MXPA02011844A - Compounds with a sulphonamide group and pharmaceutical compositions containing these compounds. - Google Patents
Compounds with a sulphonamide group and pharmaceutical compositions containing these compounds.Info
- Publication number
- MXPA02011844A MXPA02011844A MXPA02011844A MXPA02011844A MXPA02011844A MX PA02011844 A MXPA02011844 A MX PA02011844A MX PA02011844 A MXPA02011844 A MX PA02011844A MX PA02011844 A MXPA02011844 A MX PA02011844A MX PA02011844 A MXPA02011844 A MX PA02011844A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- group
- erythrocytes
- substances
- pharmaceutical compositions
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000565 sulfonamide group Chemical group 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 3
- 210000003743 erythrocyte Anatomy 0.000 abstract 3
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000005445 natural material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to compounds which, acting as a prodrug and/or support, enable an active agent to be taken up by the erythrocytes and/or an active agent to bind to the erythrocytes. The uptake of these compounds by and/or the binding thereof to the erythrocytes is made possible by a group of formula -SO2NR1R2, wherein R1 and R2, independently of each other, mean a hydrogen atom, an acyl group, an alkyl group, a cycloalkyl group, an aryl group, a cyano group or a hydroxy group. The inventive prodrugs enable active agents such as endogenic substances, natural substances and synthetic substances with therapeutically useful properties which have a high first path effect, to be administered orally effectively or significantly improve the oral activity thereof.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10027887A DE10027887A1 (en) | 2000-05-31 | 2000-05-31 | Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds |
| PCT/EP2001/005169 WO2001091797A2 (en) | 2000-05-31 | 2001-05-08 | Compounds with a sulphonamide group and pharmaceutical compositions containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA02011844A true MXPA02011844A (en) | 2004-05-17 |
Family
ID=7644802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA02011844A MXPA02011844A (en) | 2000-05-31 | 2001-05-08 | Compounds with a sulphonamide group and pharmaceutical compositions containing these compounds. |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US7507725B2 (en) |
| EP (1) | EP1294402B2 (en) |
| JP (1) | JP2003534386A (en) |
| KR (3) | KR20080038460A (en) |
| CN (1) | CN1441678A (en) |
| AT (1) | ATE315407T1 (en) |
| AU (2) | AU6593301A (en) |
| BG (1) | BG107556A (en) |
| BR (1) | BR0111294A (en) |
| CA (1) | CA2410630A1 (en) |
| CZ (1) | CZ2003621A3 (en) |
| DE (2) | DE10027887A1 (en) |
| DK (1) | DK1294402T4 (en) |
| EA (1) | EA006432B1 (en) |
| ES (1) | ES2256256T5 (en) |
| HR (1) | HRP20021038B1 (en) |
| HU (1) | HUP0301949A3 (en) |
| IL (2) | IL152932A0 (en) |
| ME (1) | MEP14608A (en) |
| MX (1) | MXPA02011844A (en) |
| NO (1) | NO20025739D0 (en) |
| NZ (1) | NZ535201A (en) |
| PL (1) | PL206462B1 (en) |
| PT (1) | PT1294402E (en) |
| SK (1) | SK2912003A3 (en) |
| UA (1) | UA76953C2 (en) |
| WO (1) | WO2001091797A2 (en) |
| YU (1) | YU90102A (en) |
| ZA (1) | ZA200209490B (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10027887A1 (en) * | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds |
| US8026229B2 (en) | 2001-08-13 | 2011-09-27 | Sterix Limited | Antitumor-active 2-alkoxyestradiol sulfamates |
| US20050277625A1 (en) * | 2004-05-21 | 2005-12-15 | Ralf Wyrwa | Estriol and estetrol prodrugs |
