MXPA00011984A - Anti-germ attachment - composition - Google Patents
Anti-germ attachment - compositionInfo
- Publication number
- MXPA00011984A MXPA00011984A MXPA/A/2000/011984A MXPA00011984A MXPA00011984A MX PA00011984 A MXPA00011984 A MX PA00011984A MX PA00011984 A MXPA00011984 A MX PA00011984A MX PA00011984 A MXPA00011984 A MX PA00011984A
- Authority
- MX
- Mexico
- Prior art keywords
- skin
- composition
- germs
- attachment
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 92
- 210000003491 Skin Anatomy 0.000 claims abstract description 73
- 239000004094 surface-active agent Substances 0.000 claims abstract description 38
- 244000052616 bacterial pathogens Species 0.000 claims abstract description 34
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 12
- 125000002091 cationic group Chemical group 0.000 claims description 37
- 229920000642 polymer Polymers 0.000 claims description 31
- 229920001296 polysiloxane Polymers 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 14
- 201000004681 psoriasis Diseases 0.000 claims description 5
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 206010061598 Immunodeficiency Diseases 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000000844 anti-bacterial Effects 0.000 claims description 2
- -1 alkyl sulfosuccinates Chemical class 0.000 description 51
- 239000000344 soap Substances 0.000 description 33
- 235000019271 petrolatum Nutrition 0.000 description 21
- 125000004432 carbon atoms Chemical group C* 0.000 description 20
- 241000894006 Bacteria Species 0.000 description 19
- 239000004264 Petrolatum Substances 0.000 description 18
- 229940066842 Petrolatum Drugs 0.000 description 18
- IAYPIBMASNFSPL-UHFFFAOYSA-N oxane Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 18
- 125000000217 alkyl group Chemical group 0.000 description 17
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 16
- 229920001577 copolymer Polymers 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 10
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- GOOHAUXETOMSMM-UHFFFAOYSA-N propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 6
- FZTWZIMSKAGPSB-UHFFFAOYSA-N phosphide(3-) Chemical group [P-3] FZTWZIMSKAGPSB-UHFFFAOYSA-N 0.000 description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 6
- 125000005373 siloxane group Chemical group [SiH2](O*)* 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 6
- 239000001993 wax Substances 0.000 description 6
- CWSZBVAUYPTXTG-UHFFFAOYSA-N 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol Chemical compound O1C(CO)C(OC)C(O)C(O)C1OCC1C(OC2C(C(O)C(OC)C(CO)O2)OCCO)C(O)C(O)C(OC2C(OC(C)C(O)C2O)CO)O1 CWSZBVAUYPTXTG-UHFFFAOYSA-N 0.000 description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 5
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 150000004676 glycans Polymers 0.000 description 5
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- 239000005017 polysaccharide Substances 0.000 description 5
- 150000004804 polysaccharides Polymers 0.000 description 5
- 235000000346 sugar Nutrition 0.000 description 5
- VAYGXNSJCAHWJZ-UHFFFAOYSA-N Dimethyl sulfate Chemical compound COS(=O)(=O)OC VAYGXNSJCAHWJZ-UHFFFAOYSA-N 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 4
- BJHIKXHVCXFQLS-UYFOZJQFSA-N Fructose Natural products OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 4
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 4
- SRBFZHDQGSBBOR-SQOUGZDYSA-N Xylose Natural products O[C@@H]1CO[C@@H](O)[C@@H](O)[C@@H]1O SRBFZHDQGSBBOR-SQOUGZDYSA-N 0.000 description 4
- 230000001580 bacterial Effects 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 239000007795 chemical reaction product Substances 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 4
- GQOKIYDTHHZSCJ-UHFFFAOYSA-M dimethyl-bis(prop-2-enyl)azanium;chloride Chemical compound [Cl-].C=CC[N+](C)(C)CC=C GQOKIYDTHHZSCJ-UHFFFAOYSA-M 0.000 description 4
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 230000002209 hydrophobic Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 3
- 229940096386 Coconut Alcohol Drugs 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Natural products OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 150000001412 amines Chemical class 0.000 description 3
- 125000004429 atoms Chemical group 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 239000003093 cationic surfactant Substances 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- NJRWNWYFPOFDFN-UHFFFAOYSA-L phosphonate(2-) Chemical compound [O-][P]([O-])=O NJRWNWYFPOFDFN-UHFFFAOYSA-L 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000008247 solid mixture Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 150000008163 sugars Chemical class 0.000 description 3
- 239000001974 tryptic soy broth Substances 0.000 description 3
- 108010050327 trypticase-soy broth Proteins 0.000 description 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N 1,2-ethanediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 2
- URZHQOCYXDNFGN-UHFFFAOYSA-N 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane Chemical compound FC(F)(F)CC[Si]1(C)O[Si](C)(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O1 URZHQOCYXDNFGN-UHFFFAOYSA-N 0.000 description 2
- HNJBEVLQSNELDL-UHFFFAOYSA-N 2-Pyrrolidone Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N Bromomethane Chemical compound BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- 240000005497 Cyamopsis tetragonoloba Species 0.000 description 2
- GZCGUPFRVQAUEE-KCDKBNATSA-N D-(+)-Galactose Natural products OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-KCDKBNATSA-N 0.000 description 2
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 2
- DENRZWYUOJLTMF-UHFFFAOYSA-N Diethyl sulfate Chemical compound CCOS(=O)(=O)OCC DENRZWYUOJLTMF-UHFFFAOYSA-N 0.000 description 2
- 210000002615 Epidermis Anatomy 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 2
- SHZGCJCMOBCMKK-DHVFOXMCSA-N Fucose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 2
- 229940097043 Glucuronic Acid Drugs 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- BKIMMITUMNQMOS-UHFFFAOYSA-N Nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N Simethicone Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 241001135917 Vitellaria paradoxa Species 0.000 description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 2
- 229960003487 Xylose Drugs 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 125000005466 alkylenyl group Chemical group 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
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- 230000000875 corresponding Effects 0.000 description 2
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- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
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- ROSDSFDQCJNGOL-UHFFFAOYSA-O dimethylaminium Chemical compound C[NH2+]C ROSDSFDQCJNGOL-UHFFFAOYSA-O 0.000 description 2
