MXPA01011220A - Shampoos providing a superior combination of anti-dandruff efficacy and conditioning - Google Patents

Abstract

Disclosed are shampoo compositions that provide a superior combination of anti-dandruff efficacy and conditioning, and a method of cleansing and conditioning the hair comprising applying to the hair and scalp an amount of said compositions. The anti-dandruff and conditioning shampoos comprise:(A) from about 5%to about 50%, by weight, of an anionic surfactant;(B) from about 0.01%to about 10%, by weight, of a non-volatile conditioning agent;(C) from about 0.1%to about 4%, by weight, of an anti-dandruff agent;(D) from about 0.02%to about 5%, by weight, of at least one cationic polymer;and (E) water. The compositions (A) have a bioavailability/coverage index value, as defined herein, of at least about 1.25;(B) have a first conditioning index value, as defined herein, of less than or equal to about 1.0;(C) have a second conditioning index value, as defined herein, of at least 1.5;and (D) have a minimal inhibitory concentration index value, as defined herein, of at least 0.125.

Description

SHAMPOO THAT PROVIDES A SUPERIOR COMBINATION OF ANTI-DUST AND CONDITIONER EFFECTIVENESS TECHNICAL FIELD OF THE INVENTION The present invention is in relation to shampoo compositions that provide a superior combination of anti-dandruff and conditioning efficacy. These compositions contain anionic surfactants, conditioning agents, anti-dandruff agents, cationic polymers and water. These anti-dandruff shampoo compositions show (a) at least a certain value of the bioavailability / coverage index-r (b) less than or equal to a certain value of the first conditioning index, (c) at least a certain value of the index of the second conditioning and (d) at least a certain value of the minimum inhibitory concentration index, as defined in this invention.

BACKGROUND OF THE INVENTION j Shampoo compositions comprising various combinations of detersive surfactants and conditioning agents, especially silicone conditioning agents, are known in the technical field and are commercially available. It has been found that many of these compositions provide excellent hair cleansing and a conditioning function. For example, Pro-Vitamin Conditioner-in-One Pantene® Shampoo Plus formulas containing anionic surfactants, a cationic polymer and silicone conditioning agents provide excellent cleansing, conditioning and benefits of a pleasant hair feel in every application . Anti-dandruff shampoos are also well known in the technical field and are also commercially available. Anti-dandruff shampoos typically incorporate anti-dandruff active ingredients and detersive surfactants. Preferred types of anti-dandruff agents are crystalline particulate antidandruff agents, such as sulfur, selenium disulfide and heavy metal salts of pyridinethione. Soluble antidandruff agents, such as ketoconazole, are also known in the technical field. Anti-dandruff shampoos that also provide conditioning benefits are also known in the technical field. For example, U.S. Patent No. 5,624,666 exemplifies and claims shampoo compositions containing anionic surfactants, cationic polymers and zinc pyridinethione as an antidandruff agent. U.S. Patent No. 5,624,666 teaches that conditioning agents such as silicone fluids can be optionally incorporated into the compositions themselves. Head & Dandruff Shampoo and Conditioner Shoulders® Dandruff is an example of a commercialized product that provides both anti-dandruff and conditioner benefits in hair shampoo applications. However, some consumers want a shampoo that provides a superior combination of anti-dandruff efficacy and conditioning performance against the products currently marketed. This superior combination of efficiency and conditioning can be difficult to achieve. For example, one way of achieving excellent conditioning benefits is the use of a fairly high level of a cationic polymer in the shampoo composition. However, the use of high levels of cationic polymers can affect the characteristics of the coacervate formed between the cationic polymer and the anionic surfactant in a manner that negatively impacts the deposition of the antidandruff active ingredients on the hair and scalp. In this way, it has hitherto been thought that the level of cationic polymers must be balanced to provide the best antidandruff conditioning and efficacy balance. Also by way of example, it was previously thought that excellent anti-dandruff efficacy could be achieved by using a coacervate to deposit antidandruff active ingredients on the hair and scalp. Unfortunately, the use of coacervates to deposit antidandruff active ingredients on the hair or scalp can negatively affect the conditioning, specifically the sensation of clean hair. In order to achieve a good conditioning, the level of the anti-dandruff agent could be reduced, resulting in a good conditioning, but with less than optimal anti-dandruff efficacy. Applicants have now discovered, however, that, surprisingly, the bioavailability and coverage of the antidandruff active ingredients are much more predictable in their efficacy than the deposition of the active ingredients on the hair or scalp. In fact, the applicants have found that, in some cases, even when the antidandruff active ingredients are very well deposited on the hair and scalp, an acceptable anti-dandruff efficacy is not achieved. Conversely, good antidandruff efficacy could be achieved in situations where the antidandruff active ingredients have a good coverage and are highly bioavailable, but not deposited superiorly on the hair or scalp. Thus, for a shampoo composition to provide a superior combination of anti-dandruff efficacy and conditioning compared to known shampoo compositions, it must meet certain criteria with respect to bioavailability and coverage, but it must not necessarily have the ability to deposit the shampoos. anti-dandruff active ingredients in top grade on the hair or scalp. Applicants have found that four requirements must be met to provide shampoo compositions that provide a superior combination of efficacy and conditioning. In particular, (1) the bioavailability and coverage of the antidandruff active ingredients are important factors for anti-dandruff efficacy; (2) the combing ability of damp hair and (3) the feeling of clean hair are important factors in consumer perception of well-conditioned hair; and (4) the inherent ability of the antidandruff active ingredients to inhibit the growth of microorganisms has an impact on the anti-dandruff efficacy as well as on the overall consumer acceptance of the shampoo product. Compliance with the criteria required for a given shampoo composition depends on a number of aspects of the shampoo formulation including, P1383 example, the level and type of cationic polymer used in the composition, the type of anti-dandruff agent used, the amount of anionic surfactant used, the level and type of polyalkylene glycol used, if used, and the rheological characteristics of the coacervate. It is an object of the present invention to provide shampoo compositions, which provide a superior combination of efficacy. anti-dandruff and conditioning. It is also an object of the present invention to provide a method for cleaning and conditioning hair. These and other objects will be readily apparent in the detailed description below.

SUMMARY OF THE INVENTION The present invention relates to a shampoo composition comprising: (A) of between about 5% and 50% by weight, of an anionic surfactant; (B) of approximately between 0.01% and 10% by weight, of a non-volatile conditioning agent; (C) of approximately between 0.1% and 4%, by weight of an antidandruff agent; (D) of approximately between 0.02% and 5%, by weight of at least one cationic polymer; and (E) water. The composition: (A) has a bioavailability / coverage index value, as defined in this invention, of at least P1383 about 1.25; (B) has a value of the first conditioning index, as defined in this invention, less than or equal to about 1.0; (C) has a value of the second conditioning index, as defined in this invention, of at least about 1.5; and (D) has a minimum inhibitory concentration index value, as defined in this invention, of at least about 0.125. The present invention furthermore relates to a method for providing anti-dandruff efficacy and hair conditioning comprising the application to the hair and scalp of an amount of the composition described above that is effective to provide those benefits.

DETAILED DESCRIPTION OF THE INVENTION The shampoo compositions of the present invention provide a superior combination of anti-dandruff efficacy and conditioning. These antidandruff conditioning shampoo compositions may comprise, consist of or consist essentially of the essential elements and limitations of the invention described herein, as well as of any additional or optional ingredient, component or limitation described in this invention. In particular, these compositions comprise anionic surfactants, conditioning agents, anti-dandruff agents, cationic polymers, and water. More particularly, these compositions exhibit certain characteristics that are measured by means of four indices, defined in this invention. The shampoo compositions of the present invention have a bioavailability / coverage index value of at least about 1.25, preferably at least about 1.5, more preferably at least about 2.0. This index is indicative of anti-dandruff efficacy. Generally, the greater the value of the composition index, the better is its anti-dandruff efficacy, due to an antidandruff agent with greater bioavailability, and to an increased coverage of the antidandruff agent, or both. Applicants have discovered that, surprisingly, the bioavailability and coverage of the anti-dandruff active ingredients are much more predictable in their efficacy than the deposition of the active ingredients on the hair or scalp. In fact, the applicants have found that, in some cases, even when the antidandruff active ingredients are deposited very well on the hair and scalp, an acceptable anti-dandruff efficacy is not achieved. Conversely, good anti-dandruff efficacy could be achieved in situations where the anti-dandruff active ingredients have good coverage and high bioavailability, but do not deposit superiorly on the hair or scalp. Applicants believe that there are several ways to increase the bioavailability of the anti-dandruff active ingredients. For example, the composition can be formulated (as will be described below) in such a way that the antidandruff active ingredients are present on the surface of the coacervate (for example, fragilely associated with the coacervate) instead of being integrated into or encapsulated by the coacervate. Another way of increasing the bioavailability of the antidandruff active ingredients is to formulate the composition (as will be described below) in such a way that the coacervate is dispersible or fluid (rather than elastic) to increase the bioavailability of any antidandruff active ingredients that are integrated inside or encapsulated by the coacervate. The shampoo compositions of the present invention have a first conditioning index value less than or equal to about 1.0, preferably less than or equal to about 0.96, more preferably less than or equal to about 0.94, preferably superlative less than or equal to about 0.91. This index is indicative of conditioning, as consumers understood the composition of the shampoo. Generally, the lower the value of the composition index, the better is its conditioning capacity, due to an easier hairstyle and a lesser amount of wet tangled hair. The shampoo compositions of the present invention have a second conditioning index value of at least about 1.5, preferably at least about 1.75, more preferably at least about 2.0, even more preferably at least about 2.25, preferably superlative of at least about 2.5. This index is indicative of conditioning, as consumers understood the composition of the shampoo. Generally, the higher the index value of the composition, the better is its conditioning capacity, due to an increased feeling of clean hair. The shampoo compositions of the present invention have a minimum inhibitory concentration index value of at least about 0.125, preferably at least about 0.25, more preferably at least about 0.5. This index is indicative of antidandruff efficacy. Generally, the higher the value of the composition index, the more effective its anti-dandruff efficacy, due to a P1383 increase in the inherent capacity of the antidandruff agent to inhibit the growth of microorganisms. The components, including those that could be optionally added, of the shampoo compositions of the present invention, as well as the methods for the preparation and methods for their use, are described in detail below. Also, the methods to evaluate the four indices are described in detail.

I. Components The antidandruff shampoo conditioner compositions of the present invention comprise an anionic surfactant, a conditioning agent, an antidandruff agent, a cationic polymer and water. Each of these ingredients is described in detail below.

A. Anionic surfactant The compositions of the antidandruff conditioning shampoo of the present invention comprise approximately between 5% and 50% by weight of the composition, preferably approximately between 8% and 30%, more preferably approximately between 10% and 25%, preferably superlative between about 12% and 18%, of an anionic detersive surfactant component suitable for application to hair or skin. It is believed that the P1383 anionic detersive surfactant provides the composition with a cleaning and foaming function. Additionally, the anionic detersive surfactant forms a coacervate, in aqueous dilution, with the cationic polymer component (described below) of the present invention. It is believed that this coacervate is important to provide the efficacy and conditioning benefits described in this invention. The anionic detersive surfactant component may comprise an anionic detersive surfactant, a zwitterionic or an amphoteric detersive surfactant having a bound moiety that is anionic, at the pH of the composition, or a combination thereof; preferably an anionic detersive surfactant. These surfactants must be physically and chemically compatible with the essential components in this invention described, and must not, on the other hand, unduly deteriorate the stability of the product, its aesthetics or performance. Some examples of anionic detersive surfactants that can be suitably used in the shampoo compositions of this invention are included, in non-exclusive form: sulfates, sulfonates, sarcosinates and sarcosine derivatives. 1. Sulfates Anionic detersive surfactants for use in the anti-dandruff conditioner shampoo compositions of the present invention are the alkyl and alkyl ether sulfates. These surfactants have the respective formula ROS03M and R (C2H40) xOS03M, wherein R is an alkyl or alkenyl having about 8 to 18 carbon atoms, x is an integer having a value from 1 to 10 and M is an cation selected from the group consisting of covalently attached moieties electropositive (for example ammonium), alkanolamines (for example triethanolamine), monovalent metals (for example sodium or potassium), polyvalent metal cations (for example magnesium and calcium) and mixtures of these. The cation M must be selected such that the anionic detersive surfactant component is soluble in water. The solubility of the surfactant will depend on the anionic detersive surfactants in particular and the cations chosen. Preferably, R has about 8 to 18 carbon atoms, more preferably about 10 to 16 carbon atoms, preferably about 12 to 14 carbon atoms, in both the alkyl and the alkyl ether sulfate. Alkyl ether sulfates are typically made as condensation products of ethylene oxide and monohydric alcohols having approximately 8 to 24 atoms P1383 carbon The alcohols may be synthetic or derived from fats, for example, coconut oil, palm kernel oil, and tallow. Lauryl alcohol and straight chain alcohols derived from coconut oil or palm kernel oil are preferred. These alcohols are reacted with 0 to about 10, preferably approximately between 2 and 5, preferably superlative with approximately 3, moles of ethylene oxide. The resulting mixture of molecular species will have, for example, an average of 3 moles of ethylene oxide per mole of alcohol, and is sulfated and neutralized. Non-limiting examples of alkyl ether sulfates may be used in the shampoo compositions of the present invention, including sodium and ammonium salts of alkyl triethylene glycol coconut ether sulfate, alkyl triethylene glycol sulfate tallow ether and tallow alkyl hexoxyethylene sulfate . Preferred alkyl ether sulfates are those comprising a mixture of individual components, wherein the compounds of the mixture have an alkyl chain length of about 10 to 16 carbon atoms and an average degree of ethoxylation of between about 1 and 4 moles of ethylene oxide. Some specific examples of preferred alkyl sulfates include, in non-exclusive form: ammonium lauryl sulfate, ammonium cocoyl sulfate, potassium lauryl sulfate, potassium cocoyl sulfate, sodium lauryl sulfate, sodium cocoyl sulfate, monoethanolamine lauryl sulfate, monoethanolamine cocoyl sulfate, diethanolamine lauryl sulfate, triethanolamine lauryl sulfate, triethylamine lauryl sulfate and combinations thereof. Especially preferred is ammonium lauryl sulfate. Some specific examples of preferred alkyl ether sulfates include, in non-exclusive form: ammonium laureth sulfate, potassium laureth sulfate, sodium laureth sulfate, monoethanolamine laureth sulfate, diethanolamine laureth sulfate, triethanolamine laureth sulfate, triethylamine laureth sulfate and its combinations. Especially preferred is ammonium laureth sulfate. Yet another class of sulfate surfactants suitable for use in the anti-dandruff conditioning shampoos of the present invention are the glyceride sulfates, an example includes, in non-exclusive form, sodium laurico-sulfate monoglyceride. 2. Sulfonates are also suitable for use in the antidandruff conditioning shampoos of the present invention those anionic detersive surfactants known as P1383 olefin sulfonates. As used in this invention, the term "olefin sulfonates" refers to compounds that can be produced by sulfonation of α-olefins by unsynchronized sulfur trioxide, followed by neutralization of the acid reaction mixture under such that any sufonates that would have formed in the reaction will hydrolyze to provide the corresponding hydroxy-alkane sulfonates. The sulfur trioxide may be liquid or gas, and usually, but not necessarily, diluted by inert diluents, for example by liquid S0, chlorinated hydrocarbons or the like, when used in the liquid form, or by means of air, nitrogen, gaseous S0, or the like, when used in gaseous form. The α-olefins from which the olefin sulfonates are derived are mono-olefins having about 10 to 24 carbon atoms, preferably about 12 to 16 carbon atoms. Preferably, they are straight chain olefins. In addition to the true alkene sulfonates and a proportion of hydroxyalkane sulphonates, the olefin sulfonates may contain minor amounts of other materials, such as alkene disulfonates depending on the reaction conditions, the proportion of reactants, the nature of the P1383 starting olefins and impurities in the raw material of olefins and side reactions during the sulphonation process. A non-limiting example of a mixture of α-olefin sulfonate is described in U.S. Patent No. 3,332,880, the disclosure of which is incorporated herein by reference. Another class of sulfonates suitable for use in the antidandruff conditioning shampoo compositions of the present invention are those anionic detersive surfactants known as β-alkoxyalkane sulfonates. These surfactants conform to the general formula (I): wherein R 1 is a straight chain alkyl group having from about 6 to about 20 carbon atoms, R 2 is a lower alkyl group having about 1 to 3 carbon atoms, preferably 1 carbon atom and M is a cation soluble in water, as those described above. Still other sulfonates suitable for use in the antidandruff conditioning shampoo compositions of the present invention are those Pl383 anionic detersive surfactants known as alkyl aryl sulfonates. Non-limiting examples of alkyl aryl sulfonates include sodium tridecylbenzene sulfonate, sodium dodecylbenzene sulfonate and combinations thereof. Other sulfonates suitable for use in the anti-dandruff conditioning shampoos of the present invention are the water-soluble salts of the organic products of the reaction with sulfuric acid which form the formula [R1-S03-M] wherein R1 is a radical of a hydrocarbon aliphatic straight or branched chain, saturated, having about 8 to 24 carbon atoms, preferably about 10 to 18 carbon atoms; and M is the cation described above. Non-limiting examples of these anionic detersive surfactants are the salts of an organic reaction product of sulfuric acid with a hydrocarbon of the methane series, including iso-, neo-, and n-paraffins and a sulfonant, example, S03, H2S04, obtained according to the known sulfonation methods. Within the sulfonation methods may include bleaching and hydrolysis. The salts preferably have about 8 to 24 carbon atoms; more preferably about 12 to 18 carbon atoms. Preferred are sulfonated, alkali metal, and ammonium C? 0_C? 8 n-paraffins.

