MXPA00008882A - Tissue paper having antimicrobial skin lotion - Google Patents

Abstract

An anhydrous lotion composition for killing viruses and bacteria in addition to imparting a soft, lubricious, lotion-like feel when applied to tissue paper and tissue paper treated with such lotion compositions are disclosed. The antiviral action of the lotion is due to the addition of an organic acid such as citric acid or salicylic acid. The antibacterial action is due to the addition of antibacterial agents such as TRICLOSAN®. The solubilization of the antiviral and antibacterial agents within the lotion matrix is aided by the addition of hydrophilic solvents and hydrophilic surfactants. The lubricious lotions also contain a plastic or fluid skin conditioning agent such as petrolatum, an optional immobilizing agent such as a fatty alcohol or fatty acid to immobilize the skin conditioning agent on the surface of the tissue paper web and a hydrophilic surfactant to improve wettability when applied to toilet tissue. Because less lotion is required to impart the desired soft, lotion-like feel benefits, detrimental effects on the tensile strength and caliper of the lotioned paper are minimized or avoided. The anhydrous nature of the lotions also aids in the maintenance of such physical properties as tensile and caliper.

Description

TISU PAPER WHICH HAS AN ANTIMICROBIAL LOTION FOR THE SKIN TECHNICAL FIELD This application relates to anhydrous skin lotion compositions having antimicrobial components, wherein the skin lotions impart to the tissue paper a soft and lubricating feel and wherein the compositions of lotion have the ability to kill certain strains of viruses and bacteria that come in contact with the paper that has the lotion. In addition to having antimicrobial components, these anhydrous lotions tend to be gentle on the skin, thus mitigating the potential irritation of the skin. The absence of water in these lotions leads to advantages in preserving the physical properties of paper such as tension and gauge. This application is further related to tissue paper treated with these antimicrobial anhydrous lotion compositions.

BACKGROUND OF THE INVENTION Regardless of whether it is the home, the workplace, an educational campus or any other place where people tend to meet, preventing the spread of germs is a difficult but desirable task. For example, it is well documented that many hours of productive work are lost because people become infected with the common cold or with the influenza virus. In addition, a lot of money is spent annually on medicines to mitigate the ailments associated with the common cold and influenza. To prevent or reduce the spread of germs within these previously indicated areas, there are antimicrobial sprays, liquid cleaning products and soaps for general sanitation and disinfection. Sprays are typically used to clean in and around sinks, bathtubs, showers and toilets. Liquid cleaners for hard surfaces with antimicrobial components are currently available to clean floors, decks and other hard surfaces. In addition, a variety of antimicrobial soaps can be purchased for cleansing the skin and body. When one suffers from the common cold or the influenza virus, the mucus itself is the source of a very high concentration of viruses. After the mucus is cleaned with a tissue, the virus inside the mucus has the potential to infect other people who come in contact with it. The transfer of this mucus in the tissue paper to another person will probably be through accidental or unintentional contact. As an example of a possible transfer scenario, consider a person with a cold who accidentally leaves a disposable handkerchief infected with mucus on a hard surface of some kind. This hard surface can be a kitchen cover, the surface of a bathroom vanity, an office desk or some other part of the furniture. Another member of the family or colleague may accidentally come in contact with the infected mucus after taking the disposable tissue to dispose of it. After coming into contact with tissue paper mucus, it is very possible that this person becomes infected with the viral condition (ie, the common cold, influenza), especially if the infected mucus comes in contact with the mucous membranes of this person . Another transmission scenario is through the disposal of disposable tissues contaminated with virus-containing mucus. After a trash can is filled with debris that contains a high concentration of infected tissue papers, it obviously needs to be discharged in some way. During this transfer of the household waste to another larger waste unit, the person carrying out the trash transfer may come into contact with the contaminated tissue paper. Again, this person is at a higher risk of contracting the virus.

P1097 Many other potential forms or modes for virus transmission are possible after the disposable tissue has been infected with the mucus. To reduce the likelihood of cold and flu transmission, the tissue paper coated with the antiviral anhydrous lotion described herein will kill some strains of both the rhinovirus and the influenza. By killing these viruses within the tissue, there is an intervention in the transmission of these viruses that causes the common cold and influenza. Kimberly-Clark's AVERT handkerchief product of a few years ago allegedly contained germ-killing drugs, although the anionic surfactant in the germ-destroying vehicle was probably very irritating to the skin. As is well known, people suffering from colds and flu usually have sore and irritated skin regions associated with the nose and lips. After the aqueous mucus is cleaned with the tissue paper, the anionic surfactant dissolves easily and is partially transferred to the irritated skin regions. These regions of sensitive skin are more prone to irritation by anionic surfactants. As indicated, irritation, swelling, and redness around the nose and lips may P1097 have several causes. The first is, of course, the clear need to frequently wipe the nose with the tissue paper and to carve the resulting nasal discharge from the nose and the surrounding area. The degree of irritation and inflammation caused by this cleaning and carving or scrubbing is directly proportional to: (1) the surface roughness of the tissue used; (2) the number of times the nose and the surrounding areas are in contact with the tissue paper; and (3) the potential irritation of any additives applied to the tissue paper. In this way, it is imperative to use ingredients that are as mild as possible within the antiviral lotion. In fact, it is more desirable to use ingredients that can provide the skin with a benefit. In addition to adverse skin reactions with AVERT, there was very little chance for dry transfer of antiviral formulations to the skin. This was partially due to the addition of the antiviral composition of the AVERT to a third sheet of tissue paper, which was then sandwiched between two outer sheets. In addition, the antiviral composition AVERT was constituted by crystalline solids. Thus, after removing a tissue paper from the dispenser box, the probability of transferring the antiviral components to the fingers was low. While, in the present P1097 invention if the lotion is applied to the outer sheets of the tissue paper, the lotion can be easily transferred either to the skin or to the inanimate objects by simply applying pressure between the tissue paper with lotion and the object being touched. In this way, the probability of surface transfer to the skin or the inanimate surface is high, making it possible to destroy viruses in animate and inanimate objects. The lotion of this invention can also be applied between sheets of tissue paper. In addition, the present invention can also be applied to toilet paper. The cleansing of the skin in the perianal region is a problem of personal hygiene that is not always easily solved. Of course, the common procedure of washing the skin with soap and water works very well, but sometimes it can not be available or it is inconvenient. While water and soap could be used to clean the perianal region after defecation, for example, this procedure would be extremely cumbersome. Perianal skin is marked by the presence of fine folds and wrinkles (furrows) and hair follicles, both of which make the perianal region one of the most difficult anatomical areas to clean. During defecation, the fecal material is excreted through the anus and tends to accumulate in hard to reach places, for example around the base of the hair and in the furrows of the surface of the skin. As fecal matter becomes dehydrated during exposure to air or contact with an absorbent cleaning implement, such as toilet paper, it adheres more tenaciously to the skin and hair causing subsequent removal of the rest of the tissues. Dehydrated waste is more difficult. Failure to remove fecal matter from the anal area can be detrimental to personal hygiene. The stool that remains on the skin after post-cleansing has a high bacterial and viral content. It is smelly and in general is dehydrated. These features increase the likelihood of perianal disorders and cause personal discomfort (eg, itching, irritation, redness, etc.). In addition, residual fecal matter stains underwear and generates unpleasant odors emanating from the anal region. In this way, the consequences of inadequate perianal cleanliness are quite unpleasant. For those people who suffer from an anal disorder, such as: anal itching, hemorrhoids, fissures, cryptitis or similar, the importance of an adequate perianal cleansing results in superlative significance. Perianal disorders are usually characterized by openings in the skin through which bacteria and viruses found in residual fecal matter can easily enter. Those affected by anal disorders should, therefore, achieve a high degree of perianal cleansing after defecation or you will have the probable risk that your disorders will be aggravated by bacteria and viruses that remain on the skin. At the same time that those suffering from anal disorders face more severe consequences from insufficient post-cleansing, they also have a greater difficulty in achieving a satisfactory level of dirt removal. Anal disorders in general make the perianal region extremely sensitive and attempts to remove fecal matter from this region, rubbing with a normal rubbing pressure, can cause pain and, in addition, irritate the skin. Attempts to improve the removal of dirt by increasing the rubbing pressure can cause severe pain. Conversely, attempts to decrease discomfort by reducing the rubbing pressure result in an increase in the amount of residual fecal matter remaining on the skin. The conventional toilet paper products used for anal cleansing are essentially dry high-density tissue papers, which rely exclusively on mechanical processes to remove fecal material from the perianal skin. These conventional products are rubbed against the perianal skin, typically with a pressure of about 1 psi (7 kilopascals) and basically scrape or abrade the fecal matter by removing it from the skin. After the first rubs, the upper portion of the dirt layer is removed because the rubbing process can overcome the cohesive dirt-grime forces that exist within the fecal material. In this way, a split is created in the dirt layer itself where the upper portion of the fecal layer is removed and the lower portion of the dirt remains adhered to the perianal skin. Conventional tissue paper products are absorbent and with each successive rubbing the fecal matter is increasingly dehydrated, thus causing it to adhere more tenaciously to the skin and perianal hair, making its removal extremely difficult. Pressing the paper with force against the perianal skin will remove more fecal matter but is intensely painful for people suffering from anal disorders and can excoriate even normal perianal skin, possibly causing irritation, inflammation, pain, bleeding, itching and infections. Hence, the irritation and inflammation potentially caused by the use of tissue paper products is a common drawback experienced by users of both toilet paper and disposable handkerchiefs. It is thought that the present invention may also be useful in reducing the incidence of recurrent urinary tract infections, a problem that tends to plague women more commonly than men. Since the lotions of this invention are practically anhydrous, they will not evaporate upon contact with the surface of the skin. Thus in comparison to non-anhydrous lotions, the practically anhydrous lotions of this invention provide more opportunity for the lotion to be retained in the skin, thereby providing a more lasting benefit to the surface of the skin. Additionally, subsequent cleanings utilizing the tissue paper of this invention tend to be more efficient. For example, with the toilet paper, during the first use of the tissue paper the lotion is transferred from the tissue paper to the skin and to the hair in the perianal area. A lubricated layer is created on the skin, which includes surfactant reducing surfactants. Fecal material that is subsequently deposited in this area is removed or removed more easily as a result of the lubricated layer. Hence, cleaning this area tends to be easier. Accordingly, it would be desirable to provide tissue lotion products with lotion, which: (1) kill or destroy within the tissue tissue the harmful viruses, such as the renovirus and the influenza viruses.; (2) to destroy harmful bacteria in the tissue, such as Escherichia coli and Staphylococcus Saprophyticus, (3) contain antibacterial and antiviral components that can reduce the risk of perineal disorders related to bacteria and viruses; (4) contains antibacterial components that can reduce the risk of recurrent urinary tract infections, (5) contain an antiviral and antibacterial anhydrous lotion that can be transferred to the skin or to inanimate objects for the possible destruction of harmful bacteria and viruses that come in contact with the skin or with the inanimate regions that have lotion; (6) does not adversely affect the tensile strength, absorbency and size of the product; (7) be gentle to the skin; (8) have a soft and lubricated feel; (9) provide benefits to the skin, associated with alpha and beta hydroxy acids; (10) contain an anhydrous lotion that limits the diffusion of the lotion and that helps maintain or preserve physical properties such as tension and caliber; (11) optionally contain a natural oil, such as eucalyptol, menthol, thymol, camphor, lemon oil, methyl salicylate, garlic oil and mixtures thereof and (12) that do not require special wrapping or barrier for packaging.