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- 150000004820 halides Chemical class 0.000 description 2
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- 125000002768 hydroxyalkyl group Chemical group 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
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- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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- 125000004437 phosphorous atoms Chemical group 0.000 description 2
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
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- 159000000001 potassium salts Chemical class 0.000 description 2
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- 150000003839 salts Chemical class 0.000 description 2
- 229940079776 sodium cocoyl isethionate Drugs 0.000 description 2
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- AEMOLEFTQBMNLQ-QIUUJYRFSA-N β-D-glucuronic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 description 2
- OMDQUFIYNPYJFM-XKDAHURESA-N (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[[(2R,3S,4R,5S,6R)-4,5,6-trihydroxy-3-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 1
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- MNLXVEGUYZHTJQ-UHFFFAOYSA-N 1-[ethyl(methyl)phosphoryl]tetradecane Chemical compound CCCCCCCCCCCCCCP(C)(=O)CC MNLXVEGUYZHTJQ-UHFFFAOYSA-N 0.000 description 1
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- CLWAXFZCVYJLLM-UHFFFAOYSA-N 1-chlorohexadecane Chemical compound CCCCCCCCCCCCCCCCCl CLWAXFZCVYJLLM-UHFFFAOYSA-N 0.000 description 1
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- VUHVIYBUEGOBMT-UHFFFAOYSA-N Dimethyl dialkyl ammonium chloride Chemical compound CCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCC VUHVIYBUEGOBMT-UHFFFAOYSA-N 0.000 description 1
- NUZWLKWWNNJHPT-UHFFFAOYSA-N Dithranol Chemical compound C1C2=CC=CC(O)=C2C(=O)C2=C1C=CC=C2O NUZWLKWWNNJHPT-UHFFFAOYSA-N 0.000 description 1
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Abstract
A method for inhibiting attachment of germs to the skin which comprises applying to the skin a compositon comprising:(a) a skin cleansing effective amount of a surfactant or mixture of surfactants;(b) a hydrocarbonaceous component in amounts effective to inhibit attachment of germs to the skin and rinsing said composition from the skin.
Description
COMPOSITION AGAINST THE UNION OF GERMS
Background of the Invention
The basic skin cleansing compositions have been examined for a long time by the personal care industry. The consuming population is looking for an additional benefit beyond the basic skin cleanliness which now includes germs as well as the removal of dirt. Recently, an intensified approach has been directed at spreading germs by touching various objects in public use such as an ATM machine, public telephones, public restrooms, the gym and the like. New compositions which fight with germs have recently been commercialized. However, many of these products use high amounts of alcohol to achieve the removal of germs from the skin. These products are aimed at eliminating pre-existing germs present on the skin before treatment. Therefore, there is a need to obtain a longer lasting "antigérmen" effect with a cleaning composition normally employed as a rinse product which inhibits further attachment of the germs to the skin after the rinsing process
Such a product should not be restricted to have an activity against only one or a small number of
germs which may be present on the skin. This should be easily applicable to a large number of germs, regardless of their gram-positive or gram-negative nature or any type of classification system under which they may be cataloged. A few compositions with active agents seem to work by stopping the binding of specific germs to the skin. However, compositions containing these agents are described as being germ-specific to only one or a small number of germs.
It has now been discovered that a relatively simple rinsing skin cleaning composition has the ability to inhibit the attachment of germs to the skin for a significant period of time after rinsing the skin. A broad spectrum of germs can be inhibited. In this way a standard rinse skin cleansing composition provides a desired benefit to the population that washes the skin every day. Additionally, it can provide a significant benefit to those individuals whose skin is in a particular need to have diminished levels of germs on it, for example, those individuals suffering from atopic dermatitis, psoriasis, conditions and immunodeficiency and the like.
An additional advantage of the composition is that the germs which are present may be
easily removed from the skin by rinsing with water after skin treatment with the composition of the invention. This occurs for a period of time after the initial rinsing of the composition has occurred.
Synthesis of the Invention
According to the invention, there is a method for inhibiting the attachment of germs to the skin which comprises applying to the skin a composition comprising:
(a) an effective skin cleansing amount of a surfactant or mixture of surfactants,
(b) a hydrocarbonaceous component in amounts effective to inhibit the attachment of the germs to the skin,
and rinsing said skin composition.
A further aspect of the invention is the composition having as an additional component a cationic material, preferably a cationic polymer.
Additionally, a composition which achieves the purpose of inhibiting the subjection of germs is the composition of (a) and (b) given above.
Still further, there is the use of a composition comprising:
(a) an effective skin cleansing amount of a surfactant or a mixture of surfactants,
(b) a hydrocarbonaceous component in effective amounts to inhibit the attachment of germs to the skin,
in the preparation of a skin cleansing material which inhibits the attachment of germs to the skin.
Composition can work its effects in many realistic situations. This can reduce the spread of germs from inanimate objects, for example door knobs, telephones, water faucets and the like as well as through skin contact to the hand, for example the greeting with the hands. In summary, the transmission of germs to the skin can be reduced by the prior contact of the skin with the composition of this invention.
Detailed description of the invention
The term "germ" is used in the description and specifications of this invention, meaning bacteria and viruses, particularly bacteria. Examples of bacteria
which are inhibited from attachment to the skin include Staphylococcus aureus, Staphylococcus epidermis, Cornebacterium mmutissium, Escherichia coli, Salmonella, Coleraesu and Marcescens serratia. Examples of viruses include human pnovirus and human rotovirus.
