps, oils, balsams or gums, subcomponents thereof and mixtures thereof.

The natural resins useful in the tooth coating compositions of the present invention are in or can be obtained from natural sources in their unmodified state. The natural resin can also be modified. The modification of the natural resin may include processing steps, such as purification, for example, to remove colored contaminants, such as chromophoric impurities and other compounds which may be undesirable for inclusion in certain embodiments of the coating composition. of the tooth. Other example modifications include the isolation of constituents to separate a subcomponent from other constituents or to increase the concentration of desired subcomponents. Such purification may result in a tooth coating that is whiter than a comparable tooth coating in which the impurities have not been removed from the natural resin.

Modified resins also include chemical derivatives, for example, maleic modified oils, phenolic modified rosin ester resins, maleic modified rosin ester resin, hydrogenated rosin, and the like. Additional chemical alterations of the natural resin include, but are not limited to, the polymerization of a resin, copolymerization of a resin, copolymerization of various resins, and the creation of a synthetic resin that essentially mimics the attributes (acid number, polarity, weight molecular, softening point, etc.) of a natural resin from a living source.

The tooth coating preferably comprises a natural film-forming resin system. The concentration of the total film-forming resin system can be from at least about 10% to about 95%, from around 15% to around 90%, from around 20% to around 85%, from around 25% or 26% to around 60%, 70%, or 80%, or from around 30% to around 60%. In the preferred embodiments, the natural resin system comprises a mixture of at least one resin derived from the plant and at least one resin derived from animal or insect. Such a natural resin system comprises a mixture of colophonium and mastic (two plants derived from natural resins) and shellac (a natural resin derived from an insect). A useful shellac here is commercially available as Bulls Eye® shellac marketed by Zinsser Company, Inc. (of Somerset, New Jersey, E.U.A.).

A tooth coating of several incorporations optionally further comprises a synthetic polymer blended with a natural resin system. The term "polymer" as used herein, may encompass both acid and salt forms of homopolymers, copolymers, block copolymers, graft copolymers, crosslinked polymers, polymerizable monomers and salts thereof, and monomers that polymerize in conjunction with the application to a tooth. Non-limiting examples of the polymers within the scope of the present invention may include polyacrylamide, polymethacrylate, polyethylene glycol, polyvinyl pyrrolidone, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, crosslinked polyvinyl pyrrolidone, polyvinyl pyrrolidone copolymer vinyl acetate, polyvinyl alcohol, polyacrylate, polyacrylic acid, crosslinked polyacrylate, crosslinked polyacrylic acid, polyethylene oxide, polyethylene glycol, polyvinyl alkyl, maleic acid ether copolymer, carboxyvinyl polymer, polystyrene and combinations thereof. In some configurations, a polyvinyl pyrrolidone may be a polyvinyl pyrrolidone provided by International Specialty Products, of Wayne, New Jersey. In some configurations, a hydroxypropyl cellulose may be the Klucel® hydroxypropyl cellulose supplied by Hercules, Inc. of Wilmington, Delaware, E.U.A. In some configurations, the synthetic polymer may comprise at least about 90%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, per at least about 99% or a greater percent of a monomeric repeat unit.

In configurations where the polymer comprises polymerizable monomers and salts thereof, a polymer may comprise at least about 90%, at least about 95%, at least about 96%, at least about 97 %, at least about 98%, at least about 99% or a greater percent of a monomer.

As noted above, in certain embodiments, the synthetic polymer can be a polyacrylate. Non-limiting examples of the polyacrylates of the present invention include of the present invention include polyacrylate, crosslinked polyacrylates, alkyl acrylates such as polymethacrylate, alicyclic, aromatic, heterocyclic and polyacrylate containing vinyl group, hydroxy containing polyacrylates, such as alkoxy polyacrylates, polyacrylates containing carboxylic acid, polycyanoacrylates, polidialquilaminoetilacrilatos, polyethyl polifluoroalquilacrilatos, polybutylacrylate such as poly n-butalacrilato and poly t-butyl acrylate, poly 2- ethylhexylacrylate, policiclohexilacrilato, polibencilacrilato, poly 2-hydroxyethyl acrylate, hydroxypropyl acrylate-poli2, polidimetilaminoetilacrilato, polidietilaminoetilacrilato, poliglicidilacrilato, politetrahidrofurfuril acrylate; poly alkyl methacrylates, such as polymethyl methacrylate, polyethyl methacrylate, poly di and tri methacrylates, polymethacrylates containing vinyl and alicyclic group, -aromatic, heterocyclic, hydroxy-containing polymethacrylates such as poly alkoxymethacrylates, poly dialkylaminoethyl methacrylates, polyfluoroalkyl methacrylates, polybutyl methacrylate such as poly n- butyl methacrylate, poly t-butyl methacrylate, poly 2-ethylhexyl methacrylate, poly cyclohexyl methacrylate, polybenzylmethacrylate, poly 2-hydroxyethyl methacrylate, poly 2-hydroxypropylmethacrylate, polydimethylaminoethyl methacrylate, polydiethylaminoethyl methacrylate, polyglycidyl methacrylate, and polytetrahydrofufurfuryl methacrylate. In the embodiment, the compositions of the present invention comprise rosin, mastic and a polyacrylate.