SUMMARY OF THE INVENTION The present invention relates to a tissue paper having a lotion composition, wherein the lotion composition comprises: (A) at least one antimicrobial; (b) at least one hydrophilic solvent; (c) at least one skin conditioning agent; and (d) at least one hydrophilic surfactant. The composition of the lotion, which is preferably practically free of water, is generally applied in an amount ranging from about 2% to about 40% by weight of the dried tissue paper. At 20 ° C, the lotion composition is preferably a solid or a semi-solid. The antimicrobial compound can be selected from the group consisting of antivirals, antibacterials and mixtures thereof. The antiviral is preferably an organic acid or acids comprising from about 1% to 60% of the composition of P1097 lotion. Optionally, an inorganic acid may be added together with the organic acid to adjust the pH. The optional inorganic acid may comprise from about 0.1% to 5% of the lotion composition. The antibacterial component of the lotion comprises from about 0.1% to 6% of the lotion composition. The hydrophilic solvent, which comprises from about 5% to 60% of the lotion composition, preferably has from about 1 to 150 carbon atoms, wherein the carbon atoms are straight chain or branched chain, saturated or unsaturated, with or without ether linkages and contain from about 1 to 302 hydroxyl groups. The skin conditioning agent of the lotion composition is preferably virtually free of water and has a plastic or fluid consistency at 20 ° C. The skin conditioning agent comprises from about 0.1% to 60% of the lotion composition. The nonionic surfactant comprising from about 1% to 50% of the lotion composition, preferably has an HLB value of at least about 4. The lotion composition may also, optionally, include an immobilizing agent comprising from about 5% to 60% of the lotion composition. The immobilizing agent preferably has a melting point of at least P1097 about 25 ° C. Other optional components that can be added to the lotion composition include natural essential oils, vitamins, panthenol, camphor, thymol, menthol, eucalyptol, geraniol, lemon oil, methyl salicylate, clove, alcohol and mixtures thereof. These other optional components may comprise from about 0.1% to 20% of the lotion composition.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a schematic representation illustrating a preferred process for applying the lotion composition of the present invention to tissue paper webs. Figure 2 is a schematic representation illustrating an alternative process for applying the lotion composition of the present invention to tissue paper webs.

DETAILED DESCRIPTION OF THE INVENTION As used herein, the term "comprising" means that the various components, ingredients or steps, may be used together in the practice of the present invention. Accordingly, the term "comprising" embraces the more restrictive terms "consisting essentially of" and "consisting of". All percentages, relationships and P1097 proportions used herein are by weight, unless otherwise specified.