The surfactants which can be used in the composition include the following families: ammonic, amphoteric, non-ionic and cationic, alone or in combination. The soap, a branched or normal carboxylic acid salt of long chain alkyl or alkenyl such as sodium, potassium, ammonium or substituted ammonium salt, may be present in the composition. Examples of the long chain alkyl or alkenyl are from about 8 to about 2 carbon atoms in length, specifically from about 10 to about 0 carbon atoms in length more specifically alkyl and more specifically normal, or normal with a little ramification. Small amounts of olefinic bonds may be present in the alkyl sections predominantly, particularly if the source of the "alkyl" group is obtained from natural products such as tallow, coconut oil and the like.
Examples of ammonium surfactants other than soap include but are not limited to alkyl sulfates, acyl sarcosinates ammonium, methyl acyl
taurates, N-acyl glutamates, acyl-isethionates, alkyl sulfosuccinates, alkyl phosphate esters, ethoxylated alkyl phosphate esters, tpdeceth sulfates, protein condensates, mixtures of ethoxylated alkyl sulfates and the like.
The alkyl chains for these surfactants are CB-C22, preferably C10-Cl8, more preferably C12-C14. The non-soap ammonium surfactants can be exemplified by the alkali metal salts of organic sulphate having in their molecular structure an alkyl radical containing from about 8 to about carbon atoms and a sulfuric acid ester radical or sulphonic acid (in the term "alkyl" is the alkyl part of higher acyl radicals) Sodium alkyl, ammonium, potassium or tpetanolamine sulfates are preferred, especially those obtained by sulfatar higher alcohols (C8-C1S carbon atoms) ), monoglyceride sulfates and sulphonates of fatty acid from coconut oil; the sodium or potassium salts of sulfuric acid esters of the reaction product of one mole of a higher fatty alcohol (for example tallow or coconut oil alcohols) and 1 to 12 moles of ethylene oxide; sodium or potassium salts of alkyl phenol ethylene oxide ether sulfate with 1 to 10 ethylene oxide units per molecule and in which the alkyl radicals contain from 8 to 12 carbon atoms, glyceryl alkyl sodium sulfonates; the product
of reaction of any fatty acids having from 10 to 22 carbon atoms esterified with ischemic acid and neutralized with sodium hydroxide; water-soluble salts of condensation products of fatty acids with sarcosm; and others known in the art.
Subamate surfactants can be exemplified by those which can be broadly described as derivatives of aliphatic quaternary ammonium compounds, phosphome and sulfonam, and which aliphatic radicals can be straight or branched chain and wherein one of the aliphatic substituents contains from 8 to 18 carbon atoms and one contains a water-to-ion-solubilizing group, for example sulphate, carboxyl, sulfonate, phosphate or phosphonate. A general formula for these compounds is:
(R3 >, I -CH, - R4
wherein R2 contains an alkyl, alkenyl or hydroxyalkyl radical of from about 8 to about 18 carbon atoms, from 0 to about 10 halides of ethylene oxide and from 0 to 1 glyceole halves; Y is selected from the group consisting of nitrogen, phosphorus and sulfur atoms, R3 is an alkyl or monohydroxyalkyl group containing from 1 to about 3 carbon atoms; X is 1 when Y is an atom
of sulfide and 2 when Y is a nitrogen or a phosphorus atom, R4 is an alkylene or hydroxyalkylene of from 0 to about 4 carbon atoms and Z is a radical selected from the group consisting of carboxylate, sulfonate, sulfate, phosphonate and phosphate groups.
Examples include 4- [N, N-d? (2-hydroxyl) -N-octadecylammonium] -butane-1-carboxylate; 5- [S-3-hydroxy? Propyl-S-hexadecylsulfonium] -3-hydroxypentane-1-sulfate; 3- [P, P-P-diethyl-P 3,6,9-tpoxatetradecyl-phosphome] -2-hydrox propane-1-phosphate; 3- [N, N-d? Prop? Lo-N-3 dodecox? - -h? Drox? Prop? Lamomo] -propane-1-phosphonate; 3- (N, N-d? -met? Lo-N-hexadec? Lamomo) propane-1-sulfonate; 3- (N, Nd? -met? Lo-N-hexadec? Lamon? O-2-h? Drox? Propane-l-sulfonate; 4 - (N, -di (-hydroxyethyl) -N- (2-hydroxydecyl) ) ammonium] -butane-1-carboxylate; 3- [S-ethyl-S- (3 -dodecox? -2 -hydroxypropyl) sulfone] -propane-1-phosphonate; 3- (P, P-dimetolo-P) -dodecylphosphonium) -propane-1-phosphonate; and 5- [N, Nd? (3-hydroxypropyl) -N-hexadecylammonium] -2-hydroxy-pentane-1-sulfate.
Examples of the amphoteric surfactants which can be used in the compositions of the present invention are those which are broadly described as derivatives of aliphatic secondary and tertiary amines in which the aliphatic radical can be straight or branched chain and wherein one of the aliphatic substituents contains from about 8 to about 18 atoms
carbon and one contains a solubilizing group in ammonium water, for example, carboxy, sulfonate, sulfate, phosphate or phosphonate. Examples of the compounds falling within this definition are sodium 3-dodecyl-nopropionate, sodium 3-dodecylammonpropane sulfonate, N-alkyl taurines, such as those prepared by reacting dodecylamine with sodium ioethionate according to the teachings of U.S. Patent No. 2,658,072, N-higher alkyl aspartic acids such as those produced in accordance with the teachings of U.S. Patent No. 2,438,091 and the U.S. Patent United of America No. 2,528,378. Other amphoteric such as betaines are also useful in the present composition.