PL383 Still other sulfonates suitable for use in the anti-dandruff shampoo conditioner compositions of the present invention are the reaction products of fatty acids, which are esterified with isethionic acid and subsequently neutralized with sodium hydroxide. Preferred fatty acids are those derived from coconut oil or palm kernel oil. Also suitable are the sodium or potassium salts of fatty acid amides of methyl tauride in which the fatty acids are derived from coconut oil or palm kernel oil. Other similar anionic surfactants are described in U.S. Patent No. 2,486,921; U.S. Patent No. 2,486,922; and U.S. Patent No. 2,396,278, the disclosures of which are incorporated herein by reference. Other sulfonates suitable for use in the anti-dandruff shampoo conditioner compositions of the present invention are succinates, examples of which include, in a non-exclusive manner, disodium N-octadecylsulfosuccinate, disodium lauryl sulfosuccinate, diammonium lauryl sulfosuccinate, N- (1, 2-) dicarboxyethyl) -N-octadecylsulfosuccinnate disodium, diamyl ester of sodium sulfosuccinic acid, sodium dihexyl ester of sulfosuccinic acid, sodium dioctyl ester of sulfosuccinic acid and combinations thereof.

P1383 3. Sarcosinates and sarcosine derivatives Also suitable for use in the antidandruff conditioning shampoos of the present invention are those anionic detersive surfactants known as sarcosinates and sarcosine derivatives. Sarcosinates are derived from sarcosines and N-methyl glycine, acylated with a fatty acid chloride. They conform to the general formula (II): OR II R-.C-N ~ CH2-C-0-O-X CH3 wherein RCO- is a fatty acid radical and wherein X is either hydrogen (in the form of an acid) or a cationic species, such as for example Na + or TEA + (salt form). Non-limiting examples of sarcosinates and sarcosine derivatives include: sodium lauryl sarcosinate, lauroyl sarcosinate, cocoyl sarcosinate and combinations thereof. The preferred sarcosinate is sodium lauryl sarcosinate.

B. Conditioner The anti-dandruff conditioning shampoo compositions of the present invention comprise P1383 approximately between 0.01% and 10%, by weight of the composition, preferably approximately between 0.1% and 8%, more preferably approximately between 0.1% and 5%, preferably superlative approximately between 0.2% and 3.5%, of an agent Conditioner suitable to be applied to hair or skin. It is believed that the conditioning agent provides improved conditioning benefits to the hair, particularly the improved feeling of clean hair and the feeling of a wet rinse. The conditioning agent comprises a water-insoluble, water-dispersible, non-volatile liquid, which forms emulsified liquid particles, or which are solubilized by means of the mycelia of the surfactant, in the anionic detersive surfactant component (described above). The conditioning agents suitable for use in the shampoo composition are those conditioning agents generally characterized as silicones (for example silicone oils, cationic silicones, silicone gums, high refractive index silicones and silicone resins), organic conditioning oils (for example hydrocarbon oils, polyolefins and fatty esters) or their combinations, or those conditioning agents which , otherwise, form liquid particles, dispersed in the matrix P1383 aqueous surfactant in there. These conditioning agents should be physically and chemically compatible with the essential components of the composition and should not, on the other hand, unduly deteriorate the stability of the product, its aesthetics or its operation. The concentration of the conditioning agent in the shampoo composition should be sufficient to provide the desired conditioning benefits, as will be apparent to those who dominate the technical field. That concentration can vary depending on the conditioning agent, the conditioning performance desired, the average size of the conditioning agent particles, the type and concentration of other components and other similar factors. 1. Silicones The conditioning agent of the anti-dandruff shampoo conditioner compositions of the present invention is preferably an insoluble silicone conditioning agent. The particles of the silicone conditioning agent may comprise volatile silicone, non-volatile silicone, or combinations thereof. Preferably the non-volatile silicone conditioning agents. In case it is P1383 present volatile silicones, will typically be incidental to use as a solvent or vehicle for commercially available forms of non-volatile silicone material ingredients, such as gums and resins. The particles of the silicone conditioning agent may comprise a fluid silicone conditioning agent and may also comprise other ingredients, such as silicone resin, to increase the efficiency of the deposition of the silicone fluid or to increase the shine of the hair (especially when silicone conditioning agents (e.g. highly phenylated silicones) of high refractive index (eg, above about 1.46) are used.The concentration of the silicone conditioning agent typically falls wi the range of between about 0.01% and 10% by weight of the composition, preferably between about 0.1% and 8%, more preferably between about 0.1% and 5%, preferably superlative between about 0.2% and 3% Non-limiting examples of suitable silicone conditioning agents and optional suspension agents for the silicone are described in the patent and the re-issued United States No. 34,584, United States Patent No. 5,104,646, and United States Patent No. 5,106,609, the descriptions of which are P1383 are incorporated herein by reference. The silicone conditioning agents to be used in the antidandruff conditioning shampoo compositions of the present invention preferably have a viscosity, measured at 25 ° C, of between about 20 and 2,000,000 centistokescentistokes, more preferably about between 1,000 and 1,800,000 centistokes, even more preferably from about 50,000 to 1,500,000 centistokes, with superlative preference of approximately between 100,000 and 1,500,000 centistokes. The dispersed particles of the silicone conditioning agent typically have an average particle diameter that is in the range of about 0.01 μm to 50 μm. For the application of small particles to the hair, the average diameter of the particles typically lies wi the range of approximately between 0.01 μm and 4 μm, preferably approximately between 0.01 μm and 2 μm, more preferably approximately between 0.01 μm and 0.5 μm. μm. For the application of larger particles to the hair, the average particle diameter is typically in the range of approximately 4 μm to 50 μm, preferably approximately 6 μm to 30 μm, more preferably approximately 9 μm and 20 μm, preferably superlative of approximately P1383 between 12 μm and 18 μm. Conditioning agents having an average particle size of less than about 5 μm can be deposited more efficiently on the hair. It is believed that the small size particles of the conditioning agent are contained wi the coacervate which is formed between the anionic surfactant component (described above) and the cationic polymer component (described below), in dilution of the shampoo. The background of the matter about silicones including the sections in which silicone fluids, resins and gums were analyzed, as well as silicone processing, are found in Encyclopedia of Polymer Science and Engineering-, vol. 15, 2d ed. , pp 204-308, John Wiley & Sons, Inc. (1989), incorporated herein by reference. i. Silicone oils Silicone fluids include silicone oils, which are flowable silicone materials having a viscosity, measured at 25 ° C, less than 1,000,000 centistokes, preferably of about 5 centistokes 1,000,000 centistokes, more preferably between about 10 centistokes and 100,000 centistokes. Silicone oils suitable for use in conditioning shampoo compositions P1383 antidandruff of the present invention include polyalkyl siloxanes, polyaryl siloxanes, polyalkylaryl siloxanes, polyether siloxane copolymers and combinations thereof. Other insoluble and non-volatile silicone fluids having hair conditioning properties can also be used. The silicone oils include polyalkyl or polyaryl siloxanes which form the following formula (III): wherein R is aliphatic, preferably alkyl or alkenyl, or aryl, R may be substituted or unsubstituted and x is an integer from 1 to about 8,000. Unsubstituted R groups for use in the anti-dandruff shampoo conditioner compositions of the present invention include, in non-exclusive form: alkoxy, aryloxy, alkaryl, arylalkyl, arylalkenyl, alkylamino, and aliphatic and aryl substituted with ether, substituted with hydroxyl and substituted with halogen. Suitable R groups also include cationic amines and quaternary ammonium groups.

P1383 The aliphatic or substituted aryl groups in the siloxane chain may have any structure so long as the resulting silicones remain fluid at room temperature, are hydrophobic and are not irritating, toxic or otherwise detrimental when applied to hair, are compatible with the other components of the shampoo compositions, are chemically stable under normal conditions of use and storage, are insoluble in the shampoo compositions described herein and are capable of being deposited on the hair and conditioning it. The two R groups on the silicon atom of each monomer unit may represent the same or different groups. Preferably, the two R groups represent the same group. Preferred alkyl and alkenyl substituents are alkyls and alkenyls of C.-C5, more preferably C1-C1, preferably superlative of C ^ -. The aliphatic portions of other alkyl-, alkenyl- or alkynyl-containing groups (such as, for example, alkoxy, alkaryl, and alkamino) can be straight or branched chains and preferably have from one to five carbon atoms, more preferably from one to four carbon atoms, still more preferably from one to three carbon atoms, preferably superlative from one to two carbon atoms. How I know Pl383 4 28 previously discussed, the R substituents may also contain amino functionalities (eg alkamino groups), which may be primary, secondary or tertiary amines or quaternary ammonium. These include mono-, di- and trialkylamino and alkoxyamino groups, in which the chain length of the aliphatic part is preferably as described above. The R substituents may also be substituted with other groups, such as halogens (for example chlorine, fluorine and bromine), halogenated aliphatic or aryl groups and hydroxy (for example hydroxy-substituted aliphatic groups) and combinations thereof. Suitable halogenated R groups could include, for example, trihalogenated alkyl groups (preferably tri-fluoro) such as -R ^ Fj, where R1 is a Cj-C alkyl ... An example of these polysiloxanes includes, in the form non-exclusive, polymethyl 3,3, 3-trifluoropropylsiloxane. Suitable R groups for use in the antidandruff shampoo conditioner compositions of the present invention include, in non-exclusive form, methyl, ethyl, propylphenyl, methylphenyl and phenylmethyl. Specific non-limiting examples of preferred silicones include: polydimethylsiloxane, polydiethylsiloxane, and polymethylphenylsiloxane. Polydimethylsiloxane is especially preferred.

P1383 Other suitable R groups include: methyl, methoxy, ethoxy, propoxy, and aryloxy. The three R groups in the final silicone capsules may represent the same or different groups. The non-volatile polyalkylsiloxane fluids that can be used include, for example, low molecular weight polydimethylsiloxanes. These siloxanes are commercially available, for example, in General Electric Company as Viscasil R and SF series, and in Dow Corning in the Dow Corning 200 series. The polyalkylaryl siloxane fluids that may be used, also include, for example, polymethylphenylsiloxanes. These siloxanes are commercially available, for example, in General Electric Company as SF 1075 methylphenyl fluid or in Dow Corning as cosmetic grade fluid 556. Polyethersiloxane copolymers that can be used include, for example, a polydimethylsiloxane modified with Polypropylene (e.g., Dow Corning DC-1248) although ethylene oxide or mixtures of ethylene oxide and propylene oxide can also be used. The concentrations of ethylene oxide and polypropylene oxide should be low enough to prevent solubility in water and in the compositions described in this invention. Silicones substituted with alkylamino P1383 suitable for use in the anti-dandruff conditioning shampoo compositions of the present invention include, in non-exclusive form, those that conform to the following general formula (IV): where x and y are integers. This polymer is also known as "amodimethicone." ii. Cationic Silicones Cationic silicone fluids suitable for use in the antidandruff conditioning shampoo compositions of the present invention include, but are not limited to, those conforming to the general formula (V): (R1) aG3_aSi - (- OSiG2) n (-OSiGb (R1) 2-b) m-0-SiG3_a (R1) a wherein G is hydrogen, phenyl, hydroxy, or an alkyl of P1383 Ci-Ca, preferably methyl; a indicates 0 or an integer with a value that is from 1 to 3, preferably 0; b is 0 or 1, preferably 1; n is a number from 0 to 1,999, preferably from 49 to 149; m is an integer from 1 to 2,000, preferably 'from 1 to 10; the sum of n and m is a number from 1 to 2,000, preferably from 50 to 150; Ri is a monovalent radical that conforms to the general formula CqH2qL, where q is an integer that has a value that is from 2 to 8 and L is selected from the following groups: -N (R2) CH2-CH2-N (R2) 2 -N (R2) 2 - N (R2) 3A ~ -N (R2) CH2-CH2-NR2H2A- wherein R is selected from the group consisting of hydrogen, phenyl, benzyl, or a saturated hydrocarbon radical, preferably an alkyl radical containing from about 1 to about about 20 carbon atoms, and A "indicates a halide ion A particularly preferred cationic silicone corresponding to formula (V) is the polymer known as" trimethylsilylamodimethicone ", which is shown below in formula (VI): P1383 m Other cationic silicone polymers that can be used in the anti-dandruff shampoo conditioner compositions of the present invention are represented by the general formula (VII): wherein R denotes a monovalent hydrocarbon radical having from 1 to 18 carbon atoms, preferably an alkyl or alkenyl radical, such as methyl; R4 denotes a hydrocarbon radical, preferably an alkylene radical of C? _C? S or an alkyleneoxy radical of Cio-Cia, more preferably an alkylenoxy radical of C? Pl383 Cs; Q ~ is a halide ion, preferably chloride; r indicates an average statistical value that is between 2 and 20, preferably between 2 and 8; s indicates a statistical value that is between 20 and 200, preferably between 20 and 50. A polymer of this especially preferred kind is known under the name UCARE SILICONE ALE 56 ™, commercially available from Union Carbide. iii. Silicone Gums Other silicone fluids that may be suitable for use in the anti-dandruff shampoo conditioner compositions of the present invention are insoluble silicone gums. These gums are polyorganosiloxane materials that have a viscosity, measured at 25 ° C, greater than or equal to 1,000,000 centistokes. Silicone gums are described in U.S. Patent No. 4,152,416; Noli and Walter, Chemistry and Technology of Silicones, New York: Academic Press (1968); and in General Electric Silicone Rubber Product Data Sheets SE 30, SE 33, SE 54 and SE 76, all of these described references are incorporated herein by reference. Silicone gums will typically have an average mass molecular weight above about 200,000, preferably between about 200,000 and 1,000,000. Specific non-limiting examples of silicone gums P1383 for use in the antidandruff shampoo conditioner compositions of the present invention include polydimethylsiloxane, (polydimethylsiloxane) copolymers (methylvinylsiloxane), copolymers of poly (di-ethylsiloxane) (diphenylsiloxane) (methylvinylsiloxane) and combinations thereof. iv. High Refractive Index Silicones Another category of insoluble, non-volatile, silicone fluid conditioning agents which are suitable for use in the anti-dandruff conditioning shampoo compositions of the present invention are the silicones known as "high refractive index silicones," which have a refractive index of at least about 1.46, preferably at least about 1.48, more preferably at least about 1.52, preferably superlative at least about 1.55. The refractive index of the polysiloxane fluid will generally be less than about 1.70, typically less than about 1.60. Within this context, the "fluid" polysiloxane includes both oils and gums. The polysiloxane fluid of suitable high refractive index includes the fluids represented by the general formula (III) above, as well as the cyclic polysiloxanes, such as those represented P1383 by the following formula (VIII): wherein R is as defined above and n is an approximate number between 3 and 7, preferably between about 3 and 5. High refractive index polysiloxane fluids contain a sufficient amount of substituents R containing aryl to increase the index of refraction to the desired level, which is described above. Additionally, R and n must be selected in such a way that the material is non-volatile. The aryl-containing substituents include those containing five or six membered aryl rings, alicyclic and heterocyclic, and substituents containing fused five or six membered rings. The aryl rings themselves may be substituted or unsubstituted. Substituents include aliphatic substituents and may also include alkoxy substituents, acyl substituents, ketones, halogens (e.g., Cl and Br), amines, and the like. Examples of aryl-containing groups include, in non-exclusive form, weirs P1383 substituted and unsubstituted, such as phenyl and phenyl derivatives, for example phenyls with C1-C5 alkyl or alkenyl substituents. Specific non-limiting examples include: allylphenyl, methylphenyl and ethylphenyl, vinylphenyls (for example styrenyl) and phenylalkynes (for example C2-C4 phenylalkynes). Heterocyclic aryl groups include, in non-exclusive form, substitutents derived from furan, imidazole, pyrrole, pyridine and the like. Examples of fused aryl ring substituents include, in non-exclusive form, naphthalene, coumarin, and purine. Generally, high refractive index polysiloxane fluids will have a degree of aryl containing substituents of at least about 15%, preferably at least about 20%, more preferably at least about 25%, even more preferably at least about 35%, preferably superlative at least about 50%. Typically, the degree of aryl substitution will be less than about 90%, more generally less than about 85%, preferably about 55% to about 80%. These high refractive index polysiloxane fluids are also characterized by relatively high surface tensions as a result of their P1383 substitution with aryl. Generally, the polysiloxane fluids will have a surface tension of at least about 24 dynes / cm2, typically at least about 27 dynes / cm2. The surface tension, for the purposes of this invention, is measured by a Nouy ring tensiometer according to Dow Corning Corporate Test Method CTM 0461 (November 23, 1971). Changes in surface tension can be measured according to the method of the above test or in accordance with ASTM Method D 1331. Preferred high refractive index polysiloxane fluids have a combination of phenyl substituents or phenyl derivatives (with superlative preference, phenyl), with alkyl substituents, preferably C? -C alkyl (preferably superlative, methyl), hydroxy or C? -C-amino alkyl (especially -R1NHR2NH2 wherein each R1 and R2, independently, is an alkyl) , alkenyl and / or C1-C3 alkoxy). High refractive index polysiloxanes are commercially available from Dow Corning, Huís America and General Electric. When the high refractive index silicones are used in the anti-dandruff shampoo conditioner compositions of the present invention, they are preferably used in solution with a diffusing agent, such as a silicone resin or a surfactant, for the purpose of reducing stress surface in an amount sufficient to increase diffusion and therefore increase the gloss (after drying) of the hair treated with the composition. Generally, a sufficient amount of diffusing agent is used to reduce the surface tension of the polysiloxane fluid of high refractive index by at least about 5%, preferably at least about 10%, more preferably at least about 15%, even with greater preference at least about 20%, preferably superlative at least about 25%. Reductions in the surface tension of the polysiloxane fluid / diffusing agent mixture can improve the shine of the hair. Also, the diffusing agent will preferably reduce the surface tension by at least about 2 dynes / cm 2, preferably at least about 3 dynes / cm 2, still more preferably at least about 4 dynes / cm 2, preferably superlative at least about 5 dynes / cm2. The surface tension of the mixture of the polysiloxane fluid and the diffusing agent, in the proportions present in the final product, is preferably less than or equal to about 30 dynes / cm 2, more preferably P1383 less than or equal to approximately 28 dynes / cm2, preferably superlative less than or equal to approximately 25 dynes / cm2. Typically, the surface tension will be in the range of about 15 dynes / cm2 to 30 dynes / cm2, more typically about 18 dynes / cm2 to 28 dynes / cm2, and more generally, about 20 dynes / cm2 and 25 dynes / cm2. The weight ratio of highly arylated polysiloxane fluid to the diffusing agent will generally be between about 1000: 1 and 1: 1, preferably between about 100: 1 and 2: 1, more preferably about between 50: 1 and 2 : 1, preferably superlative approximately between 25: 1 and 2: 1. When fluorinated surfactants, particularly highly-arylated polysiloxane fluids are used to the diffusing agent, the particularly high ratios of polysiloxane: the diffusing agent due to the effectiveness of these surfactants can be effective. In this way, it is contemplated that ratios significantly above 1000: 1 can be used. Suitable silicone fluids for use in the antidandruff conditioning shampoo compositions of the present invention are disclosed in U.S. Patent No. 2,826,551, U.S. Patent No. 3,964,500, U.S. Pat. No. 4,364,837, British Patent No. 849,433, and Silicon Compounds distributed by Petrarch Systems, Inc. (1984), all of which are incorporated herein by reference. v. Silicone Resins Silicone resins can be included in the silicone conditioning agent of the anti-dandruff shampoo conditioner compositions of the present invention. These resins are highly crosslinked polymeric siloxane systems. Crosslinking is introduced through the incorporation of trifunctional and tetrafunctional silanes with monofunctional or difunctional silanes, or both, during the manufacture of the silicone resin. As understood by those who master the technical field, the degree of crosslinking that is required in order to result in a silicone resin will vary according to the specific silane units incorporated in the silicone resin. Generally, silicone materials having a sufficient level of trifunctional and tetrafunctional siloxane monomer units (and, therefore, a sufficient level of crosslinking) so that they dry to produce a rigid or hard film, are considered to be silicone resins. The ratio of oxygen atoms to atoms of P1383 silicon is an indication of the level of crosslinking of a particular silicone material. The silicone resins suitable for use in the antidandruff shampoo conditioner compositions of the present invention generally have at least about 1.1 oxygen atoms per silicon atom. Preferably, the ratio of oxygen atoms to silicon atoms is at least about 1.2: 1.0. The silanes used in the manufacture of silicone resins include, in a non-exclusive manner, monomethyl-, dimethyl-, trimethyl-, monophenyl-, diphenyl-, methylphenyl-, monovinyl- and methylvinyl-chlorosilanes and tetrachlorosilanes, the silanes being substituted with methyl the most commonly used. Preferred resins are commercially available from General Electric as GE SS4230 and GE SS4267. Commercially available silicone resins are generally supplied in dissolved form in a volatile or non-volatile low viscosity silicone fluid. The silicone resins to be used in this invention should be supplied and incorporated into the present dissolved compositions in such a manner, as will be apparent to those who dominate the technical field. Silicone materials and silicone resins in particular, can be conveniently identified according to a naming system P1383 shorthand known by those who dominate the technical field as "MDTQ" nomenclature. Under this system, the silicone is described according to the presence of several units of the siloxane monomer which constitute the silicone. Briefly, the symbol M denotes the monofunctional unit (CH3) 3SiO0.s; D denotes the difunctional unit (CH3) 2SiO; T denotes the trifunctional unit (CH3) SiO? .5; and Q denotes the quadri- or tetrafunctional unit Si0. The premiums of the unit symbols (for example M ", D", T ", and Q ') denote non-methyl substituents and must be defined specifically for each case Typical alternative substituents include, in non-exclusive form, such groups such as vinyls, phenyls, amines, hydroxyls and the like The molar ratios of the various units, both in terms of subscripts of the symbols that indicate the total number of each type of unit in the silicone (or an average thereof) or as Specifically stated ratios in combination with molecular weight complete the description of the silicone material under the MDTQ system, relative higher molar amounts of T, Q, T 'and / or Q' to D, D 'M and / or M' in A silicone resin is indicative of higher levels of crosslinking As discussed above, however, the overall level of crosslinking can also be indicated by the reaction of oxygen to silicon.

