MXPA01000254A - Product and method for improving avian health - Google Patents

Abstract

A product and method for reducing and preventing the ingestion of substrates by avians wherein the substrates are disposed within an avian house. The product is a bird repellent in combination witha substrate disposed within an avian house. As a result of the reduced ingestion of substrates such as litter, healthier avians are achieved.

Description

PRODUCT AND METHOD FOR fc_ »PRAY BIRTH HEALTH FIELD OF THE INVENTION The present invention relates generally to the improvement of bird health. More particularly, the present invention relates to a product that comprises the combination of a bird repellent and a substrate, and more specifically straw, wherein the repellent, when applied in a poultry farm, prevents birds from pecking. the substrate, resulting in the production of healthier birds. BACKGROUND OF THE INVENTION Commercial poultry that are raised by intensive farming methods use high density growth conditions that can mitigate diseases through the vector of the poultry farm and, more particularly, of the straw. The floor of the poultry farm is basically a substrate on which the poultry stand and provides a natural target for snacking. In addition, birds peck the straw as well as naturally peck the ground in search of food and grains of sand for their gizzard. Grains of sand are used by birds in the gizzard as a means of grinding food. As birds ingest products deposited throughout the poultry farm, and particularly in Ref: 126599 straw, certain pathogenic organisms, such as bacteria, viruses and parasites, are introduced into the bird's organism. As an example, the common coccidiosis disease is transmitted from one bird to another through faeces that are mixed with straw and then ingested by birds. It is also known in the industry that the ingestion of straw by commercial poultry is a common source of several other diseases caused by pathogenic organisms such as Salmonella, Clostridia and other endoparasites, viruses and bacteria. Currently the treatment for such diseases includes the addition of anticoccidials and any other medicine to food and / or water for the treatment and / or prevention of such diseases caused by specific pathogens. Other common medications for such diseases include antibiotics such as, for example, ionophores, which include Salinomicma and Monensin.

The following references describe background information that may be useful in understanding the present invention: WO 97 37540A; 5 WO 85 00996A; EP-A-0 791 298 US-A-3 367 830; EP-A-0 591 000; Res. Avian Coccidiosis, Proc. Ga. Coccidiosis Conf. (1986), Meeting Date 1985, 246-52. Univ. GA., Dep. Poult. Sci., Athens, GA, 1986, Folz, S.D. et al .: "A novel approach for controlling avian coccidiosis"; Roe. Br. Corp. Prot. Conf. -Posts Dis. (1977), (2), 469-75, 1977, Flegg, J.J.M. et al .: "Preliminary tests of chemical repellents to bullfinches".

BRIEF DESCRIPTION t) E THE INVENTION The present invention is a product and a method for the multifunctional treatment of substrates in poultry farms, which improves the performance of the birds. More specifically, the present invention comprises the use of a bird repellent applied to any of a variety of substrates and preferably straw, which are located within poultry farms. Such poultry farm substrates coated with the bird repellent are effective in the following aspects: One aspect of the present invention is the reduction and prevention of the ingestion of straw and other substrates by the birds of a poultry farm, in such a way that Exposure to diseases of these birds decreases significantly. Another aspect of the present invention is that, due to a reduction in the intake of straw and other substrates, the birds of the poultry farm will have a generally improved health. An additional aspect of the present invention is that due to the reduction of the ingestion of straw and other substrates, there is an improvement in feed efficiency adjusted to the weight of the birds. The final aspect of the present invention is that, in the specific case of straw coated with a compound of polycyclic quinone, of sulfides by the odor conditions and decreases the sulphurous odors that may occur in a rg-tanj to poultry. DETAILED DESCRIPTION OF THE INVENTION Definitions: The term "straw" as used herein, means any material or cover used to provide a bed or bed (synonyms: material for beds or nests) for animals (some examples of straw they include remains of brushed wood, rice husks and straw as such, among others). The term "avian" or "birds" as used herein, means any warm-blooded vertebrate, with feathers, which lays eggs, provided with wings (synonyms: birds or birds). The term "poultry" as used herein, means any domestic bird that is bred to be served on a table, or eggs or feathers thereof, including broiler chickens, broiler chickens, roosters and chickens, capons, turkeys, ducks, geese and any other. The term "poultry farm" as used herein, means any building used as a shelter or den for birds, for any reason (synonyms: bird shelter, chicken cages, cages or