Examples of the betaines useful herein include the higher alkyl betamas such as cocodimethyl carboxymethyl betama, lauryl dimethyl carboxymethyl betaine, laupl dimethyl alpha-carboxyethyl betaine, cetyl dimethyl carboxymethyl betama, lauryl bis- (2-hydroxyl) et? carboxymethyl betaine, stearyl bis- (2-hydroxypropyl) carboxymethyl betaine, oleyl dimethyl gamma-carboxypropyl betama, laupl bis- (2-hydroxypropyl) alpha-carboxyethyl betamas, and so on. The sulfobetaines may be represented by cocodimethyl sulphopropyl betama, stearate dimethyl sulfopropyl betama, amidobetams, amidosulfobetams, and the like.
Many cationic surfactants are known in the art. By way of example, the following may be mentioned:
stearyldimethyl benzylammonium chloride, - dodecylphenyl ammonium chloride; nonylbenzyl ethyl dimethylamine nitrate or; tetradecylpyridimium bromide; pyridium laupl chloride; cetyl chloride pipdimo; - lauryl pyridium chloride or; isoquinolium laupl bromide; dikebo chloride (hydrogenated) dimethylammonium; dilaupl dimethylammonium chloride; and stearalco or chloride.
Additional cationic surfactants are described in U.S. Patent No. 4,303,543 see column 4, lines 58 and column 5, lines 1-42, incorporated herein by reference. Also see the CTFA Cosmetic Ingredient Dictionary, 4a. 1991 edition, pages 509-514 for various long chain alkyl cationic surfactants incorporated herein by reference.
Nonionic surfactants can be broadly defined as compounds produced by the condensation of alkylene oxide groups (hydrophilic in nature) with a
hydrophobic organic compound, which can be aliphatic or aromatic alkyl in nature. Examples of the preferred classes of non-ionic surfactants are:
1. The polyethylene oxide condensates of alkyl phenols, for example, the condensation products of alkyl phenols having an alkyl group containing from about 6 to 12 carbon atoms in either a straight chain or branched chain configuration , with ethylene oxide, said ethylene oxide being present in amounts equal to 10 to 60 moles of ethylene oxide per mole of alkyl phenol. The alkyl substituent in such compounds may be derivative of polyepped propylene, dusobutylene, octane, or nonane, for example.
2. Those derived from the condensation of ethylene oxide with the product resulting from the reaction of propylene oxide and ethylene diamine products which can be varied in the composition depending on the balance between the hydrophobic and hydrophilic elements which are desired. For example compounds containing from about 40% to about 80% polyoxyethylene by weight and having a molecular weight of from about 5,000 to about 11,000 resulting from the reaction of the ethylene oxide groups with a base hydrophobic constituted by the reaction product of
Ethylene diamine and excess propylene oxide, said base has a molecular weight in the order of 2,500 to 3,000 are satisfactory.
The reaction product of aliphatic alcohols having from 8 to 18 carbon atoms in any straight or branched chain configuration with ethylene oxide, for example, a condensate of ethylene oxide of coconut alcohol having from 10 to 30 moles of ethylene oxide per mole of coconut alcohol, the coconut alcohol fraction has from 10 to 14 carbon atoms. The reaction products of ethylene oxide are ethoxylated fatty acid esters of polyhydric alcohols (for example Tween 20-poly? Ox? Et? Leno (20) sorbitan monolaurate).
Long chain tertiary amine oxides corresponding to the following general formula:
R1R2R3N- > 0
where R? it contains an alkyl, alkenyl or monohydroxyalkyl radical of from about 8 to about 18 carbon atoms, from 0 to about 10 halides of ethylene oxide, and from 0 to 1 glycerin halves, and, R2 and R3 contain from 1 to around 3 atoms of
carbon and from 0 to about 1 hydroxyl group, for example, methyl, ethyl, propyl, hydroxyethyl, or hydroxypropyl radicals, the arrow in the formula is a conventional representation of a semi-polar bond. Examples of amine oxides suitable for use in this invention include dimethyl dodecylamine oxide, oleyl di- (2-hydroxyl) amine oxide, dimethyl octylame oxide, dimethyl decilamme oxide, dimethyl tetradecylamine oxide , 3,6,9 tpoxaheptadecildietilamma, di (2-hydroxyl) oxide, tetradecylamine oxide, 2-dodecoxethanol, dimethyllamine, 3-dodecoxy-2-hydroxypropyl di (3-hydroxypropyl) oxide of amine, dimethyl hexadecylamine oxide.
Long chain tertiary phosphide oxides corresponding to the following general formula:
RR'R "P-> 0
wherein R contains an alkyl, alkenyl or monohydroxyalkyl radical ranging from 8 to 20 carbon atoms in chain length, from 0 to about 10 ethylene oxide halves and from 0 to 1 glyceolus halves, and R 'and R "are each alkyl or monohydroxyalkyl groups containing from 1 to 3 carbon atoms.The arrow in the formula is a representation
conventional of a semi-polar link. Examples of suitable phosphine oxides are: dodecyl dimethyl phosphine oxide, tetradecyl methyl ethyl phosphine oxide, 3,6,9-trioacetyl dimethyl phosphine oxide, cetyl dimethyl phosphine oxide, 3-dodecox-2-hydroxyl propylene di (2-hydroxyl) phosphine oxide, stearate oxide dimethyl phosphine, cetyl ethyl propyl phosphine oxide, oleyl dimethyl phosphide oxide, dodecyl diethyl phosphide oxide, tetradecyl diethyl phosphide oxide, dodecyl dipropyl phosphide oxide, dodecyl di (hydroxymethyl) phosphide oxide, dodecyl oxide (2-h) drox? et? lo) phosphine, tetradecyl methyl-2-hydroxyl? propylene oxide, oleyl dimethylphosphine oxide, hydroxyl dodecyl dimethyl phosphine oxide.