A. Tissue Papers The present invention is useful with tissue paper in general, including, but not limited to, felt-pressed tissue paper in a conventional manner; densified tissue paper with high volume pattern and high volume non-compacted tissue paper. The tissue paper may have a homogeneous or multilayer construction and the tissue paper products made therefrom may have a single-sheet or multi-sheet construction. The tissue paper preferably has a basis weight of between about 10 g / m2 and about 65 g / m2, and a density of about 0.6 g / cc or less. More preferably, the basis weight will be about 40 g / m2 or less and the density will be about 0.3 g / cc or less. Most preferably, the density will be between about 0.04 g / cc and about 0.2 g / cc. See column 13, lines 61 to 67 of U.S. Patent No. 5,059,282, issued to Ampulski et al. Of October 22, 1991 and incorporated herein by reference, which describes the manner in which the density of the tissue paper (unless otherwise specified, all quantities and weights with respect to paper are on dry basis). Conventionally pressed tissue paper and methods for making this paper are well known in the art. This paper is usually made by depositing a stock on a foraminated forming mesh, often referred to in the art as Fourdrinier mesh. Once the paste is deposited on the forming mesh, it is referred to as a canvas or weft. The weft is drained by pressing the weft and drying it at an elevated temperature. The particular techniques and typical equipment for making wefts, in accordance with the process just described, are well known to those skilled in the art. In a typical process, a pulp of low consistency is supplied from a pressurized tub or headbox. The head tub has an opening for supplying a thin deposit of paper pulp on the Fourdrinier mesh to form a wet web. Then, the web is typically drained to a fiber consistency of between about 7% and about 25% (based on the total weight of the web) by vacuum dewatering and further drying by pressing operations, wherein the web is subjected to the pressure developed by opposing mechanical members, for example, cylindrical rollers. The drained web is then pressed and dried further by means of an apparatus P1097 drum with steam, known in the art as a Yankee dryer. The pressure can be developed in the Yankee dryer by mechanical means, such as with an opposite cylindrical drum that presses against the weft. Multiple Yankee dryer drums can be used, thereby optionally incurring additional pressing between the drums. The tissue paper structures that are formed are hereinafter referred to as conventional tissue paper, pressed structures. It is considered that these sheets or sheets are compacted, since the whole web was subjected to significant mechanical compression forces, while the fibers were wet and then dried while in a compressed state. Patterned densified tissue paper is characterized by having a relatively high volume field with relatively low fiber density and an array of densified zones with relatively high fiber density. The high volume field is alternatively characterized as a field of cushion regions. The densified zones are alternatively referred to as knuckle regions. The densified zones may be discretely separated within the high volume field or they may be interconnected, either totally or partially, within the high volume field. Patterns can be formed in a configuration P1097 are non-ornamental or can be formed to provide an ornamental design on the tissue paper. Preferred processes for manufacturing patterned densified tissue paper webs are disclosed in U.S. Patent No. 3,301,746, issued to Sanford et al. On January 31, 1967; U.S. Patent No. 3,974,025, issued to Ayers on August 10, 1976; U.S. Patent No. 4,191,609, issued to Trokhan on March 4, 1980; and U.S. Patent No. 4,637,859, issued to Trokhan on January 20, 1987; all of them are incorporated as a reference. In general, patterned densified webs are generally prepared by depositing a stock in a foraminous forming mesh, such as a Fourdrinier mesh to form a wet web and then juxtaposing the web against a support array. The plot is pressed against the arrangement of supports, resulting in areas densified in the plot in places that geographically correspond to the points of contact between the array of supports and the wet screen. The rest of the uncompressed frame during this operation is referred to as the high volume field. This high volume field can be further dedensified by the application of fluid pressure, such as with a vacuum type device or a through blow dryer or P1097 mechanically pressing the screen against the arrangement of supports. The web is drained and, optionally, pre-dried, in such a way that compression of the high-volume field is practically avoided. This is preferably achieved by fluid pressure, such as with a vacuum-type device or through-blow dryer or, alternatively, by mechanical pressing of the weft against an array of supports, where it is not compressed to the high-volume field . The dewatering operations, the optional predrying and the formation of densified zones can be integrated or partially integrated to reduce the total number of processing steps carried out. Subsequent to the formation of the densified zones, the dewatering and the optional pre-drying, the weft is dried until it is finished, preferably avoiding mechanical pressing. Preferably, from about 8% to about 55% of the surface of the tissue paper comprises densified knuckles having a relative density of at least 125% of the density of the high volume field. The arrangement of supports is preferably a printing carrier cloth, which has a pattern knuckle movement that operates as the arrangement of supports that facilitate the formation of densified areas thanks to the application of pressure. The boss P1097 of knuckles constitutes the support arrangement previously referred to. Suitable print carrier fabrics are disclosed in U.S. Patent No. 3,301,746, issued to Sanford et al. On January 31, 1967; U.S. Patent No. 3,821,068, issued to Salvucci et al. On May 21, 1974; U.S. Patent No. 3,974,025, issued to Ayers on August 10, 1976; U.S. Patent No. 3,573,164, issued to Friedberg et al. On March 30, 1971; U.S. Patent No. 3,473,576, issued to Amneus on October 21, 1969; U.S. Patent No. 4,239,065, issued to Trokhan on December 16, 1980; and U.S. Patent No. 4,528,239, issued to Trokhan on July 9, 1985; all incorporated as reference. Preferably, the pulp is first converted into a wet web over a carrier of foraminous formation, such as a Fourdrinier mesh. The plot is drained and transferred to a printing fabric. The pulp can, alternatively, be initially deposited on a foraminous support carrier which also functions as a printing fabric. Once formed, the wet web is drained and, preferably, thermally pre-dried to a fiber consistency selected from about 40% to about 80%. The dewatered P1Q97 is preferably carried out with suction boxes or other vacuum devices or with through blow dryers. The print of the knuckles of the printing fabric is printed on the weft, as described above, before completely drying the weft. One method to achieve this is through the application of mechanical pressure. For example, this can be done by pressing a nip roll that supports the printing fabric against the face of a dryer drum, such as a Yankee dryer, where the weft is placed between the nip roll and the dryer drum. Also, preferably, the weft is molded against the printing fabric before finishing the drying, by applying fluid pressure with a vacuum device, such as a suction box or with a through blow dryer. The fluid pressure can be applied to induce the printing of densified zones during the initial dewatering, in a subsequent separate process step or in a combination thereof. Patterned and non-compacted densified tissue paper structures are described in U.S. Patent No. 3,812,000, issued to Salvucci et al. On May 21, 1974 and U.S. Patent No. 4,208,459, issued to Becker et al. collaborators on June 17, 1980, both incorporated P1097 for reference. In general, densified and non-compacted densified tissue paper structures are prepared by depositing a paper web on a foraminated forming mesh, such as a Fourdrinier mesh, to form a wet web, drain the web and remove the additional water without mechanical compression. , until the web has a fiber consistency of at least about 80% and creping the web. The water is removed from the weave by vacuum dewatering and thermal drying. The resulting structure is a high volume, soft but weak sheet of relatively uncompacted fibers. The bonding material is preferably applied to portions of the web before creping. Patterned and compacted densified tissue paper structures are commonly known in the art as conventional tissue paper structures. In general, densified and compacted densified tissue paper structures are prepared by depositing a stock on a foraminous mesh, such as a Fourdrinier mesh, to form a wet weft, drain the weft and remove the additional water with the help of mechanical compaction. uniform (pressed) until the weft has a consistency of approximately 25 to 50%, transfer the weft to a thermal dryer, such as a Yankee and crepe the weft. In general, the water is removed from the plot P1097 by vacuum, mechanical pressing and thermal means. The resulting structure is strong and, generally of a singular density but very low volume, absorbency and softness. The papermaking fibers used for the present invention will usually include fibers derived from wood pulp. Other fibers of cellulosic fibrous pulp, such as cotton linters, bagasse, etc., may be used and are intended to be within the scope of this invention. Synthetic fibers, such as rayon, polyethylene and polypropylene fibers and MICROBAN®, a material manufactured by Microban Products Co. from Huntersville, North Carolina, may also be used in combination with natural cellulosic fibers. An exemplary polyethylene fiber that can be used is PULPEX®, available from Hercules, Inc. of Wilmington, Delaware. Applicable wood pulps include chemical pulps, such as kraft, sulphite and sulfate pulps, as well as mechanical pulps including, for example, ground wood, thermomechanical pulp and chemically modified thermomechanical pulp. However, chemical pulps are preferred, since they impart a superior tactile sensation of softness to the leaves of the tissue manufactured therefrom. Pulps derived from both deciduous trees (hereinafter referred to as P1097 also as "hardwood") and coniferous trees (hereinafter also referred to as "softwood") can be used. Also useful in the present invention are fibers derived from recycled paper, which may contain any or all of the above categories, as well as other non-fibrous materials, such as fillers and adhesives used to facilitate the manufacture of original paper. Loads comprising zinc oxide may be advantageous in the present invention, due to the potential benefits to the skin derived from its use. In addition to papermaking fibers, the raw material or pulp used to make tissue paper structures may have other components or materials added thereto that are or will become later known in the art. The types of desirable additives will depend on the particular end use contemplated for the tissue paper sheet. For example, in products such as toilet paper, paper towels, disposable handkerchiefs and other similar products, high wet strength is a desirable attribute. In this way, it is often desirable to add to the papermaking raw material chemicals known in the art as "wet strength" resins. A general dissertation of the types of P1097 wet strength resins used in the paper art can be found in the monograph of the TAPPI Serial No. 29, Wet Strength in Paper and Cardboard, Technical Association of the Pulp and Paper Industry (New York, 1965). The most useful wet strength resins have, in general, had a cationic character. For the generation of permanent wet strength, it has been found that polyamide-epichlorohydrin resins are cationic wet strength resins of particular utility. Suitable types of these resins are described in U.S. Patent No. 3,700,623, issued to Keim on October 24, 1972 and U.S. Patent No. 3,772,076, issued to Keim on November 13, 1973, of which, both are incorporated as reference. A commercial source of a useful polyamide-epichlorohydrin resin is Hercules, Inc. of Wilmington, Delaware, which markets these resins under the name KYMENE * 557H. It has also been found that polyacrylamide resins are useful as wet strength resins. These resins are described in U.S. Patents No. 3,556,932, issued to Coscia et al. On January 19, 1971 and Ho. 3,556,933, awarded to Williams et al.

P1097 January 19, 1971, of which, both are incorporated herein by reference. A commercial source of polyacrylamide resins is American Cyanamid Co. from Stamford, Connecticut, which sells this resin under the name PAREZ * 631 NC. Other cationic water-soluble resins which find utility in this invention are the urea-formaldehyde and melamine-formaldehyde resins. The most common functional groups of these polyfunctional resins are nitrogen-containing groups, such as amino groups and methylol groups attached to nitrogen. Polyethylenimine type resins may also find utility in the present invention. In addition, temporary wet strength resins, such as CALDAS 10 (manufactured by Japan Carlit) and COBOND 1000 (manufactured by National Starch and Chemical Company of Bridgewater, New Jersey) can be used in the present invention. It will be understood that the addition, to the pulp feedstock, of chemical compounds such as the above-mentioned wet strength resins and temporary wet strength resins is optional and is not necessary for the practice of the present invention. In addition to wet strength additives, it may also be desirable to include certain lint control and dry strength control additives known in the art in papermaking fibers. About, it has been found that the starch binders are particularly suitable. In addition to reducing lint formation of the finished tissue paper product, low levels of starch binders also impart a modest improvement in dry tensile strength without imparting the rigidity that could result from the addition of high levels of starch. Typically, the starch binder is included in an amount such that it is retained at a level from about 0.01 to about 2%, preferably from about 0.1 to about 1% by weight of the tissue paper. In general, starch binders suitable for the present invention are characterized by their water solubility and affinity for water, ie, by their hydrophilicity. Although it is not intended to limit the scope of suitable starch binders, representative starch materials include corn starch and potato starch, wherein industrial waxy cornstarch known as amioca starch is particularly preferred. The amioca starch differs from the common corn starch in that it is completely amylopectin, whereas the P1097 Common corn starch contains both amylopectin and amylose. Several unique characteristics of amioca starch are further described in "Amioca - The Starch From Waxy Corn", by H. H. Schopmeyer, Food Industries, December 1945, p. 106-108 (Vol. Pp. 1476-1478). The starch binder may be in granular or dispersed form, especially the granular form is preferred. The starch binder is preferably cooked in a manner sufficient to induce swelling of the granules. More preferably, the starch granules swell, by baking, to a point just before the starch granule dispersion. These highly swollen starch granules should be referred to as "fully cooked". The conditions for dispersion, in general, can vary depending on the size of the starch granules, the degree of crystallinity of the granules and the amount of amylose present. Fully cooked amioca starch, for example, can be prepared by heating an aqueous pulp, which has a consistency of about 4% starch granules, to about 190 ° F (about 88 ° C) for between about 30 and about 40. minutes P1097 Other emulsifying starch binders that may be used include modified cationic starches, such as those modified to have nitrogen-containing groups, including amino groups and methylol groups attached to nitrogen, available from National Starch and Chemical Company, of Bridgewater, New Jersey. , which have previously been used as pulp additives to increase wet and / or dry strength.