enclosures, chicken cages, bird farms). The term "weight-adjusted feed efficiency" is based on a corrected feed efficiency for a standard weight called the "weight-adjusted feed efficiency" (WAFE). The feeding efficiency can be adjusted to a standard weight of 2.00 kg. For every 31.78 grams of difference in weight, the feed efficiency can be adjusted to 0.01. For example: a) if the actual weight is greater than the standard weight, then the feed efficiency is adjusted downwards. If the actual weight is lower than the standard weight, then the feed efficiency is adjusted upwards. For example: b) suppose a treatment group that has an average weight of 2,032 kg with a feed efficiency of 2.0. c) Based on an efficiency factor of 31.78 grams of weight equal to 0.01 kg of feed efficiency, then the WAFE would be equal to 1.99 for a standard weight of 2.00 kg. The term "improved bird health" means any improvement in mortality (survival) and / or morbidity and / or losses. The term "waste" as used in the ^^^^^^^^^^^^^^^^^^^^^^^^^ * _ «- & present, means complete bodies of birds, body parts or poultry products (in addition to processed meat, eggs, etc.), which are found unacceptable for human consumption by the Government's Meat and Poultry Inspection Service. The term "improved poultry yield" as used herein means any improvement in an economic parameter used to determine better profits from the sale or barter of poultry products. For example, standing body weight, dead weight, salable meat yield, salable eggs, feed efficiency, average daily weight gain, eggs laid per hen, viable chickens, chickens produced per hen, etc. The term "bird repellent" as used herein, means a compound or preparation that causes a bird to choose alternative behavior patterns in order to avoid contact, ingestion, odor or the presence of the compound. The term "polycyclic quinone" or "PCQ" as used herein means quinicones and bicyclic, tricyclic and tetracyclic hydroquinones of fused rings, as well as precursors thereof. The term "active form of PCQ" as used herein means the formulation or finished state of the PCQ in which the PCQ molecule is more effective. The term "crude PCQ" as used herein means an active ingredient not processed. The term "non-toxic" means a substance that is judged by the United States Environmental Protection Agency as non-toxic, by qualified analytical methods. The term "adhesive propagator" as used herein, means any compound used as an adjuvant to improve the adherence of the active ingredients to the surface of a leaf or any other plant tissue. The invention The present invention relates to the application of a bird repellent to several substrates in a poultry farm. The inventors discovered that the ability to repel birds so as not to feed on substrates within a poultry farm, is an effective way to inhibit the consumption of materials such as straw carrying diseases. The The present invention, then, has the net result of affecting the performance of the birds in the following manner: (i) it improves the weight gain and feeding efficiency, resulting in a better feed efficiency adjusted to the weight; (ii) decreases exposure to avian diseases; (iii) improves the health of the birds; and (iv) in some cases, it decreases the sulfur odors inside a poultry farm. As will be described in more detail below, the bird repellent can be any compound or substance having repellent properties for birds. The bird repellent can be added to any type of substrate in a poultry farm, for the purposes of the present invention, a substrate can be any particle or surface found or located within a poultry farm. a poultry farm. For example, it is contemplated that the bird repellent may be applied to substrates such as the floor, walls or straw located in a poultry farm. BIRD REPELLENT 15 As mentioned above, any compound or substance that functions as a bird repellent can be used in the present invention. The following paragraphs summarize several characteristics of the bird repellent compounds that are preferred for use in the present invention. Initially, it is important for the effectiveness of the present invention that the bird repellent, whatever the physical form applied, be persistent. More particularly, the active material of the bird repellent applied preferably must be able to withstand the erosion by wind and rain and other environmental forces to which the treated surface may be exposed. For example, it is preferred that (1) the active form of the bird repellent has a relatively low solubility in water so that it is not easily washed away from the surface of the treated straw and (2) that the bird repellent has a melting temperature. relatively high so that it does not suffer excessive evaporation of the straw surface during exposure to high ambient temperatures. For these reasons, it is preferred that the active poultry repellent material has a water solubility under ambient temperature conditions not greater than 0.001-1000 ppm and preferably in the range of 0.001 to 200 ppm. The melting temperature of the active poultry repellent should be at least about 150 ° C and preferably