In some embodiments, the synthetic polymer can be a polyacrylamide or a substituted polyacrylamide. Non-limiting examples of polyacrylamides include polyacrylamide, crosslinked polyacrylamides, alkyl archilamides such as polymethacrylamide, polyacrylamides containing vinyl and heterocyclic group, aromatic and alicyclic, polyacrylamides containing hydroxy such as alkoxy polyacrylamides, polyacrylamides containing carboxylic acid, polydialkylaminoethyl acrylamides, polyfluoroalkyl acrylamides, polyethylacrylamide, polybutylacrylamide, as poly n-butylacrylamide and poly t-butylacrylamide, poly 2-ethylhexylacrylamide, polycyclohexylacrylamide, polybenzylacrylamide, poly 2-hydroxyethyl acrylamide, poly 2-hydroxypropyl acrylamide, polydimethylaminoethyl acrylamide, polydiethylaminoethyl acrylamide, polyglycidyl acrylamide, polytetrahydrofurfuryl acrylamide, alkyl methacrylamides, such as polymethyl methacrylamide, polyethyl methacrylamide, polymethacrylamides containing vinyl group and heterocyclics, alicyclic aromatics, polymethacrylamides containing hydroxy such as alkoxymethacrylamides, poly di and tri methacrylamide ions, polydialkylaminoethyl methacrylamides, polyfluoroalkyl methacrylamides, polybutylmethacrylamide such as poly n-butyl methacrylamide and t-butyl methylacrylamide, poly 2-ethylhexyl methacrylamide, polycyclohexyl methacrylamide, polybenzyl acrylamide, polybenzyl methacrylamide, poly 2-hydroxyethyl methacrylamide, poly 2-hydroxypropyl methacrylamide, polydimethylaminoethyl methacrylamide, polydiethylaminoethyl methacrylamide, polyglycidyl methacrylamide, and polytetrahydrofurfuryl methacrylamide.

In embodiments where the polymer is a monomer that polymerizes in conjunction with the application to a tooth, a tooth coating composition may comprise a cyanoacrylate monomer. The polymerization of the cyanoacrylate monomers can be initiated with contact with an aqueous fluid such as, for example, saliva on the surface of a tooth. Similarly, a tooth coating composition can comprise a toxic monomer which can be polymerized upon contacting the composition with an initiator soon after or before application to a tooth.

In several embodiments, the natural film-forming resin system (and the optional synthetic polymer) used in the compositions given herein may have a weight average molecular weight, an average number-average molecular weight, a Z-average molecular weight or a weight viscosity average molecular from about 100 to about 5,000,000; from around 200 to around 2,500,000; from about 500 to about 1,000,000; from about 1,000 to about 5,000,000; or from around 10,000 to around 125,000.

In several embodiments, a tooth coating is a tooth coating fluid. "Fluid" as used herein means a non-solid and non-gaseous substance. In several embodiments, the fluid may be liquid or a semi-solid. The viscosity of a fluid can vary from freely flowing, low viscosity to extremely high viscosity in which the flow is slow or almost imperceptible to a human without help under environmental conditions. For example, ordinary silica glass, such as glass comprised of a window pane, can be considered a fluid here. A fluid here can be, in certain embodiments, a thixotropic liquid. A "semi-solid" as used herein may be a gel, a colloid, a paste, an ointment or a gum. As used herein, semi-solids and liquids are distinguished fluids based on viscosity: a semi-solid is a high viscosity fluid, while a liquid has a lower viscosity. There is no definitive division line between these types of fluids. A fluid of a tooth coating composition given herein can have a viscosity, measured at 25 ° C, ranging from about 0.18 millipascal-seconds (mPa-s) to about 100,000,000 millipascal-seconds, from about 0.5. milipascal-seconds to about 10,000,000 millipascal-seconds, from about 1 millipascal-second to about 1,000,000 millipascal-seconds, from about 1.5 millipascal-seconds to around 100,000 millipascal-seconds, or from from around 2 milipascal-seconds to around 10, 000 pascal-seconds. In some configurations, a fluid of a composition herein can have a viscosity of from about 100 to about 1,000 Pa-s. Without being limited by theory, it is believed that the viscosity of a given fluid here will vary with the amount (percentage) of a natural film-forming resin system and the weight average molecular weight of natural film-forming resins.

In several embodiments, a tooth coating as described herein may be an adhesive fluid that adheres to the teeth. Without being limited by theory, it is believed that the adhesives of the fluid of the present invention will vary with the amount (percent) of the natural film-forming resin system, and the weight average molecular weight of a natural film-forming resin. Adhesiveness can be measured using standard adhesion tests known in the art, for example, the adhesive test described in United States of America patent number 6,613,812 issued to Bui et al., Issued September 2, 2003. certain embodiments, the adhesiveness between a tooth and a film formed of a fluid of the present invention can be from about 3.4 megapascals (MPa), at least 6.9 megapascals, at least 13.8 megapascals, or more.

In various embodiments of the present invention, a tooth-coating composition comprises a natural film-forming resin system that can form a film on a surface of the teeth after application thereto. In some embodiments, a formulation of a composition may comprise the natural resin system and the volatile solvent which may dissolve the resin. The solvent may be, for example, an organic solvent, such as an alcohol, for example, ethanol. In several embodiments, the compositions of the present invention comprise a solvent in an amount of from about 1% to about 70%, from about 10% to about 50%, from about 20% to about 40%. %, from around 25% to around 35%. In some embodiments, a film may be formed when the solvent is removed, for example, through evaporation. In some embodiments, a film can be formed as monomers composed of the polymerized composition. Without being limited by theory, it is believed that the longevity of a film, for example the period of time during which the film remains intact on the teeth, will vary with the percentage amount of the natural film-forming resin system in the film. and the weight average molecular weight of natural resins.

