MXPA06002673A - Enriched aqueous components of emblica officinalis - Google Patents

Abstract

In an extraction process comprising extracting a raw extract from Emblica officinalis the improvement comprising conducting the extraction under conditions of time, temperature and atmosphere, to inhibit the formation of black specks and/or oligomeric and/or polymeric tannins and/or oxidation products thereof.

Description

AQUEOUS COMPONENTS ENRIQUECIDOS DE EMBLICA OFFICINALIS Field of the Invention This invention relates to methods of removing unwanted substances, including but not limited to oligomeric / polymeric components of compositions obtained from the fruit of an Emblica officinalis plant also known as Phyllanthus Emblica and the resulting enriched compositions. This plant is usually found in India, China, Pakistan, Nepal and other countries. Accordingly, this invention is directed to extracts of Emblica officinalis from any geographical location. BACKGROUND OF THE INVENTION The compositions obtained from an extract of the fruit of the plant Emblica officinalis have been described in the prior art, for example, in the application entitled cross reference 10 / 120,156, the references referred to therein, as well as in US Patent 6,235,721 published May 22, 2001 and 6,636,162 published March 26, 2002. In North American document 6,235,721, an antioxidant product referred to as "CAPROS" is isolated from the fruit of the Emblica officinalis plant using a saline solution in very dilute aqueous or alcoholic water, for example from 0.1 to 5% (w / w), preferably 1 to 2% of a solution of sodium chloride REF.169774, potassium chloride, calcium chloride or magnesium chloride, which prevents the degradation of the antioxidant compounds in it by enzymes present in the fruits of the plant Emblica officinalis. Alternatively, the antioxidant product is isolated using a buffer solution, for example 0.1 to 5% (w / w), preferably 1 to 2%, of sodium citrate / citric acid, sodium acetate / acetic acid, sodium phosphate / phosphoric acid, in Instead of the saline solution in aqueous or alcoholic water. It is further indicated in this patent that the composition contains, by weight, Embilcanin-A and B (gallic / ellagic acid derivatives of 2-keto-glucono-d-lactone) (35-55%), Punigluconine (acid (2, 3-di-O-galoyl-O, 6- (S) -hexahydroxy-diphenoylgluconic acid) (4-15%), Pedunculagine (2, 3, 4, 6-bis- (S) -hexahydroxydiphenoyl-D-glucose) ( 10-20%), utin (flavanol-3-) glucoside (5-15%), for gallic-ellagic tannins of low to medium molecular weight (10-30%), gallic acid (0-5%) and ellagic acid (0-5%) In the North American Application 10 / 120,156, a standardized composition is described which is useful, for example, in skin lightening or bleaching of the skin.This composition, below, called "EMBLICA" is distinguished from "CAPROS", by, for example, having less than 1% by weight of total flavonoids and even a lower content of RUTIN.While, clear colored EMBLICA consists essentially of components desired for the purposes of clarification In the skin or bleaching of the skin, it has been observed that the black granules in the commercial product diminish the aesthetic appearance of the final formulations. Other commercially available products based on extracts of Emblica officinalis are even darker in color, due, in information and belief, to the presence of a greater number of black granules and oligomeric / polymeric materials insoluble in water. Detailed Description of the Invention Accordingly, an aspect of this invention is to provide at least one process for the removal of black granules in all types of Emblica officinalis extracts so that the resulting composition is macroscopically (visually) devoid of such granules. Another aspect of this invention is to provide a material substantially devoid of water-insoluble oligomeric / polymeric components. It has been found that black granules are substantially, if not totally insoluble in water, as measured at room temperature (20-25 ° C). A chemical analysis of these granules reveals that they comprise oligomeric / polymeric tanoids that do not have aromatic hydrogen. It has also been determined that the black granules have a particle size in the order of about 20 μ down to 1 micron. A) Yes, it has been observed that some black granules pass through a 5 micron filter but only some pass through a one micron filter. Without being limited by an explanation of the cause of the black granules, it is believed that the black granules are oxidation products, probably of phenolic hydroxy groups and / or oligomeric or polymeric tannins especially those having a molecular weight of above 3000. It has been found that such black granules and also the oligomeric