B. Lotion Composition The lotion compositions of the present invention at 20 ° C, ie, at ambient temperatures can be liquid, preferably semi-solid or more preferably solid. The term "semi-solid" refers to a lotion composition that has a typical rheology of pseudoplastic or plastic fluids. When a shear is not applied, the lotion compositions may have the appearance of a semi-solid but may be flowed as the cutting or shearing rate increases. This is due to the fact that, while semi-solid or solid lotion compositions contain mainly solid components, these may also include some minor liquid components. The solid or semi-solid consistency of P1097 lotions at room temperature are due to the addition of high melting point components, such as high melting point organic acids that have an antiviral function; fatty alcohols; waxes; polyethylene glycols of high molecular weight; polyoxyethylene sorbitan mono-, di- and tri- alkylates; sorbitan mono-, di- and tri-alkylates; and non-ionic ethoxylated surfactants. The fraction of high melting point and higher molecular weight alkanes of the petrolatum, which can be used as a skin conditioning agent in the present invention, can also contribute to raising the melting point of these lotions. These higher molecular weight components of the petrolatum are usually high molecular weight waxy hydrocarbons. Lotions of this invention that are solid or semi-solid at ambient temperatures do not tend to flow and migrate into the tissue paper web to which they are applied. This means that less lotion composition is required to impart the lotion-like softness and feel benefits. It also means that there is less opportunity for the release or disengagement of tissue paper that can potentially lead to reduced resistance to stress. When applied to the tissue paper, the lotion compositions of the present invention impart to the user of the P1097 3Í paper the feeling or soft touch, lubricated and lotion type. This particular sensation or touch has also been characterized as "silky", "sliding", "smooth", etc. This lubricated lotion-like touch is particularly beneficial for those with more sensitive skin due to chronic conditions such as dry skin or hemorrhoids or due to more transient conditions such as colds or allergies. The transfer of the lotion to the skin provides the potential benefits to the skin for lotions containing alpha hydroxy acids and beta hydroxy acids. Additionally, an antimicrobial component, such as an antiviral, an antibacterial or a combination of both within the lotion aids in the destruction of harmful microorganisms such as viruses and bacteria. The transfer of the lotion to the skin can potentially protect those regions against viral and bacterial infections. Finally, skin conditioning agents, such as petrolatum, mineral oil and dimethicones, can form a protective layer on the skin and provide wetting or other conditioning benefits of the skin. In addition, the hydrophobic barrier formed in the skin by additives such as petrolatum, mineral oil, dimethicones and other molecules similarly P1097, can form a protective barrier in the skin and protect it against any chemical compounds present in either the lotion or the environment, which could potentially irritate the skin. The lotions of the present invention are practically anhydrous. By practically anhydrous it is meant that water was not intentionally added to these lotions. Typically, the ingredients used in the present invention contain about 5% or less of water, preferably about 1.0% or less of water, more preferably about 0.5% or less of water and most preferably about 0.1% or less of water . The anhydrous nature of these lotions allows a more efficient dry transfer of the lotion to the skin. The intentional addition of water to the lotion would be detrimental to the physical properties of the paper, such as tension and caliper. The water helps the migration of the lotion through the entire tissue paper web. This leads to the disunion of the fibers and a smaller amount of concentrated lotion on the surface of the paper. This leads to both losses in tension and in caliber; thus, it is beneficial to maintain an anhydrous lotion condition as described herein. In addition, water tends to promote microbial growth; In this way, it is advantageous to maintain a state P1097 anhydrous lotion as described herein. Also, because the absence of water promotes a higher surface concentration of the lotion ingredients, the likelihood of a more efficient transfer to dry skin is improved if the lotion is applied to the consumer side of the outer sheets of the tissue paper. . The consumer side of the tissue paper refers to the side of the tissue paper that comes in contact with the user. Of course, the transfer to the skin is inhibited if the lotion is applied to the inner sheets of the tissue paper. The lotion compositions of the present invention comprise: (1) one or more antimicrobial components; (2) a solvent or hydrophilic solvents; (3) a skin conditioning agent or agents; (4) a surfactant or hydrophilic surfactants; (5) an optional stationary agent or agents; (6) an additive or optional additives such as natural essential oils, vitamins, aloe, panthenol, camphor, thymol, menthol, eucalyptol, geraniol, lemon oil, methyl salicylate, clove, alcohols. 1. Antimicrobial Components One of the key active ingredients in the lotion compositions of this invention is one or more antimicrobial components. The components P1097 antimicrobials can be antiviral, antibacterial or a combination thereof.

Antivirals As used herein, an antiviral refers to something that has the ability to kill or destroy viruses, such as renovirus and influenza. The antivirals that can be added to the lotions of this invention include, but are not limited to, organic acids having an antiviral function. The organic acids useful in this invention include, but are not limited to, alpha hydroxy acids, such as saturated, unsaturated and aromatic Cx to C12 carboxylic acids possessing from 1 to 4 carboxylic acid groups and having at least one substituted hydroxyl group in the C2 alpha carbon with additional hydroxyl and other functionalities (ie, phenyl, amino, etc.) optionally bound to the carbon chain and aromatic rings. A non-inclusive list of the alpha hydroxy acids that may be used includes: 2-hydroxyhexanoic acid, 2-hydroxyoctanoic acid, 2-hydroxydecanoic acid, 2-hydroxydodecanoic acid, 2-hydroxycaprilic acid, citric acid, tartaric acid, mandelic acid, ascorbic acid , ascorbyl palmitate, malic acid, glycolic acid, lactic acid, gluconic acid, hydroxycaprilic acid, 2-hydroxypropionic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid and mixtures thereof. Other examples of organic acids useful in this invention include beta hydroxy acids, such as saturated, unsaturated and aromatic Ci to Ci2 carboxylic acids possessing from 1 to 4 carboxylic acid groups and having at least one hydroxyl group substituted on the C3 beta carbon with additional hydroxyl and other functionalities (ie, phenyl, amino, hydroxyl, etc.) optionally linked to the carbon chain or the aromatic rings. A non-inclusive list of beta hydroxy acids useful with this invention includes: 3-hydroxyhexanoic acid, 3-hydroxyoctanoic acid, 3-hydroxydecanoic acid, 3-hydroxydodecanoic acid, 3-hydroxycaprilic acid, salicylic acid, 3-hydroxybutanoic acid, -hydroxypentanoic, 3-hydroxypropionic acid and mixtures thereof. A non-inclusive list of other organic acids useful in this invention includes saturated, unsaturated and aromatic Cx to C12 carboxylic acids possessing from 1 to 4 carboxylic acid groups with optional functional groups (ie, phenyl, amino, hydroxyl, etc.) substituted along the carbon chain or on the aromatic rings, such as propionic acid, hexanoic acid, octanoic acid, decanoic acid; Ci carboxylic acids a P1097 C? 2 possessing from 1 to 4 carboxylic acid groups, wherein the hydroxyl groups are substituted at the C4 carbon numbers or higher, such as 4-hydroxyhexanoic acid, 5,6-dihydroxyhexanoic acid, 6-hydroxyhexanoic acid, 4-hydroxyoctanoic acid, 5-hydroxyoctanoic acid, 6-hydroxyoctanoic acid, 6,7,8-trihydroxyoctanoic acid, 8-hydroxyoctanoic acid, 4-hydroxydecanoic acid, 5-hydroxydecanoic acid, 6-hydroxydecanoic acid, 7-hydroxydecanoic acid, acid 8-hydroxydecanoic acid, 9-hydroxydecanoic acid, 10-hydroxydecanoic acid, 4-hydroxydodecanoic acid, 5-hydroxydodecanoic acid, 6-hydroxydodecanoic acid, 11-hydroxydodecanoic acid and 12-hydroxydodecanoic acid; benzoic acid; phthalic acid; acetylsalicylic acid; dehydroacetic acid; sorbic acid, succinic acid; glutaric acid; adipic acid; sebacic acid; maleic acid; folic acid; acetic acid; phosphoric acid; boric acid; Ethylenediaminetetraacetic acid; Glycolic Acid; and mixtures thereof. Preferred organic acids include adipic acid, glutaric acid, succinic acid, lactic acid and mixtures thereof. The most preferred organic acids include acetylsalicylic acid, glycolic acid and mixtures thereof. The organic acids most preferably are salicylic acid, citric acid, tartaric acid, ascorbic acid and mixtures thereof.

P1097 Due to the pH reducing effect of these organic acids, viruses such as renovirus and influenza that come in contact with the acidified tissue paper lotion are destroyed. Some of the antiviral organic acids used in these solutions are from a class of acids called alpha or beta hydroxy acids. In addition to its antiviral function, the benefits to the skin associated with these alpha or beta hydroxy acids are also provided to the consumer. In addition to providing antiviral activity, some of these acids that are either within the alpha hydroxy class or the beta hydroxy acid class also function as skin exfoliants, thus providing additional benefits to the same. In addition to its antiviral properties, the use of solid organic acids can contribute to the hardening of the lotion and, thus, help to inhibit the migration of the lotion within the fibrous paper substrate. The high melting points of the acids can also allow the lotion to solidify more quickly on the surface of the paper. This allows a more efficient use of the lotion and the superficial confinement contributes to a more effective destruction of the viruses as well as to the potential of an improved lotion sensation. Acids with linear structure, such as octanoic acid, acid P1097 Hexane, decanoic acid, adipic acid, succinic acid and glutaric acid, are more crystalline and, thus, should lead to a faster solidification of the lotion on the surface of the paper. Inorganic acids can also be used together with the organic acids to adjust the pH. A non-inclusive list of inorganic acids useful in this invention includes hydrochloric acid, boric acid and preferably phosphoric acid. Optional inorganics comprise from about 0.1% to 5% of the composition of the lotion. There are many theories as to how organic acids deactivate viruses, such as rhinovirus and influenza. A possible mechanism for virus deactivation is the donation of protons from the acid to the amide nitrogen of one or all of the different proteins within the structure of the virus. This protonation leads to a positive net charge within the structure of the protein. This leads to the repulsion between the protonated amide moieties of the high molecular weight protein molecules, this leads to the denaturing of some or all of the protein structures within the virus. This denaturation or unfolding of the protein structure deactivates the virus.