at least 200 ° C. Even when the active poultry repellent material possesses the preferred physical properties described above and is maintained under the environmental conditions described above, the material may still have little persistence if it does not adhere well to the surface of the straw to which it is applied. This is a function of the different surface properties of straw and bird repellent material. It is also preferred that the bird repellent is not toxic to the specific birds in which it will be used. Although it is not required by the present invention that the bird repellent is non-toxic, this is preferred because, although a bird may not peck on the substrate coated with the bird repellent, it may be standing on it or being in contact with it. in several other ways. Coadjuvants In an alternative embodiment, an adjuvant with any bird repellent can be used to provide certain properties that allow a more effective application of the bird repellent to the substrate. For example, an adjuvant, as used herein, can refer to materials that have a bioactivity different from that of the bird repellents themselves. Such materials include pH adjustment, ammonia control agents, phosphate control agents, trigeminal bird repellents and mixtures thereof. Both liquid and solid adjuvants can be used in conjunction with bird repellents, depending on the manner of application (see discussion below). Suitable adjuvants for use with the present invention include sodium bisulfate, 2-hydroxyacetophenone, limonene, and other bird repellent terpenes, methyl anthranilate, alum, zeolites, sulfate of calcium, antibiotics, antiviral agents, organic and inorganic acids, among others. Adhesive Agents In a further alternative embodiment, it is suggested that the bird repellent contain an "adhesive agent", ie, a material that by itself has good adhesion to the substrate and when mixed with the bird repellent causes it to be Adhere to the substrate more firmly. Examples of preferred adhesive agents include polymeric networks aqueous, which after the evaporation of water form a polymeric mass that is highly adhesive to the surface of the straw and keeps the particles of the active material firmly adhered to the surface of the straw. Such latex adhesive agents typically contain a small amount of surfactant dissolved in the aqueous phase. It should be noted that any other adhesive agent which causes or helps the bird repellent to adhere to the substrate can be used in the present invention. Additives The inventors contemplate an additional alternative modality in which additives are combined with the bird repellent. As used herein, the term "additive" refers to materials that increase the &jj £ 5 ^ ^ £ 3 £ = ^^^^ j ^ ^^^^ -J ^ sThe effectiveness of bird repellents, but which by themselves have no bioactivity. These include materials such as surfactants, wetting agents, defoaming agents, extenders, adhesive agents, penetrating agents, plasticizers, activators, spreading agents, diluents, flavorings and the like. Polycyclic quinone composition Although any bird repellent compound can be used in the present invention, it is preferred that the The bird repellent is a non-ionic polycyclic quinone (PCQ) and, preferably, a PCQ which is selected from the group consisting of bicyclic quinones to tetracyclic quinones, hydroquinones and mixtures thereof, having a) a slight absorbance within the range of 200 to 400 nm, b) a water solubility of not more than 1000 ppm by weight, c) a melting point of not less than 102 ° C and d) a DL511 in female rats of at least 2000 mg / kg. It is the discovery of the inventors that the application to straw repels a bird by a mechanism of repellency. birds such as that described in US Patent Application No. US97 / 05662 to Ballinger et al., Which is incorporated herein by reference. A wide variety of polycyclic quinones can be used in the present invention. As used in the present, the term "polycyclic quinone" or "PCQ" is refers to quinicones and bicyclic, tricyclic and tetracyclic condensed ring hydroquinones, as well as to precursors thereof. Altogether, the nonionic polycyclic quinones and the polycyclic hydroquinones 5 (collectively referred to herein as PCQ) have a very low water solubility at room temperature. For use in the present invention, it is preferred that the PCQs have a water solubility of no greater than about 1000 ppm by weight. However, as noted above, certain PCQ precursors can also be used in the present invention, either combined with the relatively insoluble PCQs, or themselves. Such precursors include anionic salts of PCQs that are water-soluble under alkaline anaerobic conditions. However, these materials are not stable and are easily transformed into insoluble quinones when exposed to air. Thus, when the anionic PCQs are applied to the straw and exposed to air, they quickly become transform into more active, water-insoluble forms of quinone. Among the water-insoluble PCQs that can be used in the present invention are anthraquinones (AQ) such as 1,2-dihydroxyanthraquinone, 1, 4-dihydroxyanthraquinone, naphthoquinone, antron (9,10- dihydro-9-oxo-anthracene), 10-methylene-anthrone, phenanthrenequinone and the alkyl, alkoxy and amino derivatives of such quinones, 6,11-dioxo-lH-anthra [1,2-c] -pyrazole, anthraquinone-1,2-naphthacridone, 7,12-dioxo-7, 12 - 5-dihydroanthra [1,2-b] -pyrazine, 1,2-benzanthraquinone, 2,7-dimethylanthraquinone, 2-methylanthraquinone, 3-methylanthraquinone, 2-aminoanthraquinone and 1-methoxyanthraquinone. Of the above cyclic ketones, anthraquinone and 1,4-dihydroxyanthraquinone are preferred because they appear to be more effective. AQs of natural origin can be used, as well as synthetic AQs. Other PCQs can be used including more soluble AQ compounds such as 1,1-dihydroxyanthraquinone, 1-aminoanthraquinone, 1-chloroanthraquinone, 2-chloroanthraquinone, 2-chloro-3-carboxylantraquinone and 1-hydroxyanthraquinone. Various ionic derivatives of these materials can be prepared by catalytic reduction in aqueous alkaline conditions. Also, within the AQ family is a variety of anthraquinone compounds that can be used in the method of the present invention. As used herein, the term "anthraquinone compound" refers to compounds comprising the basic tricyclic structure, such as 9, 10-25 dihydroanhydroquinone, 1,4-dihydroanthrahydroquinone and «_i_i _ ?? _« _ i ________ il ________-? _M i_g_¡_ _ £ _l_L_a_tf_á_í 1,4,4a, 9a-tetrahydroanthrahydroquinone. The anthrahydroquinone itself is 9,10-dihydroxyanthracene. Water-insoluble and water-soluble forms of the anthrahydroquinone compound can be used in the present invention. Nonionic compounds are very insoluble in aqueous systems, while ionic derivatives, such as dialkali metal salts, are very water soluble. The water-soluble forms are only stable in high pH anaerobic liquids. Low pH liquids (pH less than about 9-10) will generally result in the formation of insoluble molecular anthrahydroquinone. Aerobic solutions will suffer oxidation of anthrahydroquinones to anthraquinones. Thus, anthrahydroquinones will not exist for prolonged periods in an aerated environment, such as the one experienced when sprayed. For these reasons, anthrahydroquinone treatments are usually implemented with the ionic form soluble in a caustic solution. Sodium hydroxide solutions are preferred over the hydroxides of other alkali metals, for economic reasons. With respect to PCQs in general, the specific PCQ used should preferably be in a physical form small enough to be touched by the sensory organs of birds and affect the intestines. If the - * «, _ _»,. ^ * & ¿¿^ > When particles are too large, the nerves could detect the presence of the chemical poorly. Thus, for the PCQ to be more effective as a repellent, it is preferred that the particle size 5 be sufficiently small in order to be detected effectively by the birds. In particular, it is preferred that the PCQ particles have less than about 50 microns in diameter and preferably that the particles have less than 30 microns in diameter. diameter. Similarly, smooth continuous surfaces of PCQ can not be adequately felt by birds and, of course, if the PCQ is coated with anything that is not repellent to birds or whose taste is insensitive to birds, the PCQ will not It is effective.

It is preferred that the particles have a sufficient size or have a suitable contour that contains areas that are small enough to be felt. When the PCQ is applied directly in the form of particles, the size of the particles can be controlled easily. When such particles are applied in a single layer of particles, substantially all of the PCQ would be effective. However, if the particles are applied in the form of multiple layers of particles, essentially only the top layer would be effective. An important aspect of this analysis, it is not important that the PCQ be applied in the form of a continuous coating. As mentioned above, it is preferred that the bird repellent is non-toxic. The PCQ compounds that meet these criteria of being essentially non-toxic, is because they have an LD50 of at least 2000 mg / kg in rats and preferably an LD50 in rats of 5000 mg / kg or higher. Due to this low toxicity, PCQs are not toxic to birds, animals and humans. In addition, the level of toxicity is low enough that any active material that falls to the ground does not deteriorate the normal components of the layers of fertile soil. PCQs with a degradation half-life of less than 60 days are preferred to ensure that bioaccumulation does not occur. SUBSTRATES As described above, it is preferred that the selected bird repellent be applied to a substrate within a poultry farm. For the purposes of the present invention, a substrate means any particle or substance on which a bird repellent can be deposited. Some examples of substrates include soil, walls and straw arranged inside or that are part of the interior of the farm. The use of compositions comprising a bird repellent and a substrate within a poultry farm, is beneficial in at least four important aspects: (1) the birds raised in these farms have a better health because they consume smaller quantities of the material and / or the substrate; (2) birds exhibit better feeding efficiency