In various embodiments, a skilled artisan may select a percentage amount and a weight average molecular weight of a polymer composed of a composition herein depending on the intended use. For example, a user who wishes to color their teeth for one night may use a formulation comprising a low percentage of resin and / or a resin of low average molecular weight, while a user desiring a tooth coating that lasts several months it can use a formulation comprising a high percentage of resin and / or a resin of high average molecular weight.

Colorant The coatings of the teeth of the incorporations of the present invention may comprise at least one colorant. The term "colorant" as used to describe here a substance that can impart a color when applied to a tooth. A color, as used here, can be any hue, dye or remnant perceptible, including but not limited to the spectrum colors, to the colors comprised within the color space L * a * b *, the colors comprised within the space RGB color, as well as black, brown, gray and white. A color imparted to a tooth by a tooth coating fluid described herein may be a white color or a non-white color. In various embodiments, the colorant may be a pigment or a dye. In certain embodiments, a pigment can be a white pigment that can impart a white color to a tooth.

In some configurations, the colorant may comprise a plurality of pigment particles. A pigment, as used herein, can mean a particulate colorant. In some configurations, the compositions of the present invention may comprise one or more dyes at a concentration, individually, or in total, from about 0.1% (w / w) to about 20%, from about 1% to about 19%, from about 2% to about 18%, from about 3% to about 17%, from about 4% to about 16%, or from about 6% to about of 15%. In some configurations, the pigment particles can have an average size of from about 0.1 micrometers to about 1000 micrometers, from about 0.3 micrometers to about 100 micrometers, or from about 0.5 micrometers to about 50 micrometers in size. diameter or the longest dimension.

In several embodiments, the colorant is a white pigment. The white pigment can be, for example, a white polymer. In some configurations, the white polymer can be a polymer as described in U.S. Patent No. 6,669,930 issued to Hoic. Non-limiting examples of such polymers include polyethylene, polypropylene, ethylene / propylene copolymer, polytetrafluohylene and polyhexafluoropropene. Specific examples of the white polymers include polyethylene PE220, polypropylene and polytetrafluohylene (PTFE), as supplied by Pre-Sperse, Inc. (of Somerset, New Jersey, E.U.A.). Such white polymers may be high molecular weight polymers having a weight average molecular weight, an average number molecular weight, an average Z-molecular weight, an average viscosity molecular weight of from about 100 to about 10,000,000.; from around 200 to around 5,000,000; from about 500 to about 1,000,000; from about 1,000 to about 500,000; from around 10,000 to around 100,000 or from around 20,000 to around 50,000.

In some configurations, the white pigment may comprise metal oxide such as, for example, titanium oxide, aluminum oxide, tin oxide, calcium oxide, magnesium oxide, zinc oxide or a combination thereof.

In several embodiments, the colorant is a non-white colorant. In some configurations, the non-white colorant comprises an organic pigment. In certain embodiments, the non-white colorant may be a dye tested for incorporation into a food, drug or cosmetic by a regulatory agency, such as for example FD &C or D &C pigments and dyes approved by the food administration and drugs to be used in the United States of America. Non-limiting examples of non-white dyes include FD &C red # 3 (tetraiodofluorescein sodium salt), Food red 17, 6-hydroxy-5-. { (2-methoxy-5-methyl-4-sulfophenyl) azo} -2-naphthalene sulphonic acid, food yellow 13, quinophthalone monosulfonic acid, quinophthalone disulfonic acid, 2- (2-quinolyl) indedione monosulfonic acid, 2- (2-quinolyl) indanedione disulfonic acid, FD &C yellow No 5, FD &C yellow No. 6, FD &C green No. 3, FD &C blue No. 1, FD &C blue No. 2, D &C red # 30, phthalocyanine green, salts thereof and mixtures thereof.

In some embodiments, the non-white colorant is a dye lacquer pigment. In some configurations, the dye lacquer may be an aluminum or calcium salt of an FD &C dye such as, for example, FD &C green # 1 shellac, FD &C blue # 2 shellac, D &C red # 30 lacquer or FD &C yellow # 15 lacquer, or mixtures thereof.

In several embodiments, the non-white colorant comprises an inorganic pigment. Non-limiting examples of the inorganic pigments may include certain metal oxide pigments such as, for example, copper oxide, iron oxide and chromium oxide. Other non-white inorganic pigments which may be comprised by a coating of teeth alone or in combination may be, for example, mineral pigments such as ultramarine blue (lapis lazuli).

In certain configurations, the colorant comprises a dye contained within a water insoluble polymer. In a non-limiting example, the blue FD &C # 1 dye may be contained within a water-insoluble polymer such as polyethylene such as that found in polyethylene beads (e.g., Microblue Spectrabeads, from Micropowders, Inc. Tarrytown, New York, USA). In certain embodiments, the colorant may be a non-bleeding dye.

Pearl particles The coatings of the teeth of the embodiments of the present invention may comprise pearlescent particles. In some configurations, the pearlescent particles may provide a white pearl color. In other configurations, the pearlescent particles may provide a non-white pearly color. "Pearl" and "pearl" as used herein may refer to an optical property of a material in which the material has a lustrous pearl-like appearance. A pearlized material can provide a sense of depth and brightness and can be aesthetically appealing. Without being limited by theory, pearlescent particles are believed to partially reflect and partially refract incidental light. The extent of reflection or refraction of incident light by a pearlized material may depend on the angle of incidence of light and / or the angle of vision. As used herein, "pearly" may include iridescence and opalescence. Pearl materials may appear monochromatic or appear to change color depending on the viewing angle.