and polymeric tannins are substantially, if not totally insoluble in water, and that they are biologically inactive materials. Thus, another aspect of this invention is to provide at least two processes that eliminate oligomeric and polymeric tannins insoluble in water, especially such tannins with a molecular weight of above 1000, preferably above 2000 and particularly above 3000 (hereinafter referred to as polymeric tannins). By insoluble in water it is understood that a concentration of 1% by weight of polymeric tannin in water does not exhibit a solubility of more than 10% by weight of the total tannin at 22 ° C. Yet another aspect is to provide extracts substantially soluble in water (above 95% by weight) of Phyllanthus Emblica comprising, for example, less than 5% by weight of polymeric tannins, with substantially no black granules and high levels, for example above 70% by weight of low molecular weight, bioactive, hydrolysable tannins, which have low molecular weights below 1,000. The resulting extracts can be used for all the applications previously described in the prior art: for example in cosmetic formulations, for example, skin lightening or toning, anti-aging and sunscreens, as well as in nutritional supplements and any new ones application developed in the future. A powdered composition of Emblica officinalis, wherein the composition is substantially macroscopically completely devoid of black granules, is a further embodiment of this invention. A sprayed composition of Emblica officinalis, wherein said composition contains at least 70% by weight of bioactive low molecular weight hydrolysable tannins is a further embodiment of this invention. A sprayed composition of Emblica officinalis, wherein the composition contains less than 5% by weight of oligomeric and polymeric tannins having a molecular weight above 1000, preferably less than 5% by weight of oligomeric and polymeric tannins having a molecular weight above 2000, and especially preferred less than 5% by weight of oligomeric and polymeric tannins having a molecular weight above 3000, is a further embodiment of this invention. The sprayed compositions of Emblica officinalis may preferably comprise one or more water-soluble diluents, preferably selected from the group comprising lactose, mannitol, dextrata, maltodextrin, dextrin, dextrose and sucrose. The diluents are preferably present in an amount of 10 to 60% by weight. They will become evident during the additional study of the specification and dependent claims, other aspects and advantages of the inventions. To achieve the objectives of the invention, at least one process is provided which comprises the prevention of the formation of black granules and / or precursors thereof and / or polymeric tannins. Also provided is at least one process for separating the black granules and / or precursors thereof and / or polymeric tannins from the rest of the components of Emblica officinalis extracts. In general, the process of the invention comprises the following steps: 1) providing an extract of Emblica officinalis resulting from the original extract of the plant, or from a suspension of a pulverized composition obtained after the extract is processed, for example after a drying step. 2) if necessary, physically separating the black granules and / or precursors thereof and / or polymeric tannins from the water soluble components, for example by filtration with the use of a filter aid. 3) if desired, concentrate the resulting aqueous solution of the enriched composition of Emblica officinalis, for example, in a dry powder. With respect to step (1), if it is to be subjected to step (2), it is preferred to mix the raw extract or powdered extract with an aqueous solution preferably water. (Aqueous solution means water or mixture of water and a miscible solvent). It is further preferred that the suspension contain about 5-30%, more preferably about 18-22% by weight of total solids (including dissolved and non-dissolved solids), and more preferably about 18-22%. When the extract is obtained from the fruit, the extraction is preferably conducted, under conditions to substantially prevent the formation of polymeric tannins, for example low temperature (about 20 ° C to 60 ° C) and / or preferably under a substantially no oxidation atmosphere, for example, the pressure apparatus is subjected to continuous nitrogen washing, and / or the addition of a self-oxidation inhibitor, by example a saline solution. Also, the drying step is preferably conducted under conditions of temperature, time and atmosphere to decrease the formation of black granules and / or polymeric tannins, examples of such conditions include, but are not limited to, drying at low temperature (lyophilization), short residence times in the atomizer, for example up to about 1 minute and drying under vacuum at temperatures below 50 ° C. If step (1) however is conducted under such conditions as to form black granules and / or precursors thereof, and / or polymeric tannins, it is necessary to perform step (2). As for step (2), the preferred separation method will consider the physical and / or chemical properties of the black granules and / or precursors thereof. For example, as indicated above, in "EMBLICA", the black granules have a particle size of approximately, about 20 μ or less. Ideally, it will be preferred to provide a separation method that preserves the bioactive components of EMBLICA by removing only the unwanted components. While there is a variety of separation methods that can be used, for example any of a number of well known filtration or centrifugation processes or combinations thereof, it is also contemplated that still other separation processes can be used such as, for example , sedimentation, flotation and decantation. A filter aid, for example diatomite filter aids, crosslinked polyvinylpyrrolidone as well as silica and silicate sorbents can also be used to remove the oligomeric / polymeric materials. Some of the suppliers of these filter aids are Advanced Minerals (Celpure 25, 65 &100, AW Cellite NF, MP Harborlite), International Specialty Products (Plasdone XL), United Perlite Corporation (Ultralite Perlite 505, 606C, 606F, 808 , 909C, 909F). Also, the extraction of the black granules or precursors thereof with a solvent substantially miscible with water, for example (ethanol, methanol, isopropanol or solvent mixture) is also contemplated. For further details of the separation systems, reference is made to the descriptions in the patent and chemical engineering literature, for example, section 19 (liquid-solid systems) in Perry's Chemical Engineer's Handbook, 6th edition, Perry editors. , Green and Maloney, 1984, McGraw-Hill Book Company. With respect to step (3), a concentrated composition of water soluble EMBLICA components can be produced by any number of conventional chemical engineering drying techniques, for example, those described in Section 20 of Perry 's Chemical Engineers' Handbook, 6th edition, and include, but I do not know. limited to, tray dryers, rotary dryers, agitation dryers, gravity dryers, vibratory conveyor dryers, pneumatic conveyor dryers, Glatt dryers, freeze dryers and atomizers. It is contemplated that prior to the drying step, that the aqueous solution of the desired Emblica Offinalis components may optionally be subjected to evaporation under sufficiently low temperatures as to not deleteriously affect the components. In view of the nature of the components, it is contemplated to prevent decomposition during drying, that drying under vacuum, for example, lyophilization, is preferred over a high temperature spray drying technique. Without intending to be limited by the chemical structure, the water-insoluble oligomeric / polymeric components of Phyllanthus emblica extract appear to be based on the following general structure of monomer units: wherein R represents OH or = O; and C-2 / C-3 may have an unsaturation. The heads of the arrows indicate the substitution points that mean a completely substituted aromatic product. The substituted portions comprise other monomer units which can be linked via a C-C bond and / or a C-0 bond.

Regarding the evidence of the structure described above, the 300 MHz 1 H-NMR spectrum of the acetylated product in CDC13 showed the complete absence of the Aromatic H signals. It is important to note that these oligomeric / polymeric tannins can create health problems Adverse reactions may be combined irreversibly with some proteins. Therefore, their presence should be avoided. A process for preventing the formation of oligomeric / polymeric tannins comprises the introduction of a small amount of saline solution, preferably sodium or potassium chloride, during the fruit juice process. This saline solution inhibits the easy auto-oxidation of small lactic-ellagic tanins in oligomeric / polymeric tannins. In addition to sodium or potassium chloride, it is contemplated that the addition of any of the non-reactive, soluble, ionizable compounds will increase the ionic strength of the reaction solution and thus inhibit oligomerization / polymerization. By substituting the enriched compositions of Emblica officinalis produced by the present invention for the unenriched extracts of Emblica, substantial advantages are obtained. Examples of such compositions include but are not limited to personal care and skin compositions, for example, sunscreens, as well as pharmaceutical and food compositions.