P1383 Preferred silicone resins for use in the antidandruff conditioning shampoo compositions of the present invention include, but are not limited to, the MQ, MT, MTQ, MDT and MDTQ resins. Methyl is the preferred silicone substituent. Especially preferred are the MQ silicone resins, in which the M: Q ratio is from about 0.5: 1.0 to about 1.5: 1.0 and the average molecular weight of the silicone resin is from about 1000 to about 10,000. The weight ratio of the non-volatile silicone fluid, having a refractive index below 1.46, to the silicone resin component, when used, is preferably from about 4: 1 to about 400: 1, more preferably from about 9: 1 to about 200: 1, preferably superlative from about 19: 1 to about 100: 1, particularly when the silicone fluid component is a polydimethylsiloxane fluid or a mixture of polydimethylsiloxane fluid and rubber. polydimethylsiloxane, as described above. Insofar as the silicone resin forms part of the same phase, in the compositions of this invention, the silicone fluid, i.e. the active conditioning ingredient, is Pl383 should include the sum of fluid and resin to determine the level of conditioning agent in the composition. 2. Organic Conditioning Oils The conditioning component of the anti-dandruff shampoo conditioner compositions of the present invention may also comprise about 0.05 to 3% by weight of the composition, preferably about 0.08% to 1.5%, more preferably about 0.1%, and 1%, of at least one organic conditioning oil as the conditioning agent, either alone or in combination with other conditioning agents, such as silicones (described above). It is believed that these organic conditioning oils provide the shampoo composition with an improved conditioning function when used in combination with the essential components of the composition and in particular, when used in combination with cationic polymers (described above). Conditioner oils can add shine and luster to hair. Additionally, they can increase the pleasant feeling of dry combing and drying hair. It is believed that most, or all of these organic conditioning oils, are solubilized in the mycelia of the surfactant of the shampoo composition.

It is also believed that this solubilization within the mycelia of the surfactant contributes to improving the hair conditioning function of the shampoo compositions of this invention. Organic conditioning oils suitable for use as the conditioning agent in this invention are preferably low viscosity, insoluble in water, liquids selected from the group consisting of hydrocarbon oils, polyolefins, fatty esters and combinations thereof. The viscosity, measured at 40 ° C, of these organic conditioning oils is preferably about 1 centipoise to 200 centipoise, more preferably about 1 centipoise to 100 centipoise, preferably superlative about 2 centipoise to 50 centipoise. i. Hydrocarbon Oils Organic conditioning hydrocarbon oils for use as conditioning agents in the anti-dandruff shampoo conditioner compositions of the present invention include, in non-exclusive form, hydrocarbon oils having at least about 10 carbon atoms, such as cyclic hydrocarbons, linear chain aliphatic hydrocarbons (saturated or unsaturated) and aliphatic hydrocarbons P1383 branched chain (saturated or unsaturated), including polymers and their combinations. The straight chain hydrocarbon oils will preferably have from about 12 to about 19 carbon atoms. Branched chain hydrocarbon oils, including polymeric hydrocarbons, will typically contain more than 19 carbon atoms. Specific non-limiting examples of these hydrocarbon oils include paraffin oil, mineral oil, saturated and unsaturated dodecane, saturated and unsaturated tridecane, saturated and unsaturated tetradecane, saturated and unsaturated pentadeca, saturated and unsaturated hexadecane, polybutene, polydecane and combinations thereof. The branched chain isomers of these compounds, as well as the longer chain length hydrocarbons, can also be used. Some examples include highly branched, saturated or unsaturated alkanes, such as permethyl substituted isomers, for example, the isomers substituted with permethyl of hexadecane and eicosane, such as 2, 2, 4, 4, 6, 6, 8, 8-dimethyl -10-methylundecane and 2, 2, 4, 4, 6, 6-dimethyl-8-methyl-nonane, commercially available from Permetil Corporation. Hydrocarbon polymers such as polybutene and polydecane are also useful conditioning agents. A preferred hydrocarbon polymer is polybutene, as P1383 for example the copolymer of isobutylene and butene. A commercially available material of this type is L-14 polybutene from Amoco Chemical Corporation. ii. Polyolefins Organic conditioning oils for use in the anti-dandruff shampoo conditioner compositions of the present invention may also include liquid polyolefins, more preferably liquid poly-α-olefins, preferably superlative liquid hydrogenated poly-α-olefins. The polyolefins to be used in this invention were prepared by the polymerization of olefinic monomers from 4 to about 14 carbon atoms, preferably from about 6 to about 12 carbon atoms. Non-limiting examples of olefinic monomers to be used in the preparation of the liquid polyolefins of this invention include ethylene, propylene, 1-butene, 1-pentene, 1-hexene, 1-octene, 1-decene, 1-dodecene, 1 - tetradecene, branched chain isomers such as 4-methyl-1-pentene and combinations thereof. Effluents or feed storage of refining products containing olefins are also suitable for the preparation of liquid polyolefins. The hydrogenated α-olefin monomers Preferred P1383s include, in non-exclusive form, 1-hexene to 1-hexadecene, 1-octene at 1-tetradecene and combinations thereof. iii. Fatty esters Other organic conditioning oils suitable for use as a conditioning agent in the antidandruff shampoo conditioner compositions of the present invention include, in non-exclusive form, fatty esters having at least 10 carbon atoms. These fatty esters include esters with hydrocarbyl chains derived from fatty acids or alcohols (for example monoesters, esters of polyhydric alcohol and di- and tri- esters of carboxylic acid). The hydrocarbyl radicals of the fatty esters of this invention may include or have covalent linkages to other compatible functionalities, such as amide moieties and alkoxides (e.g., ethoxy or ether linkages, etc.). Suitable for use in the antidandruff conditioning shampoo compositions of the present invention are alkyl or alkenyl esters of fatty acids having aliphatic chains with about 10 to 22 carbon atoms, and alkyl or alkenyl esters of carboxylic acid and alcohol fatty acids having an aliphatic alkyl and / or alkenyl chain derived from alcohol with about 10 to 22 Pl383 carbon atoms and their combinations. Specific examples of the preferred fatty esters include, in non-exclusive form, isopropyl isostearate, hexyl laurate, isohexyl laurate, isohexyl palmitate, isopropyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, isopropyl isostearate, dihexyldecyl adipate, lauryl lactate, myristyl lactate, cetyl lactate, oleyl stearate, oleyl oleate, oleyl myristate, lauryl acetate, cetyl propionate and oleyl adipate. Other fatty esters suitable for use in the antidandruff conditioning shampoo compositions of the present invention are the monocarboxylic acid esters, which have the general formula R'COOR, wherein R "and R are alkyl or alkenyl radicals and the sum of carbon atoms in R 'and R is at least 10, preferably at least 20. The monocarboxylic acid esters need not necessarily contain at least one chain with at least 10 carbon atoms, rather than the total number of carbon atoms of the aliphatic chain is at least 10. Specific non-limiting examples of esters of the monocarboxylic acid include: isopropyl myristate, glycol stearate and isopropyl laurate.

P1383 Still other fatty esters suitable for use in the antidandruff conditioning shampoo compositions of the present invention are di- and trialkyl and alkenyl esters of carboxylic acids, such as esters of C4-C8 dicarboxylic acids (for example C1-C22 esters preferably Ci-Cg, succinic acid, glutaric acid, adipic acid, hexanoic acid, heptanoic acid and octanoic acid). Specific non-limiting examples of di- and trialkyl and alkenyl esters of carboxylic acids include isocetyl stearate and stearoyl, diisopropyl adipate and tristearyl citrate. Other fatty esters suitable for use in the anti-dandruff conditioning shampoo compositions of the present invention are those known as polyhydroxy alcohol esters. Polyhydroxy alcohol esters include alkylene glycol esters, such as ethylene glycol mono and di fatty esters, diethylene glycol mono and di fatty esters, polyethylene glycol mono and di fatty esters, mono and di fatty acid esters of propylene glycol, propylene glycol monooleate, propylene glycol monostearate 2000, ethoxylated propylene glycol monostearate, glyceryl mono and di fatty acid esters, polyglycerol fatty acid esters, Pl383 ethoxylated glyceryl monostearate, 1,3-butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid ester, sorbitan fatty acid esters and fatty acid esters of sorbitan and polyoxyethylene. Other fatty acid esters suitable for use in the anti-dandruff conditioning shampoo compositions of the present invention are glycerides, including, but not limited to, mono, di and triglycerides, with preferably superfluous triglycerides. For use in the described shampoo compositions of this invention, the glycerides are preferably mono, di and tri-esters of glycerol and long-chain carboxylic acids, such as for example carboxylic acids of C? 0-C22- A variety of these types of materials can be obtained from vegetable and animal fats and oils, such as, for example, castor oil, castor oil, cottonseed oil, corn oil, olive oil, cod liver oil, almond oil, oil of avocado, palm oil, sesame oil, soybean oil and lanolin. Synthetic oils include, but are not limited to, triolein glyceryl dilaurate and tristearin. Other fatty esters suitable for use in conditioning shampoo compositions Anti-dandruff P1383 of the present invention are synthetic water-insoluble fatty esters. Some of the preferred synthetic esters conform to the general formula (IX): wherein R1 is a group of 7 to 9 carbon atoms, alkyl, alkenyl, hydroxyalkyl or hydroxyalkenyl, preferably a saturated alkyl group, more preferably a saturated and linear alkyl group; n is a positive integer that has a value that is from 2 to 4, preferably 3; and Y is an alkyl, alkenyl, hydroxy or substituted carboxy, having about 2 to 20 carbon atoms, preferably about 3 to 14 carbon atoms. Other preferred synthetic esters conform to the general formula (X): wherein R2 is a group of 8 to 10 carbon atoms, alkyl, alkenyl, hydroxyalkyl or hydroxyalkenyl; preferably a saturated alkyl group, with higher Pl383 preferably a linear, saturated alkyl group; n and Y are as defined in the previous formula (X). It is believed that preferred synthetic esters provide an improved feeling of wet hair when used in combination with the essential components of the shampoo compositions of the present invention, particularly when used in combination with the cationic polymer component (described below). ). These synthetic esters improve the feeling of damp hair by reducing the viscosity sensation or excessive conditioner of wet hair that has been conditioned by a cationic polymer. Specific non-limiting examples of synthetic fatty esters suitable for use in the anti-dandruff shampoo conditioner compositions of the present invention include: P-43 (Ca-Cio trimethylolpropane triester), MCP-684 (3,3-dietanol-1 tetraester) , 5 pentadiol), MCP 121 (C 8 -C 6 adipic acid diester), all of which are commercially available from Mobil Chemical Company. 3. Other conditioning agents Also suitable for use in the compositions of this invention are the agents P1383 conditioners described by Procter & Gamble Company in U.S. Patent Nos. 5,674,478, and 5,750,122, which are incorporated herein by reference in their entirety. Also suitable for use in this invention are those conditioning agents described in U.S. Patent Nos. 4,529,586 (Clairol), 4,507,280 (Clairol), 4,663,158 (Clairol), 4,197,865 (L'Oreal), 4,217,914 (L'Oreal). , 4,381,919 (L'Oreal), and 4,422,853 (L'Oreal), all of which descriptions are incorporated herein by reference. Some other preferred silicone conditioning agents for use in the compositions of the present invention include: Abil® S 201 (dimethicone / PG-propyldimethicone sodium thiosulfate copolymer), commercially available from Goldschmidt; DC Q2-8220 (trimethylsilyl amodimethicone) commercially available from Dow Corning; DC 949 (amodimethicone, cetrimonium chloride and Trideceth-12), commercially available from Dow Corning; DC 749 (cyclomethicone and trimethylsiloxysilicate), commercially available from Dow Corning; DC2502 (dimethicone cetyl), commercially available from Dow Corning; BC97 / 004 and BC 99/088 (silicone microemulsions with amino function), commercially available from Basildon Chemicals; GE SME253 P1383 and SM2115-D2 and SM2658 and SF1708 (silicone microemulsions with amino function), commercially available from General Electric; siliconized meadow seed oil, commercially available from Croda; and those silicone conditioning agents described by GAF Corp. in U.S. Patent No. 4,834,767 (quaternized aminolactam), by Biosil Technologies in U.S. Patent No. 5,854,319 (reactive silicone emulsions containing amino acids) and by Dow Corning in U.S. Patent No. 4,898,585 (polysiloxanes), the disclosures of which are incorporated herein by reference.