The pearlescent particles used in the compositions given herein can provide aesthetic or cosmetic effects such as, for example, luster or spark. In some configurations, a composition may comprise monochromatic pearlized particles. In some configurations, a composition may comprise pearlescent particles having a variety of colors. A tooth coating composition may comprise pearlescent particles of from about 0.1% to about 20%, from about 1% to about 19%, from about 2% to about 18%, from about 3% to around 17%, from around 4% to around 16%, or from around 6% to around 15%. In some configurations, the pearled particles can have an average size of from about 0.5 micrometers to about 500 micrometers, from about 1 micrometer to about 100 micrometers, or from about 2 micrometers to about 20 micrometers in diameter or of the longest dimension.

The pearlescent particles may comprise a single material or a unique chemical species, such as, for example, a silicate such as mica, or bismuth oxychloride.

By "mica" is meant any one of the group of hydrous aluminum silicate minerals with a flat morphology and a basal excision (micaceous). The mica can be, for example, sheet mica, residue mica, or leaflet mica as exemplified by the micas of the muscovite, biotite or phlogopite type. In the embodiments, the pearlescent particles may comprise a complex comprising more than one mineral or chemical species, such as, for example, mica coated with metal oxide such as titanium oxide. In some embodiments, the pearled particles may comprise at least one non-white component such as iron oxide, may comprise an optical interference composition, for example as provided by certain iridescent or opalescent minerals, such as opal, or compositions comprising mica coated with one or more layers of titanium oxide. The pearlized particles can also be of biological origin, for example fish scales or mother-of-pearl. Certain pearly particles of biological origin may comprise calcium carbonate, such as, for example, pearl, mollusk shell such as mother of pearl obtained from the oyster shell or nacre.

In some embodiments, pearlescent particles comprise those described as pigments Timiron®, Colorona® pigments, Dichrona® pigments, Soloron® pigments, Biron® powders, Biron® dispersions, dispersions Nailsyn® or Microna® matte colors (all trademarks EM Industries, Inc. of Hawthorne, New York, E.U.A., E. Merck division). For example, the mica titanium particles may be pearlescent particles such as Timiron® particles.

The white or pearlescent mica titanium particles can be, for example, the "Silverwhite" Timiron® particles such as Timiron® Starluster MP-115, Timiron® Supersheen MP-1001, Timiron® Sparkle MP-47, Timiron® Supersol, MP-1005, Timiron® Peral Flake MP-10, Timiron® Pear Sheen MP-30, Timiron® Super Silver Fine, Timiron® Gleamer Flake MP-111, Timiron® Ultraluster MP-45, Timiron® Transwhite MP-18, Timiron® Diamond Cluster MP-149, Timiron® Super Silver, Timiron® Stardust MP-80, Timiron® Arctic Silver or Timiron® Snowflake MP-99.

In some configurations, the mica particles may comprise mica and a metal oxide such as titanium oxide in a non-white color, presenting for example, an interference-based or iridescent color. For example, a tooth coating may comprise a gold pigment such as Timiron® Gold Plus MP-25, Timiron® Sun Gold Sparkle MP-29, Timiron® Fine Gold MP-20, Timiron® Transgold MP-28 or Timiron® Karat. Gold MP-24; an interfering pigment, such as Timiron® Super Green, Timiron® Super Blue, Timiron® Super Red, Timiron® Gold MP-127, Timiron® Blue MP-155, Timiron® Super Gold, Timiron® Gold Glow MP-26, Timiron® Silk gold, Timiron® silk red, Timiron® silk blue, Timiron® silk green, Timiron® super copper, Timiron® super violet, Timiron® red starlight, Timiron® blue starlight, Timiron® gold starlight, Timiron® green starlight, Timiron® Splendid gold, splendid red Timiron®, splendid blue Timiron®, splendid green Timiron®, splendid Copper Timiron® or splendid Violet Timiron® or a metallic-colored pigment such as Timiron® MP-60 Bronze or Timiron® MP-65 Copper. In some configurations, a fluid may comprise multiple types of pigments for cosmetic or aesthetic effects.

Non-Polymer Material In various configurations, the coating fluid of the teeth of the present invention further comprises one or more additional components, such as in non-limiting examples, a non-polymeric organic hydrophobic material. The organic non-polymeric material can be, for example, a wax, such as a beeswax, for example a white beeswax or a paraffin. In various embodiments, the composition may comprise a non-polymeric hydrophobic material at a level of from about 0.01% to about 2% (w / w).

In the preferred embodiments, a tooth coating of the present invention comprises a natural resin system, an alcohol solvent, and a non-polymeric hydrophobic material. For example, a tooth coating of the present invention may comprise a natural resin system comprising rosin, slab, and shellac; an ethanol and paraffin solvent as the non-polymeric hydrophobic material. The natural resin system may be present in the coating of. tooth at about 70%, ethanol may be present at less than about 30%, and paraffin may be present at less than about 1%. Specifically, the natural resin system may comprise about 33% rosin, about 12% slab and about 22% shellac of the tooth coating.

Sweeteners In several embodiments, a sweetener is employed in the tooth coatings of the present invention. Sweeteners among those useful herein include orally acceptable nutritive or non-nutritive, natural or artificial sweeteners. Such sweeteners include dextrose, polydextrose, sucrose, maltose, dextrin, dried invert sugar, mannose, xylose, ribose, fructose, levulose, galactose, corn syrup (including high fructose corn syrup and corn syrup solids), partially starch hydrolyzed, hydrolyzed hydrogenated starch, sorbitol, mannitol, xylitol, maltitol, isomalt, aspartame, neotame, saccharin and salts thereof, sucralose, intense sweeteners based on dipeptide, cyclamates, dihydrochalcones and mixtures thereof. One or more sweeteners are optionally present in a total amount depending strongly on the particular sweeteners or selected sweeteners, but typically at levels of from about 0.01% to about 5% by weight, and preferably from about 0.5% to about 2% by weight. Sodium saccharin is preferred for certain additions.