Without further elaboration, it is believed that one skilled in the art can, using the preceding description, utilize the present invention to its fullest extent. The following modalities are, therefore, interpreted as merely illustrative and not limiting in any way to the rest of the description. (These modalities have not necessarily been conducted or prepared at present). Examples EXAMPLE 1 To 20% by weight of an aqueous dispersion of powder of EMBLICA was prepared by mixing the EMBLICA in water in a stainless steel container with a manual mixer for approximately 15 minutes to obtain a uniform dispersion. The properties of EMBLICA powder were as indicated below: Low molecular weight tannins -77.8% by CLAR Water-insoluble material -12.2% Pale yellow powder The resulting dispersion was then subjected to centrifugal filtration using a centrifuge (Heinkel HF 300 , 300 mm diameter of the vessel, 0.1 m2 of the filter area). 3 1 of a 10% solution of EMBLICA were filtered at a centrifugation speed of 1500 rpm. The filtration was completed within 10 minutes and produced the filtration weight curve described in Figure 1. The porosity of the filter cloth was 5 μm. The filtered material was dried to a powder using an atomizer. EXAMPLE 2 Using the same centrifuge used in Example 1, two tests were carried out at 33% by weight of the concentration of EMBLICA in purified water but with different centrifugation rates, ie different forces g were applied to the product. Two first tests of 3 1 each were filtered at 1500 rpm (~ 375 g) and the liquid was recovered. In a second stage, 8 1 was filtered in several parts at 3000 rpm (~ 1500 g) to determine if additional liquid extraction can be performed. A 1 μm porosity filter (model 3 54 FC) was chosen since it gave a reasonable liquid transverse flow. Also, this is the same filter used in the previous filtration test with a 20% solution that gave good results. The EMBLICA used in these tests has the same characteristics as described in Example 1. Test 1 3 1 of a 33% solution of EMBLICA were filtered at a centrifugation speed of 1500 rpm. Filtration was slower than 20% but almost finished after 15 minutes. The resulting filtered solution constituting approximately 2/3 by weight of the original solution was opaque and approximately 70% of the initial material was recovered. To increase recovery, a second test was done at a high centrifugation speed. No black particles were observed visually (macroscopically) in the filtrate but many were observed in the residue in the filter. Test 2 33% of the EMBLICA solution was filtered using the same filter but at a higher centrifugation speed of 3000 rpm. The filtration was only slightly improved despite a 4 times higher acceleration. Out of 12 kgs of initial material, only 8.3 kgs were obtained. No black particles were observed in the filtered solution. Therefore, the filtration tests with a solution at 33% w / w of EMBLICA show satisfactory elimination of black particles, similar to the previous tests with 10 and 20% solutions. However, 33% by weight of the concentration seems too high for the maximum product yield. Therefore filtration of 18-22% is preferred. EXAMPLE 3 The solutions of Example 2 obtained by filtration at 1500 and 3000 rpm were spray-dried separately. The conditions were: an inlet temperature of 345 + 5 ° F, an outlet temperature of 230 ± 5 ° F and a feed rate of 100 ml / min. The atomizer was a 30-inch Bowen Lab unit. The laboratory results were as follows: First Processing: solution at 3000 rpm ENTRADA-.8.2 kgs EXIT: 1.395 kgs (+ 1.2 kgs) followed by solution at 1500 rpm ENTRY: 3.7 kgs EXIT: 1.06 kgs (+ 0.37 kgs) The OUTPUT weights correspond to the direct product obtained thus as the weight of the sticky product brushed from the walls of the container. The last product caused by the hot steel walls of