and body weight gain due to their better health; (3) birds have lower mortality and morbidity rates due to low consumption of the material and / or substrate; and (4) as a result of these benefits, birds can be raised at higher densities in whatever area of the substrate is available. It is particular The fact that all these benefits are simultaneous when raising birds on such compositions is important. Special breeding or environmental conditions are not required to obtain these advantages, beyond the use of the substrate of the present invention as a means of aging. In a preferred embodiment, the substrate on which the bird repellent is applied comprises the straw for birds. It is a discovery of the inventors that the use of a combination of straw and a bird-repellent compound has the net effect of improving the agronomic conditions of the production of the birds bred in this medium. Straw comes in several forms, which include nesting materials made of natural or synthetic materials. Examples of natural materials are grass, hay, straw, grain husks, brushed wood waste and sawdust, chopped, macerated or pelleted paper derived from cardboard, kraft cardboard or newsprint. Synthetic materials suitable for use as straw include synthetic foamed polymers and inorganic adsorbents such as silica. When using these materials as straw for birds, these materials are usually mixed with varying amounts of excrement, spilled food and feathers. As described above, straw is often mixed with various activating and active materials, either before or during use. Other substrates include any floor or wall material used in a poultry farm. The bird repellent can be applied to the floor and / or walls of a poultry farm to prevent birds from picking at them. 15 METHODS OF APPLICATION The bird repellent compound can be applied to the substrate of interest in any way that allows the present invention to work. It is preferred that the substrate of interest be coated and / or saturated with the repellent of selected birds, or with precursors thereof, by spraying the external surface or, alternatively, by immersing the substrate in a liquid dispersion of the bird repellent or a liquid dispersion of a precursor thereof. A particularly way Preferred to coat the substrate, includes spraying directly the substrate with the bird repellent or with a precursor thereof. The selected bird repellent can be applied to the selected substrate in any amount that is effective. In the particular case of a PCQ bird repellent, it is preferred that fine droplets of the PCQ dispersion formulated at 50% PCQ by weight be sprayed at a rate such that the upper layer of the substrate is treated at a ratio between 0.01 gallons per thousand square feet and 10 gallons per thousand square feet and preferably between 0.066 gallons per thousand square feet and 0.33 gallons per thousand square feet. The treatment material can also be sprayed onto the substrate while being fluidized in air. HE can apply both bird repellents and precursors thereof in this manner. Although the substrate can be coated by immersion in the treatment solution, this method is not the most preferred because it involves intensive drying. As long as the coating is sufficient to provide an operable quantity of particles, a greater thickness of the coating is not needed, for example, in the specific case of PCQs, it is only necessary to apply small concentrations of PCQ or a PCQ precursor to the substrate. The advantageous properties of the present invention are they can be observed with reference to the following examples, which illustrate the present invention. EXAMPLE 1 Evaluation of the effectiveness of AQ applied to the straw 5 used in broiler chicken farms In the experiment a total of 3,456 broiler chickens of one day of age were used, from Ross x Hubbard HyY. There were six treatments with eight replicates per treatment and 72 birds per replication. The individual cages were the 10 experimental unit. The experimental treatments used were the following: 1. Negative control = without coccidiostat or antibiotics that promote growth and without straw treatment. 2. Positive control = BioCox (full dose) + BMD + 15 3-Nitro and without straw treatment. 3. BioCox® (full dose) + BMD® + 3-Nitro + 0.5X straw treatment * ® ® 4. BioCox (full dose) + BMD + 3-Nitro + 1. OX straw treatment AQ ** 5. BioCox® (half dose) + BMD® + 3-Nitro + 0.5X of AQ straw treatment 6. BioCox (half dose) + BMD + 3-Nitro + 1. OX from AQ straw treatment. - & á ^ £ 3 * -. ^ ^ g ** ^ * * 0.5X solution of AQ- 1/8 gallon / 44, 000 ft2 ** 1.0X solution of AQ-gallons / 44,000 ft. TABLE 1 Data of 42 days * the values with the same letters are not significantly different. Results and Conclusions The results of this study are established in the Table 1 above. Table 1 shows that the weight gain at 42 days for the positive control improved significantly with respect to the negative control (p <0.05). The weight gain for treatments 3, 4, 5 and 6 improved significantly with respect to control Negative (p <0.05), but was not different from the positive control (p <0.05) at 42 days.