Flavoring Agent The bleaching compositions of the teeth of the present invention optionally comprise a flavoring agent. Flavors among those useful herein include any material or mixture of operable materials to improve the flavor of the composition. Any orally acceptable natural or synthetic flavor may be used, such as flavor oils, flavoring aldehydes, esters, alcohols, similar materials and combinations thereof. Flavors include vanillin, sage, marjoram, parsley oil, spearmint oil, cinnamon oil, pyrrole oil (methyl salicylate), peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, citrus oils, oils and fruit essences, including those derived from lemon, orange, lime, grapefruit, peach, banana, grape, apple, strawberry, cherry, pineapple, bean and nut derived flavors such as cocoa, coffee, cola, peanut , almonds, etc., adsorbed and encapsulated flavorings and mixtures thereof. Also encompassed within the flavorings cited herein are ingredients that provide fragrance and / or other sensory effect in the mouth, including cooling or heating effects. Such ingredients include menthol, menthyl acetate, methyl lactate, camphor, eucalyptus oil, eucalyptol, acetol, eugenol, cassia, oxanone, a-irisone, propenyl guaietol, thymol, linalool, benzaldehyde, cinnamaldehyde, N-ethyl-p-methane. 3-carboxamine, N, 2, 3-trimethyl-2-isopropylbutanamide, 3-1-methoxypropane-1, 2-diol, cinnamaldehyde glycerol acetal (CGA), methane glycerol acetal (MGA), and mixtures thereof. One or more flavors are optionally present in a total amount of from about 0.03% to about 5% by weight, optionally in several additions of from about 0.2 to about 1% by weight.

Systemic and Oral Care Assets In several embodiments, an active material is included in the bleaching compositions of the present invention. In some additions, the optional active ingredient is a "systemic active" which is operable to try to avoid a disorder which, in whole or in part is not of a disorder of the oral cavity. In several embodiments, the active is an operable "oral care asset" to try to avoid a disorder or provide a cosmetic benefit within the oral cavity (e.g., teeth, gums, or other hard or soft tissues of the oral cavity). The oral cavity The assets for oral care among those useful here include bleaching agents, anti-cavity agents, tartar control agents, periodontal actives, abrasives, breath fresheners agents against odor, tooth desensitizers, saliva stimulators, antibacterial agents, and combinations thereof.It is still understood when the general attributes of each of the above categories of assets may differ, there may be Some common attributes and any given material can serve multiple purposes within two or more of such asset categories. of the active materials are described in U.S. Patent No. 6,596,298 issued to Leung et al., and in U.S. Patent Application No. 10 / 739,803, issued to Boyd et al. and filed on October 18. December 2003.

The compositions of the present invention can also be used for the treatment or prevention of systemic disorders, such as the improvement of overall systemic health characterized by the reduction in the risk of the development of systemic diseases, such as cardiovascular disease, shock, diabetes, severe respiratory infection, infants of low birth weight and premature births (including dysfunction after childbirth depending on development / neurological) and an increased risk of mortality. Such methods include those described in U.S. Patent Application No. 2003/0206874, issued to Doyle et al., Published November 6, 2003.

In some configurations, a bleaching agent can be, in a non-limiting example, a peroxide, a hypochlorite, a peroxide acid, a metal chlorite, a perborate, a percarbonate such as sodium percarbonate, a persulfate such as oxone as described in the patent of the United States of America number 6,419,906 granted to Xu et al., and granted on July 16, 2002, or an oxidoreductase. A peroxide compound can be, for example, a hydrogen peroxide, a urea peroxide, or a calcium peroxide. A metal chlorite can be, for example, a calcium chlorite, a barium chlorite, a magnesium chlorite, a lithium chlorite, a sodium chlorite or a potassium chlorite. An oxidoreductase can be, for example, an enzyme described in U.S. Patent No. 5,989,526 issued to Aaslyng et al. On November 23, 1999, such as laccase, an oxidase or a peroxidase.

The compositions of the present invention optionally comprise an antimicrobial agent (eg, antibacterial). One or more such agents may be present. Suitable examples include without limitation the copper (II) compounds such as copper (II) chloride, fluoride, sulfate and hydroxide, sources of zinc ion such as zinc acetate, zinc citrate, zinc gluconate, zinc glycinate. , zinc oxide, zinc sulfate and zinc sodium citrate, salts and phthalic acid thereof such as magnesium monopotassium phthalate, hexetidine, octenidin, sanguinarin, banzalkonium chloride, dominoen bromide, alkyl pyridinium chlorides such as chloride of cetylpyridinium (CPC) (Including combinations of CPC with zinc and / or enzymes), tetradecylpyridinium chloride and N-tetradecyl-4-ethylpyridinium chloride, iodine, sulfonamides, bisbiguanides such as alexidine, chlorhexidine and digulconato chlorohexidine, piperidino derivatives such as delmofinol and octapinol , magnolia extract, grapeseed extract, menthol, geraniol, citral, eucalyptol, antibiotics such as augmentin such, amoxicillin, tetracycline, doxycycline, minocycline, metronidazole, neomycin, kanamycin and clindamycin, and the like.