Long chain dialkyl sulfoxide, a short chain alkyl or a hydroxyalkyl radical of from 1 to about 3 carbon atoms (usually methyl, and a long hydrophobic chain which contains alkyl, alkenyl, hydroxyalkyl or ketoalkyl radicals; from about 8 to about 20 carbon atoms, from about 0 to about 10 miads of ethylene oxide, and from 0 to 1 half of glycepal Examples include: octadecyl methyl sulfoxide, 2-cetotpdec sulfoxide methyl, 3, 6, 9-tpoxaoctadec? l 2-h? drox? et? l sulfoxide, dodecyl methyl sulfoxide, oleyl sulfoxide 3-hydroxypropyl, tetradecyl sulphoxide methyl, sulfoxide 3-
methyl methoxitpdecyl, 3-h? drox? tdec? l methyl sulfoxide, 3- h? drox? -4-dodecox? Butyl Methyl Sulfoxide
7. Alkylated polyglycosides wherein the alkyl group is from about 8 to about 20 carbon atoms, preferably from about 10 to about 18 carbon atoms and the degree of polymerization of the glycoside is from about 1 to about 3, preferably from about 1.3 to about 2.0.
Component B can typically be a hydrocarbonaceous material such as wax, petrolatum, mineral oil, beeswax or a "permethyl" made of longer chain branched hydrocarbons available from Permethyl Corporation. The permethyl are of the general formula:
CH, CH3 CH3 (- C-CH2-) n CH- CH3 I
CH,
where n can vary from about 4 to about 200. Products they were n = 4, 16, 38, 214 respectively and are marketed as Permethyl 102A, 104A, 106A and 1082a.
Additional hydrocarbonaceous materials include lanolins, lanoleic materials, coconut butter,
Shea butter and long chain alkyl esters and lanolin ethers.
The petrolatum useful in the present invention can be any kind of white or yellow petrolatum recognized in the art as being suitable for human application. The preferred petrolatum is that a melting point in a range of from about 35 ° C to about 70 ° C, more preferably from about 50 to about 60 ° C. The petrolatum of the composition may include mixtures of hydrocarbon formulated with mineral oil and / or in combination with waxes of paraffins of various melting points; all in small amounts compared to petrolatum. A petrolatum without additional materials is preferred. Examples of the waxes, particularly useful in the solid compositions are the microcrystalline waxes, generally those waxes which are known as paraffin wax, beeswax, natural waxes derived from plants, shea wax and the like.
Although not essential, the presence of the cationic polymer in the composition is preferred.
Cationic polymers include, but are not limited to the following groups:
(i) cationic polysaccharides;
(n) cationic copolymers of sacapdos and synthetic cationic monomers, and (m) synthetic polymers selected from the group consisting of:
to. polyalkylene imam catiómcas b. Ethoxypolyalkylenes catioes c. poly [N- (3- (dimethylammonium) propyl] N '[3- (ethyleneoxyethylene dimethylamine or) propyl] urea dichloride] d) in general a polymer having a quaternary ammonium or substituted ammonium ion.
The class of cationic polysaccharide covers those polymers based on sugars of 5 or 6 carbons and derivatives which have been made cationic by grafting cationic moieties on the polysaccharide column. These may be composed of one type of sugar or more than one type. For example copolymers of the aforementioned derivatives and cationic materials. The monomers may be in straight chain or branched chain geometrical arrangements. Cationic polysaccharide polymers include the following: cationic celluloses and hydroxyethyl celluloses; cationic starches and hydroxyalkyl starches; cationic polymers based on arabinose monomers such as those which
they can be derived from arabmosa vegetable gums; cationic polymers derived from xylose polymers found in materials such as wood, pa, cottonseed husks and corn cobs, cationic polymers derived from fucose polymers found as a component of cell walls in algae; cationic polymers derived from fructose polymers such as Inulin found in certain plants; cationic polymers based on sugars containing acid such as galacturonic acid and glucuronic acid, the cationic polymers based on amine sugars such as galactosamm and glucosamm; cationic polymers based on polyalcohols of 5 and 6 membered rings; cationic polymers based on galactose monomers which occur in plant gums and mucilages; cationic polymers based on mannose monomers such as those found in plants, yeasts, and red algae, cationic polymers based on galactomannan copolymer known as guar gum obtained from the guar bean endosperm.
Specific examples of the members of the cationic polysaccharide class include the cationic hydroxyethylcellulose JR 400 made by Union Carbide Corporation; Stalo ® 100, 200, 300 and 400 cationic starches made by
Staley, Inc .; cationic galactomanans based on guar gum from the Galactasol 800 series from Henkel, Inc., and the series
Jaguar from Celanese Corporation.
The cationic copolymers of saccharides and synthetic cationic monomers useful in the present invention encompass those containing the following sacapdas: glucose, galactose, mannose, arabmosa, xylose, fucose, fructose, glucosamine, galactosamine, glucuronic acid, galacturomic acid and ring polyalcohols. or 6 members. Also included are the hydroxymethyl, hydroxyethyl and hydroxypropyl derivatives of the sugars mentioned above. When the saccharides are joined to each other in the copolymers, they can be joined through any of vain arrangements such as 1,4-OÍ; 1,4-ß; l, 3cx; 1,315 and 1,6 links. Synthetic cationic monomers for use in these copolymers may include dimethyl diallyl ammonium chloride, dimethylamino ethyl methacrylate, diethyl diallyl ammonium chloride, N, N-d? Al?, N-N-dialkyl ammonium halides, and the like. A preferred cationic polymer is polyquaternium 7 prepared with dimethyl dialkylammonium chloride and acplamide monomers.