| US7534780B2 (en) * | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
| DE102004025986A1 (en) * | 2004-05-21 | 2005-12-15 | Schering Ag | Steroid prodrugs with androgenic effects |
| US20050282793A1 (en) * | 2004-05-21 | 2005-12-22 | Ralf Wyrwa | Steroid prodrugs with androgenic action |
| DE102004025966A1 (en) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estradiol prodrugs |
| DE102004025985A1 (en) * | 2004-05-21 | 2005-12-15 | Schering Ag | Estriol and estetrol prodrugs |
| DE102005057225A1 (en) * | 2005-11-29 | 2007-05-31 | Bayer Schering Pharma Ag | New 8-beta-substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders |
| US20070197488A1 (en) * | 2005-11-29 | 2007-08-23 | Olaf Peters | Prodrugs of ERbeta-selective substances, process for their production, and pharmaceutical compositions that contain these compounds |
| US20070123500A1 (en) * | 2005-11-29 | 2007-05-31 | Gerd Mueller | Prodrugs of ERbeta-selective substances, processes for their preparation and pharmaceutical compositions comprising these compounds |
| DE102005057224A1 (en) * | 2005-11-29 | 2007-05-31 | Bayer Schering Pharma Ag | New 9-alpha substituted estratriene derivatives esterified with a sulfamoylphenyl-substituted acid residue, are prodrugs useful as carboanhydrase inhibitors for treating estrogen deficiency disorders |
| US20070135399A1 (en) * | 2005-11-30 | 2007-06-14 | Ralf Wyrwa | Heteroaromatic sulphonamide prodrugs |
| DE102005057408A1 (en) * | 2005-11-30 | 2007-05-31 | Bayer Schering Pharma Ag | New sulfamoylsulfonate prodrugs e.g. useful for protecting red blood cells from attack by parasites or for hormone replacement therapy, female fertility control or treating hormone-associated diseases |
| US20070135375A1 (en) * | 2005-11-30 | 2007-06-14 | Ralf Wyrwa | Sulfamoyl sulfonate prodrugs |
| DE102005057421A1 (en) * | 2005-11-30 | 2007-05-31 | Bayer Schering Pharma Ag | New heteroaromatic sulfonamide prodrugs, useful for delivering e.g. antimalarials and steroids for e.g. fertility control or hormone replacement therapy |
| CN104905631B (en) | 2008-05-20 | 2017-07-11 | 格里南实业公司 | fluid delivery assembly and method of fluid delivery |
| US8777182B2 (en) | 2008-05-20 | 2014-07-15 | Grinon Industries | Fluid transfer assembly and methods of fluid transfer |
| US9100458B2 (en) * | 2008-09-11 | 2015-08-04 | At&T Intellectual Property I, L.P. | Apparatus and method for delivering media content |
| CN101987102A (en) * | 2009-08-05 | 2011-03-23 | 天津金耀集团有限公司 | Ophthalmic anti-inflammatory composition of glucocorticoid heteroaryl sulfamoyl carboxylate |
| CN101987104A (en) * | 2009-08-05 | 2011-03-23 | 天津金耀集团有限公司 | Ophthalmic composition of heteroaryl sulfamoyl carboxylic ester carbonic anhydrase inhibitor |
| MX363934B (en) * | 2011-12-30 | 2019-04-08 | Grinon Ind | Fluid transfer assembly and methods of fluid transfer. |
| WO2015006691A1 (en) | 2013-07-11 | 2015-01-15 | Evestra, Inc. | Pro-drug forming compounds |
| WO2017089286A1 (en) | 2015-11-27 | 2017-06-01 | Sanofi-Aventis Deutschland Gmbh | A drug delivery device with a cap |
| EP3173113A1 (en) * | 2015-11-27 | 2017-05-31 | Sanofi-Aventis Deutschland GmbH | An injection needle assembly |
| MX2020003470A (en) | 2017-10-19 | 2020-10-01 | Evestra Inc | Longer-acting progestin prodrug contraceptives. |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1203042B (en) * | 1963-11-21 | 1965-10-14 | Schering Ag | Fungicides |
| GB1593609A (en) | 1978-01-31 | 1981-07-22 | Christiaens Sa A | Pyridine sulfonamides |
