MXPA05012190A - Synergistic phytoceutical compositions. - Google Patents

Abstract

Phytoceutical compositions for the prevention and treatment of circulatory disorders, feminine endocrine disorders, and dermal disorders. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects, with minimal side effects.

Description

SYNERGISTIC FITOCEUTIC COMPOSITIONS FIELD OF THE INVENTION The invention relates to phytoceutical formulations used to treat a variety of diseases. In particular, the formulations are particular combinations of plants and have a synergistic effect once they are combined. Principles for selecting beneficial formulations are described.

BACKGROUND OF THE INVENTION The academic study of medicinal plants for the treatment of various diseases has been almost as widespread as the study of Western medicines have been extracted from plants, the active ingredients of many traditional medicines, the curative agents have been identified and the action mechanisms. Botanical-based medicines are generally well tolerated and have fewer severe side effects as well as a lower incidence of such side effects. However, despite the excellent medicinal qualities of many plants, individually these are insufficient to achieve the remission of chronic degenerative diseases. By contrast, although synthetic drugs can have very high efficacy, their use is often complicated by severe side effects. What is required in this field are better treatment regimens that allow a greater tolerance on the part of the patient while offering sufficient efficacy.

BRIEF DESCRIPTION OF THE INVENTION A number of known charities have been classified according to their ability to improve the three main elements of health support in general: Energy (E), Bio-intelligence (I) and Organization (O). A synergistic effect is expected when the three categories of herbs (E, I, O) are included in a formulation, preferably at least two, three or four plants of each category. Therefore, a conception of the invention offers a method for selecting additional formulations for the treatment of diseases according to these principles. Three examples of formulations prepared in this way are described and additional formulations are currently prepared and tested.

Another conception of the invention offers an effective natural composition for the treatment of circulatory diseases. The composition can be used alone or combined with the simultaneous use of one or more pharmaceutical compositions. It can be used for the treatment of diabetic lesions, arteriosclerosis obliterans, Leriche syndrome (aorto-iliac obliteration), Buerger's disease (thromboangiitis obliterans), thrombophlebitis, chronic venous insufficiency, varicose veins, varicose ulcers, hemorrhoids and the like.

Another conception of the invention offers a composition for the treatment of endocrine diseases of women, which can be used alone or in combination with drugs. Said composition offers an effective medicine in diseases such as polycystic ovarian syndrome, ovarian cysts, fibrocystic breast disorder, uterine fibroids, dysfunctional uterine hemorrhage, female infertility, premenstrual syndrome, amenorrhea and the like.

Another conception of the invention offers a composition for chronic skin disorders. It can be used alone or in combination with drugs and can be used in the treatment of diseases such as psoriasis, dermatitis, skin infections, shingles, boils, eczema, rashes, acne or burns and the like.

DETAILED DESCRIPTION OF THE INVENTION The term "pharmaceutically acceptable excipients" is used herein in accordance with accepted meanings in the art and includes those ingredients necessary to formulate a medicine for use in mammals, including the use of gelatin capsules.

The terms "synergistic" or "synergistic" are used in this document to mean that the effect is more than their additive property. In preferred conceptions, the synergy is multiplied 1, 5, 2, 5, or 10 times.

By the use of the term "plants" what is meant in this document is that the plant (or that portion that possesses medicinal activity) is used complete, ground or as an extract. In addition, this term refers to the purified active ingredients and their derivatives. However, it is believed that the highest efficiency of the plants referred to in this document is achieved with the use of the whole plant or its extracts instead of the use of its isolated active ingredients.

In addition, although the plants are mentioned here according to the commonly used nomenclature, by improving the taxonomy the plants are generally reclassified. Each time reference is made to a plant, such reference includes species related to similar active ingredients.

The following examples are purely illustrative and should not be taken into account as an undue limitation of the invention.

EXAMPLE 1 : PLANT CHARACTERISTICS, CIRCULATORY DISORDERS Angelica sinensis (Dong Quai or Angelica, or Angelica Archangelia, Angélica Pubescens and Angelica Sylvestris) contains terpenes (terpenes, mainly β-phellandrene, with β-bisabolene, β-caryophyllene, β-phellandrene, α- and β-pinene, limonene , lináloe, borneol, acetaldehyde, mentadins and nitromentadines), macrocyclic lactones (including tridecanolide, 12-methyl tridecanolide, pentadecanolide), phthalates (such as hexamethylphthalate), coumarins (especially furocoumarin glycosides such as marmesine and apterin.), angelicin and biakangelicin derivatives (ostol, umbelliferone, psoralen, bergapten, imperatorene, xantotoxol, xantotoxin, oxypeucedanin and others), as well as various sugars, vegetable acids, flavonoids and sterols.

The Acantopanax senticosus (Russian Ginseng, Siberian Ginseng, Eleuthero, Devil's Shrub, Touch-me-not, Wild Pepper, Shigoka, Acantopanacis senticosus) contains terpenoids (oleanolic acid), glycosides (Eleutheroside A, daucosterin), B1, C-G, I, K, L, M), phytosterols (ß-sitosterol), coumarins (Eleutherósido B1 and B3, isofraxidina), polysaccharides (eleutherans), volatile oils, caffeic acid, coniferil aldehyde and sugars. It has been shown that Eleuthero binds to the estrogen, progestin and mineralocorticoid receptors and stimulates the production of T lymphocytes and natural killer cells. It has antiplatelet aggregation activity similar to aspirin as well as anti-oxidant activity. Russian Ginseng contains at least 40 active ingredients.

The Raponticum carthamoides (Leuzea or Maral Root) contains a mixture of compounds called "levseins". The levseins represent a complex of more than 10 ecdisterones, including 20-beta-ecdisterone, makisterone C, 24-dehydromakisterone A, cartamosterone, polypodin B, and ajugasterone C. Researchers have extracted and purified several ecdysteroids of the Raponticum and have discovered that the ecdysteroids increase the developing quail mass in a dose-dependent manner where the rate of increase is proportional to the content of the ecdysteroids. The Soviets have manufactured a synthetic version of this powerful substance for their very successful. A short time later, the US version, called Mesobolina, was circulating on the black market for a long time. The incorporation of this phytomedicine in a composition contributes at least 10 active ingredients in each individual therapy.

The main active components of Panax ginseng (Chine ginseng, panax, ren shen, jintsam, ninjin, Asiatic ginseng, Japanese ginseng, Oriental ginseng, Korean ginseng) are ginsenosides (Ral, Ra2, Rb1, Rg1, Rd, Re, R1, R2, R3, F1, F2, F3) and panoxides, which have been shown to have a variety of beneficial effects, including anti-inflammatory, antioxidant and anti-carcinogenic effects. The results of clinical research studies demonstrate that Panax ginseng can improve psychological function, immune function and disorders associated with diabetes. Studies indicate that Panax ginseng improves phagocytosis, the activity of natural killer cells and the production of interferon, improves physical and mental performance in mice and rats, promotes vasodilation, increases resistance to exogenous stress factors and affects hypoglycemic activity. Stimulates hepatic glutathione peroxidase and phytosterols inhibit the synthesis of prostaglandins. In addition, it shows vascular activity because saponins act as calcium antagonists in the vasculature. The incorporation of this phytomedicine provides at least 86 active ingredients in each individual therapy.