Still further examples of the cationic polymers include polymethylated materials such as quaternary ammonium salts, copolymers of various materials such as hydroxyethyl cellulose, and dialkyldimethylamino chloride, acpramide and betamethacploxy ethyl trimethylamine methosulfate, the methyl quaternary ammonium salt and Stearate dimethyl ammoethyl methacrylate quaternized with dimethyl sulfate, quaternary ammonium polymer formed
by the reaction of diethyl sulfate, a copolymer of viml pyrrolidone and dimethyl aminoethyl methacrylate, quaternized gums and guar gums and the like. Examples of the cationic polymers which can be used to make the complexes of this invention include those described in the CTDFA International Cosmetic Ingredient Dictionary (4th Edition 1991, pages 461-464); pol? quatermum-1, 2, 2-4 (a copolymer of hydroxyethyl cellulose and of diallyldimethyl ammonium chloride) -5 (the copolymer of acplamide and betamethacploxyethyl triemethylammonium methosulfate) -6 (a polymer of dimethyl diallylammonium chloride) -7 (the polymeric quaternary ammonium salt of ammonium diallyl dimethyl diacrylamide monomer, -8 (the polymeric 5-methyl quaternary ammonium salt and dimethyl ammoethyl dimethyl ammoethyl ester quaternized with dimethyl sulfate), -9 (the polydimethyl polymer quaternary ammonium salt aminoethyl methacrylate quaternized with methyl bromide) -10 (a polimépca quaternary ammonium salt of hydroxyethyl cellulose reacted with an epoxide-substituted methylmethoxamine), -11 (a quaternary ammonium polymer formed by the reaction of diethyl sulfate and a copolymer of viml pyrrolidone and dimethylaminoethyl methacrylate) -12 (a polymeric quaternary ammonium salt prepared by the reaction of ethyl meta-platelet / to diethyl meta-platelet / diethyl ammoethyl methacrylate copolymer with dimethyl sulfate), -13 (a polymeric quaternary ammonium salt prepared by the reaction of ethyl meta-platelet / oleyl metaclate / diethyl ether copolymer
ammoethyl methacrylate with dimethyl sulfate), -14, -15 (the copolymer of acplamide and betamethacryloxyethyl t-methylammonium chloride), -16 (a polymeric quaternary ammonium salt formed of methyl vinyl imidazolinium chloride and vinyl pyrrolidone, -17, -18 , -19 (a polymeric quaternary ammonium salt prepared by the reaction of polyvinyl alcohol with 2, 3-epox? -prop? Lam? Na), -20 (the polymeric quaternary ammonium salt prepared by the reaction of polyvinyl octadecyl ether with 2,3-epox? Propylamma), -22-24 a polymeric quaternary ammonium salt of hydroxyethyl cellulose reacted with laupl dimethylamine or substituted epoxide), -27 (the block copolymer formed by the reaction of Pol? Quatern? Um- ( qv) with Pol? quatern? um-17 (qv)) -28, - 9 (it is chitosan (qv) which has been reacted with propylene oxide and quaternized with hepichlorohydrin) and -30.
An additional component which may be present and which does not need to be present at all is a silicone. The silicone as used herein is preferably a silicone fluid as opposed to a silicone rubber. A silicone fluid is defined herein as silicone with viscosities ranging from about 5 to about 600,000 centistokes, more preferably from about 350 to about 100,000 centistokes at 25 ° C. Polyalkyl siloxanes such as polydimethyl siloxanes generally
known as "dimethicones" are preferred for use as silicone.
The silicone materials useful in the present invention are generally non-volatile and can be either a polyalkyl siloxane, a polyaryl siloxane, a polyalkylaryl, a functionalized siloxamelated, a polysiloxane such as a polysiloxane with an ammo functional substitution, an alkoxylated silicone, such as ethoxylated or propoxylated and a polyether siloxane copolymer. The silicones useful in the present invention can be capped with any number of moieties including, for example, methyl, hydroxyethyl, ethylene oxide, propylene oxide, amino, trialkyl silane (preferably methyl) carboxyl, and the like. Mixtures of these materials can also be used and are preferred in certain implementations. Additionally, the volatile silicones can be used as part of the silicone mixture as long as the final mixture is at least essentially non-volatile.
Polyalkyl silicones that can be used herein include for example polydimethyl siloxanes with viscosities ranging from about 5 to about 600,000 centistokes at 25 ° C. These siloxanes are available, for example, from General Electric Company as the Viscasil series and from Dow Corning as the Dow Corning 200 series. The viscosity
can be measured by means of a glass capillary viscometer as set forth in Dow Corning Corporate Test Method CTM0004, July 20, 1970. Preferably the viscosities range from about 50 centistokes to about 150,000 centistokes and more preferably from about 350 centistokes to about 100,000 centistokes.
The polyalkylploy silicones that can be used include, for example, the polymethyl p-siloxanes having viscosities of from about 15 to about 65 centistokes at 25 ° C. These siloxanes are available, for example from General Electric Company as SF 1075 methyl phenyl fluid or from Dow Corning as cosmetic class fluid 556. Additionally, the poly (dimethylsiloxane) copolymers (difl siloxane) having a viscosity in the range of Around 10 to about 100,000 centistokes at 25 ° C are useful. The polyether siloxane copolymer which can be used is for example a dimethyl polysiloxane modified with propylene oxide (for example Dow Corning DC-1248 even though ethylene oxide or mixtures of ethylene oxide and propylene oxide can also be used .
References describing suitable silicones include U.S. Patent Nos. 2,826,551 issued March 11, 1958; Green; Patent of the United States of America No. 3,964,500 granted on June 22
from 1967 to Drakoff; 4,364,837 granted on December 21, 1982 to Pader and British patent No. 849,433 issued to Wooston and published on September 28, 1960. All of these patents are incorporated herein by reference. Also incorporated herein by reference are silicone compounds distributed by Petrarch Systems, Inc., 1984. This reference provides a good listing of a suitable silicone material.
Other components may also be present in the composition. These components include preservatives, dyes, ultraviolet stabilizers, fragrances, antibacterial agents and the like. Antibacterial agents include chlorhexidine, tpclosan, trichlorocarban and the like at their typically used concentration, for example from about 0.1 to about 15% by weight, preferably about 100% by weight.
0. 15 to about 1.2% by weight of the composition. When present in the compositions of the invention there is a dual effect.
Not only is there an inhibition of the germ attachment after cleaning the skin, but also the antibacterial effect of the antibacterial agents on the bacteria present on the skin during the cleansing of the skin.
