MXPA05011509A - 3,3-difenilpropilaminas (tolterodina) sustituidas con halogenos que presentan actividad antimuscarinica. - Google Patents

3,3-difenilpropilaminas (tolterodina) sustituidas con halogenos que presentan actividad antimuscarinica.

Info

Publication number
MXPA05011509A
MXPA05011509A MXPA05011509A MXPA05011509A MXPA05011509A MX PA05011509 A MXPA05011509 A MX PA05011509A MX PA05011509 A MXPA05011509 A MX PA05011509A MX PA05011509 A MXPA05011509 A MX PA05011509A MX PA05011509 A MXPA05011509 A MX PA05011509A
Authority
MX
Mexico
Prior art keywords
diphenylpropylamines
alkyl
halogen
optionally substituted
independently represent
Prior art date
Application number
MXPA05011509A
Other languages
English (en)
Inventor
Robert John Kaufman
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of MXPA05011509A publication Critical patent/MXPA05011509A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novedosas 3,3 -difenilpropilaminas de la formula OR, y cualesquiera estereoisomeros de los mismos; en donde R1 representa -H o -CH3; R2 representa -CX3r -CR2_1X2r -CR2-1R2_2X o -CR2_1R2_2H, en donde X representa halogeno, y R2_1 y R2_2 representan independientemente -H o- (alquiloC1-C4 ), opcionalmente sustituido con halogeno; R3 y R4 independientemente representan -H, -OCH3r -OH, -CONH2r -SO2NH2, -F, -CI, -Br, -I, -CF3, O - (alquilo C1-C4), opcionalmente sustituido con uno o dos -OH,- (alcoxiC1-C4), -COOH, o -CO-O- (alquilo C1-C3); y R5 y R6 representan independientemente alquilo C1-C6 opcionalmente sustituido con hidroxil, en donde R5 y R6 unidos contienen al menos tres atomos de carbono y en donde R5 y R6 pueden formar un anillo junto con la amina nitrogeno; con la condicion de que R2 comprenda al menos un halogeno; o una sal acida de adicion fisiologicamente aceptable de la misma; las 3,3-difenilpropilaminas para usarse como medicamento, el uso de las 3,3-difenilpropilaminas para la fabricacion de medicamentos especificos y composiciones farmaceuticas que comprenden las 3,3-difenilpropilaminas. La presente invencion tambien incluye un metodo de tratamiento que involucra la administracion de 3,3-difenilpropilaminas.
MXPA05011509A 2003-04-25 2004-04-15 3,3-difenilpropilaminas (tolterodina) sustituidas con halogenos que presentan actividad antimuscarinica. MXPA05011509A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46537203P 2003-04-25 2003-04-25
PCT/IB2004/001333 WO2004096751A1 (en) 2003-04-25 2004-04-15 Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity

Publications (1)

Publication Number Publication Date
MXPA05011509A true MXPA05011509A (es) 2005-12-15

Family

ID=33418235

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011509A MXPA05011509A (es) 2003-04-25 2004-04-15 3,3-difenilpropilaminas (tolterodina) sustituidas con halogenos que presentan actividad antimuscarinica.

Country Status (7)

Country Link
US (3) US20050004223A1 (es)
EP (1) EP1620389A1 (es)
JP (1) JP2006524677A (es)
BR (1) BRPI0409653A (es)
CA (1) CA2523226A1 (es)
MX (1) MXPA05011509A (es)
WO (1) WO2004096751A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957073A1 (en) 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
US6890920B2 (en) * 2001-10-26 2005-05-10 Pharmacia & Upjohn Company Quaternary ammonium compounds
DE10315917A1 (de) * 2003-04-08 2004-11-18 Schwarz Pharma Ag Hochreine Basen von 3,3-Diphenylpropylaminmonoestern
JP2006524677A (ja) * 2003-04-25 2006-11-02 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗ムスカリン活性を有するハロゲン置換３，３−ジフェニルプロピルアミン（トルテロジン）
KR101029643B1 (ko) 2004-07-24 2011-04-15 일동제약주식회사 엔-메틸-3,3-디페닐프로필아민의 제조방법
KR100647068B1 (ko) 2005-09-15 2006-11-23 하나제약 주식회사 라세믹ｎ,ｎ-디이소프로필-3-(2-히드록시-5-메틸페닐)-3-페닐프로판아민의 제조방법
CN100430370C (zh) * 2006-11-03 2008-11-05 华东理工大学 一种丙胺衍生物及其在制备托莫西汀中的应用
US8076516B2 (en) * 2007-11-01 2011-12-13 Acucela, Inc. Amine derivative compounds for treating ophthalmic diseases and disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8800207D0 (sv) 1988-01-22 1988-01-22 Kabivitrum Ab Nya aminer, deras anvendning och framstellning
SE9203318D0 (sv) 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
EP0957073A1 (en) * 1998-05-12 1999-11-17 Schwarz Pharma Ag Novel derivatives of 3,3-diphenylpropylamines
US6890920B2 (en) * 2001-10-26 2005-05-10 Pharmacia & Upjohn Company Quaternary ammonium compounds
JP2006524677A (ja) * 2003-04-25 2006-11-02 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗ムスカリン活性を有するハロゲン置換３，３−ジフェニルプロピルアミン（トルテロジン）

Also Published As

Publication number Publication date
EP1620389A1 (en) 2006-02-01
US20060004106A1 (en) 2006-01-05
CA2523226A1 (en) 2004-11-11
US20060281812A1 (en) 2006-12-14
JP2006524677A (ja) 2006-11-02
BRPI0409653A (pt) 2006-04-25
US7119121B2 (en) 2006-10-10
US20050004223A1 (en) 2005-01-06
US7291648B2 (en) 2007-11-06
WO2004096751A1 (en) 2004-11-11

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