the container showed a distinctly darker color (orange-brownish) than the direct drying product (grayish to light beige). To overcome such stickiness it is contemplated that the production containers include additional wall insulation which will reduce, if not eliminate, this effect. No significant loss of material occurs during the spray drying process. The resulting product powder is absolutely dry, spongy and slightly whiter than the original. The greatest loss of product occurred during the centrifugal filtration stage due to the initial high concentration in the test. A much higher filtration performance can be obtained using a 20% solution / p. The following table provides a chromatographic analysis of 2 batches. E B JCA ™ (sample dried by Spraying - Centrifugal); Calculation of data assets of CLAR S areas of active peaks% of small tanoids = Total area of the chromatogram Lot No. F15 Areas for assets: Emblicanine A + Emblicanin B + Punigluconin + Pedunculagine = Areas of peaks 1, 3, 6, 8 = 894.95 + 513.28 + 261.87 + 891.97 = 2,562.07 Total area per CLAR: 2,929.93% of assets = 2,562.07 / 2,929.93 = 87.45%% of Emblicanine A = 894.95 / 2,929.93 = 30.55%% of Emblicanin B = 513.28 / 2,929.93 = 17.52% Punigluconon% = 261.87 / 2,929.93 = 8.95%% of Pedunculagina = 891.97 / 2,929.93 x 83.80 = 30.44% Lot No. F30 Areas for assets: Emblicanin A + Emblicanan B + Punigluconine + Pedunculagina + peak areas 1, 3, 6, 8 = 904.51 + 502.66 + 251.66 + 889.70 = 2,548.53 Total area per CLAR: 2,995.03% of assets = 2,548.53 /2,995.03 = 85.10%% of Emblicanin A = 904.51 / 2,995.03 = 30.20%% of Emblicanin B = 502.66 / 2,995.03 = 16.79%% of Punigluconon = 251.66 / 2,995.03 = 8.40%% of Pedunculagina = 889.70 / 2,995.03 = 29.70% EXAMPLE 4 A 20% by weight of an aqueous dispersion of the EMBLICA powder (100 kg) was prepared by mixing the EMBLICA in water in a stainless steel vessel filled with a mechanical stirrer for about 1 hour to obtain a uniform dispersion. Approximately 5 kg of a diatomite filter aid (Celpure 1,000) was then mixed appropriately to bind oligomeric / polymeric tannins. The suspension was mixed for approximately 30 minutes at room temperature. The residue was removed by centrifugation (i.e., in a Beckman ™ J6B rotating a liter rotor bucket at 3000 rpm for 5 min), or by pressure filtering (i.e., through a Cuno ™ coarse cellulose. of depth CPX-01A, with a pressure of 5 psi, 35 kPa). The filtered aqueous solution was then dried using a lyophilizer or atomizer. EXAMPLE 5 15% by weight of an aqueous dispersion of the EMBLICA powder (10 kg) was prepared by mixing the EMBLICA in water in a stainless steel vessel filled with a mechanical stirrer for about 1 hour to obtain a uniform dispersion. Light heating at approximately 30 to 40 ° C can accelerate the dispersion process. Then, approximately 0.5 to 1 kg of a diatomite filter aid (Celpure 1,000) was mixed appropriately to bind oligomeric / polymeric tannins well. The suspension was mixed for about 30 minutes at room temperature and allowed to stand for about 5 to 10 hours. The almost clear liquid in the lid was siphoned and then passed through a coarse filtration (cheese cloth) to remove any undesirable insoluble particles. The aqueous solution was then dried using a lyophilizer or a vacuum dryer (at about 55-60 ° C). EXAMPLE 6: The antioxidant fraction of Emblica is obtained directly from the fruits following a three-stage process: (1) Extraction: The fruits of Emblica officinalis were extracted with water or by squeezing the flesh of the fruit. (2) Elimination of water-insoluble material: The extract of water or fresh juice was then subjected to centrifugation and the supernatant was siphoned. Alternatively, the water or juice extract was mixed with a filter aid and then filtered to remove the insoluble material in water. (3) Drying: The water soluble