, - ¿¿«S < .- », rtS £ fc - ^. ^. ^. J & fa- The 42-day feed conversion for the positive control significantly improved (p <0.05) with respect to the negative control. Treatments 3, 4, 5 and 6 indicated a significant improvement (p <0.05) of the feeding efficiency with respect to the negative control. Treatments 4 and 6 showed a significant improvement (p <0.05) in the feeding efficiency with respect to the positive control, while treatment 5 showed no improvement with respect to the positive control. Mortality at 42 days for treatments 3 and 6 indicated a significant improvement (p <0.05) compared to the negative control. However, treatments 3, 4, 5 and 6 were not different from the positive control. Based on the data obtained, the AQ applied to the straw at a dose of 1. OX resulted in an improvement in the feeding efficiency both at full dose and at a half dose of coccidiostat in the feed. EXAMPLE 2 Evaluation of the effectiveness of AQ applied to the straw used in broiler chickens In the experiment a total of 6,912 broiler chickens of one day of age were used, from Ross x Hubbard HyY.

There were 12 treatments with 8 replications per treatment and 72 birds per replication. The individual cages were the experimental unit. The experimental treatments used - ^^^^^^^^ & They were as follows:% 1. Negative control -Without coccidiostat or antibiotics growth promoters -Without straw treatment. 2. Without straw treatment -BioCox (half dose) 3. Straw treatment with 4X of AQ -Without feed additives 4. Straw treatment with 4X of AQ -BioCox (half dose) 5. Straw treatment 10. OX AQ-No food additives ® 6. Straw treatment with 4. OX from AQ + BioCox (dose low) + BMD® + 3-Nitro ® 7. Straw treatment with 4. OX from AQ + BioCox (dose low) + BMD® + 3-Nitro ® 8. Treatment of pa with 10X of AQ + BioCox (average dosage) ® ® 9. BioCox positive control (full dose) + BMD + 3- Nitro ® 10. Treatment of straw with 4X of AQ -BioCox (dose complete) + BMD + 3-Nitro 11. Straw treatment with 10X of AQ -BioCox ® (average dose) + BMD® + 3-Nitro 12. Treatment of pa with 10X of AQ -BioCox ® (dose ® complete) + BMD + 3-N? Tro AQ solution 4X - 1 gallon / 44, 000 ft2 = 4.2 ml per 48 ff (one cage) AQ solution 10X - 5 gallons / 44, 000 ft2 = 21 ml TABLE 1 Data of 42 days * values with the same letters are not significantly different TABLE 2 Results of intestinal lesions * the values with the same letters are not significantly different TABLE 3 Data of 42 days Sk tik * ^ », * .. ^ n ^ m ^ ._ £ ___-_ ^ .A ^ ffi ^ * standard weight of 2.0 kg 31.78 grams of weight is equal to 0.01 less KG of feed Results and Conclusions: The weight gain at 42 days for the positive control improved significantly with respect to the negative control (p <0.05). The weight gain for treatment 3 was not different from the negative control. Treatment 5 improved significantly with respect to the negative control, but was significantly lower than the positive control (p <0.05) at 42 days of age. Treatments 2, 4 and 8 showed a significantly better weight gain compared to the negative control, but it was significantly lower than the p ^ ial control (p <0.05). The weight gain at 42 days for "treatments 6, 7 and 11 improved significantly (p <0.05) with respect to the negative control, treatments 6 and 7 were not different with respect to the positive control, but treatment 11 it improved significantly with respect to the positive control (p <0.05) .Treatments 10 and 12 improved significantly with respect to the negative control (p <0.05) but only treatment 12 was significantly better than the positive control for weight gain (p <0.05), while treatment 10 was not different from the positive control (p <0.05). In this dose titration study, it can be concluded that the addition of AQ to straw tends to improve numerically the increase in weight. When the dose of 10X AQ was used for the treatment of the straw and was combined with the diets typically used in birds, the weight gain improved significantly (p <0.05) with respect to the positive control. The feed conversion for the positive control was significantly improved (p <0.05) with respect to the negative control. Treatments 3 and 5 indicated a significant improvement (p <0.05) in feed efficiency with respect to the negative control, but were not different from the positive control. Treatments 2 and 4 were not different from the negative control, while treatment 8 was significantly different (p <0.05) from the negative control, but was not different from the positive control for feed efficiency. Treatments 6 and 7 improved significantly (p <0.05) with respect to the negative control and were not different with respect to the feed efficiency of the positive control. Treatment 11 was significantly better (p <0.05) with respect to positive and negative controls in terms of feed efficiency. Treatments 10 