C. Antidandruff agent The anti-dandruff conditioning shampoo compositions of the present invention comprise between about 0.1% and 4% by weight of the composition, preferably about between 0.1% and 3%, preferably superlative, and about between 0.3% and 2% , of an anti-dandruff agent suitable for application on hair or skin. The anti-dandruff agent provides the shampoo compositions with antimicrobial activity. The antidandruff agent can be particulate or soluble. Non-limiting examples of suitable particulate anti-dandruff agents include: pyridinothione salts, P1383 selenium sulfide, particulate sulfur and combinations thereof. Preferred are the pyridinothione salts. A non-limiting example of suitable soluble anti-dandruff agents is ketoconazole. This antidandruff agent must be physically and chemically compatible with the essential components of the composition, and must not, on the other hand, unduly deteriorate the stability of the product, its aesthetics or its operation. 1. Pyridinothione salts The anti-dandruff particles of pyridinothione, especially the salts of l-hydroxy-2-pyridinothione, are highly preferred particulate antidandruff agents for use in the anti-dandruff conditioning shampoo compositions of the present invention. The concentration of the anti-dandruff particles of pyridinothione is typically in the range of between about 0.1% and 4% by weight of the composition, preferably between about 0.1% and 3%, preferably superlative of about between 0.3% and 2% . Preferred pyridinothione salts include those formed from heavy metals such as zinc, tin, cadmium, magnesium, aluminum and zirconium, preferably zinc, more preferably the l-hydroxy-2-pyridinothione zinc salt (known as "pyridinothione"). of zinc "or" ZPT "), preferably superlative salts of 1- P1383 hydroxy-2-pyridinothione with particles in the form of plates, wherein the particles have an average size of up to about 20 μ, preferably up to about 5 μ, preferably superlative up to about 2.5 μ. Salts formed with other cations, such as sodium, may also be suitable. Pyridinothione antidandruff agents are described, for example, in U.S. Patent No. 2,809,971; U.S. Patent No. 3,236,733; U.S. Patent No. 3,753,196; U.S. Patent No. 3,761,418; U.S. Patent No. 4,345,080; U.S. Patent No. 4,323,683; U.S. Patent No. 4,379,753; and U.S. Patent No. 4,470,982, all of which are incorporated herein by reference. It is contemplated that when the ZPT is used as antidandruff particles in the shampoo compositions of this invention, the growth or re-growth of hair may be stimulated or regulated, or both, or that hair loss may be reduced or inhibited, or that the hair may seem thicker or more whole. 2. Selenium sulfide Selenium sulfide is an antidandruff agent in P1383 particles suitable for use in the antidandruff shampoo conditioner compositions of the present invention, effective concentrations are in the range of between about 0.1% and 4% by weight of the composition, preferably between about 0.3% and 2.5%, more preferably between about 0.5% and 1.5%. Selenium sulfide is generally considered to be a compound that has one mole of selenium and two moles of sulfur, although it can also take the form of a cyclic structure that conforms to the general formula SexSy, where x + y = 8. Average particle diameters for selenium sulfide are typically less than 15 μm as measured by an advanced laser light scattering device (e.g., a Malvern 3600 instrument), preferably less than 10 μm. Selenium sulfide compounds are described, for example, in U.S. Patent No. 2,694,668; U.S. Patent No. 3,152,046; U.S. Patent No. 4,089,945; and U.S. Patent No. 4,885,107, the disclosures of which are incorporated herein by reference. 3. Sulfur Sulfur can also be used as a particulate antidandruff agent in shampoo compositions P1383 antidandruff conditioner of the present invention. Effective concentrations of sulfur in particles are typically from about 1% to about 4%, by weight of the composition, preferably from about 2% to about 4%. 4. Ketoconazole Ketoconazole can also be used as a soluble antidandruff agent in the antidandruff conditioning shampoo compositions of the present invention. The effective concentrations of ketoconazole are typically from about 0.1% to about 4%, by weight of the composition, preferably from about 0.3% to about 2%.

D. Cationic Polymers The antidandruff conditioning shampoo compositions of the present invention comprise from about 0.02% to 5% by weight of the composition, preferably from about 0.05% to 3%, more preferably from about 0.1% to 2%. %, preferably superlative of approximately between 0.5% and 1%, of at least one organic, cationic deposition and conditioning polymer suitable for application to the hair or skin. It is believed that polymers P1383 cationics provide an increase in anti-dandruff efficacy and an increase in the conditioner of the shampoo compositions described in this invention. These cationic polymers must be physically and chemically compatible with the essential components described in this invention, and must not, on the other hand, unduly impair the stability of the product, its aesthetics or performance. 1. Characteristics of the cationic polymers The cationic polymers useful in the present invention should be selected and should be present at a level such that the cationic polymers are soluble in the shampoo composition and are preferably soluble in a coacervate complex phase. in the shampoo composition, in dilution. That coacervate is described in detail later. The physical properties of the cationic polymers and suitable counterions are also detailed. i. Coacervate formed from a cationic polymer A coacervate is formed, in dilution in the shampoo composition, between the cationic polymer and the anionic detersive surfactant component (described above) of the present invention. It is believed that the cationic half of the polymer bonds with the anionic half P1383 of the surfactant forms an insoluble complex that precipitates, in dilution (the coacervate). The coacervate complexes of the cationic polymer can also be formed with other optional anionic components of the shampoo composition (described below). The formation of the coacervate depends on a variety of criteria, such as molecular weight, component concentration and proportion of ionic components that interact, ionic strength (including the modification of ionic strength, for example, by adding salts), charge density of the cationic and anionic components, pH and temperature. Coacervate systems and the effect of these parameters are described, for example, in J. Caelles, et al., "Anionic and Cationic Compounds in Mixed Systems", Cosmetics & Toiletries, vol. 106, (April 1991), pp. 49-54; C. J. van Oss, "Coacervation, Complex-Coacervation and Flocculation ", J. Dispersion Science and Tech., Vol.9 (5.6), (1988-89), pp 561-73; and in D. J. Burgess, "Practical Analysis of Complex Coacervate Systems, "J. of Colloid and Interface Science, Vol 140, No. 1, (November 1990), pp 227-38, the descriptions of which are incorporated herein by reference.The shampoo compositions described herein invention, typically have a ratio of anionic detersive surfactant component to cationic polymer component of about 25: 0.02 to P1383 about 1: 1, preferably from about 20: 0.1 to about 12: 1. It is believed that coacervates provide conditioning benefits, especially benefits of conditioning during the use of the product when the hair is wet, helping to deposit conditioning agents on the hair and scalp. It is known in the technical field that coacervates also aid in the deposition of other types of particulate agents. It is believed that this occurs by concentrating the particles within the limits of the coacervate in dilution. It has also been found that the characteristof the polymer in those compositions can affect the bioavailability / coverage of the antidandruff particles, those characteristinclude the molecular weight of the cationic guar rubber polymer and the charge density. Guar gums with lower molecular weight are preferred, guar gums with lower charge density are preferred. Guar gums with lower molecular weight and lower charge density are highly preferred. It is believed that those selected guar gums impart modified physical properties (e.g. rheology) to the formed coacervates. The techniques for analyzing the formation of coacervate complexes are known in the technical field.

P1383 For example, microscopic analyzes of the shampoo compositions, at any chosen dilution step, can be used to identify whether a coacervate phase has been formed. That coacervate phase can be identified as an additional emulsified phase in the composition. The use of dyes can help distinguish the coacervate phase from other insoluble phases dispersed in the shampoo composition. ii. Physical Properties of the Cationic Polymer The average molecular weight of the cationic conditioning polymers suitable for use in this invention is typically from about 5,000 to 10,000,000, preferably from about 100,000 to 2,000,000, more preferably from about 200,000 to 1,500,000, more preferably about 250,000 to 850,000, more preferably about 350,000 to 500,000. The polymers have a cationic charge density typically of between about 0.1 meq / g and 7 meq / g, measured at the pH of the shampoo composition to be used, preferably about 0.2 meq / g and 5 meq / g, of preferably about 0.5 meq / gm to 2 meq / g, more preferably about 0.6 meq / g to 1 meq / g, more preferably about 0.6 meq / g to 0.9 meq / g.

P138-S The pH of the shampoo composition to be used is typically in the range of from about pH 3 to about pH 9, preferably from about pH 4 to about pH 7. iii. Counterions used in the formation of a cationic polymer Any anionic counterion can be used in association with the cationic polymers as long as the cationic polymers remain soluble in water, in the shampoo composition, or in a coacervate phase of the shampoo composition, and provided that the counterions are physically and chemically compatible with the essential components of the shampoo composition or that, on the other hand, do not, unduly, impair the performance of the product, its stability or aesthetics. Non-limiting examples of counterions include: halides (eg, chloride, fluoride, bromide, iodide), sulfate, methylisulfate, and combinations thereof. 2. Types of cationic polymers Examples of cationic polymers that might be suitable for use in the shampoo compositions of this invention include, in non-exclusive form, cationic polysaccharides (e.g., cellulose derivatives) P1383 cationic and cationic guar gums), copolymers of vinyl monomers, copolymers of vinylpyrrolidone, modified cationic proteins and certain quaternary salts of polymers. The cationic polymers are described in detail below. i. Cationic polysaccharides Preferred cationic polymers for use in the anti-dandruff conditioning shampoo compositions of the present invention are those known as cationic polysaccharides. Cationic polysaccharides are those sugar-based polymers having from 5 to 6 carbon atoms and their derivatives that have been made cationic by means of the insertion of cationic moieties into the polysaccharide backbone and include homopolymers, copolymers, terpolymers, etc. , quaternary ammonium or cationic monomer units with substitution of an amine, optionally, in combination with non-cationic monomers. The polysaccharides can be composed of one type of sugar or more than one type of sugar. The cationic amines may be primary, secondary or tertiary amines (preferably secondary or tertiary), depending on the particular species and the selected pH of the shampoo composition. The monomers can be in a straight chain or a branched chain with geometric arrangements. All P1383 monomer units can have cationic halides containing bound nitrogen, preferably some of the monomer units do not have those halves bound. Non-limiting examples of cationic polysaccharides are described in the CTFA Cosmetic Ingredient Dictionary, 3d ed. , edited by Estrin, Crosley, and Haynes, (The Cosmetic, Toiletry, and Fragrance Association, Inc., Washington, DC (1982), the disclosure of which is incorporated herein by reference.) Polymers of cationic polysaccharides include the following: celluloses and cationic hydroxyethylcelluloses; cationic starches and hydroxyalkyl starches; cationic polymers based on the galactomannan copolymer known as guar gum obtained from the guar bean endosperm; cationic polymers based on arabinose vegetable gums; cationic polymers derived from xylose polymers (such as those found in wood, straw, cottonseed crust, and corn cob); cationic polymers derived from fucose polymers (such as those found as cell wall components in marine algae); cationic polymers derived from fructose polymers (such as inulin, which is found in certain plants); Cationic polymers based on sugars that contain acids (such as galacturonic acid and acid P1383 glucouronic); cationic polymers based on sugars and amines (such as galactosamine and glucosamine); cationic polymers based on polyalcohols of 5 and 6 membered rings; cationic polymers based on galactose monomers (such as those found in plant gums and mucilagen); and cationic polymers based on mannose monomers (such as those found in plants, fungi and algae networks). Preferred are celluloses and cationic hydroxyethylcelluloses; cationic starches and hydroxyalkyl starches; cationic polymers based on guar gum and their combinations. to. Cationic Cellulose Derivatives Cationic polysaccharide polymers suitable for use in the antidandruff shampoo conditioner compositions of the present invention are cationic cellulose derivatives and cationic starch derivatives. Cationic polymers include those that conform to the general formula (XI): wherein A is a residual group of anhydroglucose (for example a starch or residual cellulose group of P1383 anhydroglucose); R is an alkynene, oxyalkyloene, polyoxyalkyloene or hydroxyalkyloene group, or a combination thereof; R1, R2, and R3 are independent groups of alkyl, aryl, alkylaryl, arylalkyl, alkoxyalkyl or alkoxyaryl, each group containing up to about 18 carbon atoms and the total number of carbon atoms for each cationic moiety (eg, the sum of carbon atoms in R1, R2, and R3) preferably being about 20 or less; and X is an anionic counterion described above. The cationic cellulose polymers include, in non-exclusive form, those polymers commercially available from Amerchol Corporation, in the JR and LR polymer series, such as the hydroxyethylcellulose salts which reacted with trimethyl ammonium with epoxide substitution, known in the industry ( CTFA) as Polyquaternium 10 (for example JR 30M®, commercially available from Amerchol Corporation). Preferred Polyquaternium polymers 10 for use in this invention typically have a charge density of about 0.3 meq / g to 3 meq / g and a molecular weight of about 200,000 to 1,500,000. Another non-limiting example of a preferred type of cationic cellulose includes the quaternary ammonium salt of hydroxyethylcellulose polymer that is reacted with an epoxide P1383 of ammonium substituted lauryl dimethyl, known in the industry (CTFA) as Polyquaternium 24, (for example Polymer LM 200®, commercially available from Amerchol Corporation). Also suitable for use in this invention are those copolymers of quaternary nitrogen-containing cellulose, the copolymers of hydroxyethylcellulose which are reacted with diallyldimethylammonium chloride, known in the industry (CTFA) as Polyanartenium 4 (for example Celquat® H-100). , commercially available from National Starch Corporation). The quaternary nitrogen containing cellulose ethers suitable for use in this invention are described in U.S. Patent No. 3,962,418, and still other etherified cellulose and starch copolymers suitable for use in this invention are described in the US Pat. United States No. 3,958, 581, both descriptions are incorporated herein by reference. b. Cationic guar gum derivatives Other cationic polysaccharide polymers suitable for use in the antidandruff conditioning shampoo compositions of the present invention are the cationic guar gum polymers. Guar gums Pl383 are substituted by galactomannan gum derivatives (guar). The molecular weight of these derivatives is in the range typically of about 50, 000 to about 2,500,000, preferably from about 50,000 to about 1,000,000, more preferably from about 50,000 to about 700,000, more preferably from about 100,000 to about 350,000. Guar gums to be used in the preparation of guar gum derivatives are typically obtained as a natural material from the seeds of the guar plant. The guar molecule alone is a straight chain with branches of mannan at regular intervals with single-member galactose units on alternating moieties. The mannose units are linked to one another by means of ß (1-4) glycosidic linkages. The galactose branching arises via a bond to (1-6). The cationic derivatives of guar gums are obtained by means of the reaction between the hydroxyl groups of the polygalactomannan and the reactive quaternary ammonium compounds. The degree of substitution of the cationic groups on the structure of the guar gum must be sufficient to provide the required cationic charge density, described above.