| US4244940A (en) * | 1978-09-05 | 1981-01-13 | Bio-Rad Laboratories, Inc. | Single-incubation two-site immunoassay |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| GB8327256D0 (en) * | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| US5001234A (en) | 1987-04-16 | 1991-03-19 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US4792569A (en) | 1987-08-27 | 1988-12-20 | Mcneilab, Inc. | Anticonvulsant phenethyl sulfamates |
| US5116828A (en) | 1989-10-26 | 1992-05-26 | Nippon Zoki Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of osteoporosis |
| US5025031A (en) | 1989-11-30 | 1991-06-18 | A. H. Robins Co., Inc. | Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| DE4236237A1 (en) | 1992-10-27 | 1994-04-28 | Behringwerke Ag | Prodrugs, their preparation and use as medicines |
| US5384327A (en) * | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
| IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
| DE4429397C2 (en) | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5 (10) -triene derivatives, processes for their preparation and pharmaceutical compositions containing these compounds |
| DE4447715C2 (en) | 1994-08-09 | 1998-02-05 | Jenapharm Gmbh | Oestrogen compsn contg. 3-sulphamoyl:oxy-oestratriene cpd. |
| US5571933A (en) | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
| DE19540233B4 (en) | 1995-10-19 | 2005-08-25 | Schering Ag | Sulfamate derivatives of 1,3,5 (10) estratriene derivatives, process for their preparation and pharmaceutical compositions containing them |
| US5705495A (en) * | 1995-10-19 | 1998-01-06 | Jenapharm Gmbh & Co. Kg. | Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds |
| DE19712488A1 (en) | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroid sulfamates, processes for their preparation and use thereof |
| DE19723794A1 (en) * | 1997-06-06 | 1998-12-10 | Jenapharm Gmbh | Non-estrogenic derivatives of estradiol with antioxidant activity |
| US6259967B1 (en) * | 1998-07-29 | 2001-07-10 | Crisplant A/S | Parcel singulation system |
| US6583130B1 (en) | 1999-09-13 | 2003-06-24 | Schering Ag | C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds |
| US6958327B1 (en) * | 1999-11-02 | 2005-10-25 | Schering, Ag | 18 Norsteroids as selectively active estrogens |
| KR20020087930A (en) * | 2000-01-14 | 2002-11-23 | 스테릭스 리미티드 | Composition |
| AU2001273945A1 (en) | 2000-04-12 | 2001-10-23 | Schering Aktiengesellschaft | 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives |
| DE10027887A1 (en) | 2000-05-31 | 2001-12-13 | Jenapharm Gmbh | Compounds with a sulfonamide group and pharmaceutical compositions containing these compounds |
| US6355666B1 (en) | 2000-06-23 | 2002-03-12 | Medinox, Inc. | Protected forms of pharmacologically active agents and uses therefor |
| EP1363898A4 (en) | 2001-03-02 | 2004-12-08 | Bristol Myers Squibb Co | Compounds useful as modulators of melanocortin receptors and pharmaceutical compositions comprising same |
| US20020156068A1 (en) * | 2001-03-22 | 2002-10-24 | Behan Dominic P. | Anti-psychosis combination |
| US6956031B2 (en) | 2002-03-27 | 2005-10-18 | Schering Aktiengesellschaft | 11β-Substituted 19-nor-17-α-pregna-1,3,5(10)-trien-17β-ols with a 21,16α-lactone ring |
| DE10226326A1 (en) | 2002-06-11 | 2004-01-15 | Schering Ag | 9-alpha-substituted estratrienes as selective estrogens |
| US7414043B2 (en) | 2002-06-11 | 2008-08-19 | Schering Ag | 9-α-substituted estratrienes as selectively active estrogens |