Other suitable antibacterial agents include the nonionic and anionic antibacterial agents known to one skilled in the art. Exemplary nonionic antibacterial agents include water insoluble non-cationic antibacterial agents essentially such as alkylphenoxy phenols; the cycloalkyl phenoxyphenols; 9,10- dihydrophenanthrenol; alkylphenols; cycloalkyl phenols; phenolic compounds; halogenated carbanilides; halogenated salicylanilides; benzoic esters; halogenated diphenyl ethers and mixtures thereof. A particularly suitable nonionic antibacterial agent is a diphenyl ether such as 2,4,4'-trichloro-2'-hydroxyphenyl ether (Triclosan) and 2,2'-dihydrixi-5, 5'-dibromodiphenyl ether. An additional illustrative list of useful antibacterial agents is provided in U.S. Patent No. 5,776,435 issued to Gaffar et al., July 7, 1998 and incorporated herein by reference. One or more antimicrobial agents are optionally present in a total antimicrobial effective amount, typically from about 0.05% to about 10%, for example from about 0.1% to about 3% by weight, of the composition.

The compositions of the present invention optionally comprise an antioxidant. Any orally acceptable antioxidant can be used, including butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenols, ascorbic acid, herbal antioxidants, chlorophyll, maltonin and mixtures thereof.

The compositions of the present invention optionally comprise an orally acceptable zinc ion source useful, for example, as an antimicrobial agent, against the calculation or refreshing of the breath. One or more such sources may be present. Suitable zinc ion sources include without limitation zinc acetate, zinc citrate, zinc gluconate, zinc glycinate, zinc oxide, zinc sulfate, sodium zinc sulfate and the like. One or more sources of zinc ion are optionally and illustratively present in a total amount of from about 0.05% to about 3%, for example from about 0.1% to about 1%, by weight of the composition.

The compositions of the present invention optionally comprise an agent against the plate (eg plate switch). One or more of such agents may be present in a total antiplaque effective amount. Suitable antiplaque agents include without limitation the stannous, copper, magnesium and strontium salts, the dimethicone copolyol, such as copolyol cetyl dimethicone, papina, glucoamylase, glucose oxidase, urea, calcium lactate, calcium glycerophosphate, strontium polyacrylates of agents chelators such as citric and tartaric acids and alkali metal salts thereof.

The compositions of the present invention optionally comprise an anti-inflammatory agent. One or more of such agents may be present in a total effective anti-inflammatory amount. Suitable anti-inflammatory agents include without limitation spheroidal agents such as flucinolone and hydrocortisone, and non-steroidal agents (NSAIDs) such as ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodolac, indomethacin, sulindac, tolmetin, ketoprofen , fenoprofen, piroxicam, nabucometone, aspirin, diflunisai, meclofenamate, mefenamic acid, oxifenbutazone and phenylbutazone. One or more anti-inflammatory agents are optionally present in the composition in an anti-inflammatory effective amount.

The compositions of the present invention optionally comprise a histamine H2 receptor antagonist. The H2 antagonists useful herein include cimetidine, etintidine, ranitidine, ICIA-5165, thiothidine, ORF-17578, lupitidine, donetidine, famotidine, roxatidine, pifatidine, lamtidine, BL-6548, BMY-25271, zaltidine, nizatidine, mifentidine, BMY- 42368, SKF-94482, BL-5341A, ICI-162846, ramixotidine, Wy-45727, SR-48042, BMY-25405, loxitidine, da-4634, bisfentidine, sufotidine, ebrotidine, HE-30-256, D-16637, FRG-8813, FRG-8701, impromidine, L-643728, HB-408.4 and mixtures thereof.

The compositions of the present invention optionally comprise a tooth sensitivity or desensitizing agent. One or more such agents may be present. Suitable desensitizing agents include without limitation potassium salts such as potassium citrate, potassium tartrate, potassium chloride, potassium sulfate and potassium nitrate. Another suitable desensitizing agent is sodium nitrate. Alternatively or in addition a local systemic analgesic such as aspirin, codeine, acetaminophen, sodium salicylate or triethanolamine salicylate can be used. One or more desensitizing and / or analgesic agents are optionally present in an analgesic and / or desensitizing effective amount, typically from about 0.05% to about 5%, for example from about 0.1% to about 3% by weight, of the composition.

In some configurations, a scale control agent can be, in a non-limiting example, a dialkali metal or tetralcalin pyrophosphate salt such as Na4P207, K4P207, a2K2P2? 7, Na2H2P2? 7 and K2H2P207; and a long chain polyphosphate such as sodium hexametaphosphate; and a cyclic phosphate such as sodium trimetaphosphate. In some configurations, a polyphosphate may be a β-phase calcium pyrophosphate as described in U.S. Patent No. 6,241,974 issued to White Jr., et al., Issued June 5, 2001.

In some configurations, a breath freshening agent can be an odor reducing agent. An odor reducing agent may be a sulfide precipitating agent. Non-limiting examples of the sulfide precipitating agents include metal salts, such as copper salt and zinc salt. Non-limiting examples of such salts include copper gluconate, zinc citrate and zinc gluconate.

The compositions of the present invention optionally comprise a nutrient. Suitable nutrients include vitamins, minerals, amino acids and mixtures thereof. Vitamins include vitamins C and D, thiamin, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalmin, para-aminobenzoic acid, bioflavonoids and mixtures thereof. Nutritional supplements include amino acids (such as L-tryptophan, L-lysine, methionine, threonine, levocarnitine and L-carnitine), lipotropic agents (such as choline, inositol, betaine, and linoleic acid), fish oil (including components of such as polyunsaturated fatty acids omega-3 (N-3) eicosapentaenoic acid and docosahexaenoic acid), coenzyme Q10 and mixtures thereof.