The preferred surfactant is an ammonium surfactant such as soap, such as alkyl-isethionate such as sodium cocoyl-isethionate, a sulfonate, a sulfate (optionally ethoxylated) and the like. Mixtures of
surfactants There may be enough surfactant present to bring a cleansing effect. The preferably ammonium surfactant or mixtures thereof involves one or more of the other families of illustrated surfactants (amphoteric, nonionic and the like) with or without an additional ammonium surfactant, which may be present in the composition in various amounts. For example, broad minima of the surfactant can be present in 1, 2, 3, 4, 5, 10, 15 or 20% by weight of the compositions, particularly where the aqueous composition is a liquid. With respect to the liquid, the aqueous compositions, the ammonium surfactant is from about 2 to about 25% by weight of the composition, specifically about 5 to about 20% by weight. Other surfactants may be present such as an amphoteric, particularly a betama and a nonionic, particularly an alkylated polyglycoside. Their amounts are from about 1 to about 20% by weight of the compositions. Generally the total surfactant in a liquid composition is at least about 3 or 4% by weight, preferably at least about 5% by weight and is generally not more than about 30% by weight, preferably no more than about 25% by weight but can be as low as no more than about 10, 15, or 20% by weight. For a solid composition, the total surfactant can be from about 60 to about 90% by weight, preferably from about 70 to about 85% by weight of the composition. The soap can be present at around 15
to about 100% by weight of the total surfactant. The "soap bars" generally have from about 65 to about 90% by weight of soap there with less than about 10% by weight, preferably less than about 5% by weight and another surfactant there. More preferably, there is zero or zero about 2% by weight of another surfactant there. The bars have a smaller amount of soap within the described range of soap usually have a mild synthetic surfactant there such as sodium cocoyl isethionate at moderate to high levels.
The amount of hydrocarbonaceous component must be present in at least about 0.1, preferably from about 0.5% by weight of the composition. Although the maximum may be up to about 7 or 8% by weight of the composition, it is preferred to have a maximum of about 5% by weight, preferably 45% by weight of the composition.
If a silicone is present in the composition, the minimum amount is about 0.01% by weight of the composition, preferably at least about 0.1% by weight. The maximum may vary but is generally not above about 7 or 8% by weight, preferably about 5% by weight, more preferably about 4.5% by weight of the composition.
When a cationic polymer is used in the composition, the amount of the polymer is from about 0.01 to about 3.0% by weight of the composition, preferably about 0.02% by weight as a minimum and more preferably about 0.03%. by weight as a minimum. The maximum is generally no more than about 0.9% by weight, or about 0.75% by weight, even when the lowest maximums such as about 0.6% by weight can be employed.
The physical nature of the composition is not critical and may be solid, liquid or gel.
The inhibition of germ attachment to the skin is assessed quantitatively by using vain bacteria in the protocol given below. The test bacteria listed are employed. The number reflects the ATCC catalog number.
• Staph, aureus 6538 • Staph, epidermis 12228 • C. Minutissimum, 23347 • E. coli 11229 • Serratia marcescens 14756 • Salmonella choleraesuis 10708
The test bacteria are radiolabelled in the following way:
The test bacteria are cultured in a log phase in 30 ml trypticase soy broth (TSB). The next day, the bacteria are centrifuged at 3,000 revolutions per minute for 20 minutes at 4 ° C. The bacterial pellet is resuspended in 20 ml of sterile salt water in OD adjusted to 0.1 to 620 nm. Approximately 105 bacteria (0.1 ml) are inoculated into 5 ml of culture medium (2 ml of methionine assay medium + 3 ml of TSB for radiolabelling.) 50 microliters of 14C methionine (= uCi) are added to the tube and They are incubated overnight at 37 ° C in a shaker incubator.The next day, the bacteria are pelleted by centrifugation at 3 K revolutions per minute for 15 minutes at 4 ° C. The step is repeated for a total of 3 times for remove the free 14 C. Each time, 25 μl of supernatant and 25 μl of resuspended pellets are collected in scintillation vessels for activity measurement.Usually after three washes, very little activity remains in the supernatant.
The following bars of soap are prepared having about 10% by weight of water and 1% of fragrance. The control soap bar of 1% fragrance, 10% water and the rest essentially soap is used. The amount of soap is low test rods is reduced by the amount of petrolatum, silicone and polyquatermum employed.
The soap bar containing petroleum-3.5% by weight of Penreco petrolatum as Snow White petrolatum - mp of 50-60 ° C. Petrolatum plus silicone plus polyquat containing soap bar 3.5% by weight of Penreco petrolatum as Snow White petrolatum - mp of 50 - 60 ° C. Dimethicone 1% by weight of GE has a viscosity of 600,000 centistokes. Polyquat-6 as Merquat 100 (active ingredient at 40%), 0.6% by weight of the composition.
Preparation of the Product
Solutions of 5% of the product are made in water (5 grams of weight and dissolved in 100 ml of water taken up by gentle heating).
Product Application
The cotton ball soaked with the product solution and rubbed on a piece of pig skin from
about 2.5 centimeters was obtained from the tummy region for 15 seconds? - foam for 45 seconds and finally rinse for 15 seconds in tap water (30 ° C) tap water.
Bacterial fixation
Wait until there is no moisture on the skin. Apply 25 μl of the labeled bacterial suspension on the skin using a positive displacement pipette. Elute 2 minutes after the deposit or after 30 minutes of the deposit) with 0.5 ml of broth leteen three times and collect in a scintillation glass.
Control for Inoculation
Transfer 25 μl of labeled bacteria to the containers in triplicate for entry control.
The results below show the amount of bacteria left on the skin samples after the removal of the bacterial suspension after a contact time of 1-2 minutes or 30 minutes.