The Panax quinquefolius (American Ginseng, Anchi, Canadian Ginseng, Five Fingers, Ginseng, American, North American Ginseng, Red Berry, Ren Shen, Tienchi) is related to Panax ginseng but is a distinct species with higher levels of ginsenoside Rb1 and without the ginsenoside Rf. It is believed that ginsenoside Rb1 limits or prevents the growth of new blood vessels, which makes it useful for the treatment of tumors. The research suggests that several of the active ingredients of ginseng also exert a beneficial influence on platelet aggregation. In addition, it exhibits an antiatherosclerotic action, apparently mediated by a correction in the imbalance between prostacyclin and thromboxane. In other studies, it has been discovered that panaxinol or the lipophilic fraction is the most potent antiplatelet agent in ginseng, mainly due to an inhibition of thromboxane formation.

Possibly, this occurs through the regulation of cGMP and cAMP levels and the prolongation of the time interval between the conversion of fibrinogen into fibrin. It has also been shown that ginsenosides are relatively potent antagonists of platelet activating factor. It has antioxidant, anti-inflammatory and hypolipidemic effects. The incorporation of this phytomedicine into a composition provides at least 206 active ingredients in each individual therapy.

Pfaffia paniculata (Suma, Brazilian Ginseng, Pfaffia, Para Toda, Corango-acu, also Hebanthe paniculata, Gomphrena paniculata, G. eriantha, Iresine eriantos, I. paniculata, I. tenuis, P. eriantha, Xeraea paniculata) contains active glycosides (beta-ecdysone and three ecdysteroids), factoid acids, phytosterols (sitosterol and estimaste rol). In addition, it contains saponins. Its germanium content is probably responsible for its properties as an oxygenator at the cellular level and its high content of iron would explain its traditional use in the treatment of anemia. This herb increases oxygenation at the cellular level and has anabolic activity at the muscular and cardiac levels that improves myocardial contraction, decreases arrhythmias and stabilizes the membranes of cardiac cells. The incorporation of this phytomedicine provides 44 active ingredients in each individual therapy.

Rhodiola rosaa (Golden Root, Rosaroot) is mainly phenylpropanoids (rosavin, rosin, rosarin (specific for R. rosaa), derivatives of phenyletanol (salidroside, rodioloside, tyrosol), flavonoids (catechins, proanthocyanidins, rodiolin, rhodionine, rhodiosin, acetyldalgin, tricine), monoterpenes (rosiridol, rosaridine), triterpenes (daucosterol, beta-sitosterol) and phenolic acids (chlorogenic, hydroxycinnamic and Gallic). In addition, it contains organic acids (gallic, caffeic and chlorogenic acids) and p-Tyrosol. There are many species of Rhodiola, but it seems that the Rosavinas are exclusive to R. Rosaa and this is the preferred species. Its therapeutic properties include a strong property of binding with estrogens. In addition, it has vasodilation properties through the activation of mu opioid receptors in cardiac muscles and is a hypolipidemic that reduces cholesterol and triglyceride levels. The incorporation of this phytomedicine provides at least 20 active ingredients in each individual therapy.

The Equinaacea angustifolia or purpurea (Black Sampson, Purple Coneflower, Rudbeckia, Missouri Snakeroot, Red Sunflower) contains alkaloids (Isotussilagine, tussilagine), amides (equinacin, isobutylamides), carbohydrates (equinacin), polysaccharides (heteroxylan and arabinogalactan), inulin, fructose , glucose, pentose), glycosides (echinacoside), terpenoids (Germacrane), chicoric acid, betaine, methyl-para-hydroxycinnamate, vanillin, phytosterols and volatile oils. Equinaacea has undergone hundreds of clinical and scientific studies in which, primarily, an extract of the root and portions of botany has been used. The rich content of polysaccharides and phytosterols in Equinaacea is what makes it a powerful stimulant of the immune system.

The sesquiterpene esters also have immunostimulant effect. It has also been discovered that Equinaacea possesses antifungal and antibiotic properties. This component of Equinaacea has effects similar to those of cortisone that can stimulate wound healing and help control inflammatory reactions. The incorporation of this phytomedicine in the compositions contributes at least 70 active ingredients in each individual therapy.

Ganoderma lucidum (Reishi, also G. tsugae, G. valesiacum, G. oregonense, G. resinaceum, G. pfezfferi, G. oerstedli and G. ahmadii) is an edible fungus containing bitter triterpenoids (ganoderic acid), ß- D-glucan, coumarins, alkaloids and ergoesteroles. It has vasodilatory effects and is useful in the treatment of angina. It is hypolipidemic and antiarterotic. It contains at least 32 active ingredients.

La Grifóla frondosa (Maitake, Dancing Mushroom, also G. sordulent, Polyporus umbellatus and Meripilus giganteus) contains the primary polysaccharide, β-D-glucan in forms 1, 3 and 1, 6. In addition, it contains alpha glucan, lipids, phospholipids and ergosterol. Animal studies suggest that maitake can lower serum cholesterol and triglycerides. In addition, Beta-D-glucan is recognized as an effective immunostimulant. This substance increases the activity of macrophages and other immunocompetent cells that destroy tumor cells. In addition, this substance improves the immunological efficacy of said cells by increasing the production of cytokines IL-1, IL-2 and lymphokines.

The end result is an increase in defenses against infectious diseases.

The incorporation of this phytomedicine provides at least six active ingredients for therapeutic use.

Hydrastis canadensis (golden seal, yellow root, turmeric root) contains mainly isoquinoline alkaloids (xantopuccine, berberine, hydrastine, hydrastatin, beta-hydrastine, canada and canadalin). These give anti-inflammatory, bacteriostatic, bactericidal and vasodilatory effects. In general, its antibacterial action is directed to metabolic inhibition, the inhibition of enterotoxin formation and the inhibition of bacterial adhesion. It produces vasodilation by inhibiting smooth muscle contraction and platelet aggregation. This plant provides at least 34 active ingredients for therapeutic use.