P1097 Another potential mechanism for deactivation by organic acids is through the hydrolysis of proteins and other molecules within the structure of the virus. This acid-catalyzed hydrolysis most likely occurs by cleaving the amide functionalities of the proteins that make up the complex structure of the virus. This hydrolysis and rupture of the protein bonds of the virus structure deactivates the virus and renders it ineffective in attacking healthy cells within the body. For enveloped or enveloped viruses, such as influenza, where the structure is surrounded by a layer or lipid shell, the acid can also cause deactivation by hydrolysis of this lipid layer. In addition, some surfactants, such as ethoxylated alcohol type, can dissolve this lipid shell and inactivate the virus. The antiviral components of the lotion comprise from about 1% to 60% of the lotion composition. Mixtures of the antivirals can also be used.

Antibacterial components Antibacterial or simply antibacterial components within the lotion can also help the lotion's ability to destroy harmful microorganisms, such as Escherichia coli and Staphylococcus P1097 Saprophyticus. Antibacterials useful in this invention include, but are not limited to: Pyrithiones, especially sodium omadine and the zinc complex (ZPT). OCTOPIROX® Dimethyldimethylol Hidantoin (GLYDANT®) Methylchloroisothiazolinone / methylisothiazolinone (KATHON CG®) Sodium Sulfite Sodium Bisulfite Imidazolidinyl Urea (GERMALL 115®) Diazolidinyl Urea (GERMALL II®) Benzyl Alcohol 2-Bromo-2-nitropropane-l, 3-diol (BRONOPOL®) Formalin (formaldehyde) Yodopropenyl Butylcarbamate (POLYPHASE P100®) Chloroacetamide Methanamine Methyldibromonitrile Glutaronitrile (1,2-Dibromo-2,4-dicyanobutane or TEKTAMER). Glutaraldehyde 5- romo-5-nitro-1,3-dioxane (BRONIDOX®) Fenethyl Alcohol o-Phenylphenol / o-phenylphenol sodium Sodium hydroxymethylglycinate (SUTTOCIDE A®) Oxazolidine Polymethyl Bicyclic (NUOSEPT C®) P1097 Dimetoxan Thiomersal Dichlorobenzyl alcohol Captan Clorphenenesin Dichlorophene Chlorbutanol Glyceryl Laurate Halogenated Diphenyl Ethers 2,4,4'-Trichloro-2'-Hydroxy-Diphenyl Ether (TRICLOSAN® or TCS). 2, 2'-Dihydroxy-5,5'-dibromo-diphenyl ether Phenol-2-phenol-3-methylphenol 4-methylphenol 4-ethylphenyl-2, -dimethylphenol 2,5-dimethylphenol 3,4-dimethylphenol 2, 6-phenol compounds Dimethylphenol 4-n-Propylphenol 4-n-Butylphenol 4-n-Amylphenol P1097 4-tere-Amylphenol 4-n-Hexylphenol 4-n-Heptyphenol Mono- and Polyalkyl and Aromatic Halofenols p-Chlorophenol Methyl p-Chlorophenol Ethyl p-Chlorophenol n-Propyl p-Chlorophenol n-Butyl p-Chlorophenol n-Amyl p -Clorophenol sec-Amyl p-Chlorophenol n-Hexyl p-Chlorophenol Ciciohexyl p-Chlorophenol n-Heptyl p-Chlorophenol n-Octyl p-Chlorophenol o-Chlorophenol Methyl o-Chlorophenol Ethyl o-Chlorophenol n-Propyl o-Chlorophenol n-Butyl o-Chlorophenol n-Amyl o-Chlorophenol tert-Amyl o-Chlorophenol n-Hexyl o-Chlorophenol n-Heptyl o-Chlorophenol o-Benzyl p-Chlorophenol P1097 o-Benzyl-m-methyl p-chlorophenol o-Benzyl-m, m-dimethyl p-chlorophenol o-phenylethyl p-chlorophenol o-phenylethyl-m-methyl p-chlorophenol 3-methyl p-chlorophenol 3, 5-dimethyl p-Chlorophenol 6-Ethyl-3-methyl p-chlorophenol 6-n-Propyl-3-methyl p-chlorophenol 6-iso-Propyl-3-methyl p-chlorophenol 2-ethyl-3,5-dimethyl p-chlorophenol 6 -sec-Butyl-3-methyl p-Chlorophenol 2-iso-Propyl-3,5-dimethyl p-chlorophenol 6-Diethylmethyl-3-methyl p-chlorophenol 6-iso-propyl-2-ethyl-3-methyl p-chlorophenol 2-sec-Amyl-3, 5-dimethyl p-chlorophenol 2-Diethylmethyl-3,5-dimethyl p-chlorophenol 6-sec-Octyl-3-methyl p-Chlorophenol p-Chloro-m-cresol p-Bromophenol Methyl p-Bromophenol Ethyl p-Bromophenol n-Propyl p-Bromophenol n-Butyl p-Bromophenol n-Amyl p-Bromophenol sec- Amil p-Bromophenol n-Hexyl p-Bromophenol Ciciohexyl p-Bromophenol o-Bromophenol tert-Amyl o-Bromophenol n-Hexyl o-Bromophenol n-Propyl-m, m-Dimethyl or-Bromophenol 2-Phenylphenol 4-chloro-2-methy1phenol 4-chloro-3-methylphenol 4-chloro-3,5-dimethylphenol 2,4-dichloro-3,5-dimethylphenol 3,4,5,6-terabromo-2-methylphenol 5 -Methyl-2-styphenol 4-Isopropyl-3-methylphenol Para-chloro-meta-xyleneol (PCMX) Chlorotimol Phenoxyethanol Phenoxyisopropanol 5-Chloro-2-hydroxydiphenylmethane Resorcinol and its Derivatives Resorcinol Methyl Resorcinol Ethyl Resorcinol n-Propyl Resorcinol n-Butil Resorcinol ÍO97 n-Amyl Resorcinol n-Hexyl Resorcinol n-Heptyl Resorcinol n-Octyl Resorcinol n-Nonyl Resorcinol Phenyl Resorcinol Benzyl Resorcinol Phenylethyl Resorcinol Phenylpropyl Resorcinol p-Chlorobenzyl Resorcinol 5-Chloro 2,4-Dihydroxydiphenyl Methane 4'-Chloro 2, 4- Dihydroxydiphenyl Methane 5-Bromo 2, 4-Dihydroxydiphenyl Methane 4 '-Bromo 2, 4-Dihydroxydiphenyl Methane Bisphenolic Compounds 2,2' -Methylene bis (4-chlorophenol) 2,2 '-Methylene bis (3,4,6-trichlorophenol) ) 2,2 '-Methylene bis (4-chloro-6-bromophenol) bis (2-hydroxy-3, 5-dichlorophenyl) sulfide bis (2-hydroxy-5-chlorobenzyl) sulfide steres Benzoic (Parabens) Methylparaben Propylparaben Butylparaben Ethylparaben P1097 Isopropyparaben IsobutyIparaben Benzylparaben Methylparaben Sodium Propylparaben Sodium Halogenated Carbanilides 3,4,4 'Trichlocarbanilides (TRICLOCARBAN® or TCC) 3-Trifluoromethyl-4,4'-dichlorocarbanilide (CLOFLUCARBAN). 3, 3 ', 4-Trichlorocarbanilide Compounds of Quaternary Ammonium Benzalkonium Chloride Bencethonium Chloride Biguanides Polyhexamethylene Biguanide Hydrochloride Chlorhexidine Chlorhexidine derivatives Chlorhexidine digluconate Chlorhexidine dihydrochloride Chlorhexidine diacetate Chloroxylenol Oxiquinolines 8-Hydroxyquinoline Iodine iodine P1097 Povidone Iodine Hexamidine Alcohols Ethanol Butyl Alcohol Isopropanol 2 -Fenoxyethanol Antibiotics Bacitracin Neomycin Polymyxin B Nistatin Organic Acids and Acid Donors Citric Acid Ascorbic Acid Malic Acid Tartaric Acid Benzoic Acid Triacetin Sphingosine D-sphingosine Amphoteric surfactants Dodecyl-di (aminoethyl) glycine Polymers of Ioneno Onámero M P1097 Modified Phospholipids Coconut Chloride Amidopropyl Phosphatidyl PG-dimonium Linole Chloride Amidopropyl Phosphatidyl PG-dimonium Coconut Chloride Phosphatidyl PG-dimonium Another class of antibacterials, which are useful in the present invention, are the so-called "natural" antibacterial actives, referred to as natural essential oils. These assets derive their names from their natural occurrence in plants. The antibacterial assets of typical natural essential oils include oils of anise, lemon, orange, rosemary, wintergreen, thyme, lavender, cloves, hops, tea plant, citronella, wheat, barley, lemon grass, cedar leaf, cedar wood, canale, psyllium plantago, geranium, sandalwood, violet, blueberry, eucalyptus, verbena, peppermint, benzoin gum, basil, fennel, fir, balsam, menthol, ocmea origanum, Hydastis carradensis, Berberidaceae daceae, Ratanhiae and Curcuma longa. Also included in this class of natural essential oils are the key chemical components of the plant oils that have been found to provide the antimicrobial benefit. These chemical compounds include, but are not limited to, anethole, catechol, camphene, carvacol, eugenol, eucalyptol, ferulic acid, farnesol, hinochitol, tropolone, limonene, menthol, methyl salicylate, thymol, P1097 terpineol, verbenone, berberine, ratanhiae extract, cariofelene oxide, citronellic acid, curcumin, nerolidol and geraniol. Additional active agents are the antibacterial metal salts. This class generally includes salts of metals of groups 3b to 7b, 8 and 3a to 5a. Specifically, there are the aluminum, zirconium, zinc, silver, gold, copper, lanthanum, tin, mercury, bismuth, selenium, strontium, yttrium, cerium, praseodymium, neodymium, prometheus, samarium, europium, gadolinium, terbium, dysprosium salts. , holmium, erbium, thulium, ytterbium, lutetium and mixtures thereof. Preferred antibacterials for use herein are the broad-spectrum actives, selected from the group consisting of TRICLOSAN®, TRICLOCARBAN®, OCTOPIROX®, PCMX, ZPT, natural essential oils and their main ingredients and mixtures thereof. The most preferred antibacterial active for use in the present invention is TRICLOSAN®. The antibacterial component comprises from about 0.1% to 6% of the lotion composition, preferably from about 0.3% to 3% and more preferably from about 0.5% to 1.5%. Although the antibacterials can be mixed with others and / or mixed with the antivirals of this invention, some mixtures P1097 within the scope of this invention may result in the formation of a precipitate. Some of the lotion components of this invention have multiple functionality. For example, citric acid and ascorbic acid both have an antiviral and antibacterial function. Additionally, antibacterials and some of the antivirals also act as preservatives by preventing the growth of harmful microorganisms in the same lotion composition. 2. Hydrophilic Solvents Other important components of these lotions is the incorporation of hydrophilic solvents to help the solubilization of organic antiviral acids. Suitable solvents include, but are not limited to, solvents having from about 1 to 150 carbon atoms, wherein the carbons may be straight or branched chain, saturated or unsaturated, with or without ether linkages and containing from about 1 to 302 hydroxyl groups. These solvents include, but are not limited to, glycol-type solvents, such as polyethylene glycols, glycerin, ethylene glycol, propylene glycol, polypropylene glycol, ethanol, isopropanol, hexylene glycol, and mixtures thereof. It is preferred to polyethylene glycol that P1097 has a molecular weight range from about 200 to 3000. Most preferred solvents include those solvents having from about 1 to 25 carbon atoms and from about 1 to 8 hydroxyl groups. With an even greater preference is propylene glycol and polyethylene glycols, wherein the polyethylene glycols have a molecular weight range of about 200 to 1500 or mixtures thereof. In addition to allowing the solubilization of the antiviral organic acids, some of the glycol type solvents are known to be also antiviral in nature, such as propylene glycol and triethylene glycol. Also, some of these glycol-type solvents may provide an increase in the viscosity of the lotion and, thereby, prevent undesirable migration of the lotion components within the fibrous web of paper. These glycol-based solvents can also function as humectants and thus provide the benefit of wetting to the skin. Although, its main use in this particular application is to help the solubilization of the antiviral organic acid. The hydrophilic solvent comprises from about 5% to 60% of the lotion composition.