fraction was then dried under vacuum or lyophilized. The HPLC analysis showed that the powder of Emblica's antioxidant fraction contains 74.3% low molecular weight, hydrolysable tannins, the key bioactive components of the invention. Step 7: Skin Care Lotion Procedure: Combine A and heat of 70-75 ° C. Combine B and heat of 70-75 ° C. Add B to A while stirring. Add phase C to 30 ° C. Adjust the pH to 5.0-6.0 with phase D. Add phase E. Mix until uniform. * "Present invention" means enriched EMBLICA that has a decreased concentration of black granules and oligomers / polymers. Step 8: Skin Rinse Lotion Procedure: Disperse A-2 in A-l and heat at 70-75 ° C. Combine B and heat at 70-75 ° C. Add B to A while stirring. Homogenize until the mixture cools to 60 ° C. At 30 ° C add phase C. Adjust the pH with TEA to 4.0-5.0. Add phase E. Mix until uniform. Example 9: Skin Lightening Lotion Procedure: Disperse A-2 in A-l and heat at 70-75 ° C. Combine B and heat at 70-75 ° C. Add B to A while stirring. Homogenize until the mixture cools to 60 ° C. At 30 ° C add phase C. Adjust the pH with TEA to 4.0-5.0. Add phase E. Mix until uniform. Example 10: Anti-wrinkle lotion Procedure: Disperse A-2 in A-l and heat at 70-75 ° C. Combine B and heat to 70-75 ° C. Add B to A while stirring. Homogenize until the mixture cools to 60 ° C. At 30 ° C add phase C. Adjust the pH with TEA to 5.0-6.0. Add phase E. Mix until uniform. Example 11: Sunscreen Lotion Procedure: Heat phases A and B separately at 80 ° C. Shake phase A. Homogenize. At 30 ° C, add phase C. Adjust the pH with sodium hydroxide to 5.5. Add final phase E to the emulsion. Example 12: OIL FREE ANHYDRIDE GEL Procedure: Mix the ingredients in Phase A; heat with mixed until light and even. Add bismuth oxychloride and disperse with mixing. Mix the ingredients individually in Phase C; the mixture should equalize and not contain pieces. Cool Phase A / B to 50 - 60 ° C and add Phase C with mixing. When the mixture is already uniform, it can be packaged. Example 13: Capsules & Tablets Procedure: 1 is granulated with paste to make it a free flowing powder. All ingredients, except 4, are combined for 25 minutes in a mixer. Sift in 4 and mix for an additional 5 minutes. It is compressed into tablets using a standard 7/16 inch concave stamper.

Alternatively, the mixed material can be filled into appropriate capsules. Example-14 Tablets and Capsules Ingredient Composition (w / w,%) Amount per tablet (mg) 1. Composition of the 60.0 250.0 5 invention 2. Avicel pH 101 20.0 84.0 3. Starch 1500 or 17.5 75.5 Maltodestrin 4. Steric acid, N.F. 2.0 8.5 (dust) 5. Cab-O-Sil .05 2.0 Note: The water-soluble extract of Emblica officinalis is either granulated with paste or maltodextrin to make it a free-flowing powder. Procedure: Mix all the ingredients, except 4, for 25 min in a mixer. Sift in 4 and mix for an additional 5 minutes. Compress into tablets using a standard 7/16 inch concave press.

Alternatively, the mixed material can be filled into appropriate capsules. Example 15 CHEWABLE TABLETS Ingredient Composition (w / w, in%) Amount per tablet (mg) 1. Composition of 9.26 26.60 Q Invention 2. Sodium Ascorbate, USP 36.26 81.60 3. Avicel pH 101 19.12 38.50 4. Sodium Saccharin, (powder), 0.56 1.25 N.F. 5. DiPac 29.30 66.00 6. Stearic acid, N.F. 2.50 5.60 7. Imitation of Orange Flavor 1.0 2.25 8. FD coloring & C yellow 0.5 1.12 # 6 9. Cab-O-Sil 0.5 1.12 Procedure: Mix all ingredients, except 6, for 20 minutes in a mixer. Sift in 6 and mix for an additional 5 minutes. Compress into tablets using a standard 7/16 inch concave stamper. Example 16 DRINKS Ingredient Quantity per 500 ml 1. Present invention 10 mg-2gm 2. Excipients: Carbonated Water, cs Food Starch, Modified, Corn Syrup and / or Sucrose and / or Sugar, Sodium Benzoate, Caffeine, Glycerol Ester Wood resins, flavors, dyes.