The compositions of the present invention optionally comprise proteins. Suitable proteins include milk proteins and enzymes such as peroxide-producing enzymes, amylase, plaque-disrupting agents, such as papain, glucoamylase and glucose oxidase.

The compositions of the present invention optionally comprise additional ingredients such as plate buffers such as urea, calcium lactate, calcium glycerophosphate and strontium polyacrylates.

METHODS In several embodiments, the present invention provides methods for coloring a tooth in a mammal. The mammal can be a human or a non-human higher order mammal such as a cat, dog or horse for example. The methods may comprise applying to a tooth a coloring amount of teeth of a fluid comprising one or more cosmetic coloring agents and a natural film-forming resin system or a synthetic polymer. In some compositions of the present invention, the synthetic polymer or natural resin is present at a level of at least about 10%, of at least about 15%, of at least about 20%, of at least about 25%, of at least about 26% or at least about 30%. In some embodiments, the natural resin is present at a level of at least 25%, 26% or at least about 30%. The coating of the tooth can be a fluid as described above. In some configurations, the coloring agents may comprise one or more white and / or pearly coloring agents. In a preferred embodiment, the white or pearlescent coloring agent comprises titanium oxide, titanium mica or a white polymer as described herein.

The application of a fluid composition of the present invention can be accomplished using any suitable method known in the art. For example, an applicator such as a brush may be immersed in a tooth coating fluid described herein, and the fluid may then be painted on a tooth. In addition to brush application, other non-limiting methods of application may comprise applying a rinse comprising a tooth coating fluid, applying a semi-solid tooth coating fluid from a bar that resembles a lipstick, applying a semisolid using a crayon-type bar, a spray on the fluid, smearing on the fluid using a wipe, or transferring the fluid from an adhesive strip. After the application of a fluid of the invention to the specific teeth, a film adherent to the teeth comprises the natural resin system, a dye and a pearled particle can be formed. The addition of a film to a tooth can be promoted by allowing the fluid to dry after application to the tooth so that a film forms on the teeth. A film once formed can remain on the tooth for at least 1 hour to about 1 year, from from about 1 day to about 6 months, from about 1 week to about 3 months, or from about 2 weeks to about 2 months. A film formed on a tooth can be removed, for example, by friction, for example by providing by brushing teeth or mechanical scraping or in some embodiments, through the application of a solvent, such as for example ethanol. Furthermore, in some configurations, the application of a composition of the invention to a tooth can have a beneficial therapeutic effect, even without the presence of a therapeutic active in the composition, since the composition prevents the acids present in the oral cavity from contact with the tooth.

In certain embodiments, the application of a fluid of the present invention to the teeth does not require special equipment or training; for example, the fluid can be self-applied by an individual user or applied by a beautician. In some configurations, prior to application to the target teeth, the teeth can be cleaned, for example by brushing to promote good adhesion of the fluid. Alternatively, a dental professional such as a dental hygienist or a dentist can clean the target teeth more fully using professional equipment and methods prior to fluid application. Immediately after the application, the solvent composed of the applied fluid can be removed, for example, through evaporation or polymerization of monomers to form a polymer can be allowed to occur. In some configurations, a tooth coating composition that is expected to last for an extended period, for example, for six months after application, may be applied by a dental professional such as a dentist or dental hygienist.

Certain embodiments of the present invention may be illustrated by the following non-limiting examples.

EXAMPLE 1 This example illustrates the composition of the invention comprising a natural resin system with white and pearl pigments. In this example, a fluid comprising a mixture of the following substances can be provided in the amounts designated as shown in table 1: Table 1 EXAMPLE 2 This example illustrates a method for making the composition described in Example 1.

In this example, titanium dioxide in an amount of 14% (w / w) and a mica titanium Timiron® in an amount of 16.7% (w / w) are mixed with the "Duraphat®; Placebo "(Colgate-Palmolive Company) at 69.3% (w / w). 'Duraphat® Placebo is the oral adherent pharmaceutical sodium fluoride product of Duraphat® teeth prepared without sodium fluoride.The composition of the Duraphat® Placebo provided in table 2.

Table 2 EXAMPLE 3 This example illustrates a formulation for a resin blend alternated to the Duraphat® Placebo.

As shown in Table 3, the Duraphat® Placebo of the formulation present in Table 2 can be replaced with a mixture of the formulation presented in Table 3. This formulation is expected to provide increased whiteness to the final composition (already the user's teeth) compared to the Duraphat® Placebo due to a natural resin (shellac) which can be amber, which is replaced with a synthetic polymer without color (polyacrylate).

Table 3 The examples and other embodiments described herein are an example and are not intended to be limiting in the description of the full scope of the compositions and methods of this invention. Equivalent changes, modifications and variations of the specific incorporations, materials, compositions and methods can be made within the scope of the present invention with essentially similar results.

Claims (25)

R E I V I ND I C A C I O N S

1. A coating for tooth comprising: at least 10% by weight of a film formed of a natural resin system comprising at least two natural resins; a colorant; Y pearled particles,

2. A tooth coating as claimed in clause 1, characterized in that the natural resin is selected from the group consisting of plant resins, animal resins, and combinations thereof.

3. A tooth coating as claimed in clause 2, characterized in that said natural resin system comprises at least one plant resin and at least one insect resin.

4. A tooth coating as claimed in clause 1, characterized in that at least one of said natural resins is selected from the group consisting of dam ars, East Indies, copal, acroids, elemi, almacigo, sandarac, colophonium, shellac and mixtures thereof.

