MXPA01013406A - Vla-4 inhibitor compounds. - Google Patents

Vla-4 inhibitor compounds.

Info

Publication number
MXPA01013406A
MXPA01013406A MXPA01013406A MXPA01013406A MXPA01013406A MX PA01013406 A MXPA01013406 A MX PA01013406A MX PA01013406 A MXPA01013406 A MX PA01013406A MX PA01013406 A MXPA01013406 A MX PA01013406A MX PA01013406 A MXPA01013406 A MX PA01013406A
Authority
MX
Mexico
Prior art keywords
vla
inhibitor compounds
inhibitor
compounds
Prior art date
Application number
MXPA01013406A
Other languages
Spanish (es)
Inventor
Edward Mcdonald
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of MXPA01013406A publication Critical patent/MXPA01013406A/en

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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MXPA01013406A 1999-06-30 2000-06-30 Vla-4 inhibitor compounds. MXPA01013406A (en)

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Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU784813B2 (en) 2000-01-17 2006-06-29 Bayer Aktiengesellschaft Substituted aryl ketones
DE10006453A1 (en) * 2000-02-14 2001-08-16 Bayer Ag New piperidylcarboxylic acid derivatives, are integrin antagonists useful for treating inflammatory, autoimmune or immunological diseases, e.g. atherosclerosis, asthma, diabetes, rheumatoid arthritis or transplant rejection
JP2004516237A (en) 2000-06-21 2004-06-03 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー Piperidine amides as modulators of chemokine receptor activity
CA2430978C (en) 2000-12-28 2012-05-15 Daiichi Pharmaceutical Co., Ltd. Vla-4 inhibitors
WO2003002531A2 (en) 2001-06-27 2003-01-09 Smithkline Beecham Corporation Fluoropyrrolidines as dipeptidyl peptidase inhibitors
GB0123765D0 (en) * 2001-10-03 2001-11-21 Bayer Ag Para-amino benzoic acids
US7956219B2 (en) * 2002-05-09 2011-06-07 Baker IDI Heart and Diabetes Amino acid analogues
RU2340605C2 (en) 2002-06-27 2008-12-10 Ново Нордиск А/С Arylcarbonyl derivatives as therapeutic agents
CA2744893A1 (en) 2002-06-27 2004-01-08 Novo Nordisk A/S Aryl carbonyl derivatives as glucokinase activators
AU2003241836A1 (en) 2002-10-03 2004-04-23 Ono Pharmaceutical Co., Ltd. Lpa receptor antagonists
GB0225944D0 (en) * 2002-11-06 2002-12-11 Glaxo Group Ltd Novel compounds
JPWO2004099136A1 (en) 2003-05-09 2006-07-13 第一製薬株式会社 Method for producing pyrrolidine derivative
TWI340134B (en) 2003-07-24 2011-04-11 Daiichi Seiyaku Co Cyclohexanecarboxylic acids
EP1680109A4 (en) * 2003-10-07 2009-05-06 Renovis Inc Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
MXPA06007667A (en) 2004-01-06 2006-09-01 Novo Nordisk As Heteroaryl-ureas and their use as glucokinase activators.
JP2005350417A (en) * 2004-06-11 2005-12-22 Dai Ichi Seiyaku Co Ltd Method for producing pyrrolidine derivative using reductive etherification method
EP1781686B1 (en) * 2004-08-16 2009-05-06 Merck & Co., Inc. Vla-4 antagonists
EP1961750B1 (en) 2005-12-13 2013-09-18 Daiichi Sankyo Company, Limited Vla-4 inhibitory drug
CN101827826A (en) 2007-10-16 2010-09-08 诺瓦提斯公司 4-phenyl-5-oxo-imidazole derivatives, pharmaceutical compositions and uses therof
EA019033B1 (en) * 2008-03-26 2013-12-30 Новартис Аг Hydroxamate-based inhibitors of deacetylases b
PT2513085T (en) * 2009-11-18 2016-11-14 Suven Life Sciences Ltd Bicyclic compounds as alpha4beta2 nicotinic acetylcholine receptor ligands
EP2694472B1 (en) 2011-04-05 2020-03-11 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
CN112040945A (en) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 Therapeutic use of glucokinase activators in combination with insulin or insulin analogs
CA3115820A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of .alpha.4.beta.7 integrin
CA3114240C (en) 2018-10-30 2023-09-05 Gilead Sciences, Inc. Imidazopyridine derivatives as alpha4beta7 integrin inhibitors
WO2020092375A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
CN112969504B (en) 2018-10-30 2024-04-09 吉利德科学公司 Compounds for inhibiting alpha 4 beta 7 integrin
BR112021010400A2 (en) 2019-02-26 2021-08-24 Bayer Aktiengesellschaft Condensed bicyclic heterocyclic derivatives as pest control agents
CA3148613A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Phenylalanine derived compounds and their use as inhinitors of alpha 4 beta 7 integrin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
US6248713B1 (en) * 1995-07-11 2001-06-19 Biogen, Inc. Cell adhesion inhibitors
CA2291778A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
WO1999020272A1 (en) * 1997-10-21 1999-04-29 Merck & Co., Inc. Azapeptide acids as cell adhesion inhibitors
SK5462000A3 (en) * 1997-10-31 2001-02-12 Aventis Pharma Ltd Substituted anilides
WO1999054321A1 (en) * 1998-04-21 1999-10-28 Aventis Pharma Limited Substituted diamines and their use as cell adhesion inhibitors
EA004792B1 (en) * 1998-06-30 2004-08-26 Пфайзер Продактс Инк. Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune and respiratory diseases

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BR0012068A (en) 2002-05-14
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