EXAMPLE 17 CEREALS Ingredient Quantity per 1 Kg 1. Summary of the Invention 500 mg-10 gm 2. Excipients: Whole Oat Grains, Oat Bran, cs, Sugar, Modified Corn Starch, Brown Sugar Syrup, Salt, Carbonate Calcium, Trisodium Phosphate, Wheat Flour, Vitamin E (Mixed Tocopherols), Zinc & Iron (Mineral Nutrients), Niacinamide (Vitamins A B), Vitamin B6 (Pyridoxine HCl), Vitamin B2 (Riboflavin), Vitamin B1 (Thiamine Mononitrate), Vitamin A (Palmitate and Vitamin A B (Folic Acid1), Vitamin B12, Vitamin D Example 18 MULTIVITAMIN MAINTENANCE TABLETS AND CAPSULES Ingredient Composition Amount per (w / w,%) tablet (mg) 1. Vitamin A acetate 5.5 11.0 2. Thiamine mononitrate, USP 0.8 1.65 3. Riboflavin, USP 1.1 2.10 4. Pirodoxian HCl, USP 1.0 2.10 5. 1% Cyanocobalamin (in gelatin) 1.0 2.10 6. Calcium-D Pantothenate, USP 3.75 7.50 7. Composition of the Invention, free flowing 32.25 65.50 8. Niaciamide 11.0 22.00 9. DiTab 13.1 26.20 . Microcrystalline cellulose, N.F. 25.0 50.00 11. Talc, USP 3.0 6.00 12. Stearic acid, (powder), N.F. 1.5 3.00 13. Magnesium stearate (powder), N.F. 1.0 2.00 Procedure: Mix all the ingredients for 20 minutes in a suitable mixer. Sift in 12 and mix for an additional 5 minutes. Compress to a 200 mg tablet weight using a standard 3/8 inch concave press. Alternatively, the mixed material is filled into a capsule containing 200 mg of muitivitamins. These tablets or capsules can be used as food supplements. Despite the details of the foregoing embodiments, it should be understood that there are several broad concepts in the present invention. The first broad concept refers to the treatment of a crude extract of Emblica officinalis. Once it is known that it is important to adjust the time, and / or temperature, and / or atmosphere and / or the chemistry of the extraction conditions in terms of inhibiting the formation of polymeric tannins and / or black granules, a chemical engineer or similar may adjust such variables to inhibit the formation of undesired components. This will require measuring the degree of unwanted components without adjusting the variables and then adjusting the variables to provide an improved process. For example, lower temperatures and shorter residence times should result in a lower degree of oligomerization or polymerization. Also, less oxygen in the atmosphere, there will be less chance of oxidation to form unwanted impurities. Accordingly, by adjusting at least one of the variables, it is possible that only one variable needs to be adjusted to obtain the desired inhibition, for example, temperature. However, it is also contemplated that two or more variables can also be adjusted to arrive at optimal conditions. Another basic concept of the invention relates to the concentration of the extract, for example to form a powder. Again, the temperature, time and atmosphere in which the concentration is conducted will have an effect on the degree of impurities in the resulting dry composition. Accordingly, a chemical engineer or the like may adjust at least one of the variables to obtain a product that is substantially completely devoid of black particles when viewed visually (macroscopically), preferably at least 95%, more preferably at least 99%). By "substantially devoid" it is understood that the black particles are diminished in number in comparison to the number of black particles that would be present in the absence of the adjustment of the variables. Preferably, the composition should be completely devoid of black granules) but it is contemplated that it will be sufficient for aesthetic purposes of the composition containing not more than 100, preferably below 10 black granules per 500 grams of composition).

Another concept of the invention relates to the reduction of potentially adverse components biologically in the extract. This is achieved, for example, by eliminating at least a portion of polymeric tannins having a molecular weight above 1000, and especially above 3000. Thus, taking into consideration various concepts and aspects of the invention, the preceding examples are they can repeat with substantially similar success substituting generic or specifically the stages and / or operating conditions described for them indicated in the examples. The full description of all the applications, patents, and publications cited above, including references set forth in the applications, patents and publications are hereby incorporated by reference. From the previous description, one skilled in the art can easily determine the essential characteristics of this invention and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various uses and conditions. Figure 1: Weight filtration curve obtained according to Example 1. It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is the clear result of the present description of the invention.

Claims (23)

2. Having described the invention as above, it is claimed as property contained in the following claims: 1. Extraction process, characterized in that it comprises the extraction of a crude extract of Emblica officinalis, where the extraction is conducted under conditions of time, temperature and atmosphere, to inhibit the formation of black granules and / or oligomeric and / or polymeric tannins and / or oxidation products thereof. Process in accordance with claim 1, characterized in that it comprises inhibiting the formation of oilomeric and / or polymeric tannins having a molecular weight above 1000.