TABLE 1
Bacteria Product Bacteria Reatando Subjection to the skin (% after a time of contact bacteria for 1-2 minutes remaining) 30 minutes
S aure s Soap 39,420 (16 9.}. 84, 941 (36 2)
235,000 Soap + 3 5% Petrolatum 27, 716 (11 9) 57,753 (24 7) Soap + Pet + Sil + 18,098 (7 8.}. 51,495 (22 0) Polyquaternure S ep i derm Soap 24,822 (23 1) 30,940 ( 28 8)
107,506 Soap + 3 5% Petrolatum 18,872 (17 6) 27,006 (25 1) Soap + Pet + Sil + 16,842 (15 7) 19,908 (18 5) Poliquaternium C minuCis Soap 61,950 (25 7) 104,895 (43 6)
240,000 Soap + 3 5% Petrolatum 40,110 (16 6) 59,265 (24 6) Soap + Pet + Sil + 21,270 (8 7) 47,910 (19 8.} Poliquatermum E coli Soap 50,508 (19 0) 66,544 (25 0)
266,000 Soap + 3 5% Petrolatum 14,972 (5 6) 40,956 (15 4) Soap + Pet + Sil + 3,360 (1 3) 13,772 (5 2) Poliquatemium S maree scen Soap 31,892 (10 8) 61,368 (20 8)
295,000 Soap + 3 5% Petrolatum 5,948 (2 0) 21,034 (7 1.} Soap + Pet + Sil + 5,260 (1 8) 13,888 (4 7) Poliquaternrum S choleraesu Soap 12,754 (9 2). 13,912 (10 2) )
236,000 Soap + 3 5% Petrolatum 6,574 (4 8) 17,893 (13 2.} Soap + Pet + S l + 5,512 (4 1) 10,132 (7 4) Poliquaterniu
These data clearly show that the presence of petrolatum inhibits the attachment of vain bacteria to the skin. The additional presence of the silicone and the cationic polymer also inhibits the attachment of the bacteria to the skin.
As well as the rinsing of the compositions, the inhibiting effect of the germ subjection also occurs with leaving the compositions such as creams, lotions and the like. These latter compositions are characterized by the fact that they are not intended to be left on the skin for an extended period of time as opposed to an ordinary cleaning composition which is rinsed with water after a relatively short contact time with the skin. . After the rinsing of these "left-over" compositions of the skin, inhibition of the attachment of the germ to the skin occurs. It is desirable to inhibit the attachment of bacteria to the skin. There is no need for a surfactant in the cleaning quantities present to leave them. Below are exemplary compositions of the compositions of the invention.
4. The compositions of the invention in rinsing formulas or that are left are oil-in-water emulsions.
These, as well as the solid compositions, perform the inhibition of the attachment of the germs without any topically active drugs or medication present in the compositions, particularly those drugs or medicaments associated with the alleviation or minimization of the conditions in the target group such as Atopic dermatitis, psoriasis, immunodeficiency conditions and the like. Examples of such agents include amcinonide, diacetate diflorazone, hydrocortisone and the like for dermatitis; and anthralin methoxalen, carbon and the like for psoriasis. Therefore, such topical agents and medicaments may be desirably completely left out of all the compositions of this invention or they may be present in the composition in amounts which are not sufficient to carry out their intended function with respect to the target group, particularly those that have atopic dermatitis, psoriasis, immunodeficiency conditions and the like.
Claims (12)
1. A method for inhibiting the attachment of germs to the skin which comprises applying to the skin a composition comprising: (a) an effective skin cleansing amount of a surfactant or mixture of surfactants, (b) a hydrocarbonaceous component in amounts effective to inhibit the attachment of the germs to the skin, and rinsing said skin composition.
2. The method, as claimed in clause 1, characterized in that the cationic polymer is also present.
3. The method, as claimed in clause 1, characterized in that a silicone is also present.
4. The method, as claimed in clause 2, characterized in that a silicone is also present.
5. The rnetode, as claimed in clause 2, characterized in that a silicone is absent.
6. The use of a composition comprising: (a) an effective skin cleansing amount of a surfactant or mixture of surfactants, (b) a hydrocarbonaceous component in amounts effective to inhibit the attachment of the germs to the skin, in the preparation of a skin cleansing material which inhibits the attachment of germs to the skin.
7. A method for inhibiting this attachment of germs to the skin of the agent having a skin condition selected from the group consisting of atopic dermatitis, psoriasis or immunodeficiency conditions comprising applying to the skin a composition having: (a) an effective skin cleansing amount of a surfactant or mixture of surfactants, (b) a hydrocarbonaceous component in amounts effective to inhibit the attachment of the germs to the skin, and rinsing said skin composition.
8. The method, as claimed in clause 1, characterized in that (b) is present in from from about 0.1 to about 8% by weight of the composition.
9. The method, as claimed in clause 2, characterized in that the cationic polymer is present in about 0.01 to about 3% by weight of the composition.
10. The method, as claimed in clause 3, characterized in that the silicone is present in about 0.1 to about 8% by weight of the composition.
11. The method, as claimed in clause 1, characterized in that the antibacterial effective amount of an antibacterial agent is in the composition.
12. A method for inhibiting the attachment of germs to the skin which comprises applying to the skin a composition comprising: (a) a hydrocarbonaceous component in effective amounts to inhibit the attachment of germs to the skin wherein when the composition is a rinse composition there is also present there an effective skin cleansing amount of a surfactant or a mixture of surfactants. SUMMARY A method for inhibiting the attachment of germs to the skin comprising applying to the skin a composition comprising: (a) an effective skin cleansing amount of a surfactant or mixture of surfactants; (b) a hydrocarbonaceous component in effective amounts to inhibit the attachment of the germs to the skin, and to rinse said skin composition.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60/087,533 | 1998-06-01 | ||
US09/226,304 | 1999-01-07 | ||
US09/304,098 | 1999-05-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA00011984A true MXPA00011984A (en) | 2001-07-31 |
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