The Petiveria alliacea (Anamú, Apacin, Apacina, Apazote de Zorro, Aposina, Ave, Aveterinaryte, Calauchin, Chasser Vermine, Congo Root, Douvant-douvant, Emeruaiuma, Garlic Guinea Henweed, Wink, Wink, Guinea, Guinea hen leaf, Gully Root, Herbé Aux Poules, Grass of the hen, Cat Egg, Kojo Root, Kuan, Kudjuruk, Lemtewei, Lemuru, Mal Pouri, Mapurit, Mapurite, Mucura-caa, Mucura, Mucuracaa, Ocano, Payche, Pipi, Tipi, Verbena Hedionda, Verveine Puante, Skunk) contains allantoin, arborinol, Arborinoliso Astilbina, Benzaldehyde, Benzyl-2-hydroxy-5-ethyl-trisulfide of benzoic acid, coumarin, trisulfide dibenzyl, engeletin, alpha-friedelinol, Isoarborinol, Isoarborinol acetate, isoarborinol cinnamate, isothiocyanates, Kno3, Leridal, Leridol, Leridol-5-methyl ether, lignoceric acid, lignoceryl alcohol, lignoceril lignocerate, linoleic acid, myrithril, nonadecanoic acid, oleic acid, palmitic acid, pinitol, polyphenols, proline, trans -n-methyl-4-methoxy, Senfol, β-Sitosterol, stearic acid, tannins and tritiolaniacin. Its therapeutic activities include anti-inflammatory, immunostimulant and antimicrobial effects. This phytomedicine provides about 25 active ingredients.

The Sutherlandia frutescens (Cancer Bush, also Sutherlandia Microphylla) contains L-canavanina, pinitol, GABA (gamma-aminobutérico acid) and asparagine. In addition, the novel triterpenoid glycoside known as "SU1" has been isolated and characterized. Therapeutic indications include anti-inflammatory effects, antioxidants, immunomodulators and vasodilators. This phytomedicine provides at least five active ingredients.

The extract of Tabebuia avellanedae (Pau d'arco, Ipé, Lapacho, Tahuari, Taheebo, Trumpet Tree, Tabebuia Ipé, Tajy, also T. pe, T. nicaraguensis, T. schunkeuigoi, T. serratifolia, T. altissima, T palmeri, T. impetiginosa, T. heptaphylla, Gelseminum avellanedae, Handroanthus avellanedae, H. mpetiginosus, Tecoma adenophylla, Tec. avellanedae, Tec. eximia, Tec. impetiginosa, Tec. integral, Tec. ipe) contains various quinone derivatives and a small amount of benzenoids and flavonoids, including beta-lapachone, xyloidone, tabebuine, quercetin, tecomin and steroid saponins. A important ingredient is lapacol, which was patented a derivative in 1975.

It has anti-inflammatory and antibacterial effects. The incorporation of this phytomedicine to a composition contributes at least 32 active ingredients in each individual therapy.

The Uncaria tomentosa (cat's claw, Peruvian cat's claw, Samento, Saventaro, Cat's claw, also Uncaria guianensis) contains several alkaloids, including pentacyclic oxindole alkaloids (POA) (isomitrafilina, isopteropodina, mitrafilina, pteropodina, especiofilina, uncarina F ), tetracyclic oxindole alkaloids (TOA) (isorincophylline, rincofilin), glycosides (triterpene quinic acid glycosides), hirsutin, tannins, catechins, phytosterols (beta-sitosterol, campesterol, stigmasterol), triterpenes, polyphenols, flavanols and oligomeric proanthocyanidins ( OPC). It is immunostimulant, anti-inflammatory, vasodilator and antioxidant. In laboratory tests, rincofilin shows ability to inhibit platelet aggregation and thrombosis, suggesting that cat's claw may be useful to prevent embolisms and reduce the risk of heart attacks by reducing blood pressure, increasing circulation, inhibiting the formation of plaques in the arterial walls and the formation of blood plugs in the brain, heart and arteries. This phytomedicine provides at least 10 active ingredients.

The Alliacea Petiveria (Anamú, Apacin, Apacina, Apazote de Zorro, Aposina, Ave, Aveterinaryte, Calauchin, Chasser Vermine, Congo Root, Douvant- douvant, Emeruaiuma, Gariic Guinea Henweed, Wink, Wink, Guinea, Guinea hen leaf, Gully Root, Herbé Aux Poules, Grass of the hen, Cat's egg, Kojo Root, Kuan, Kudjuruk, Lemtewei, Lemuru, Mal Pouri, Mapurit, Mapurite, Mucura-caa, Mucura, Mucuracaa, Ocano, Payche, Pipi, Tipi, Verbena Hedionda, Verveine Puante, Zorrillo) contains allantoin, arborinol, arborinoliso astilbin, benzaldehyde, benzyl-2-hydroxy-5-ethyl-triaulfide of benzoic acid, coumarin , dibenzyl trisulfate, engeletin, alpha-friedelinol, isoarborinol, isoarborinol acetate, isoarborinol cinnamate, isothiocyanates, kno3, leridal, leridol, leridol-5-methyl ether, lignoceric acid, lignoceryl alcohol, lignoceril lignocerate, linoleic acid, myristin, acid nonadecanoic, oleic acid, palmitic acid, pinitol, polyphenols, proline, trans-n-methyl-4-methoxy, senfol, β-sitosterol, stearic acid, tannins and tritiolaniacin. Your activities . Therapeutic treatments include anti-inflammatory, immunostimulant and antimicrobial effects. This phytomedicine provides approximately 25 active ingredients.

Angelica sinensis (Dong quai or Angelica, also Angelica archangelia, Angelica pubescens and Angelica sylvestris) contains terpenes (terpenes, mainly β-phellandrene, with β-bisabolene, β-caryophyllene, β-phellandrene, α- and β-pinene, limonene , lináloe, borneol, acetaldehyde, mentadins and nitromentadines), macrocyclic lactones (including tridecanolide, 12-methyl tridecanolide, pentadecanolide), phthalates (such as hexamethylphthalate), coumarins (especially furocoumarin glycosides such as marmesine and apterin), angelicin and derivatives of biakangelicina (ostol, umbeliferona, psoraleno, bergapteno, imperatoreno, xantotoxol, xantotoxina, oxipeucedanino and others), as well as various sugars, vegetable acids, flavonoids and sterols. These components have vasodilator activity, increase coronary flow and are antithrombotic. The incorporation of this phytomedicine in the compositions contributes at least 70 active ingredients in each individual therapy.

Crataegus oxiacantha (Hawtorn, see also C. monogina) contains mainly flavonoids (such as flavonoglycosyls, hyperoside, rutin, flavonol, kaempferol, quercetin) and oligomeric procyanadins (1-epicatecol), which relax arterial expansion to decrease vascular resistance peripheral. In addition, it contains derivatives of amines (phenylethylamine, tyramine, O-methoxyphenethylamine), flavon (apigenin, luteolin), vitexin glycosides, tannins, saponins and cyanogenetic glycosides. The incorporation of this phytomedicine in a composition contributes at least 52 active principles in a single therapeutic plant.

The Crotón lechleri (Dragon's blood, Blood of Degree, Blood of Water, also C. draconoides, C. palanostigma, C. erythrochilus C. salutaris and C. gossypifolius) produces a distinctive red exudate of its trunk, which contains a considerable amount of secondary plant metabolites, most of which are hydrolyzing flavonoids, proanthocyanidins (mainly catechin, epicatechin, gallocatechin and / or galloepicatechin), as well as taspina. Among its other components are lignin dihydrobenzofuran, six simple phenols and its derivatives, three steroids, unsaturated fatty acids, diterpenoids (hardwickiic acid, bincatriol, crolequinaol, crolequinaic acid, coberine A, coberine B) and diterpenoids. It is used to heal wounds and ulcers of vascular origin. The incorporation of this phytomedicine in a composition contributes at least 23 active ingredients in each individual therapy.