3. 3. Process for producing a powdered extract of Emblica officinalis, characterized in that it comprises the stage of drying an aqueous solution of the extract, wherein drying is conducted under conditions of time, temperature and atmosphere to inhibit the formation of oligomeric and / or polymeric tannins and / or oxidation products thereof and / or black granules.
4. Process according to claim 3, characterized in that it comprises the inhibition of the formation of oligomeric and / or polymeric tannins having a molecular weight above 1000.
5. 5. Process comprising enriching an extract of Emblica officinalis, characterized in that it comprises the steps of: A) providing an aqueous suspension of Emblica officinalis, the aqueous suspension containing dissolved components of Emblica officinalis and water insoluble components comprising black granules and / or oligomeric and polymeric tannins; and B) separating the insoluble components from the dissolved components to obtain an enriched aqueous extract of Emblica officinalis.
6. 6 Process according to claim 5, characterized in that it additionally comprises a preceding step of dispersing a powdered extract of Emblica officinalis in an aqueous solution to form the aqueous suspension.
7. Process according to at least one of claims 5 to 6, characterized in that the separation comprises subjecting the suspension to centrifugation or pressure filtration.
8. Process according to at least one of claims 5 to 7, characterized in that the separation comprises the addition of a filter aid to the aqueous suspension and the filtration of the insoluble components of the suspension to obtain the enriched aqueous filtrate of Emblica officinalis.
9. Process according to at least one of claims 5 to 8, characterized in that the aqueous suspension has a concentration of 5-30% by weight, preferably 18-22% by weight of the total solids of Emblica officinalis.
10. 10. Process according to at least one of claims 5 to 9, characterized in that it comprises subjecting the aqueous suspension to sufficient centrifugation to obtain an enriched extract of Emblica officinalis substantially macroscopically so that it is completely devoid of black granules.
11. 11. Process according to at least one of claims 5 to 10, characterized in that it additionally comprises drying the enriched aqueous extract separated from Embal i ca offi cinal i s.
12. Process according to at least one of claims 5 to 11, characterized in that the drying step comprises spray drying or freeze drying.
13. Process according to at least one of claims 5 to 12, characterized in that it comprises drying the solution of Emblica officinalis under conditions of time, temperature and atmosphere to inhibit the formation of oligomeric and / or polymeric tannins having a molecular weight by above 1000.
14. 14. Emblica officinalis extract, characterized in that it is produced by the process according to any of claims 1, 3, 5 or 6.
15. 15. Powdered composition of Emblica officinalis, characterized in that the improvement of the composition is that is substantially or completely macroscopically devoid of black granules.
16. 16. Powdered composition of Emblica officinalis, characterized in that it contains at least 70% by weight of bio-active hydrolysable tanins of low molecular weight.
17. 17. Powdered composition of Emblica officinalis, characterized in that it contains less than 5% by weight of oligomeric and polymeric tannins having a molecular weight above 1000, preferably less than 5% by weight of oligomeric and polymeric tannins having a molecular weight by above 2000, and especially preferred less than 5% by weight of oligomeric and polymeric tannins having a molecular weight above 3000.
18. 18. Powdered composition of Emblica officinalis according to at least one of claims 15 to 17, characterized in that it comprises one or more water-soluble diluents, preferably selected from the group comprising lactose, mannitol, dextrates, maltodextrin, dextrin, dextrose, and sucrose, wherein the diluents are preferably present in an amount of 10 to 60% by weight.
19. 19. Composition for personal care, skin or hair, characterized in that it is formed of ingredients comprising a sprayed composition according to at least one of claims 15 to 18.
20. 20. Composition for personal care or skin care according to claim 19, characterized in that it is in the form of a lotion, cream, stick, spray or gel.
21. 21. Composition for personal care or skin according to at least one of claims 19 to 20, characterized in that it contains approximately 0.05 to 5% tannins.
22. 22. Pharmaceutical or nutritional composition characterized in that it is formed of ingredients comprising a pulverized composition according to at least one of claims 15 to 18 in the form of tablets, capsules, elixir, syrup or drinks.
23. 23. Pharmaceutical or nutritional composition according to claim 22, characterized in that approximately 0.05 to 20% of the pulverized composition is formed.