P1097 3. Skin Conditioning Agents The one or more other active ingredients in these lotion compositions are one or more skin conditioning agents. As used herein, a skin conditioning agent is a material that softens, mitigates, soothes, coats, lubricates, moisturizes or cleanses the skin. A skin conditioning agent typically accomplishes several of these objectives, such as mitigating, moisturizing and lubricating the skin. For the purposes of this invention, these skin conditioning agents have a plastic or fluid consistency at 20 ° C, that is, at ambient temperatures. This particular consistency of the skin conditioning agent allows the lotion composition to impart a smooth, lubricated lotion-like feel. The skin conditioning agents useful in the present invention are also practically free of water. By the term "virtually water-free" it is meant that the water was not intentionally added to the skin conditioning agent. The addition of water to the skin conditioning agent or to the lotion is not necessary during the preparation or use of the lotion compositions of the present invention and may require an additional drying step. In fact, it is undesirable and unnecessary to add water to these lotions P1097 antivirals. The addition of water could lead to potential microbial growth in the lotions. In addition, the water would lower the melting point of the lotion and help the migration of the other components of the lotion into the paper fiber substrate. This would likely have a negative impact on the tension and caliper properties of the lotion paper. Nevertheless, minor amounts or traces of water in the skin conditioning agent that are collected as a result of, for example, environmental humidity, can be tolerated without adverse effects. Normally, the skin conditioning agents used in the present invention contain about 5% or less of water, preferably about 1.0% or less of water, more preferably about 0.5% or less of water and most preferably about 0.1%. or less water. The skin conditioning agents useful in the present invention may be petrolatum-based, such as mineral oil and petrolatum, fatty acid ester type, fatty alcohol type, dimethicones which include derivatives with dimethicone function, polyethylene glycols or mixtures of these skin conditioning agents. Oil-based skin conditioning agents include hydrocarbons or hydrocarbon mixtures that have chain lengths from 16 to 32 P1097 carbon atoms. Oil-based hydrocarbons that have these chain lengths include mineral oil (also known as "liquid petrolatum") and petrolatum (also known as "mineral wax", "petroleum jelly" and "mineral jelly"). Mineral oil usually refers to less viscous mixtures of hydrocarbons that are liquid at room temperature. Petrolatum usually refers to more viscous mixtures of hydrocarbons having from 16 to 32 carbon atoms. Petrolatum is a particularly preferred skin conditioning agent for lotion compositions of the present invention, due to its exceptional skin moisturizing benefits. Dimethicones and functionalized derivatives of dimethicones are also very effective paper softeners. Aminofunctional polydimethylsiloxanes are especially effective paper softeners. Preferred are dimethicones having a viscosity range of about 20 to 12,500 centistokes at 25 ° C. Thus, a material such as dimethicone or the other skin conditioning agents mentioned above could not only provide a soft feel to the paper and skin but could provide the protective benefit of the skin if transferred thereto. This benefit would be particularly advantageous if it were desirable P1097 prevent a particularly rough ingredient from contacting the skin. Fatty alcohols are also particularly preferred, due to their linear crystalline structure. The high melting points of the fatty alcohols increases the melting point of the lotion and thus helps to prevent the migration of the lotion throughout the fiber network. The linear structure of the fatty alcohols gives the lotion crystalline attributes and should lead to faster crystallization / solidification on the surface of the paper substrate. Thus, during application to the paper surface, the lotion should be installed and solidified faster on the surface of the paper substrate. This concentrates the lotion on the surface and gives the lotion paper product a superior feel and also leads to a more efficient use of antimicrobials. The hydroxyl group in the fatty alcohol can also contribute to the antimicrobial action of the lotion. Suitable skin fatty acid ester conditioning agents include those derived from C ?2-C28 fatty acids / preferably saturated C ?6-C22 fatty acids and short-chain monohydric alcohols (Ci to C8, preferably Cx to C3). Representative examples of these esters include palmitate P1097 methyl, methyl stearate, isopropyl laurate, isopropyl myristate, isopropyl palmitate, ethylhexyl palmitate and mixtures thereof. Suitable fatty acid ester skin conditioning agents can also be derived from fatty esters of higher chain length fatty alcohols (C 2 -C 28, preferably Ci 2 -C 8) and shorter chain fatty acids, for example , lactic acid, such as lauryl lactate and cetyl lactate. In addition to petroleum-based skin conditioning agents, skin conditioning agents based on dimethicone, fatty acid ester skin conditioning agents and fatty alcohol skin conditioning agents, conditioning agents of the skin useful in the present invention may include minor amounts (eg, up to about 10% of the total skin conditioning agent) of other conventional skin conditioning agents. These other conventional skin conditioning agents include propylene glycol, glycerin, hexylene glycol, polyethylene glycols, triethylene glycol, liposomes, spermaceti, squalene, cholesteryl or other waxes. (such as C50 waxes), fatty acids and fatty alcohol ethers having from 12 to 28 carbon atoms in their fatty chain, such as stearic acid, fatty alcohols P1097 propoxylates; glycerides, acetoglycerides and ethoxylated glycerides of C? 2-C28 fatty acids; other fatty esters of polyhydric alcohols; lanolin and its derivatives; polyether-silicone copolymers, and polysiloxanes such as aminofunctional polydimethylsiloxanes having a viscosity at 20 ° C of about 5 to about 2,000 centistokes, as disclosed in U.S. Patent No. 5,059,282, issued to Ampulski et al. October 1991, which is incorporated as a reference. The amount of the conditioning agent that can be included in the lotion composition will depend on a variety of factors including the particular skin conditioning agent involved, the desired lotion-like benefits, the other components in the composition of the lotion and the like. The lotion composition may comprise from about 0.1% to about 60% of the skin conditioning agent, more preferably from about 5% to about 50%. 4. Hydrophilic Surfactants In many cases, the lotion compositions according to the present invention will be applied to tissue paper webs that will be used as toilet paper.