Ginkgo biloba (Ginkgo) contains ginkgolides, bilobalides, bioflavones and glycosides flavones. The glycosides flavones include quercetin, 3-methylquercetin and kaempferol. Quercetin, mircetin and the rest of the flavonoid fraction of the extract have antioxidant and free radical scavenging effects. Flavonoids decrease the infiltration of neutrophils to increase blood flow. Its antioxidant properties and the stabilizing activity of the membranes increase tolerance to hypoxia. These improve the cellular metabolism and protect against the damage caused by ischemia. Ginkgolide B is a powerful inhibitor of platelet activating factor, which binds to its membrane receptors and antagonizes platelet aggregation. Similarly, it has anti-inflammatory effects by decreasing vascular permeability and possesses vasodilatory activity by inhibiting the release of thromboxane B2 and prostaglandins. Controlled double-blind clinical trials conclusively demonstrate the efficacy of Gingko biloba in treating peripheral arterial insufficiency. The incorporation of this phytomedicine in a composition contributes at least 59 active ingredients in each individual therapy.

The Asian Hydrocotile (Gotu Kola, Bramhi, Pennywort, Marsh Penny, Pennywort; also Asiatic Asian Hydrocotile) contains terpenoids (triterpenes, asiaticósido, brahmósido and brahminósidea, (glycosides of saponinas) agliconas, asiaticentoico acid, cenlic acid, centoic acid and madecasic acid), sesquiterpenos (carioflenero, trans-B-farneseno), oils volatile (Germacrene D), alkaloids (hydrocotilin), flavones (Quercetin, kaempferol, sesquiterpenes, stigmasterol and sitosterol) and valerin, fatty acids, resin and tannins. It is used to treat chronic venous insufficiency, varicose veins and venous hypertension. The incorporation of this phytomedicine in a composition contributes at least 59 active ingredients in each individual therapy.

Ruscus aculeatus (Butcher's Broom, Box Holly, Jew's Mirtle, Knee Holly, Kneeholm, Pettigree, Sweet Broom) contains as primary active ingredients steroid saponins (ruscogenin and neoruscogenin), but other constituents have been isolated, including flavonoids, tetracosanoic acid, chrysopanic acid, sitosterol, campesterol, stigmasterol, triterpenes, coumarins, espartein, tyramine and glycolic acid. Its ingredients reduce vascular permeability, have antielastic properties and are vasoconstrictors. The incorporation of this phytomedicine in a composition contributes at least 28 active ingredients.

Vaccinium mirtillus (European blueberry, closely related to the American blueberry and sour cranberry) contains anthocyanins such as: cyanadins, malvidins, petunidins and peonidins. Other ingredients include arbutin, asperuloside, astragalin, beta-amyrin, caffeic acid, catechin, chlorogenic acid, cyanadin-3-O-arabinoside, dihydroxycinnamic acid, epicatechin, epigallocatechin, epimirtine, ferulic acid, gallic acid, gallocatechin, hydroquinone, hyperoside, isoquercitrin, lutein, coumaric acids, m-hydroxybenzoic acid, monotropein, mirtillin, mirtillol, mirtin, neomirtillin, protocatechuic acid, quercetin, quinic acid, resin acid, syringic acid, ursolic acid and vanillic acid. Evidence suggests that anthocyanosides may be beneficial for the retina and to strengthen the walls of blood vessels, reduce inflammation and stabilize tissues that contain collagen. Anthocyanosides improve the activity of lactic dehydrogenase, glucose-6-phosphatase and phosphoglucomutase enzymes, each of which is involved in vascular damage processes. These enzymes reduce arterial deposits and stimulate the production of vasodilators, such as prostaglandin (PG12), thus protecting the vascular wall. Likewise, anthocyanosides have powerful antioxidant properties. The incorporation of this phytomedicine in a composition provides at least 63 active ingredients in each individual therapy.

EXAMPLE 2: COMPOSITION- CIRCULATORY DISORDERS A particularly preferred composition is indicated in Table 1. The proportions reflect the concentration of active ingredient on the state natural and the amounts indicated are milligrams of extract. Obviously, the amount should be increased in cases where the strength is reduced and vice versa.

EXAMPLE 3: PLANT CHARACTERISTICS ENDOCRINE DISORDERS OF WOMEN Panax quinquefolius. The active principles responsible for its therapeutic effects are triterpensaponidas, of which more than 25 different classes have been identified. These are called protopanaxadiols (ginsenosides Rc, Rd, Rb1, Rb2) and protopanaxatriols (ginsenosides -Re, -Rf, -Rg 1, etc.). In addition, Panax contains water-soluble polysaccharides (panaxans A-U) and polyacetylenes (ginsenosides A-K, panaxinol and panaxatriol). These substances confer energizing properties because they increase the synthesis of ATP. On the other hand, they reduce the secretion of prolactin by increasing dopaminergic activity or by activating the dopamine receptors at the level of the pituitary gland. previous. Prolactin is a hormone involved in the appearance of anovulatory cycles and dysfunctional uterine hemorrhages, menorrhea, the fibrocystic mammary state and cyclic mastalgia. The reduction of this hormone explains the recovery in the treatment of dysfunctional uterine hemorrhages, Polycystic ovary syndrome (PCOS), ovarian cysts, fibromiomatous uterus and infertility.

Pfaffia paniculata. Its most important active ingredients are: Beta-ecdysone and three ecdysteroid glycosides, six different factoid acids, phytosterols and nortriterpene glycosides. These substances are energizing by increasing the synthesis of ATP and oxygenation at the cellular level. In addition, their phytosterols act as originators of hormones and have shown efficacy in the management of various disorders related to hormonal imbalance, such as: premenstrual syndrome, dysmenorrhea, infertility, dysfunctional uterine bleeding and menopause.

Rhodiola rose. See previous reference on this component.

Astragalus membranaceus (Huang-Q¡). This plant contains three main classes of active ingredients. Isoflavones, which act as antioxidants; Astragallanos, which act as immunostimulants and anti-inflammatory agents by stimulating the phagocytic activity of macrophages, the response cytotoxic of the T and NK lymphocytes and of the production and activity of interferon, as well as astragalanos, which act as modulators of the hypothalamic-pituitary-adrenal axis response.

Equinaacea. See previous reference on this component.

Dioscorea villosa (Reumatism root, bones of the devil, Yuma, Yam, Wild Yam, Chinenese Yam, Mexican Yam, Chinese root and colic root) contains steroid sapogenins (dioscin, dioscorin and diosgenin) as active ingredients. Diosgenin can be changed into ecdysone, pregnenolone and progesterone. Therefore, diosgenin is a hormonal precursor that contributes to the modulation of the neuroendocrine system. On the other hand, diosgenin has shown its important pro-apoptotic effects in the therapy of benign and malignant tumors, including cysts of the breast and ovary and in uterine fibroids.