P1383 The quaternary ammonium compounds to be used in the formation of the cationic guar gum polymers include those conforming to the general formula (XII): wherein R1, R2 and R3 are methyl or ethyl groups; R4 is either an epoxyalkyl group with the general formula (XIII): or R4 is a halohydrin group with the general formula (XIV): wherein R5 is an alkynene having from 1 to 3 carbon atoms; X is chloride or bromide and Z is an anion such as Cl ", Br", I "or HS04". The polymers of cationic guar gum (cationic guar gum derivatives) formed from the reagents described above are represented by the general formula (XV): P1383 where R is a guar gum. Preferably, the cationic guar rubber polymer is guar hydroxypropyltrimethylammonium chloride, which can be more specifically represented by the general formula (XVI): cationic guar gum polymers Specific non-limiting examples of cationic guar gum polymers that conform to formula XVI include: Jaguar® C 13S, which has a cationic charge density of 0.8meq / g (commercially available from Rhodia Company) and Jaguar® C 17, which it has a cationic charge density of 1.6 meq / g (commercially available from Rhodia Company). Other cationic polymers of guar gum include the hydroxypropylated cationic guar gum derivatives. Still other suitable cationic polymers include copolymers of esterified guar gum, some examples which are described in U.S. Patent No. 3,958,581, the disclosure of which is incorporated herein by reference.

P1383 ii. Copolymers of vinyl monomers Other cationic polymers suitable for use in the anti-dandruff conditioning shampoo compositions of the present invention are the copolymers of vinyl monomers, having functionalities of a cationic ammonium or quaternary ammonium, which are reacted with monomers soluble in water. Non-limiting examples of those monomers include: acrylamide, methacrylamide, alkyl and dialkyl acrylamides, alkyl and dialkyl methacrylamides, alkyl acrylate, alkyl methacrylate, vinyl caprolactone, vinyl pyrrolidone and combinations thereof. Preferred substituted alkyl and dialkyl monomers have alkyl groups having from 1 to 7 carbon atoms, more preferably alkyl groups having from 1 to 3 carbon atoms. Other suitable monomers include vinyl esters, vinyl alcohol (made by the hydrolysis of polyvinyl acetate), maleic anhydride, propylene glycol, ethylene glycol and combinations thereof. Suitable protonated and quaternary ammonium cation monomers suitable for inclusion in the cationic polymers of the shampoo composition in this invention include vinyl compounds substituted with dialkylaminoalkyl acrylate, methacrylate P1383 dialkylaminoalkyl, monoalkylaminoalkyl acrylate, monoalkylaminoalkyl methacrylate, methacryloxyalkyl trialkyl ammonium salt, acryloxyalkyl trialkyl ammonium salt, quaternary ammonium dialkali salts; and quaternary ammonium vinyl monomers having cationic nitrogen containing cyclic rings such as pyridinium, imidazolium and quaternized pyrrolidones, such as for example alkylvinyl imidazolium salts, alkylvinyl pyridinium and alkylvinyl pyrrolidone. The alkyl portions of these monomers are preferably lower alkyls such as alkyls having from 1 to 3 carbon atoms. Amine-substituted vinyl monomers suitable for use in this invention include dialkylaminoalkyl acrylamide and dialkylaminoalkyl methacrylamide, wherein the alkyl groups are preferably hydrocarbyls having 1 to 7 carbon atoms, more preferably alkyls having 1 to 3 carbon atoms. iii. Vinylpyrrolidone copolymers Other cationic polymers suitable for use in the antidandruff shampoo conditioner compositions of the present invention include: l-vinyl-2-pyrrolidone copolymers and l-vinyl-3-methylimidazole salts P1383 (for example chloride salts), known in the industry (CTFA) as Polyquaternium 16 (for example Luviquat® FC 370, and obtainable from BASF Wyandotte Corporation); copolymers of l-vinyl-2-pyrrolidone and dimethylaminoethyl methacrylate, known in the industry (CTFA) as Polyquaternium 11 (for example, Gafquat® 755N, and obtainable from ISP Corporation); polymers containing quaternary diallylated cationic ammonium, including, for example, dimethyldiallylammonium chloride homopolymer, known in the industry (CTFA) as Polyquaternium 6; copolymers of acrylamide and dimethyldiallylammonium chloride, known in the industry (CTFA) as Polyquaternium 7; and salts of aminoalkyl mineral acids of unsaturated C3 and C5 homopolymers and copolymers of carboxylic acids, carboxylic acids, such as those described in U.S. Patent No. 4,009,256, the disclosure of which is incorporated herein by reference. i. Cationic modified proteins and polymeric quaternary salts Still other cationic polymers for use in the antidandruff shampoo conditioner compositions of the present invention are cationic modified proteins, such as for example hydroxypropyl lauryldiammonium collagen P1383 (for example Croquat® L, and which can be obtained from Croda Corporation), or hydrolyzed hair keratin hydroxypropyl cocoammonium (for example Croquat® HH, available from Croda Corporation). Other cationic polymers include the polymeric quaternary salt prepared by the reaction of adipic acid and dimethylaminopropylamine, which reacts with dichloroethyl ether, known in the industry (CTFA) as Polyquaternium 2 (for example Mirapol® AD-1, and obtainable in Rhodia) and the polymeric quaternary salt prepared by the reaction of azelaic acid and dimethylaminopropyl ether, known in the industry (CTFA) as Polyquaternium 18 (for example Mirapol® AZ-1 and that can be obtained from Rhodia Corporation). v. Other cationic polymers Still other cationic polymers suitable for use in this invention are the Arquad® series of quaternary ammonium salts, commercially available from Akzo Nobel. Other preferred cationic polymers for use in this invention include: Polymer KG30M (Polyquaternium 10 and quaternized cellulose), Incroquat® behenyltrimonium methosulfate (cetearyl alcohol and behentrimonium methosulfate), commercially available from Croda; Merquat® 5 (quaternary ammonium resin), P1383 commercially available at Calgon; Gafquat® series 440 (cationic quaternized copolymers), commercially available from ISP; Akypoquat® 131, commercially available from Kao; Saleare® SC 60 (quaternary ammonium resin), or Saleare® SC95 or SC96 (cationic liquid dispersion thickeners), all commercially available from Ciba; and Meadowquat® HG (PEG-2-dimeadowfoamamidoethylammonium methosulfate), commercially available from Fanning.

E. Water The anti-dandruff shampoo conditioner compositions of the present invention comprise between about 20% and 94.75%, by weight of the composition, preferably between about 50% and 94.75%, more preferably between about 60% and 85%, of water.

II. Optional Components The anti-dandruff shampoo conditioner compositions of the present invention may, in addition, in some embodiments, comprise additional optional components known or otherwise effective for use in hair care or personal care products. Additional surfactants, suspending agents, polyalkylene glycols, regulating agents of the P1383 hair growth and other optional components that are described in detail below.

A. Other Surfactants The antidandruff shampoo conditioner compositions of the present invention can, in some embodiments, further comprise between about 0.5% and 25% by weight of the composition, preferably between about 1% and 20%, preferably superlative between 1% and 10%, of a surfactant different from the anionic surfactants described above, suitable for application to hair or skin. These other optional surfactants must be chemically and physically compatible with the essential components of the shampoo composition, and should not, on the other hand, unduly impair the performance of the product, its aesthetics or stability. Other suitable surfactants include, in non-exclusive form, zwitterionic, cationic, nonionic amphoteric and combinations thereof. Amphoteric detersive surfactants suitable for use in this invention include, in non-exclusive form, those surfactants widely described as derivatives of secondary and tertiary aliphatic amines in which the aliphatic radical can be a straight or branched chain and wherein one of the substituents Aliphatic P1383 contains about 8 to 18 carbon atoms and one contains a water-soluble anionic group such as carboxy, sulfonate, sulfate, phosphate or phosphonate. The zwitterionic detersive surfactants suitable for use in this invention include, in non-exclusive form, those surfactants widely described as aliphatic quaternary ammonium derivatives, phosphonium and sulfonium compounds, wherein the aliphatic radicals can be straight or branched chains and wherein one of the aliphatic substituents contains from about 8 to about 18 carbon atoms and one contains an anionic group such as carboxy, sulfonate, sulfate, phosphate or phosphonate. The preferred detersive zwitterionic surfactants are the betaines. Suitable cationic detersive surfactants for use in this invention include, but are not limited to, surfactants containing quaternary nitrogen moieties. Examples of quaternary cationic surfactants are those corresponding to the general formula (XVIII): P1383 wherein R1, R2 # R3 and R4 are independently selected from an aliphatic group having from 1 to 22 carbon atoms or an aromatic, alkoxy, polyoxyalkyloene, alkylolamido, hydroxyalkyl, aryl or alkylaryl group having up to about 22 carbon atoms, preferably an alkyl of 1 to 22 carbon atoms; and X is a salt-forming anion, such as those selected from a halogen (eg, chloride, bromide) and acetate, citrate, lactate, glycolate, phosphate, nitrate, sulfate and alkyl sulfate radicals. The aliphatic groups may contain, in addition to the carbon and hydrogen atoms, ether linkages and other groups, such as amino groups. The longest chain (for example C12 and greater) of aliphatic groups can be saturated or unsaturated. Preferred cationic detersive surfactants are those containing two long alkyl chains and two short alkyl chains or those containing one long alkyl chain and three short alkyl chains. These long alkyl chains have, preferably, from 12 to 22 carbon atoms, more preferably they have from 16 P1383 up to 22 carbon atoms. The short alkyl chains preferably have from 1 to 3 carbon atoms, more preferably they have from 1 to 2 carbon atoms. Nonionic detersive surfactants suitable for use in this invention include, in non-exclusive form, those compounds produced by condensation of alkylene oxide groups (hydrophilic in nature) with an organic hydrophobic compound, which may be aliphatic or aromatic alkyl in nature. Non-limiting examples of other amphoteric, zwitterionic, cationic and non-ionic detersive surfactants suitable for use in the anti-dandruff shampoo conditioner compositions of the present invention are described in McCutcheon's, Emulsifiers and Detergents, (1989), published by MC Pub. Co. . , and in U.S. Patent No. 2,438,091; U.S. Patent No. 2,528,378; U.S. Patent No. 2,658,072; U.S. Patent No. 3,155,591; U.S. Patent No. 3,929,678; U.S. Patent No. 3,959,461; U.S. Patent No. 4,387,090; U.S. Patent No. 5,104,646; U.S. Patent No. 5,106,609; and U.S. Patent No. 5,837,661, the descriptions of which are P1383 incorporated herein by reference.

B. Suspension Agents The antidandruff conditioning shampoo compositions of the present invention may, in some embodiments, comprise between about 0.1% and 10% by weight of the composition, preferably between about 0.3% and 5%, more preferably between about 0.3% and 2.5%, of a suitable suspension agent for application on hair or skin. It is believed that the suspending agent suspends the water-insoluble dispersed material found in the shampoo compositions. That suspension agent must be physically and chemically compatible with the essential components of the composition, and should not, on the other hand, unduly deteriorate the stability of the product, its aesthetics or its functionality. Examples of suspending agents which may be suitable for use in shampoo exposures in this invention include, in non-exclusive form, acyl derivatives, long chain amine oxides, xanthan gum and combinations thereof. These and other suitable suspending agents are described in detail below. 1. Acyl derivatives and long-chain amine oxides Acyl-derived suspension agents include, but are not limited to, glyceryl esters, long-chain hydrocarbyls, long-chain esters of long-chain fatty acids, long-chain alkanol esters long chain amides. Another group of suitable suspending agents includes long chain amine oxides. Acyl-derived suspension agents and long-chain amine oxides are described in U.S. Patent No. 4,741,855, the disclosure of which is incorporated herein by reference. Preferred acyl derivative suspending agents for use in this invention are glyceryl esters, which include esters of fatty acids having from 16 to 22 carbon atoms of ethylene glycol. More preferred are tileglycol stearates, both mono- and di-stearates, more preferably ethylene glycol distearate containing about 7% or less of monostearate. Also suitable for use in the shampoo compositions in this invention are the long chain hydrocarbyls (for example Cs-C2), which include N, N-dihydrocarbylamidobenzoic acid and its soluble salts (e.g., Na, K) and species of this family of P1383 amidobenzoic acid, commercially available from Stepan Company. Non-limiting examples of long chain esters of long chain fatty acids include: stearyl stearate and cetyl palmitate. Non-limiting examples of long-chain esters of long chain alkanol amides include: stearamide diethanolamide distearate and stearamide monoethanolamide stearate. Non-limiting examples of suitable long-chain amine oxides to be used as suspending agents in this invention include the amino-dimethyl-e-C22-alkyl oxides (for example, amino-dimethyl-stearyl oxide). 2. Xanthan gum Also suitable as a suspending agent in this invention is xanthan gum. The concentration of xanthan gum is typically in the range of about 0.1% to about 3%, by weight of the composition, preferably from about 0.4% to about 1.2%. The use of xanthan gum as a suspending agent in shampoo compositions containing silicone is described, for example, in the patent of the United States No. 4,788,006, the disclosure of which is incorporated herein by reference. Combinations of long chain acyl derivatives and xanthan gum can also be used as a suspending agent in shampoo compositions, as described in U.S. Patent No. whose description is incorporated herein by reference. 3. Other suspending agents Still other suspending agents suitable for use in the anti-dandruff conditioning shampoo compositions of the present invention include carboxyvinyl polymers. Preferred among these polymers are copolymers of acrylic acid crosslinked with polyallyl sucrose, as described in U.S. Patent No. 2,798,053, the disclosure of which is incorporated herein by reference. Examples of these polymers include Carbopol 934,940,941, and 956, commercially available from B. F. Goodrich Company. Another suitable suspending agent for use in this invention includes primary amines with fatty alkyl moieties having at least about 16 carbon atoms (e.g. palmitamine, and steramine) and secondary amines having two fatty alkyl moieties each having at least about 12 carbon atoms (for example dipalmitoylamine, and di- (hydrogenated tallow) -amine). Also suitable are phthalic acid amides di- (tallow) P1383 hydrogenated) and the vinyl ether copolymer crosslinked with maleic anhydride. Yet another suitable suspending agent can be used in shampoo compositions, including those that can impart a gel-like viscosity to the composition, such as water soluble or colloidal water soluble polymers such as cellulose ethers (eg, methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose and hydroxyethylcellulose) , guar gum, polyvinyl alcohol, polyvinyl pyrrolidone, hydroxypropyl guar gum, starch and starch derivatives and other thickeners, viscosity modifiers, gelling agents and their combinations. A preferred viscosity modifier useful as a suspending agent is trihydroxystearin (for example Thixin R ™, commercially available from Rheox Company).

C. Polyalkylene Glycol The antidandruff conditioning shampoo compositions of the present invention may, in some embodiments, further comprise between about 0.005% and 1.5% by weight of the composition, preferably between about 0.05% and 1%, more preferably between 0.1 % and 0.5%, with superlative preference between P1383 approximately 0.1% and 0.3%, polyalkylene glycol selected suitable for application on hair or skin. It is believed that the selected polyalkylene glycols provide an improved foam function, that they improve the shampooing ability of the shampoo and when an antidandruff agent is used, it increases the antidandruff efficacy, to the compositions described in this invention. These polyalkylene glycols must be physically and chemically compatible with the essential components described in this invention and should not, on the other hand, unduly deteriorate the stability of the product, its aesthetics or its functionality. It has been found that those polyalkylene glycols, when added to the shampoo compositions described in this invention, increase the function of formation of esp-uma leaving a richer and denser foam that correlates the consumer's perception of a conditioning function of the hair. It has also been found that, in those embodiments containing silicone conditioning agents, the selected polyalkylene glycols can reduce the concentration of the anionic detersive surfactant necessary to provide a hair cleaning. In those reduced surfactant compositions, hair cleaning and conditioner function remain good, while improving P1383 the global function of foam formation. It is known that polyethylene glycols, for example, are used to improve the foaming function in cleaning compositions, as described in U.S. Patent No. 5,837,661, the disclosure of which is incorporated herein by reference. It has also been found that these selected polyalkylene glycols, when added to a silicone-containing shampoo composition, improve the spreadability of the shampoo compositions on the hair. The improved smearing ability of the shampoo composition during application also provides the perception in consumers of an improved conditioning function. This function is especially surprising in the selected polyalkylene glycol known to be a thickening agent and as a thickening agent it would be expected that it would deteriorate rather than improve the ability of the shampoo compositions on the hair to be smeared. The polyalkylene glycol suitable for use in the shampoo compositions in this invention are characterized by having the general formula (XVII): P1-S83 HCOC ^ CDn-OH R wherein R is hydrogen, methyl or combinations thereof, preferably hydrogen, and n is an integer having an average value of between about 1,500 and 120,000, preferably between about 1,500 and 50,000, more preferably between about 2,500 and 25,000 , and with superlative preference of between approximately 3,500 and 15,000. When R is hydrogen, these materials are polymers of ethylene oxide, which are also known as polyethylene glycol. When R is methyl, these materials are polymers of propylene oxide, which are also known as polypropylene glycol. When R is methyl, it is also understood that several positional isomers of the resulting polymers may exist. Preferred for use in this invention are polyethylene glycol, polypropylene glycol and combinations thereof. Specific non-limiting examples of polyethylene glycol polymers to be used in the anti-dandruff conditioning shampoo compositions of the present invention include: PEG 2M, wherein R is hydrogen and n has an average value of about 2,000 (for example Poliox WSR® N-10, commercially available in Union Carbide); PEG P1383 5M, wherein R is hydrogen and n has an average value of about 5,000 (for example Poliox WSR® N-35 and Poliox WSR® N-80, both commercially available from Union Carbide); PEG 7M, wherein R is hydrogen and n has an average value of about 7,000 (for example Poliox WSR® N-750, commercially available from Union Carbide); PEG 9M, wherein R is hydrogen and n has an average value of about 9,000 (for example Poliox WSR® N-3333, commercially available from Union Carbide); PEG 14 M, wherein R is hydrogen and n has an average value of about 14,000 (for example Poliox WSR® N-3000, commercially available from Union Carbide); PEG 23M, wherein R is hydrogen and n has an average value of about 23,000 (for example Poliox WSR® N-12k, commercially available from Union Carbide); PEG 90M, wherein R is hydrogen and n has an average value of about 90,000 (for example Poliox WSR® 301, commercially available from Union Carbide); and PEG 100M, wherein R is hydrogen and n has an average value of about 100,000 (for example Carbowax PEG 4600 ™, commercially available from Union Carbide). Preferred polyethylene glycol includes PEG 7M, PEG 14M, PEG 25M, PEG 90M, and combinations thereof.