and 12 demonstrated significant improvement (p <0.05) in feed efficiency over the negative control. Treatment 10 was not different with respect to the positive control, while treatment 12 showed a significant improvement (p <0.05) with respect to the positive control. In this dose titration study, it can be concluded that when the 10X dose of AQ is used for the treatment of straw and combined with the diets typically used for birds, the feeding efficiency is significantly improved (p <0.05). with respect to positive control. When using the 10X dose of AQ for the treatment of straw and the diet did not contain coccidiostat or antibiotics as additives, there was a significant difference between this treatment and the negative control (p <0.05) and there were no differences with regarding positive control. The results of intestinal lesions at day 14 show no statistical differences between the positive and negative control (p <0.05), which indicates that the challenge in the cages was not severe enough to cause injuries in non-medicated birds. Treatment 4 indicated a significant improvement (p <0.05) in the results of injuries when compared with the positive and negative controls. Treatment 8, although it was not statistically significant (p <0.05) with respect to the positive and negative controls, was biologically significant with respect to the negative control. This means that the difference in injury results was greater than 1 unit (range of ratings from 0 to 4). Treatments 7 and 11 showed a significant improvement (p <0.05) with respect to the negative control, but were equal to the positive control. Treatment 6 was not different from positive or negative control (p <0.05). Treatments 10 and 12 were significantly different from positive and negative controls (p < 0.05). Based on the data from day 14, it can be concluded that when a dose of 10X or 4X of AQ is used for the treatment of straw and combined with the diets typically used for birds, the results of intestinal coccidia improve significantly (p <0.05) with respect to controls positive and negative. When the feeding efficiency is adjusted for the weight, the adjusted feeding efficiency shows an improvement with respect to the negative control for each treatment (Table 3). No statistics could be made regarding the adjusted feed efficiency. It is noted that in relation to this date, the best method known by the applicant to bring to practice the aforementioned invention, is the conventional one for the manufacture of the objects to which it refers.

Claims (12)

1. CLAIMS Having described the invention as an antecedent, the content of the following claims is claimed as property: 1. A composition characterized in that it comprises a substrate in a poultry farm and a polycyclic quinone compound, characterized in that the substrate comprises the floor, walls or the straw 2. The composition according to claim 1, characterized in that the polycyclic quinone compound is applied as a coating on the surface of the substrate. 3. The composition according to claim 1, characterized in that the polycyclic quinone compound further comprises an anthraquinone compound. 4. A method for improving bird health, characterized in that it comprises applying an effective amount of a polycyclic quinone compound to a substrate, wherein the substrate comprises the floor, walls or straw. 5. The method according to claim 4, characterized in that the polycyclic quinone compound comprises an anthraquinone compound. 6. The method according to claim 4, It is characterized because the effective amount of the polycyclic quinone compound varies from 0.04 liters / 1000 square meters to 400 L / 1000. square meter. 7. A method for improving weight-adjusted feeding efficiency in poultry, characterized in that it comprises applying an effective amount of a polycyclic quinone compound to a substrate, wherein the substrate comprises the floor, walls or straw. 8. The method according to claim 7, characterized in that the polycyclic quinone compound comprises an anthraquinone compound. The method according to claim 7, characterized in that the effective amount of the polycyclic quinone compound varies from 0.04 liters / 1000 meters 15 squares at 400 L / 1000 square meters. 10. A method for reducing and preventing the ingestion of a substrate by birds, characterized in that it comprises applying an effective amount of a polycyclic quinone compound to a substrate, wherein the substrate comprises 20 the floor, walls or straw. The method according to claim 10, characterized in that the polycyclic quinone compound comprises an anthraquinone compound. 12. The method according to claim 25, characterized in that the effective amount of the compound of polycyclic quinone varies from 0.04 liters / 1000 square meters to 400 L / 1000 square meters. Í ^^ É¡ | g¡ ^ ?? ^^? ^ S ^ ¡¡