Ganoderma lucidum and Grifóla frondosa. The active principles of these fungi are sterols and beta-proteoglycans that impart anti-inflammatory and immunomodulatory properties, because they increase the phagocytotic capacity of macrophages and increase the production - and life - of CD4 lymphocytes.

Tabebuia avellanedae contains various substances derived from quinones, such as Alfa and Beta lapachona [2-hydroxy-3- (3-methyl-2-butenyl) -1, 4-naphthoquinone] and dialdehydes cyclopentanes. These give it important anti-inflammatory, pro-apoptotic, antimitotic and cytostatic effects in the treatment of benign and malignant tumors, including cysts of the breast and ovary and in uterine fibroids.

Uncaria tomentosa See previous reference on this component.

Vitex agnus castus (Chaste Tree or chaste berry). An essential oil is extracted from the fruit of this plant, two iridoid glycosides (aucubin and agnuside); a flavon (casticin, which seems to be the primordial active principle) and three minor flavonoids derived from kaempferol and quercetin. These active principles act on the D2-dopaminergic receptors of the anterior pituitary, modulating the secretion of prolactin. This hormone is involved in the appearance of anovulatory cycles and dysfunctional uterine hemorrhages, menorrhea, fibrocystic mammary state and cyclic mastalgia. Vitex agnus castus modulates the secretion of LH from the pituitary gland, which acts on the ovary, initiating the luteal phase and the secretion of progesterone. Consequently, Vitex helps in dysfunctional uterine hemorrhages, premenstrual syndrome, PCOS, infertility, ovarian cysts, menopause and fibromatosus uterus.

Asian Hydrocotile. See previous reference on this component.

In addition, the active ingredients include triterpenas pentacyclic saponins. The active ingredients are asiaticósidos and madecasósidos. Other minor saponins are the centellósida, the brahmósidos, the brahminósidos and the saponinas B, C and D of Asian Hydrocotile. Mucopolysaccharides are the building blocks of the cell matrix. The biomechanical action of these active principles reduces the levels of liposomal enzymes associated with the degradation of mucopolysaccharides. On the other hand, the active principles act on the connective tissue fibroblasts, modulating the synthesis of collagen and inhibiting inflammatory processes. This decreases the processes of fibrosis, important for the states of mammary and uterine fibrosis.

EXAMPLE 4: COMPOSITION - WOMAN'S ENDOCRINE TRANSPLANTS A particularly preferred composition is indicated in Table 2.

EXAMPLE 5: AS PLANT CHARACTERISTICS SKIN DISORDERS Lepidium meyenii (Maca). Its active principles are: alkaloids (Macaridina, Lepidiline A and B); benzyl isothiocyanate and glucosinolates; macamides; Beta-ecdysone and phytosterols. These substances activate the synthesis of ATP, which gives it energizing properties.

Raponticum carthamoides. See previous reference on this component.

Panax ginseng The active principles responsible for its therapeutic effects are triterpensaponides, of which more than 25 different classes have been identified. These include protopanaxadiols (ginsenosides Rc, Rd, Rb1, Rb2) and protopanaxatriols (ginsenosides -Re, -Rf, -Rg 1, etc.). In addition, Panax contains water-soluble polysaccharides (panaxans A-U) and polyacetylenes (ginsenosides A-K, panaxinol and panaxatriol). These substances confer energizing properties as they increase the synthesis of ATP.

Rhodiola rose. See previous reference on this component. In addition, the active principles of this plant (phenylpropanoids, phenylethanol derivatives, flavonoids, monoterpenes and phenolic acids) activate the synthesis of ATP in mitochondria and stimulate restorative energy processes.

Andrographis paniculata (King of Bitters, Chirettta, Kalmegh and Kiryat). The active principles associated with the Andrographis are: flavonoids, glucosides and diterpenic lactones (andrograf olidas). These substances have immunomodulatory and anti-inflammatory properties. Although its specific mechanism of action is unknown, studies suggest that it stimulates the immune systems and activates macrophages.

Angelica sinensis contains alkyl phthalides (Ligustilide); terpenes, phenylpropanoids (ferulic acid) and benzenoids. These substances stimulate the actions of the immune system through various lymphokines and have an anti-inflammatory effect by inhibiting 5-lipoxygenase and elastase, as well as by selectively inhibiting the production of 12- (S) -HHTrE, a marker of the activity of the cyclo-oxygenase.

Astragalus membranaceus See previous reference on this component. In addition, Astragalus membranaceus inhibits 5-lipoxygenase and elastase, which indicates that it is valuable in the management of skin pathologies that involve chronic inflammation, such as psoriasis.

Equinaacea. See previous reference on this component.

Hydrastis canadensis. The most important active principles of Hydrastis are isoquinoline alkaloids (Berberine, hydrastine, Hydrastatin, Canadina, Canadalina), which impart anti-inflammatory and immunomodulatory properties. Berberine inhibits the activation of protein 1 (AP-1), a key factor in the transcription of inflammation. In addition, it exerts a significant inhibitory effect on the transformation of lymphocytes, in such a way that its anti-inflammatory action seems to be due to the inhibition of DNA synthesis in activated lymphocytes or to the inhibition of the release of aracdonic acid from phospholipids of the cell membrane. In addition, it has immunomodulatory properties by increasing the production of immunoglobulins G and M and stimulating the phagocytotic capacity of macrophages.

Ganoderma lucidum The active principles of this fungus are sterols and beta-proteoglycans that impart anti-inflammatory and immunomodulatory properties by increasing the phagocytotic capacity of macrophages and increasing the production and life of CD4 lymphocytes.

Uncaria tomentosa. See previous reference on this component.

Equisetum arvense (Horsetail). This plant contains abundant mineral salts, particularly silicic acids and silicates. It also contains phytosterols, phenolic acids, flavonoids (mainly glycosides of quercetin and apigenin) and saponins (equisetonin). These active ingredients block the release of aracdonic acid, which decreases inflammation and reduces the proliferation of keratinocytes, while inducing the capture of G2 / M in them. The mechanism of action is due in part to the inhibition of the mitotic activity of the p34cd2 kinase and the disturbance of cyclin B1 levels.

Asian Hydrocotile. See previous reference on this component.

Tabebuia avellanedae contains various quinone derivatives, such as alpha and beta-lapachone, cyclopentane dialdehydes and a small amount of benzenoids and flavonoids, including xyloidone, tabebuine, quercetin, tecomin and steroidal saponins. These compounds inhibit the growth of keratinocytes and offer anti-inflammatory and antibacterial effects, which are of great importance in the treatment of psoriasis.