D. Hair growth regulating agents P1383 The compositions in this invention can optionally also comprise, in addition to zinc pyrithione, another hair growth regulating agent. That agent can be chosen from a wide variety of molecules that can function in different ways to improve the hair growth effects in a compound of the present invention. These optional agents, when present, are typically used in the compositions of this invention at a level of between about 0.001% and 15%, preferably of about 0.10 and 10%, preferably superlative of between about 0.5% and 5% by weight of the composition. As used in this invention, the term "hair growth regulator" includes: stimulating hair growth and / or hair thickening; prevention, reduction and / or retardation of hair loss and / or thinning of the hair-increase in the speed of hair growth; induction of the formation of a greater number of hair streaks; increase in the diameter of the stretch marks of hair; growth of hair streaks; hair follicle change from hair to terminal; conversion of follicles from telogen phase to anagen phase (thus increasing the overall proportion of phase follicles P1383 anagena in relation to the follicles of the telogen phase); alopecia treatment; and any combination. Vasodilators such as potassium channel antagonists including, for example, minoxidil and derivatives of such as aminaxyl and such as those described in U.S. Patent No. 3,382,247, U.S. Patent No. 5,756,092, issued on 26 May 1998, U.S. Patent No. 5,772,990, issued June 30, 1998, U.S. Patent No. 5,760,043, issued June 2, 1998, U.S. Patent No. 328,914, granted on July 12, 1994, U.S. Patent No. 5,466,694, issued November 14, 1995, 5,438,058, issued August 1, 1995, and U.S. Patent No. 4,973,474, issued on June 27, 1995; November 1990, (all of which are incorporated herein by reference), and chromacalin and diazoxide can be used as optional hair growth regulating agents in the compositions herein. An optional class of optional enhancers of the activity to be used are antiandrogens. Examples of suitable antiandrogens may include, unrestrictedly, 5-a-reductase inhibitors, such as, for example, finasteride and those described in the US Pat.

P1383 United States No. 5,516,779, issued May 14, 1996 (which is incorporated herein by reference) and in Nnane et al., "Cancer Research 58," Effects f Some Novel Inhibitors of C17.20-Lyase and 5a-Reductase in Vitro and in Vivo and their Potential Role in the Treatment of Prostate Cancer, as well as cyproterone acetate, azelaic acid and its derivatives and the compounds described in U.S. Patent No. 5,480,913, issued January 2, 1996, flutamide, and those described in United States patents 5,411,981 issued May 2, 1995 and 5,565,467 issued October 15, 1996 and United States Patent 4,910,226 issued March 20, 1990, all incorporated to the present, as a reference. Another suitable class of hair growth regulating agent are immunosuppressants such as: 1) cyclosporin and cyclosporin analogues including those described in U.S. Provisional Patent Application No. 60 / 122,925, Fulmer et al., "Method of Treating Hair Loss Using Non-Immunosuppressi and Compounds ", published March 5, 1999, incorporated herein by reference and 2) F 506 analogs such as those described in U.S. Provisional Patent Application No. 60 / 102,449, Mclver et al., "Heterocyclic 2-Substituted P1383 Ketoamides ", published on September 30, 1998, U.S. Provisional Patent Application No. 60 / 102,448, Mclver et al.," 2-Substituted Ketoqmides ", filed September 30, 1998, patent application Provisional No.60 / 102, 539, Mclver et al., "2-Substituted Heterocyclic Sulfonamides", filed September 30, 1998, United States Provisional Patent Application No.60 / 102, 458 Tiesman et al., "Method of Treating Hair Loss Using Ketoamides", filed September 30, 1998 and United States Provisional Patent Application No. 60 / 102,437, Mclver et al., "Method of Treating Hair Loss Using Sulfonamides", filed on September 30, 1998, all of which are incorporated herein by reference.

Another suitable class of optional hair growth regulating agent are antimicrobials such as selenium sulfide, ketoconazole, triclocarbon, triclosan, zinc pyrithione, itraconazole, Asian acid, hinoquiithiol, mipirocin and those described in EPA 0,680,745 (incorporated herein) as a reference), clinazine hydrochloride, benzoyl peroxide, benzyl peroxide and minocycline. Other anti-inflammatories may also be incorporated into the compositions in this invention as P1383 optional activity intensifiers. Examples of suitable anti-inflammatories may include glucocorticoids such as hydrocortisone, mometasone furoate and prednisolone, non-steroidal antiinflammatories including cyclooxygenase or lipoxygenase inhibitors such as those described in U.S. Patent No. 5,756,092, and benzydamine, salicylic acid and those compounds described in EPA 0,770,399, published May 2, 1997, WO 94/06434, published March 31, 1994 and FR 2,268,523 published November 21, 1975, all of which are incorporated herein by reference. Another suitable class of optional hair growth regulating agent are thyroid hormones and their analogous derivatives. Examples of suitable thyroid hormones for use in this invention may include triiodothyronine. Examples of thyroid hormone analogues which may be suitable for use herein include those described in U.S. Provisional Patent Application No. 60 / 136,996, Zhang et al., "Method of Treating Hair Loss", filed on June 1, 1999, U.S. Provisional Patent Application No. 60,137,024, Zhang et al., "Method of Treating Hair Loss Using Biphenyl Compounds", filed on June 1, 1999, the provisional patent application ofP1383 United States No. 60 / 137,022, Zhang et al., "Method of Treating Hair Loss Using Carboxyl Derivatives", filed June 1, 1999, provisional application of United States Patent No. 60 / 137,023, Zhang et al. al., "Method of Treating Hair Loss Using Sulfonyl Thyromimetic Compounds," filed June 1, 1999, U.S. Provisional Patent Application No. 60 / 137,052, Youngquist et al., "Biaryl Compounds," filed on 1 June 1999, U.S. Provisional Patent Application No. 60 / 137,063, Youngquist et al., "Sulfur-Bridged Compounds", filed June 1, 1999 and U.S. Provisional Patent Application No. 60 / 136,958, Youngquist et al., "Substituted Biaryl Ether Compounds", filed June 1, 1999. Prostaglandin agonists can also be used as optional hair growth regulating agents in the compositions herein. Examples of prostaglandin agonists or antagonists include latanoprosta and those described in WO 98/33497, Johnstone, published August 6, 1998, WO 95/11003, Stjernschantz, published April 27, 1995, JP 97- 100091, and Ueno, JP 96-134242, Nakamura. Another class of hair growth regulating agents, optional to be used in this P1383 invention, are the retinoids. Suitable retinoids may include isotretinoin, acitretin, tazarotene. Non-limiting examples of penetration enhancers that can be used as optional hair growth regulating agents in this invention include, for example, 2-methylpropan-2-ol, propan-2-ol, ethyl-2-hydroxypropanoate, hexan -2, 5-diol, POE (2) ethyl ether, di (2-hydroxypropyl) ether, pentan-2,4-diol, acetone, POE (2) methyl ether, 2-hydroxypropionic acid, 2-hydroxyoctanoic acid, propan-1 -ol, l, 4-dioxane, tetrahydrofuran, butan-1,4-diol, propylene glycol diperlargonate, polyoxypropylene 15 stearyl ether, octyl alcohol, oleyl alcohol ester POE, oleyl alcohol, lauryl alcohol, dioctyl adipate, dicapryl adipate, adipate di-isopropyl, di-isopropyl sebacate, dibutyl sebacate, diethyl sebacate, dimethyl sebacate, dioctyl sebacate, dibutyl suberate, dioctyl azelate, dibenzyl sebacate, dibutyl phthalate, dibutyl azelate, ethyl myristate, dimethyl azelate, butyl myristate, succ dibutyl inate, didecyl phthalate, decyl oleate, ethyl caproate, ethyl salicylate, isopropyl palmitate, ethyl laurate-, 2-ethylhexyl pelargonate, isopropyl isostearate, butyl laurate, benzyl benzoate, benzoate of butyl, laurate P1383 hexyl, ethyl caprate, ethyl caprylate, butyl stearate, benzyl salicylate, 2-hydroxypropanoic acid, 2-hiroxyoctanoic acid, methylsulfoxide, N, N-dimethylacetamide, N, N-dimethylformamide, 2-pyrrolidone, 1-methyl -2- pyrrolidone, 5-methyl-2-pyrrolidone, 1,5-dimethyl-2-pyrrolidone, l-ethyl-2-pyrrolidone, phosphine oxides, sugar esters, tetrahydrofurfural alcohol, urea, diethyl-m-toluamide , l-dodecylazacylheptan-2-one and those described in U.S. Patent No. 5,015,470, issued May 14, 1991 and U.S. Patent No. 5,496,827, issued July 15, 1994 (which they are incorporated herein by reference in their entirety). Another class of hair growth regulating agent to be used in this invention includes flavinoids, ascomycin derivatives and their analogues, histamine antagonists such as diphenhydramine hydrochloride, other triterpenes such as oleanolic acid and ursolic acid, and those described in U.S. Patent No. 5,529,769, JP 10017431, WO 95/35103, U.S. Patent No. 5,468,888, JP 09067253, WO 92/09262, JP 62093215, U.S. Patent No. 5,631,282, U.S. Pat. of the United States No. 5,679,705, JP 08193094, saponins such as those described in EP 0,558,509 to Bonte et al.

P1383 al, published September 8, 1993 and WO 97/01346 to Bonte et al, published January 16, 1997 (which are incorporated herein by reference in their entirety), proeoglycanase or glycosaminoglycanase inhibitors such as those disclosed in U.S. Patent No. 5,015,470, issued May 14, 1991, U.S. Patent No. 5,300,284, issued April 5, 1994, and U.S. Patent No. 5,185,325. , issued February 9, 1993 (which are incorporated herein by reference in their entirety), estrogen agonists and antagonists, pseudoterines, cytokines and growth factor promoters, analogs or inhibitors such as interleukin-1 inhibitors, Interleukin-6 inhibitors, interleukin-10 promoters and tumor necrosis factor inhibitors, vitamins such as vitamin D analogs and parathyroid hormone antagonists, an biologics of vitamin B12 and panthenol, interferon agonists and antagonists, hydroxy acids such as those described in U.S. Patent No. 5,550,158, anticonvulsants of benzophenones and hydantoin such as phenytoin. Other hair growth agents are described in detail in, for example, JP 09-157,139 to Tsuji et al published on June 17, 1997; EP 0277455 Al a P1383 Mirabeau, published on August 10, 1988; WO 97/05887 to Cabo Soler et al, published on February 20, 1997; WO 92/16186 to Bonte et al, published March 13, 1992; JP 62-93215 to Okazaki et al, published on April 28, 1987; U.S. Patent No. 4,987,150 to Kurono et al issued January 22, 1991; JP 290811 to Ohba et al, published October 15, 1992; JP 05-286,835 to Tanaka et al, published on November 2, 1993, FR 2,723,313 to Greff, published on August 2, 1994, United States Patent No. 5,015,470 to Gibson issued May 14, 1991, U.S. Patent No. 5,559,092, issued September 24, 1996, U.S. Patent No. 5,536,751 issued July 16, 1996, U.S. Patent No. 5,714,515, issued February 3, 1998 , EPA 0,319,991 published June 14, 1989, EPA 0,357,630 published October 6, 1988, EPA 0,573,253 published December 8, 1993, JP 61-260010 published November 18, 1986, United States Patent No 5,772,990 issued June 30, 1998, United States Patent No. 5,053,410 issued October 1, 1991 and United States Patent No. 4,761,401 issued August 2, 1988, all of which are incorporated in this invention by reference. Some regulatory agents of growth of Preferred hair for use in this invention are zinc salts of carboxylic acids, saponins, triterpenes, oleanolic acid, ursolic acid, betulinic acid, crataegolic acid, celastrol, Asian acid, 5-a-reductase inhibitors, progesterone, 1,4 -methyl-4-azasteriods, 17-ß-N, N-diethylcarbonyl-4-methyl-aza-5-a-yrostan-3-one, pyrogen receptor antagonists, cyproterone acetate, minoxidil, azaléic acid and derivatives, cyclosporine, triiodothyronine, diazoxide, potassium channel openers, cromakaline, phenytoin, ketoconazole, finiesteride, dutasteride, coal tar, zinc gluconate, glucocorticoids, macrolides, aminaxyl and combinations thereof.

E. Other Optional Ingredients The antidandruff shampoo conditioner compositions of the present invention may, in some embodiments, further comprise additional optional components known or otherwise effective for use in hair care or personal care products. The concentration of those optional ingredients is generally in the range from zero to about 25%, more typically between about 0.05% and 25%, even more typically from about 0.1% to 15% by weight of the composition.

P1383 These optional components must also be physically and chemically compatible with the essential components described in this invention, and must not, on the other hand, unduly deteriorate the stability of the product, its aesthetics or its operation. Non-limiting examples of optional components to be used in the shampoo composition include antistatic agents, foam propellants, anti-dandruff agents in addition to the anti-dandruff agents described above, viscosity adjusting agents and thickeners, pH adjusting agents (eg, sodium citrate) , citric acid, succinic acid, phosphoric acid, sodium hydroxide and sodium carbonate), preservatives (for example DMDM hydantoin), antimicrobial agents (for example triclosan or triclocarbon), dyes, organic solvents or diluents, nacreous aids, perfumes, fatty alcohols, proteins, active skin agents, sunscreen, vitamins and pediculocids. Optional antistatic agents such as water insoluble cationic surfactants can be used, typically in concentrations that are between about 0.1% and 5% by weight of the composition. These antistatic agents should not, on the other hand, interfere with the use and operation and final benefits of the P1383 shampoo composition; in particular, antistatic agents should not interfere with the anionic surfactant. A specific non-limiting example of suitable antistatic agents is tricetylmethylammonium chloride. Optional foam propellants for use in the shampoo compositions described in this invention include fatty esters (for example C8-C22) mono- and di (C1-C5, especially C1-C3) alkanolamides. Specific non-limiting examples of the foam propellants include coconut monoethanolamide, coconut diethanolamide and combinations thereof. Optional viscosity modifiers and thickeners may be used typically in effective amounts for the antidandruff conditioning shampoo compositions of the present invention to generally have an overall viscosity of between about 1,000 and 20,000 centistokes, preferably about 3,000 to 10,000 centistokes. Specific non-limiting examples of those viscosity modifiers and thickeners include: sodium chloride, sodium sulfate and combinations thereof.

III. Methods of Processing The antidandruff conditioning shampoo compositions of the present invention can be prepared P1383 by any known or otherwise effective technique, suitable for providing a shampoo composition as long as the resulting composition provides the excellent feeling of hair benefits described in this invention. The methods for preparing the antidandruff conditioning shampoos of the present invention include conventional formulations and blending techniques. A method such as that described in U.S. Patent No. 5,837,661, the disclosure of which is incorporated herein by reference, may be used, wherein the anti-dandruff agent of the present invention would typically be added in the same step as the silicone premix is added in the description of 661.

IV. Methods of Use The anti-dandruff shampoo conditioner compositions of the present invention are used in a conventional manner for cleansing and conditioning the hair or skin are, in particular, used in a conventional manner to treat the condition commonly known as dandruff. An effective amount of composition for cleansing and conditioning the hair or skin is applied to the hair, or to another region of the body, which has preferably been moistened, generally with water, and P1383 subsequently the composition is rinsed. Effective amounts are typically in the range of about 1 g to about 50 g, preferably from about 1 g to about 20 g. Application to hair typically involves a job of penetrating the composition through the hair in such a way that most, or all the hair is in contact with the composition. This method of providing anti-dandruff efficacy and conditioning of the hair comprises the steps of: (a) wetting the hair with water, (b) applying an effective amount of the shampoo composition to the hair, and (c) rinsing the shampoo composition of the hair. Hair using water. These steps can be repeated as many times as desired to achieve the cleaning, conditioning and anti-dandruff benefits sought. It is also contemplated that when the anti-dandruff particle used is zinc pyrithione and / or another optional hair growth regulating agent if it is used, the shampoo compositions of the present invention can provide a regulation of hair growth. The method of using these shampoo compositions on a regular basis comprises steps a, b and c (above).