| JP2007512279A (en) | 2003-11-26 | 2007-05-17 | シエーリング アクチエンゲゼルシャフト | Selective estrogens 8β-vinyl-estradi-1,3,5 (10) -triene-3,17β-diol, and 17β-fluor-9α-vinyl-estradi-1,3,5 (10) -triene-3, Prevention and treatment of hypertensive heart disease with 16α-diol |
| DE102004025966A1 (en) | 2004-05-21 | 2005-12-15 | Schering Ag | Estradiol prodrugs |
| DE102004025985A1 (en) | 2004-05-21 | 2005-12-15 | Schering Ag | Estriol and estetrol prodrugs |
| DE102004025986A1 (en) | 2004-05-21 | 2005-12-15 | Schering Ag | Steroid prodrugs with androgenic effects |
| US20050277625A1 (en) | 2004-05-21 | 2005-12-15 | Ralf Wyrwa | Estriol and estetrol prodrugs |
| US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
| AR053845A1 (en) | 2005-04-15 | 2007-05-23 | Tibotec Pharm Ltd | 5-TIAZOLILMETIL [(1S, 2R) -3 - [[(2-AMINO-6-BENZOXAZOLIL) SULFONIL)] (2-METHYLPROPIL) AMINO] -2-HYDROXY-1- (PHENYLMETIL) PROPIL] CARBAMATE AS A PHARMACY IMPROVER METABOLIZED BY THE CYCROCHROME P450 |
-
2000
- 2000-05-31 DE DE10027887A patent/DE10027887A1/en not_active Ceased
-
2001
- 2001-05-08 NZ NZ535201A patent/NZ535201A/en unknown
- 2001-05-08 ES ES01943329T patent/ES2256256T5/en not_active Expired - Lifetime
- 2001-05-08 DE DE50108674T patent/DE50108674D1/en not_active Expired - Lifetime
- 2001-05-08 DK DK01943329T patent/DK1294402T4/en active
- 2001-05-08 ME MEP-146/08A patent/MEP14608A/en unknown
- 2001-05-08 IL IL15293201A patent/IL152932A0/en active IP Right Grant
- 2001-05-08 KR KR1020087009746A patent/KR20080038460A/en active IP Right Grant
- 2001-05-08 EA EA200201201A patent/EA006432B1/en not_active IP Right Cessation
- 2001-05-08 US US10/296,973 patent/US7507725B2/en not_active Expired - Fee Related
- 2001-05-08 EP EP01943329A patent/EP1294402B2/en not_active Expired - Lifetime
- 2001-05-08 KR KR1020027016148A patent/KR20030017524A/en not_active Application Discontinuation
- 2001-05-08 PL PL361426A patent/PL206462B1/en not_active IP Right Cessation
- 2001-05-08 AT AT01943329T patent/ATE315407T1/en not_active IP Right Cessation
- 2001-05-08 CA CA002410630A patent/CA2410630A1/en not_active Abandoned
- 2001-05-08 JP JP2001587809A patent/JP2003534386A/en active Pending
- 2001-05-08 BR BR0111294-5A patent/BR0111294A/en not_active Application Discontinuation
- 2001-05-08 MX MXPA02011844A patent/MXPA02011844A/en active IP Right Grant
- 2001-05-08 SK SK291-2003A patent/SK2912003A3/en not_active Application Discontinuation
- 2001-05-08 PT PT01943329T patent/PT1294402E/en unknown
- 2001-05-08 KR KR1020097014971A patent/KR20090090398A/en not_active Application Discontinuation
- 2001-05-08 AU AU6593301A patent/AU6593301A/en active Pending
- 2001-05-08 AU AU2001265933A patent/AU2001265933B2/en not_active Ceased
- 2001-05-08 CN CN01810337A patent/CN1441678A/en active Pending
- 2001-05-08 CZ CZ2003621A patent/CZ2003621A3/en unknown
- 2001-05-08 WO PCT/EP2001/005169 patent/WO2001091797A2/en active IP Right Grant
- 2001-05-08 HU HU0301949A patent/HUP0301949A3/en unknown
- 2001-05-08 YU YU90102A patent/YU90102A/en unknown
- 2001-08-05 UA UA20021210409A patent/UA76953C2/en unknown
-
2002
- 2002-11-19 IL IL152932A patent/IL152932A/en not_active IP Right Cessation
- 2002-11-21 ZA ZA200209490A patent/ZA200209490B/en unknown
- 2002-11-29 NO NO20025739A patent/NO20025739D0/en not_active Application Discontinuation
- 2002-12-30 HR HR20021038A patent/HRP20021038B1/en not_active IP Right Cessation
-
2003
- 2003-02-14 BG BG107556A patent/BG107556A/en unknown
-
2008
- 2008-06-19 US US12/142,332 patent/US20090023896A1/en not_active Abandoned
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