Shilajit (Mumiyo). Mumiyo is a substance of natural complexes, whose active principles are carboxylic acids: (hydroxylated derivatives of benzoic, phenylacetic and hippuric acids), fulvic and humic acids, minerals and amino acids. Of the known properties of Mumiyo, the most important are its ability to reduce excessive inflammatory reactions and stimulate the regeneration of tissues. The oral intake of Mumiyo has been used to treat burns, trophic wounds difficult to heal, eczema and other skin diseases, such as psoriasis. It has been established that fulvic / humic stimulates respiration and oxidative phosphorylation in liver mitochondria, increases the mechanical resistance of collagen fibers, activates human leukocytes, reduces excessive inflammatory reactions and stimulates the regeneration of tissues.

Shark cartilage. This natural compound reduces the vascularization of the psoriatic plaque. It inhibits the proliferation of endothelial cells by competitive blockade of the endothelial growth factor at the receptor level.

In addition, it inhibits EGF tyrosine and phosphorylation dependent on EGF-2, while increasing the induced permeability of EGF. In addition, shark cartilage induces apoptosis of endothelial cells, inducing the activation of caspase 3, 8 and 9 and the release of cytochrome C from mitochondria to the cytoplasm. In addition, shark cartilage fibrinolytic activity by increasing the secretion, activity and affinity of tissue plasminogen activator (tPA) by endothelial cells. In addition, it inhibits the degradation of the extracellular matrix by inhibiting the metalloproteinases matrices MMP-2, MMP-7, MMP-9, MMP-12 and MMP-13. In addition, it stimulates the production of angiostatin.

Schizandra chinensis. The active principles of Schizandra (also known as Wuweizi and Wurenchum) are lignans called schizandrins. These substances have known hepato-protective and hepato-regenerative properties. Maintains the integrity of hepatocyte cell membranes; increases hepatic levels of ascorbic acid; inhibits the oxidation of NADPH; inhibits lipid peroxidation at the level of hepatic microsomes, as well as the formation of hepatic malondialdehyde decreases the production of carbon monoxide in the liver and has an inductive effect on hepatic cytochrome P-450 enzymatic, microscopic antitoxic, increases bile flow and the excretion of toxic substances, promotes the recovery of hepatic functions, induces the formation of mRNA for the Hepatocyte Growth Factor (HGF), stimulates the proliferation of the endoplasmic smooth reticulum of hepatocytes and accelerates the proliferation of hepatocytes, increases the activity of the ornithine decarboxylase as well as the mitotic index, facilitates the synthesis of DNA and liver proteins, increases the levels of glutathione, glutathione reductase and glucose-6-phosphate, thereby improving the regeneration capacity of the liver.

Silybum marianum (Milk Thistle). The active ingredients of this plant are flavonolignan, including silybin, silicristin and silidianin and isosilibinin, collectively known as silymarin. This compound has the highest degree of hepatoprotective, hepato-generating and anti-inflammatory activity. The mechanisms that explain its hepato-protective characteristics are diverse and include antioxidation, antiperoxidation of lipids, increased detoxification through the competitive inhibition of toxic substances, as well as protection against depletion of glutathione. One of the mechanisms that can explain its hepato-regenerative properties is the increase in the synthesis of proteins, obtained thanks to a significant increase in ribosome formation, the synthesis of DNA and proteins at a liver level, because the principles active bind with a specific polymerase receptor, which stimulates the formation of ribosomes. Its anti-inflammatory effect is due to the stabilization of mast cells, the inhibition of neutrophils, a strong inhibition of leukotriene (LT) synthesis and the formation of prostaglandins. Silymarin inhibits intestinal beta-glucuronidase enzymes, which improves glucuronization, which is an important step for liver detoxification. Many more body toxins are eliminated through glucuronization than through other detoxification pathways.

It pits kurroa. The most important active constituents are the glycoside iridoid glycosides I, II, III and kutkoside, collectively known as kutkin. Although less investigated than the Silybum, it seems to have similar applications and mechanisms of action. When compared with the Silybum, it was discovered that the healing efficacy of the Picroriza is similar or, in many cases, superior to the effect of the Silybum. Picrorriza has an important antioxidant activity, by reducing lipid peroxidation and free radical damage. Like silymarin, it has an effect on liver regeneration. In addition, Picrorriza has anti-inflammatory effects, which inhibit the infiltration of proinflammatory cells. One of its minor components, apocynin, shows powerful anti-inflammatory effects, without affecting beneficial activities such as phagocytosis, chemokaxis or humoral immunity.

Smilax spp. (sarsaparilla). Its active principles are: phytosterols, steroid saponins, phenolic acids, flavonoids and minerals. These substances adhere to the toxins within the gastrointestinal tract, thus reducing their absorption by the circulatory flow. On the other hand, it improves the excretory functions of the liver and kidneys, which facilitates the elimination of toxic substances and debris found in cells, blood vessels and the lymphatic system. In addition, phytosterols block the synthesis action of prostaglandins, which explains their anti-inflammatory action and its use for the treatment of psoriasis.

Vaccinium mirtillus. Angiogenesis seems to be an early fundamental inflammatory response in the pathogenesis of psoriasis and the significant abnormalities of vascular morphology and vascular endothelial growth factor (VEGF) play a crucial role in the vascularization of psoriatic plaques. In the course of inflammatory diseases of the skin, such as psoriasis, the skin initiates angiogenesis through VEGF and the active principles of this plant (anthocyanosides, flavonoids, quercetin, tannins, iridoids and phenolic acids) significantly inhibit the expression of the VEGF through human keratinocytes, thereby reducing the angiogenesis of psoriatic plaque.

EXAMPLE 6: COMPOSITION- SKIN DISORDERS A particularly preferred composition is indicated in Table 3.

EXAMPLE 7: TOLERANCE STUDIES A multicentre, retrospective study was conducted on 100 healthy volunteers with the intention of evaluating the tolerance and side effects of the herbal combination. Each participant was administered a capsule with a content of 700 mg of the herbal remedies indicated in Table 1, three times a day for five days. During this period, a physician evaluated them, who recorded any finding or symptom reported by each subject. The average age of the participants was 37.4 years with an SD of 8.2 years. The genders were 55% female and 45% male. The average weight of the subjects was 70 kilos with an SD of 12.3 kilos. No undesirable effects were observed in 96% of the subjects. Minor undesirable effects were reported in four percent (4%) of the subjects.

The study showed that herbaria were well tolerated - only minor symptoms were reported in four of the 100 subjects. These results demonstrated the absence of toxicity of the Herbaria, which showed that the formulation is safe. Similar results have been obtained with respect to formulations for polycystic ovary syndrome and psoriasis.

EXAMPLE 8: CLINICAL STUDIES To evaluate the efficacy of the combination, 110 patients affected with various degrees of foot lesions of the diabetic, underwent a retrospective, multicenter, descriptive study of two years. Of these patients, 50 had lesions of grades III to V and had been diagnosed with surgical amputation of the affected area. The patients were treated as indicated above, with ten capsules of 700 mg of the herbal three times a day, but the treatment was continued according to the need for periods that varied from 1, 5 to 10 months. The information is summarized in Table 4.