5. A tooth coating as claimed in clause 1, characterized in that said natural resin is provided in a form selected from the group consisting of: natural unmodified resins, modified natural resins, synthetic natural resins, rosins, distillates, oils salvia, balsams, gums, subcomponents thereof and mixtures thereof.

6. A coating for tooth as claimed in clause 4, characterized in that the natural resin system comprises a mixture of colophonium, almacigo and shellac.

7. A tooth coating as claimed in clause 1, characterized in that the natural resin system comprises from about 10% to about 95% by weight of said coating of the teeth.

8. A tooth coating as claimed in clause 7, characterized in that the natural resin system comprises from about 30% to about 60% by weight of said tooth coating.

9. A tooth coating as claimed in clause 1, characterized in that it comprises a film-forming polymer selected from the group consisting of: polyacrylates, polyacrylamides, polyvinyl pyrrolidones, polyvinyl alcohols, polyethylene glycols, polyethylene oxides, polystyrenes, hydroxypropyl methyl celluloses, hydroxypropyl celluloses, hydroxyethyl celluloses, methyl celluloses, carboxymethyl celluloses, copolymers, block copolymers, graft copolymers, crosslinked polymers and combinations thereof.

10. A tooth coating as claimed in clause 1, characterized in that said dye comprises a white dye selected from the group consisting of titanium oxide, aluminum oxide, tin oxide, calcium oxide, magnesium oxide, zinc, polyethylene, polypropylene, ethylene / propylene copolymer, polytetrafluoroethylene, polyhexafluoropropene, and mixtures thereof.

11. A tooth coating as claimed in clause 1, characterized in that said dye comprises a non-white dye selected from the group consisting of copper oxide, chromium oxide, ferric oxide, ultramarine blue, phthalocyanine green, FD &C green No. 1, lacquer, FD &C blue NO. 2 Lacquer, D &C red NO. 30 LACQUER, FD &C YELLOW No. 15 lacquer, FD &C red No. 3, D &C red No. 30, food red No. 17, disodium salt of 6-hydroxy-5-. { (2-methoxy-5-methyl-4-sulfophenyl) azo} -2-naphthalenesulfonic acid, food yellow No. 13, sodium salt of a mixture of mono- and disulfonic acids of quinophthalone or 2- (2-quinolyl) indanedione, FD &C yellow No. 5, FD &C yellow No. 6 , FD &C green No. 3, FD &C blue No. 1, FD &C blue No. 2, and combinations thereof.

12. A coating for tooth as claimed in clause 10, characterized in that said dye comprises titanium oxide.

13. A tooth coating as claimed in clause 1, characterized in that said pearlescent particles are selected from the group consisting of bismuth oxychloride, nacre, mollusk shell, fish scales, pearls, silicate selected from the group consisting of mica. , opal and silica and combinations thereof.

14. A tooth coating as claimed in clause 13, characterized in that said pearlized particles further comprise a metal oxide coating wherein the metal oxide is selected from the group consisting of titanium oxide, iron oxide, aluminum, tin oxide, copper oxide, calcium oxide, magnesium oxide, various oxide, chromium oxide and combinations thereof.

15. A tooth coating as claimed in clause 14, characterized in that said pearlized particles comprise particles of mica titanium.

16. A tooth coating as claimed in clause 1, characterized in that said dye is at a concentration of at least 1% by weight and said pearlized particles are at a concentration of at least about 3% by weight.

17. A tooth coating as claimed in clause 1, characterized in that the coating of the teeth is a tooth coating fluid or a varnish suitable for application to a surface selected from the group consisting of natural hard dental surfaces, surfaces artificial hard teeth, crowns, restorative veneers, partial dentures, compounds and combinations thereof.

18. A tooth coating composition comprising: at least 10% of a natural film-forming resin system comprising at least two natural resins; a colorant; Y an active material

19. A tooth coating as claimed in clause 18, characterized in that said natural resin is selected from the group consisting of dammars, East Indies, copal, acroids, elemi, almacigo, sandarac, colophonium, shellac and mixtures thereof. same.

20. A tooth coating as claimed in clause 18, characterized in that said natural resin is provided in a form selected from the group consisting of: natural unmodified resins, modified natural resins, synthetic natural resins, rosins, distillates, oils salvia, balsams, gums, subcomponents thereof and mixtures thereof.

21. A coating for tooth as claimed in clause 19, characterized in that the natural resin system comprises a mixture of colophonium, almacigo and shellac.

22. A tooth coating as claimed in clause 18, characterized in that said dye comprises a white dye selected from the group consisting of titanium oxide, aluminum oxide, tin oxide, calcium oxide, magnesium oxide, zinc, polyethylene, polypropylene, ethylene / propylene copolymer, polytetrafluoroethylene, polyhexafluoropropene, and mixtures thereof.

23. A tooth coating as claimed in clause 18, characterized in that said pearlized particles are selected from the group consisting of bismuth oxychloride, nacre, mollusk shell, fish scales, pearls, silicate selected from the group consisting of mica. , opal and silica and combinations thereof.

24. A tooth coating as claimed in clause 18, characterized in that said active material is selected from the group consisting of antimicrobials, anti-oxidants, anti-caries agents, anti-plaque agents, anti-calculus agents, bleaching agents, breath fresheners, anti-inflammatories, desensitizing agents, nutrients, pins and mixtures thereof.

25. A composition for coating the tooth comprising: at least 10% of a natural resin system comprising rosin, almacigo and shellac; titanium dioxide; Y mica titanium. E S U M E N A coating for the tooth comprising at least 10% by weight of a natural resin system comprising at least two natural resins; a colorant; pearled particles. Methods for coloring a tooth and methods to avoid or treat conditions for oral care are also provided.