P1097 In these cases, it is highly desirable that the paper web treated with the lotion composition be sufficiently wettable. Depending on the particular immobilizing agent used in the lotion composition of the present invention, an additional surfactant, preferably a hydrophilic surfactant (or a mixture of hydrophilic surfactants) may or may not be required to improve wettability. For example, some immobilizing agents, such as N-cocoyl-N-methoxypropyl glucamide have HLB values of at least about 7 and are sufficiently wettable without the addition of a hydrophilic surfactant. Other immobilizing agents, such as C? 6-C? 8 fatty alcohols and waxes having HLB values less than about 7, will require the addition of a hydrophilic surfactant to improve wettability if the lotion composition will be applied to paper webs. used as toilet paper. Similarly, a hydrophobic skin conditioning agent, such as petrolatum or mineral oil, will require the addition of a hydrophilic surfactant. It should be noted that water absorbency will be more critical in a product such as toilet paper. A lotion applied to a disposable tissue may not require a surfactant for purposes of absorbency. However, a surfactant may be required to emulsify and stabilize the components P1097 hydrophilic and hydrophobic contained in the lotion. Suitable hydrophilic surfactants will be miscible in the skin conditioning agent, the optional immobilizing agent and in other ingredients of the composition to form homogeneous mixtures. Due to the possible sensitivity of the skin of those who use paper products to which the lotion composition is applied, these surfactants must also be relatively mild and non-irritating to the skin. Normally, these hydrophilic surfactants are non-ionic, since this type of surfactant tends to be less irritating to the skin than the anionic and cationic surfactants. Additionally, nonionic surfactants are also easier to formulate in the lotion compositions of the present invention. Nonionic surfactants of higher melting point are preferred. Because maintaining a softness of the skin is an important factor in the production of lotion tissue products, the use of nonionic surfactants is preferred, because they are softer for the skin than the surfactants under load. This is not to state that all surfactants under load are skin irritants. Although, as a general rule, most charged surfactants are skin irritants. The non-ionic surfactants used in these antimicrobial lotions P1097 perform several important functions. A critical function is to allow the hydrophilic acid / solvent mixture to mix with the hydrophobic skin conditioning agents. This allows a stable mixture of the hydrophobic components to be prepared with the hydrophilic components. In addition to providing the stability of the lotion, the surfactant also allows the lotion paper to absorb water and mucus at a reasonable speed. If a surfactant was not formulated in the lotion, the lotion paper product may in some cases repel water and mucus, possibly causing negative consumer reactions in this way. Lotion formulations consisting of no surfactant and these hydrophobic skin conditioning agents, such as petrolatum, mineral oil and dimethicone will be especially hydrophobic. As indicated, the inclusion of the surfactant also helps to solubilize the organic acids in these hydrophobic skin conditioning agents. It is important that tissue paper with lotion (especially in the case of toilet paper) according to the present invention is absorbent and / or wettable, as reflected by its hydrophilicity. The hydrophilicity of tissue paper refers, in general, to P1097 the tendency of tissue paper to get wet with water. The hydrophilicity of the tissue paper can be quantified partially by determining the time required for the dried tissue paper to be completely wetted with water. This period of time is referred to as the "wetting" (or "soaking") time. In order to provide a consistent and repeatable test for the wetting time, the following procedure can be used for the wetting time determinations: first, a paper sample (the environmental conditions for the test of paper samples are 23 ± 1 ° C and 50 ± 2% RH, as specified in Method T 402 of the TAPPI), approximately 2.5 inches x 3.0 inches (approximately 6.4 cm x 7.6 cm) is cut from a stack of 8 sheets of thickness of conditioned paper sheets; Secondly, the paper sample of 8 sheets of cut thickness is placed on the 2500 ml surface. of distilled water at 23 ± 1 ° C and simultaneously a timer is set as the lower sheet of the sample touches the water; third, the timer is stopped and read when the wetting of the paper sample is finished, ie when the top sheet of the sample is wetted or completely wetted. The total humidification is observed in visual form. The preferred hydrophilicity of tissue paper P1097 depends on your intended end use. It is desirable that the tissue paper used in a variety of applications, eg, toilet paper, be completely wetted in a relatively short period of time to avoid clogging once the toilet is discharged. Normally, the wetting time is 4 minutes or less, preferably the wetting time is 90 seconds or less, more preferably 30 seconds or less and most preferably, the wetting time is 10 seconds or less . The hydrophilicity of the tissue paper can, of course, be determined immediately after manufacture. However, significant increases in hydrophobicity may occur during the first two weeks after the tissue paper was made: that is, after the paper has matured or aged two (2) weeks after its manufacture. In this way, the stated wetting times are preferably measured at the end of this two week period. Accordingly, the wetting times measured at the end of an aging period of two weeks at room temperature are referred to as "wetting times after two weeks". Higher melting nonionic surfactants may also contribute to hardening or P1097 solidification of the lotion and, in this way, help to confine the lotion on the surface of the paper substrate. Importantly in relation to the antiviral activity, the surfactant may function to help solubilize the lipid shell layer of the enveloped virus class. This solubilization of the lipid shell increases the ability of antiviral acids to penetrate the structure of the virus and deactivate it. It should be noted that the lotion of this invention can, potentially, be prepared without adding a hydrophilic surfactant, depending on which hydrophilic solvent was used, the melting point of the lotion, the desired end use of the paper (i.e. toilet paper or disposable handkerchief). ) or if the lotion will be applied to a paper in a discontinuous pattern, so that some areas of the paper are covered with the lotion while others do not. Suitable nonionic surfactants will practically not migrate after the lotion composition is applied to the tissue web and will normally have HLB values in the range of about 4 to about 20, preferably from about 7 to about 20. So that be migratory, these non-ionic surfactants will normally have melting temperatures higher than the temperatures commonly encountered during storage, shipping, P1097 marketing and use of tissue paper products, for example, of at least about 30 ° C. In this regard, these nonionic surfactants will preferably have melting points similar to those of optional immobilizing agents. Suitable nonionic surfactants for use in the lotion compositions of the present invention include alkyl glycosides; alkyl glycoside ethers, as described in U.S. Patent No. 4,011,389, issued to Langdon et al. on March 8, 1977; alkyl polyethoxylated esters, such as PEGOSPERSE 1000MS, available from Lonza Inc. of Fair Lawn, New Jersey; ethoxylated mono-, di- and / or tri-esters of sorbitan and C 2 -C 8 fatty acids having an average degree of ethoxylation of from about 2 to about 20, preferably from about 2 to about 10, such as TWEEN 60 ( esters of sorbitan and stearic acid having an average degree of ethoxylation of about 20), TWEEN 20 (sorbitan esters and lauric acid having an average degree of ethoxylation of about 20) and TWEEN 61 (esters of sorbitan and stearic acid having an average degree of ethoxylation of about 4) and the condensation products of aliphatic alcohols of about 1 to about 54 moles of P1097 ethylene. The alkyl chain of the aliphatic alcohol is usually a straight chain (linear) configuration and contains from about 8 to about 22 carbon atoms. Particularly preferred are the condensation products of alcohols having an alkyl group containing from about 8 to about 22 carbon atoms with an average of about 2 to 30 moles of ethylene oxide per mole of alcohol. Examples of these ethoxylated alcohols include the condensation products of myristyl alcohol with an average of about 7 moles of ethylene oxide per mole of alcohol, the condensation products of cetearyl alcohol with about 2 to 20 moles of average ethylene oxide, the condensation products of stearyl alcohol with approximately 2 to 20 moles of average ethylene oxide, the condensation products of cetyl alcohol from 2 to 20 moles of average ethylene oxide, the condensation products of lauryl alcohol from 2 to 20 moles of oxide of average ethylene and the condensation products of coconut alcohol (a mixture of fatty alcohols having alkyl chains ranging in length from 10 to 14 carbon atoms) with an average of about 6 moles of ethylene oxide. Various suitable ethoxylated alcohols are available in commercial form, including TERGITOL 15-S-9 (the condensation product of Cn-Cis linear alcohols with an average of about 9 moles of ethylene oxide), available from Union Carbide Corporation of Danbury, Connecticut.; the surfactants under the trade name NEODOL, marketed by Shell Oil Co. of Houston, Texas, in particular NEODOL 25-12 (condensation product of C? 2-C? 5 linear alcohols with an average of approximately 12 moles of ethylene oxide) and NEODOL 23-6.5T (condensation product of C? 2-C? 3 linear alcohols with an average of about 6.5 moles of ethylene oxide that has been distilled (blunt) to remove certain impurities) and, especially the surfactants with name commercial PLURAFAC, marketed by BASF Corp. of Mount Olive, New Jersey, in particular PLURAFAC A-38 (a condensation product of a C de 8 straight chain alcohol with an average of approximately 27 moles of ethylene oxide). (Some of the hydrophilic surfactants, in particular the ethoxylated alcohols such as NEODOL 25-12, may also function as alkyl ethoxylated skin conditioning agents). Other examples of preferred ethoxylated alcohol surfactants are supplied by the Imperial Chemical Company (ICI) of Wilmington, Delaware. These include the class of BRIJ surfactants and mixtures thereof, where BRIJ 76 (ie, Steareth-10) and BRIJ 56 (ie Ceteth-10) are especially preferred according to P1097 is indicated, mixtures of cetyl alcohol and ethoxylated stearyl alcohol up to an average degree of ethoxylation of about 10 to about 20 can also be used as a hydrophilic surfactant. Another type of surfactant suitable for use in the present invention includes AEROSOL OT, a dioctyl ester and sodium sulfosuccinic acid, marketed by Cytec Industries Inc. of West Paterson, New Jersey. Other types of suitable surfactants for use herein, manufactured by General Electric of Fairfield, Connecticut, include silicone copolymers such as SF 1188 from General Electric (a copolymer of a polydimethylsiloxane and a polyoxyalkylene ether) and SF 1228 of General Electric (a silicone polyether copolymer). These silicone surfactants can be used in combination with the other types of hydrophilic surfactants described above, such as the ethoxylated alcohols. It has been found that these silicone surfactants are effective at concentrations as low as 0.1%, more preferably from about 0.25 to about 1.0% by weight of the lotion composition. These silicone surfactants as well as other dimethicone copolyols can also be effective for emulsifying non-functionalized dimethicone fluids, such as SF96-20, SF96-50, SF96-100 and P1097 SF96-350 from General Electric. The amount of hydrophilic surfactant required to increase the wettability of the lotion composition to a desired level will depend upon the HLB value of the surfactant, the concentration of immobilizing agent used, the HLB value of the other ingredients of the formulation and like factors. The lotion composition may comprise from about 0.1% to about 60% of the hydrophilic surfactant when it is necessary to increase the wettability properties of the composition. Preferably, the lotion composition comprises from about 5% to about 50% and most preferably from about 10% to 30% of the hydrophilic surfactant.