CdV stands for Quality of Life It is significant that the treatment with Herbariums prevented amputation in 40 patients (80% of the study population) who had already been diagnosed with the surgical removal of portions of the foot. By contrast, during the normal course of routine medical treatment, almost 100% of these patients could have expected partial or total amputation. This results Superiors are unexpected and clearly demonstrate the novel and not-so-obvious qualities of the formulation.

Likewise, 129 patients with chronic varicose ulcers were evaluated. The treatment (six 700 mg capsules three times a day) improved ulcers in 79% of the population and remission was achieved in 21% of the population in only two months (Table 5). In addition, the systemic treatment significantly improved the most frequent symptoms (cramps, 71, 4%, pain, 78%, and edema, 88.7%). In contrast, most patients with chronic varicose ulcers do not achieve remission with existing pharmaceutical treatments and are at high risk of amputation.

In a study of 35 patients with Polycystic Ovarian Syndrome (PCOS), the treatment improved pelvic pain in 20 of the symptomatic patients, menstrual disorders (amenorrhea, dysmenorrhea, menometrorrhea, oligomenorrhea) in 22 symptomatic patients; asthenia and headache in 17 symptomatic patients, as well as acne and hirsutism in 8 of 9 symptomatic patients. The pelvic ecosonograms revealed that 29 patients (82.9%) experienced a total disappearance of the cysts, while another six (17.2%) reported a decrease in the size of the cysts. By contrast, the majority of patients with polycystic ovary syndrome do not achieve relief of symptoms without surgical intervention and very few of them, if at all, have a complete disappearance of the cysts (Table 6). The dosage was six capsules of 650 mg three times a day.

Likewise, in a study of 123 patients with severe psoriasis, clinical remission was observed in 77% of the patients and almost two thirds of these achieved a clinical improvement in less than 45 days (Table 7). By contrast, most patients with severe psoriasis do not achieve remission but only symptomatic relief with existing pharmaceutical approaches. The dosage was seven capsules of 650 mg three times a day.

In conclusion, these results indicate that the synergistic combinations of phytopharmaceuticals, selected scientifically from each category of the herbal tonic described in the next section, are surprisingly effective.

EXAMPLE 9: PRINCIPLES FOR SELECTING SYNERGISTIC COMBINATIONS In order to expand the range of formulations covered by the invention, we have categorized beneficial plants into one of three groups, each of which must be present to achieve the synergistic effect. The classifications are Energy, Bio-Intelligence and Organization. Plants classified in the Energy group are associated with the synthesis of ATP (such as the Krebs cycle, oxidative phosphorylation, beta-oxidation, etc.). The plants classified in the Bio-Intelligence group are those that regulate the neuroendocrine and immune systems and the cellular processes, and that therefore control the interactions between the various systems of the body. Finally, plants classified in the Organization group are those that are related to the structure and function of specific organs. The combinations of plants from these three classification groups have a synergistic effect because they deal with each necessary component of cellular and organic health, in fact they provide the triangle on which healing is based in its entirety.

A group of plants was classified (along with some vitamins, etc.) according to this system based on what is known in the literature about its active ingredients and form of action. The classification is presented in Table 8.

Table 8 is representative only: on the basis of the criteria described in this document, other plants can be easily categorized as their form of action is determined.

An illustrative example of synergy in medicinal plants is an in vitro study demonstrating how the alkaloid activity of Berberine herb is strongly enhanced by the action of the herb 5'-methoxyhydrocarpin (5'-MHC). It shows a strong accumulation of berberine in the cells in the presence of the 5'-MHC, which indicates that this plant compound effectively deactivated the mechanism of bacterial resistance against the antimicrobials of berberine, and thus demonstrating the synergy of both substances. Stermítz, F. R., et al., Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhyd nocarpin, to multidrug pump inhibitor. Proc Nati Acad Sci USA. Feb 15, 2000; 97 (4): 1433-7.

We hope to further demonstrate the synergistic effect at the molecular level by studying changes in gene expression profile in response to various plant ingredients and combinations of these. Currently, experiments are carried out that demonstrate the expression profile in response to the formulations. In this work we will have help because researchers have already begun to study the expression profiles of various medicinal plants, which will have a knowledge database from which we can continue. E.g., Gohil, et al., MRNA Expression Profile of a Human Cancer Cell Line in Response to Ginkgo Biloba Extract: Induction of Antioxidant Response and the Golgi System, Free Radie Res. Dec. 2001; 33 (6): 831- 849.

In addition, we are testing combinations of plants to check the synergistic effects by using the mouse model for diabetic lesions, as described in Mastropaolo, et al., Synergy in Polymicrobial Infections in a Mouse Model of Type 2 Diabetes Infection and Immunity, September 2005, p. 6055-6063, Vol. 73, No. 9. In summary, obese diabetic mice of strain BKS.Cg-m + / + Leprdb / J are injected subcutaneously with mixed cultures containing Escherichia coli, Bacteroides fragUis and Clostridium períringens. The progress of infection (usually, such as abscess formation) is monitored by examining bacterial populations and white blood cell numbers on days 1, 8, and 22 after infection.

Various plant ingredients and combinations of these can be used to show a synergistic effect. In addition, the model can be used to demonstrate synergy when the formulations of the invention are combined with existing drugs, such as antibiotics.

Claims (17)

1) A synergistic phytoceutical composition composed of: to. at least two plants selected from the group consisting of Acantopanacis, Ajuga, Codonopsis, Cordyceps, Cornu Cervi pantrotichum, llex, L-arginine, Lepidium, Ocimum, Panax, Pfaffia, Ptychopetalum, Raponticum, Rodiola and Schizandra; b. at least two plants selected from the group consisting of Agaricus, Aloe, Andrographis, Annona, Aralia, Astragalus, Camellia, Coriolus, Equinaacea, Ganoderma, Grifola, Hydrastis, Lactoferrin, Lentinus, Lobostemon, Morinda, Petiveria, Polygonum multiflorum radix, Radix apeoniae alba , Radix polygalae, Sutherland, Tabebuia, Turnera, Uncaria, Valeriana and Vitex Uncaria; c. at least two plants selected from the group formed by Angelica, Bupleurum, Cimicifuga, Chitin fiber, Chondroitin sulfate, Crataegus, Croton, Curcubita, Turmeric, Dioscorea, Equisetum, Eucommia bark, Fructus ligustri lucidum, Fructus lycii, Gentiana, Ginkgo, Glucosamin, Glycyrriza , Ginostemma, Harpagophytum, Herba epimedii, Hydrocotile, Linum, Minerals, Mumiyo, Opuntia ficus, Picroriza, Plant enzymes, Ptycopetalum, Pygeum, Ramnus, Ruscus, Salix, Sargassum, Seine, Serenoa, Silibum, Smilax, Solanum, Tribulus, Ulmus, Urtica, Uva ursi, Vaccinium and Viburnum; d. and with pharmaceutically acceptable excipients or carriers.