P1383 ANALYTICAL METHODS The anti-dandruff shampoo conditioner compositions of the present invention, when applied to hair in a manner consistent with the methods of use described below, provide a superior combination of anti-dandruff efficacy and conditioning. Shampoo compositions, when applied to the hair exhibit certain physical characteristics, which are measured by means of the bioavailability / coverage index, the first conditioning index (wet detangle), the second conditioning index (clean hair feeling) and the index of minimum inhibitory concentration. The methods used to determine the values of these indices are described in detail below.

A. Methods for evaluating the bioavailability / coverage index The bioavailability / coverage index of a shampoo composition is indicative of the anti-dandruff efficacy provided by the shampoo. Generally, the greater the value of the composition index, the better its anti-dandruff efficacy, due to the increased bioavailability of the anti-dandruff agent, the increased coverage of the anti-dandruff agent, or both.

P1383 1. Principle Product, control and placebo samples are applied to portions of pork skin, which are soaped and rinsed. Contact agar boxes inoculated with Malassezia fúrfur are exposed to the surface of the pig skin and after an incubation period, the boxes are analyzed using commercially available software to determine the area of the agar surface in which there has been growth of colonies of M. fúrfur. Indices are calculated by comparing the colonized area in a relative control with the colonized area in each sample. The inhibition of the growth of M. fúrfur on the boxes is indicative of the bioavailability of the anti-dandruff agent and of the coverage of the antidandruff agent, which, together and independently, are indicative of the global antidandruff efficacy. 2. Equipment Pig skin sterilized via irradiation; shaved, full thickness, size = dependent on the number of products examined P1383 (typically at least 2100 cm2 approximately) Product 1.5 ml per product to be examined Control 1.5 ml per control to be examined Placebo 1.5 ml per placebo to be examined Beaker 3000 ml Petri dishes 1 per sample to be examined; size = 15 mm x 150 mm; sterilized 4 agar boxes per sample to be examined; size = 35mm x 10mm contact Microrganism 10 μl of M. fúrfur (ATCC 14521) in culture broth per sample to be examined Variable volumetric pipettes 10 μl-100 μl ImagePro Plus® data system training software P1383 imaging, available from Fryer Company (Hundey, Illinois), or equivalent Microsoft Excel® statistical software software, available from Microsoft Corporation, or equivalent; executed in two rows, hornoscedastico, test T. 3. Reagents A. Broth formulation (adjusted to pH 5.6 with 5N HCl) Component Quantity Oxigall1 15.0 g / l Polypeptone2 5.0 g / l Peptone Gelisato3 5.0 g / l Palmitic acid 1.0 ml / l Miristic Acid 1.0 ml / l Sodium lactate 10.0 ml / l P1383 (agar) 15.0 g / l 1. Fresh dehydrated bile, commercially available in Difco Co pany. 2. Pancreatic casein digestion and peptic digestion of animal tissue, commercially available from the BBL Company. 3. Pancreatic gelatin digestion, commercially available from the BBL Company.

B. Control and placebo formulations (% by weight, of the composition) Component Control Placebo Sulfate 15.00 15.00 ammoniumlaureth-3 Sulfate laurel 5.00 5.00 ammonium Sodium Lauroil 1.50 1.50 Sarcosinate1 Distearate 1.50 1.50 ethylene glycol Polyquaternium 102 0.025 0.025 Polyethylene glycol3 0.125 0.125 Pyridinetiona 1.00 zinc4 P1383 Sodium sulphate 0. 875 0. 875 DMDM hydantoin 0. 2035 0. 2035 Lauryl alcohol 0. 15 0. 15 Perfume 0. 65 0. 65 Water5 amount sufficient i-nn Ht-e- 1. Hamposil L-30, as an active 30% solution, commercially available from Hampshire Chemical Company. 2. UCARE Polymer JR 30M, available in Amerchol. 3. Carbowax 600 (known as PEG 12), commercially available from the Sentry Company. 4. ZPT with an average particle size of approximately 2.5 μm, commercially available from Arch / Olin. 5. After the control and placebo are prepared, adjust the pH of the control and placebo to within the range of about pH 5 to about pH 7, using conventional pH modifiers. 4. Experimental procedure A. Preparation of the contact boxes 1) Add 7.5 ml of molten agar to a Petri dish lid and allow the agar to solidify. 2) Store the box from approximately 12 hours to approximately 24 hours at 30 ° C.

P1383 B. Preparation of pig skin 1) Store pig skin at 0 ° C until needed. 2) Thaw the pork skin at room temperature for 3 hours and dry it with paper towels. 3) Cut the pork skin into pieces of 10 cm x 10 cm; 3 pieces for each product, control and placebo to be examined. 4) Place the pieces of pork skin in Petri dishes separately until they are ready to wash.

C. Test Setup 1) Wash each piece of pig skin by applying 0.5 ml of sample to the surface of the pig skin and soaping for 1 minute over the entire surface. 2) Gently rinse the surface of the pig skin by immersing it in a beaker for 5 seconds. 3) Perform steps 1 and 2 on two additional pieces of pig skin for a total of 3 per sample to be examined. 4) Allow the surface of the skin to dry with air in a sterile petri dish (with the lid cracked) for about 2 hours. 5) Inoculate the contact boxes with 10 μl of M. fúrfur (suspended in a broth at a concentration of P1383 1.3 x 105 cfu / ml). 6) Press each box of contact agar (4 per piece of pig skin, a total of 12 per product, control and placebo to be examined) firmly against the surface of treated pig skin for 15 minutes. Remove the contact boxes and incubate them for approximately 72 hours at approximately 168 hours at 30 ° C. i) At periodic times during the incubation, analyze the control contact boxes and the placebo contact boxes using the imaging software to determine the area of the contact surface of the boxes in which there has been growth of colonies of M. fúrfur. ii) Compare the average colonized area of the control contact boxes against the colonized average area of the placebo contact boxes and calculate the proportion by dividing the colonized average area of the control contact boxes by the average colonized area of the boxes of placebo contact. iii) When the ratio is between approximately 0.40 to approximately 0.60, finish the incubation.

D. Analysis of antimicrobial activity P1383 1) After incubation, analyze the contact boxes of the product using the imaging software to determine the average surface area of the contact boxes in which growth of M. fúrfur colonies occurred. 2) Apply a statistical standard T test to determine if the products tested are significantly different from the P value less than or equal to 0.10. These tested products can be significantly different at this level. 5. Determination of the value of the index Compare the average colonized area of the control contact boxes against the colonized average area of the product contact boxes and calculate a proportion by dividing the colonized average area of the control contact boxes by the average of the colonized area of the contact boxes of the product. For example, if the average colonized area of the control contact boxes is 400 mm2 and the colonized average area of the contact boxes of the product is 500 mm2, then the index is 400 mm2 / 500 mm2, which is equal to one value of the index of 0.80.

B. Method to evaluate the index of the first conditioning P1383 * 8 The value of the first conditioning index is related to the conditioning, as understood by the consumers of the shampoo composition.

Generally, the lower the value of the index of the composition, the better is its conditioning, due to a better wet hairstyle and a less tangled wet hair. 1. Principle Product samples are ied to a horsetail of false hair, which is then soaped and rinsed. The conditioning is graded by the force required to pull a comb through the hair. That force is measured using a force transducer or a load cell. The hair is fixed to be hung vertically in the force transducer. When a force, when combed, is ied to the force transducer, the force units are represented by a voltage that is proportional to the ied force. The voltage signal of the load cell is transferred to a computer through a commercially available digital analog interface. The voltage signal is converted into a numerical value by commercially available computer software. Each time the force is ied to the force transducer, a P1383 force / time curve. Within the run of a single sample of multiple ied forces, the generated value is the sum of the integration of these force / time curves. That value is called combing force. Because the device is not calibrated to the computer, all multiple sample tests are evaluated by a relative comparison. The conditioning of a sample is reported as an index against a control. 2. Equipment Straight hair Dark brown, European hair, virgin combination; weight = 4 grams of hair to be worked; length = 8 inches; commercially available in International Hair Importers and Products; 15 hair changes by product to examine (6 for products and 9 for controls) Sink Conventional laboratory sink with a horizontal bar placed P1383 ^ oximately 20 inches above it Water temperature = 100 ° F, fed through a flexible hose Combs 1 for tested hair; barber plastic comb, oximately 9 teeth / inch Stopwatch That can measure seconds Product 3cc product / change Computer Capable of running software Rash-8, or equivalent Load cell force transducer of lOOOg, Model # FTD-G-1000, commercially available from Schaevitz Company, or equivalent Dash-8® analog / digital interface commercially available in Metrabyte Company, or equivalent Dash-8® Software, commercially available from Metrabyte Company, or equivalent P1383 3. Reagents A. Control composition Raw material (weight%) Ammonium laureth sulfate-3 15.00 Ammonium lauryl sulfate 5.00 Sodium Lauroil Sarcosinate1 1.50 Ethylene glycol distearate 1.50 Poliquat 10 '0.025 Zinc pyridinethione3 1.00 Polyethylene glycol4 0.125 Sodium sulfate 0.875 DMDM Hidantoin 0.2035 Lauryl alcohol 0.15 Water5 cbp 1. Hamposyl L-30, as a 30% active solution, commercially available from Hampshire Chemical Company. 2. UCARE Polymer JR 30M, commercially available in Amerchol. 3. ZPT with an average particle size of oximately 2.5 μm, commercially available in Pl383 Arch / Olin. 4. Carbowax 600 (known as PEG 12), commercially available from Sentry Company. 5. Adjust the pH from about pH 5 to about pH 7, using conventional pH modifiers.

B. Composition of initial hierarchical hair classification Raw material weight% Laureth-3 ammonium sulfate 51.24 Lauryl ammonium sulfate 36.38 Cocamide DEA 2.30 Ammonium xylene sulphonate 3.50 Perfume 0.50 Water sufficient amount 4. Experimental procedure A. Initial hierarchical hairstyle classification 1) All false hair must be cleaned and classified hierarchically before conducting each test to determine the index of the first conditioning in order to adjust the function of the uncontrollable variables between each non-permanent hair. treated within a given set. This procedure of P1383 classification groups specific hair in subsets or groups, in such a way that the function of all the groups together is uniform. 2) Collect all the hair that will be used in the test. 3) Treat the pile hair according to the protocol detailed in Part B below, using the initial composition of hair classification instead of the test products, however, use the composition of the control where designated. 4) Select the hair that has combing forces within the same range of the lower force (typically 2 standard deviations of the lower). 5) Fix the hair in groups in such a way that the combing force of the baseline is evenly distributed across all the treatment groups. For example, if 12 changes are going to be used in 3 test groups, then classify them according to: the hair with the highest hairstyle is placed in Group 1, the hair with the second highest in Group 2, the hair with the third highest in Group 3, the hair with the fourth highest in Group 1, etc.

P1383 B. Hairline Treatment 1) Hang a hairline above the sink on a horizontal bar and wet it completely using water at 100 ° F and at a flow rate of 1.5 gallons / minute. 2) Squeeze the excess water. 3) Apply 0.4 cc of a test or control sample uniformly under the false hair, using at least 8 false hair per product examined. Apply the samples to the artificial hair in a round-robin fashion, for example to the hair # 1 of each set-sample # 1, then to the hair # 1 of each set, sample # 2, etc. An example is to apply in the following order: ÍA, IB, 1C, 2A, 2B, 2C, 3A, 3B, 3C, etc., where the letters refer to a product to be tested and the numbers refer to a replicative number. 4) Using the thumb and the index finger, extract a sample to the change of false hair for 30 seconds. 5) Rinse the hair with water at 100 ° F for 30 seconds. Support the back of the hair, while waiting for the water to wet the hair completely. 6) Squeeze the excess water.

P1383 7) Apply 0.4 cc of test sample or control uniformly down the hair, again in a circular (round-robin). 8) Work the product on the hair while detaching the hair, using a side-to-side movement, for 30 seconds. 9) Rinse with water at 100 ° F for 60 seconds. 10) Squeeze the excess water. 11) After all treatments are completed, untangle the hair while it is still wet, using a comb, as described below (Part C).

C. Unraveling and data collection 1) Use a force transducer, interfaced with an analog / digital computer program to accumulate and integrate the force / time data. 2) Firmly secure the hair in the transducer clamp, so that the hair will hang vertically. 3) When the measuring device is ready to run a test, start combing the hair in the tangled part, starting at the bottom of the hair. Be careful not to grab the hair with the other end because it could be recorded as P1383 unwinding force blocking the registered force. Work with the comb gradually to the top of the hair as the knots are removed. 4) When the hair can be combed hair without getting stuck in any knot, make three more combing strokes and then stop combing. 5) Indicate to the software that the test was completed for each sample. 6) Remove the hair from the transducer clamp. 7) Carry out steps 1-6 (previous) for each change, conduct the hairstyle round-robin through the whole set of hair. 8) Calculate the average values and statistical differences using the Fisher's procedure Least Significant Difference (LSD-Fisher's Minor Significant Difference), with a P value less than or equal to 1.0. The tested products must be significantly different at this point.

. Determination of the value of the index Compare the average combing force of each product examined against the average combing force of the control and calculate the proportion by dividing the combing force of the test product between the combing force P1383 of the control. For example, if the test product receives a combing force of 1500 force / time units and the control receives a combing force of 1300 force / time units, then the value of the index of the test product is 1500/1300, which is equal to an index value of 1.15.

C. Method for evaluating the index of the second conditioning The index of the second conditioning is indicative of conditioning, as observed by the consumers of the composition of the shampoo. Generally, the value of the highest composition index, better is the conditioning, because the sensation of clean hair is increased. 1. Principle Product samples and control are applied to the horsetail of the hair using brushes. Trained sensory panelists will evaluate the "clean feeling" attribute of each change treated with product and each change treated with the control samples, using their thumb and index finger. The trained sensory panelists assign a numerical value from 0 to 10, with 10 being the highest amount of cleansing sensation. Within each test of P1383 cleaning sensation, two test samples are evaluated against two anchors identified and a bandaged internal control. The index is calculated by comparing the value of the cleaning sensation attribute of the test product with respect to the value of the cleaning sensation attribute of the control. How well it qualified in the feeling of cleanliness is indicative of the conditioning function. 2. Equipment Caucasian hair, horsetail, weight = 20 grams; length = 8 inches, commercially available at International Hair Importers and Products; 15 changes per product to test (6 for products, 9 for controls) Trained panelists 12 sensory panelists Conventional laboratory sink with a horizontal bar placed approximately 20 inches above it Water temperature = 100 ° F, P1383 powered through a flexible hose Brushes 1 for tested hair; plastic brush commercially available in Goody Combs 1 for tested hair; barber plastic comb, approximately 9 teeth / inch Stopwatch Able to measure seconds Product 30cc of product per hair 3. Reagents Raw Material Ancora Ancora Control High Internal Media Laureth-3 Sulfate 10.00 15.00 13.50 Ammonium Lauryl Sulfate 6.00 5.00 4.50 Ammonium Sarcosinate 1.50 1.50 Lauroyl Sodium MEA Cocamide 0.80 Pl383 Distearate of 1.50 1.50 1.50 ethylene glycol Dimethicone2 1.00 Dimethicone3 1.35 Polyquate 104 0.50 Polyquat 105 0.025 Guar gum 0.10 hydroxypropyltrimonium6 PEG 7M7 0.10 PEG 128 0.325 0.125 Phenidintiona zinc9 1.00 Homopolymer 1-decene 0.30 10 Capil Caprilato 0.10 trimethylpropane11 Cetyl alcohol 0.90 Sodium sulfate 0.875 0.875 DMDM Hydantoin 0.2475 0.2035 0.2035 Lauryl alcohol 0.15 0.15 Perfume 0.5 0.65 0.7 Water12 sufficient quantity- 1. Hamposyl L-30, as an active solution to 3 ( P1383 commercially available from Hampshire Chemical Company. 2. A mixture of dimethicone rubber SE-76 in proportion, based on weight, of 40 (gum) / 60 (fluid), commercially available in General Electric Silicones and a dimethicone fluid with a viscosity of 350 centistokes. 3. 300,000 centistokes silicone, commercially available in General Electric Silicones. 4. UCARE Polymer LR 400, commercially available in Amerchol. 5. UCARE Polymer JR 30M, commercially available in Amerchol. 6. Jaguar C 17, commercially available in Rhodia. 7. Poliox WSR N-750, commercially available from Union Carbide. 8. Carbowax 600, commercially available from Sentry Company. 9. ZPT with an average particle size of approximately 2.5 μm, commercially available from Arch / Olin. 10. Puresyn 6, commercially available in Mobil. 11. Mobil P43, commercially available in Mobil. 12. Adjust the pH of approximately pH 5 to P1383 approximately pH 1, using the conventional pH modifiers. 4. Experimental procedure A. Preparation of false hair 1) All false hair must be cleaned and classified hierarchically before conducting each test to determine the index of the first conditioning in order to adjust the function of the uncontrollable variables between each untreated hair. of a given set. This classification procedure groups specific hair pieces into subsets or groups, so that the function of all the groups together is uniform. 2) Collect all the hair that will be used in the test. 3) Treat the hair in accordance with the protocol detailed in Part B below, using the initial composition of hair classification instead of the test products, however, still use the composition of the control where designated. 4) Two or three trained panelists should feel the hair and select a set of 3 false hair that feels similar. (A panelist is considered trained if the person is able to choose P1383 the anchors high and low in a blind context as well as placing the internal control in the appropriate range. ) 5) These similar hair strands will be used to test 2 products and for internal control. The false hair for the high and low anchor are not classified.