2) The synergistic phylogenetic composition according to claim 1, characterized in that it also contains: to. at least two plants or nutraceuticals selected from the group consisting of Acantopanacis senticosus, Ajuga turkestanica, Codonopsis pilosula, Cordyceps sinensis, Cornu Cervi pantrotichum, llex paraguariensis, L-arginine, Lepidium meyenii, Ocimum sanctum, Panax ginseng, Panax quinquefolius, Pfaffia paniculata, Ptychopetalum olacoids, Raponticum carthamoides, Rhodiola rosaa, Schizandra chinensis and Ubiquinone (Coenzyme Q10); b. at least two plants or nutraceuticals selected from the group consisting of Agaricus blazei, Aloe vera, Andrographis peniculata, Annona muricata, Aralia Mandshurica, Astragalus membranaceus, Beta 1.3 glucan, Beta 1.6 glucan, Camelia sinensis, Coriolus versicolor, Equinaacea angustifolia, Equinaacea purpurea, Ganoderma lucidum, Grifolus frandosa, Hydrastis canadensis, Lactoferrin, Lentinus edodes, Lobostemon trigonus, Morinda citrifolia, Petiveria alliacea, Polygonum multiflorum radix, Radix apeoniae alba, Radix polygalae, Shark cartilage, Sutherland frutescens, Tabebuia avellanedae, Turnera aphrodisiaca, Uncaria tomentosa, Valeriana officinalis and Vitex agnus castus; c. at least two plants or nutraceuticals selected from the group formed by Angélica sinensis, Bupleurum chínense, Cimicifuga racemosa, Chitin fiber, Chondroitin sulfate, Crataegus oxiacantha, Croton lechleri; Curcubita pepo, Curcuma longa, Dioscorea villosa, Equisetum arvense, Eucommia bark, Fructus ligustri lucidum, Fructus lycii, Fulvic acid, Gentiana lutea, Ginkgo biloba, Glucosamin, Glycyrriza glabra, Ginostemma, Harpagophytum procumbens, Herba epimedii, Asian Hydrocotile, Linum usitatissimum, Minerals, Mumiyo, Opuntia ficus indica, Picroriza kurroa, Plant enzymes, Ptycopetalum olacoides, Pygeum africanum, Ramnus purshiana, Ruscus aculeatus, Salix alba, Sargassum fusiforme, Sena alejandrina, Serenoa repens, Silibum marianum, Smilax china, Solanum nigrum, Tribulus terrestris, Ulmus fulva, Urtica dioica, Uva ursi, Vaccinium mirtillus, Viburnum spp. and Vitamins.

3) The phytoceutical composition according to claim, further characterized because it is composed of plants or extracts or active ingredients derived from each of the following plants: Ginkgo, Vaccinium, Angelica, Crataegus, Hydrocotile, Ruscus, Croton, Equinaacea, Eleutherococcus, Ganoderma, Grifola, Hydrastis, Panax, Pfaffia, Raponticum, Rhodiola, Tabebuia, Panax, Uncaria, Petiveria and Sutherlandia, together with pharmaceutically acceptable excipients.

4) The phytoceutical composition according to claim 3, further characterized in that it contains Ginkgo biloba, Vaccinium mirtillus, Angelica sinensis, Crataegus oxiacantha, Asian hydrocotyle, Ruscus aculeatus, Croton lechleri, Equinaacea purpurea, Equinaacea angustifolia, Eleutherococcus senticosus, Ganoderma lucidum, Grifol leafy, Hydrastis canadensis, Panax ginseng, pancreatic Pfaffia, Raponticum carthamoides, Rhodiola rosaa, Tabebuia avellanedae, Panax quinquefolius, Uncaria tomentosa, Petiveria alliacea and Sutherlandia frutescens.

5) The phytoceutical composition according to claim 3, further characterized in that it contains the relative amounts of ingredients indicated in Table 1 and optionally, even water or gelatin.

6) The phytoceutical composition according to claim 1, further characterized in that it contains plants or extracts or active ingredients derived from each of the following plants: Rhodiola, Vitex, Equinaacea, Astragalus, Ganoderma, Uncaria, Grifóla, Dioscorea, Tabebuia, Pfaffia, Panax, Asian Hydrocotile, together with pharmaceutically acceptable excipients.

7) The phytoceutical composition according to claim 6, further characterized by containing Rhodiola rosaa, Vitex agnus castus, Equinaacea angustifolia, Equinaacea angustifolia radix, Equinaacea purpurea, Equinaacea purpurea radix, Astraglus membranaceous, Uncaria tomentosa, Grifola frondosa, Dioscorea villosa, Tabebuia avellanedae, Pfaffia paniculata, Panax quinquefolius, Asian Asian Hydrocotile.

8) The phytoceutical composition according to claim 6, further characterized in that it contains the relative amounts of ingredients indicated in Table 2.

9) The phytoceutical composition according to claim 1, further characterized in that it contains plants or extracts or active ingredients derived from each of the following plants: Raponticum, Rhodiola, Szchisandra, Angelica, Astragalus, Equinaacea, Ganoderma, Hydrastism, Lepidium, Panax, Silibum, Tabebuia, Uncaria, Equisetum, Hidrocotile, Picroriza, Smilax and Vaccinium, plus shark cartilage and fulvic acid, together with pharmaceutically acceptable excipients.

10) The phytoceutical composition according to claim 9, further characterized in that it is composed of Raponticum carthamoides, Rhodiola rosaa, Szchisandra chinensis, Angelica sinensis, Astragalus membranaceus, Equinaacea angustifolia, Equinaacea angustifolia radix, Equinaacea purpurea, Equinaacea purpurea radix, Ganoderma lucidum, Hydrastis canadensis, Lepidium meyenii, Panax ginseng, Silibum marianum, Tabebuia avellanedae, Uncaria tomentosa, Equisetum arvense, Asian hydrocotyle, Picroriza kurroa, Smilax officinalis and Vaccinium mirtillus.

11) The phytoceutical composition according to claim 9, further characterized in that it contains the relative amounts of ingredients indicated in Table 3.

12) A phytoceutical composition that contains: a composition selected from the group consisting of the compositions of Table 1, Table 2 and Table 3, together with pharmaceutically acceptable excipients.

13) A phytoceutical composition used to treat a disease and which consists of administering to a patient an effective amount of the synergistic phytoceutical composition sufficient to alleviate said disease.

14) The composition according to claim 13, further characterized in that the disease is a circulatory disease, an endocrine disorder of the woman or a skin disorder.

15) The composition according to claim 13, further characterized in that the composition is one of those listed in Table 1, and is used to treat diabetic lesions.

16) The composition according to claim 13, further characterized in that the composition consists of one of those mentioned in Table 2 and is used to treat PCOC.

17) The composition according to claim 13, further characterized in that the composition consists of one of those mentioned in the Table 3 and is used to treat psoriasis.