B. Hairline Treatment 1) Hang a hair strand above the sink on a horizontal bar and wet it completely using water at 100 ° F and at a flow rate of 1.5 gallons / minute. 2) Squeeze the excess water. 3) Apply 0.4 cc of a test sample or control uniformly down of the hair, using at least 8 false hair per product examined. Apply the samples to the hair in a round-robin fashion, for example hair # 1 of each set-sample # 1, then hair # 1 of each set, sample # 2, etc. An example is to apply in the following order: LA, IB, 1C, 2A, 2B, 2C, 3A, 3B, 3C, etc., where the letters refer to a product to be tested and the numbers refer to a replicative number. 4) Brush the hair for 30 seconds at a speed of one brushed per second.

P1383 5) Rinse hair with water at 100 ° F for 30 seconds. Support the back of the hair, while waiting for the water to wet the hair completely. 6) Flip the hair and apply 5cc of the same sample to the other side of the hair and work the product inside. 7) Brush the product through the artificial hair for 30 seconds at a speed of one brushed / second. 8) Rinse the hair for 30 seconds at a rate of approximately one brush / second. Support the back of the hair, while allowing water to pass down the entire hair. 9) Perform steps 1-8 a second time. 10) Perform steps 1-8 a third time.

C. Hairline evaluation 1) After completing steps 1 to 10 (formerly in Part B) trained panelists will evaluate false hair. 2) Hang five changes in the sink, identifying each change treated with the major looper and a change treated with the lower looper. Identify the hair P1383 postizo that was treated with the internal control and the hair hair treated with the two different test products, simply as "A," "B," and "C." The internal control label must vary between test and test to prevent bias. 3) Trained panelists should evaluate the hair using the following protocol: 4) Trained panelists should not soak their hair, but can comb it (using a different comb on each change) to realign the hair. 5) With one hand, the trained panelists' thumb is placed in front of the hair while the index and middle fingers are on the back of hair. Using moderate pressure, the hair is pushed with the thumb. This movement continues downward along the hairline. It is important to make an up and down movement, as opposed to side to side, as the sensations are different. 6) Using the high and low anchors as guides, the trained panelists should assign a numerical value to each hairline marked A, B, and C evaluating the cleanliness, the hair feeling of each one. The low looper must be assigned a value of 0 and the high locus of 10.

(While for panelists it is unknown, the value of the internal control is typically about 2.5 to P1383 approximately 4.0.) 7) Each set of treated hair is evaluated by four panelists and then removed. 8) Record all values assigned to all false hair by all trained panelists. 9) Calculate the average values and the statistical difference using Fisher's Minor Significant Difference (LSD) procedure, with a P value less than or equal to 1.0. The tested products must be significantly different at this level.

. Determination of the value of the index Compare the average value of the cleanliness attribute of the test product against the average value of the cleanliness attribute of the internal control and calculate a proportion by dividing the value of the cleanliness attribute of the test product between the value of the cleaning sensation attribute of the internal control. For example, if the test product receives a value of the cleanliness attribute of 2.0 and the internal control receives a value of the clean feeling attribute of 3.5, then the index of the test product is 2.0 / 3.5, which is the same to an index value of 0.57.

P1383 D. Minimum inhibitory concentration The minimum inhibitory concentration index is indicative of anti-dandruff efficacy. Generally, the higher the value of the composition index, the better the anti-dandruff efficacy, due to an increased inherent ability of the antidandruff agent to inhibit the growth of microorganisms. 1. Principle Malassezia fúrfur is incubated in a flask containing the mDixon medium (see E. Gueho, et al., Antoinie Leeuwenhoek (1996), No. 69, 337-55, the description of which is incorporated in this invention). Dilutions of the solubilized antimicrobial active are added to the test tubes containing the melted agar of mDixon. The inoculum of M. fúrfur is added to each tube of molten agar, the tube with vortex, and the contents are poured into sterile Petri dishes separately. After the boxes are incubated, the visible growth of M. fúrfur is observed. The lowest antimicrobial active test dilution that does not produce growth is defined as the minimum inhibitory concentration (MIC). A value of the MIC index is calculated by comparing the MIC value for the antimicrobial active with the MIC value for ZPT. The MIC index value is indicative of the power of an asset Pl383 antimicrobial. 2. Equipment / Reagents Microorganism Malassezia fúrfur (ATCC 14521) Erlenmeyer flask 250 ml Agar medium 9.5 ml mDixon agar by concentration per active to be tested Solvent water, dimethyl sulfonyl oxide ("DMSO"), others suitable for active ingredients to be examined Pyridinthione zinc ZPT with a particle size of approximately 2.5 μm, preserved in Darvan, commercially available from Arch / Olin Test tubes 2 tubes per active antimicrobial by concentration per active to be examined, sterilized, size = 18 mm x 150 mm Petri dishes 2 boxes per asset Pl383 antimicrobial by concentration to be tested, sterilized, size = 15 mm x 100 mm 3. Experimental procedure 1) Cultivate Malassezia fürfur in a 250 ml Erlenmeyer flask containing 100 ml of mDixon medium at 320 rpm and 30 ° C until cloudy. 2) Prepare the selected dilutions, using a series of dilutions in half, of the antimicrobial active in solvent, which allows the sample asset to be solubilized before adding it to the final test. For each concentration of ZPT samples, the solvent can be DMSO; For other samples, the solvent must be water or DMSO or other suitable solvents. 3) Add dilutions of 0.25 ml of the antimicrobial active to the test tubes containing 9.5 ml of molten mDixon agar (at 45 ° C in a water bath). 4) Add 0.25 inoculum of M. fúrfur (adjusted to 5 x 105 cfu / ml per direct count) to each test tube of molten agar. 5) Vortex each tube and pour the contents into Petri dishes separately. 6) After the agar has solidified, Pl383 invert the boxes and incubate them at 30 ° for 5 days. 7) Observe in the boxes a visible growth of M. fúrfur. 4. Determination of the value of the index Determine the value of the MIC index by comparing the MIC for each antimicrobial active in relation to that of ZPT, dividing the MIC value by ZPT between the MIC value for the tested antimicrobial active. For example, if the MICZPT value is 1.0 μg / g and the MlCtest value is 4.0 μg / g, then the index for the test asset is 1.0 μg / g / 4.0 μg / g, which is equal to the value of the 0.25 index. .

EXAMPLES The following are non-limiting examples of compositions of the antidandruff conditioning shampoo of the present invention. The examples are given for illustrative purposes only and should not be translated as limitations of the present invention, since any of their variations are possible without departing from the spirit and scope of the invention, which will be recognized by those who dominate the technical field. In the examples, all concentrations are listed as percentages by weight, unless otherwise specified. As used in this Pl383 invention, "minor" refers to optional components such as preservatives, viscosity modifiers, pH modifiers, fragrances, foam propellants and the like. As is evident to those who dominate the technical field, the selection of those minors will vary depending on the physical and chemical characteristics of the ingredients particularly selected to elaborate the present invention, as described in this invention. A suitable method for the preparation of antidandruff shampoo compositions described in Examples I-IX (below) reads: Approximately one third of all ammonium laureth sulfate (added as 25% by weight of the solution) is added to a jacketed tank and heated from about 60 ° C to about 80 ° C with slow stirring to form a solution of the surfactant. Cocamide MEA and fatty alcohols, (where applicable), are added to the tank and allowed to disperse. The salts (for example sodium chloride) and the pH modifiers (for example citric acid, sodium citrate) are added to the tank and allowed to disperse. The ethylene glycol distearate ("EGDS") is added to the mixing vesicle and is to be infused. After the EGDS is melted and dispersed, a preservative is added to the solution of the P1383 surfactant. The resulting mixture is cooled from about 25 ° C to about 40 ° C and collected in a finishing tank. As a result of this cooling step, the EGDS crystallizes to form a crystalline lattice in the product. The remaining ammonium laureth sulfate and other components, including the silicone and the antidandruff agent, are added to the finishing tank with agitation to ensure a homogeneous mixture. The cationic polymer is dispersed in the water as an aqueous solution of about 0.1% to about 10% and added to the final mixture. Once all the components have been added, additional viscosity and pH modifiers can be added, as needed, to the mixture to adjust the viscosity and pH of the product as desired.

Sample number I II III IV V Laureth Ammonium Sulfate 1 111 9 10 10 11.5 Lauryl ammonium sulfate 6 7 6 7 6.5 Polyquaternium-1O1 0.35 0.35 0.5 0.1 0.45 Chloride Guar 0.25 0.25 0.4 Hydroxypropyltrimonium2 PEG7M3 0.1 0.05 0.1 0.05 0.15 Zinc pyrithione4 1 1 1 1 1 Homopolymer of 1-decene5 0.25 0.4 0.3 0.25 0.3 Capil Caprilato of 0.1 0.2 0.1 0.1 0.15 trimethylpropane6 Dimethicone7 2.55 3.25 1.35 3.25 2.55 Ethylene glycol distearate 1.25 1.0 1.5 1.0 1.5 Cocamida MEA 1.0 0.6 0.8 0.6 0.8 Cetyl alcohol 0.6 0.6 0.9 0.9 1.0 Water and less enough Sample number vi VII VIII IX Laureth Ammonium Sulfate 10 10 11 10 Lauryl ammonium sulfate 6 6 6 7 Polyquaternium-101 0.5 0.6 0.35 Chloride Guar 0.5:: 0.15 Hydroxypropyltrimonium2 PEG7M3 0.1 0.1 Zinc pyrithione4 1 1 1 1 Homopolymer of 1-decene5 0.4 0.4 0.3 0.4 Capil Caprilato 0.1 0.1 0.1 0.1 trimethylpropane6 Dimethicone7 2.5 2.25 1.5 1.5 Ethylene glycol distearate 1.5 1.5 1.0 1.25 Cocamida MEA 0.8 1.0 0.9 0.6 Cetyl alcohol 0.9 0.9 1-1 1.0 Water and minors P1383 1. UCARE Polymer LR400, available from Amerchol. 2. Guar with a molecular weight of approximately 200,000, and with a charge density of approximately 0.71 meq / g, available from Aqualon. 3. Poliox WSR N-750, available from Union Carbide. 4. ZPT with a particular average size of approximately 2.5μm, available in Arch / Olin. 5. Puresyn 6, available on Mobil. 6. Mobil P43, available in Mobil. 7. Visasil 330,000 centistokes, available in General Electric Silicones.

Next, the four values of the indexes of examples III, VI, and VII are tabulated.

Example Number III VI VII Index value of 2.48 2.02 3.25 coverage / bioavailability Index value of the first 0.92 0.91 0.92 conditioning Index value of 2.62 1.74 2.30 second conditioning Index value of 1.0 1.0 1.0 P1383 minimum inhibitory concentration P138

Claims (14)

CLAIMS;

1. A shampoo composition with the feature that it comprises: a) from 5% to 50% by weight, of an anionic surfactant; b) from 0.01% to 10% by weight, of a non-volatile conditioning agent; c) from 0.1% to 4% by weight, of an antidandruff agent; d) from 0.02% to 5% by weight, of a cationic polymer; e) water; where this composition: i) has a bioavailability / coverage index value of at least 1.25; ii) has a first value of the conditioning index, less than or equal to 1.0; iii) has a second value of the conditioning index, of at least 1.5; and iv) it has a value of the minimum inhibitory concentration index of at least 0.125.

2. A shampoo composition according to claim 1, wherein the composition has a value Pl383 of the coverage / bioavailability index of at least 1.5, preferably at least 2.0, and a minimum inhibitory concentration index value of at least 0.25, preferably at least 0.50.

3. A shampoo composition according to any preceding claim, wherein the composition has a first conditioning index value less than or equal to 0.96, preferably less than or equal to 0.91, and a second conditioning index value of at least 1.75. , preferably of at least 2.50.

4. A shampoo composition according to any preceding claim, wherein the composition further comprises from 0.1% to 10%, by weight of the composition, of a suspending agent, preferably wherein the suspending agent is ethylene glycol distearate.

5. A shampoo composition according to any preceding claim, wherein the non-volatile conditioning agent is a dispersed silicone.

6. A shampoo composition according to any preceding claim, wherein the anti-dandruff agent is selected from a group consisting of: ketoconazole and a zinc salt of l-hydroxy-2-pyridinothione, preferably wherein the zinc salt of the -hydroxy-2-pyridinothione are platelet-shaped particles.

7. A shampoo composition according to any P1383 preceding claim, wherein the composition is characterized in that it comprises from 0.1% to 1% of the cationic polymer.

8. A shampoo composition according to any preceding claim, wherein the cationic polymer is selected from the group consisting of: guar derivatives, preferably guar hydroxypropyltrimonium chloride; cellulose derivatives, preferably Polyquaternium-10; and its combinations.

9. A shampoo composition according to any preceding claim, wherein the guar derivatives have a molecular weight of 50,000 to 2,500,000, preferably from 50,000 to 700,000, and a charge density of 0.1 meq / g to 0.9 meq / g, and in wherein the cellulose derivatives have a charge density of 0.1 meq / g to 1.0 meq / g, preferably 0.2 meq / g to 0.6 meq / g and a molecular weight of 250,000 to 850,000, preferably 350,000 to 500,000. A shampoo composition according to any preceding claim, wherein the composition further comprises from 0.005% to 1.5% by weight of the composition, preferably from 0.5% to 1.0% of a polyalkylene glycol corresponding to the formula: P1383 a) wherein R is selected from the group consisting of hydrogen, methyl and combinations thereof, and b) wherein n is an integer having an average value of from 1,500 to 120,000, preferably from 3,500 to 15,000. 11. A shampoo composition characterized in that it comprises: a) from 10% to 25% by weight, of an ammonium surfactant; b) from 0.01% to 5%, by weight of the composition, of an insoluble and non-volatile silicone conditioning agent; c) from 0.3% to 2%, by weight of the composition, of a zinc salt of l-hydroxy-2-pyridinothione; d) from 0.1% to 1.0%, by weight of the composition, of a cationic polymer; e) water; wherein the composition: i.) has a value of the coverage / bioavailability index, as defined in this P1383 invention, of at least 1.5; ii) has a first value of the conditioning index, as defined in this invention, less than or equal to 0.96; üi) has a second value of the conditioning index, as defined in this invention, of at least 1.5; and iv) has a value of the minimum inhibitory concentration index, as defined in this invention, of at least 0.25. 12. A method for providing anti-dandruff efficacy and for conditioning hair characterized in that it comprises: a) wetting the hair with water; b) application to the hair of an effective amount of a shampoo composition according to any preceding claim; and c) rinsing the hair shampoo composition using water. A shampoo composition according to any preceding claim, wherein the composition is further characterized in that it comprises from 0.001% to 15% of a hair growth regulating agent selected from the group consisting of zinc salts of carboxylic acids, saponins, triterpenes, oleanolic acid,P1383 ursolic acid, betulinic acid, betulonic acid, crataegolic acid, celastrol, Asian acid, inhibitors of 5-a-reductase, progesterone, 1,4-methyl-4-azesteroids, 17-ß-N, N-diethylcarbamyl-4- methyl-4-aza-5-a-hydrostan-3-one, hydrogen receptor antagonists, cyproterone acetate, minoxidil, azelaic acid and its derivatives, cyclosporin, triiodothyronine, diazoxide, potassium channel openers, cromakaline, phenytoin, ketoconazole, finasteride, dutasteride, coal tar, zinc gluconate, glucocortisoids, macrolides, aminaxyl, and combinations thereof. 14. A method for regulating hair growth characterized in that it comprises: a) wetting the hair with water; b) application to the hair of an effective amount, of a shampoo composition according to any preceding claim; c) rinsing the hair shampoo composition using water. Pl383