. Optional Immobilizing Agents An optional component of the lotion compositions of the present invention is one or more agents that have the ability to immobilize the skin conditioning agent on the surface of the paper to which the lotion composition is applied. Because some of the skin conditioning agents, surfactants, solvents and optional ingredients in the composition have a plastic or fluid consistency at 20 ° C, they tend to flow or migrate, even when subjected to a shear P1097 modest. When applied to a tissue paper web, especially in a fused or melted state, the skin conditioning agent will not primarily remain on the surface of the paper. Instead, the skin conditioning agent will migrate and flow into the paper. This migration of the skin conditioning agent into the paper may cause the undesirable detachment of the paper by interfering with the normal hydrogen bond between the paper fibers. This normally leads to a decrease in the tensile strength of the paper. It also means that much more skin conditioning agent has to be applied to the paper to obtain the desired lubrication-like lotion-like benefits on the paper surface. The increase in the level of the skin conditioning agent increases not only the cost but also exacerbates the problem of paper detachment. The caliber can also receive a negative impact if immobilizing agent is not used. Without stationary, the lotion migrates through all the fibers of the paper instead of concentrating on the surface of the paper. In several cases where liquid skin conditioning agents are used, the caliper can actually be reduced. The immobilizing agent counteracts this P1097 tendency of the skin conditioning agent to migrate or flow by keeping the skin conditioning agent located primarily on the surface of the paper to which the lotion composition is applied. It is believed that this must be, partially, to the fact that the immobilizing agent forms hydrogen bonds or bonds with the paper. By this hydrogen bonding, the immobilizing agent is placed or located on the surface of the paper. Since the immobilizing agent is also miscible in the skin conditioning agent (or is solubilized in the skin conditioning agent with the aid of a suitable emulsifier), it also traps the skin conditioning agent on the surface of the paper. Immobilization is also improved by a more crystalline structure of the immobilizing agent. If the immobilizing agent has a more crystalline structure, the immobilization molecules will tend to rapidly form seeds of nucleation sites where the lotion can solidify. The more amorphous immobilization agents tend to solidify at lower speeds than their more crystalline counterparts. However, some amorphous high-melting microcrystalline waxes can effectively trap the lower molecular weight hydrocarbon components of mineral oil and petrolatum. This effect of P1097 entrapment can help prevent the skin conditioning agent system from migrating through the entire paper structure. Thus, even though their crystallization kinetics may be slower than those of their paraffin wax counterparts, amorphous high-melting microcrystalline waxes may be effective in inhibiting the flow of liquid hydrocarbon components. In addition, highly branched immobilization agents, such as microcrystalline waxes, can increase the viscosity of the lotion. This increase in viscosity can also help keep the lotion on the surface of the paper by increasing the resistance to flow to the mass of the paper. Thus, it is advantageous to have a lotion that both crystallizes and solidifies rapidly on the surface of the paper while at the same time having a high viscosity to reduce the flow of the lotion towards the paper mass. It is also advantageous to secure the immobilizing agent on the surface of the paper. As previously indicated, this can be achieved by using immobilizing agents that crystallize rapidly (ie, solidify) on the surface of the paper. In addition, the external cooling of paper treated by blowers, fans, etc., can accelerate the crystallization of the P1097 immobilizing agent. In addition to being miscible (or solubilized) in the skin conditioning agent, the immobilizing agent needs to have a melting point of at least about 25 ° C. This is so that the same immobilizing agent has no tendency to migrate or flow. Preferred immobilizing agents will have melting points of at least about 40 ° C. Typically, the immobilizing agent will have a melting point in the range of from about 50 ° to about 150 ° C. The viscosity of the immobilizing agent should also be as high as possible to prevent the lotion from flowing into the interior of the paper. Unfortunately, high viscosities can also lead to lotion compositions that are difficult to apply without processing problems. Therefore, a balance must be obtained, so that the viscosities are high enough to keep the immobilizing agent located on the surface of the paper but not so high as to cause processing problems. Suitable viscosities for the immobilizing agent will usually vary from about 5 to about 200 centipoise, preferably from about 15 to about 100 centipoise, measured at 60 ° C. Immobilizing agents suitable for the present invention may comprise C12-C22 fatty alcohols; C 2 -C 22 fatty acids; sorbitan stearates; sorbitan alkylates; polyoxylated sorbitan mono-, di- and tri-alkylates; mono-, di- and tri-alkylates of sorbitan; clays; waxes and mixtures thereof. Preferred immobilizing agents include C6-Ci8 fatty alcohols, more preferably, cetyl alcohol, stearyl alcohol, and mixtures thereof. Particularly preferred are mixtures of cetyl alcohol and stearyl alcohol. Behenyl alcohol (C22) is also an excellent fatty alcohol and is available commercially for use as an immobilizing agent in the present formulas. Other preferred immobilizing agents include C 16 -C 8 fatty acids, most preferably, palmitic acid, stearic acid, and mixtures thereof, particularly mixtures of palmitic acid and stearic acid. Other preferred immobilizing agents include paraffin-type waxes, sorbitan stearates and mixtures thereof. Preferably, the fatty alcohols and the fatty acids are linear. Importantly, these preferred immobilizing agents, such as the Cis-Cia and C22 fatty alcohols increase the rate of crystallization of the lotion, causing the lotion to crystallize rapidly on the surface of the substrate. Lower levels of lotion P1097 can, therefore, be used so that a superior lotion feeling can be delivered. Traditionally, larger quantities of lotion were necessary to generate softness, due to the flow of these liquids towards the mass of the paper substrate. Other types of immobilizing agents may be used in combination or instead of the fatty alcohols, fatty acids, sorbitan stearates and waxes described above. Normally, only minor amounts of these other types of immobilizing agents would be used (ie, up to about 10% of the total immobilizing agent). However, the use of higher amounts of these other types of these immobilizing agents (ie, up to 100%) is within the scope of the present invention. Examples of these other types of immobilizing agents include polyhydroxy fatty acid esters, polyhydroxy fatty acid amides, clays, clay derivatives and mixtures thereof. To be useful as immobilizing agents, the polyhydroxy portion of the ester or amide must have at least one free hydroxy group. It is believed that these free hydroxy groups are those that are co-cross-linked by forming hydrogen bonds with the cellulosic fibers of the tissue paper web to which the lotion composition is applied, as well as homo-crosslinking, by forming cross-linkages. hydrogen with P1097 hydroxy groups of the alcohol, acid, ester or amide, thereby trapping and immobilizing the other components in the lotion matrix. It is also believed that molecules such as long chain fatty alcohols can orient themselves and interact with others to form a lamellar structure. In this lamellar structure, the hydroxyl groups and the alkyl chains of neighboring alcohol molecules are oriented and interact with each other to form an organized structure. In this packing arrangement, the hydroxyl groups of the alcohols form hydrogen bonds with the polar functionalities of the cellulose (eg, hydroxy or carbonyl) to immobilize the alcohols on the surface of the paper. Since the alcohols are miscible in the preferred skin conditioning agents, anchoring and / or immobilization of the skin conditioning agent will occur. Preferred esters and amides will have three or more free hydroxy groups in the polyhydroxy moiety and are usually nonionic in nature. Due to the possible skin sensitivity of those who use paper products to which the lotion composition is applied, these esters and amides must also be relatively mild and non-irritating to the skin. The polyhydroxy fatty acid esters suitable P1097 for use in the present invention will have the formula: wherein R is a C5-C3 hydrocarbyl group, preferably straight chain C7-C19 alkyl or alkenyl, more preferably straight chain C9-C17 alkyl or alkenyl, most preferably Cn-C? 7 alkyl or alkenyl of Straight chain or mixtures thereof; Y is a polyhydroxy hydrocarbyl portion having a hydrocarbyl chain with at least 2 free hydroxyls directly connected to the chain and n is at least 1. Suitable Y groups can be derived from polyols such as glycerol, pentaerythritol; sugars such as raffinose, maltodextrose, galactose, sucrose, glucose, xylose, fructose, maltose, lactose, mannose and erythrose; sugar alcohols such as erythritol, xylitol, malitol, mannitol and sorbitol; and anhydrides of sugar alcohols such as sorbitan. A class of polyhydroxy fatty acid esters suitable for use in the present invention comprises certain sorbitan esters, preferably the sorbitan esters and saturated C ?6-C22 fatty acids.

P1097 Due to the manner in which they are normally manufactured, these sorbitan esters usually comprise mixtures of mono, di-, tri-, etc., esters. Representative examples of suitable sorbitan esters include sorbitan palmitates (e.g., SPAN 40 manufactured by ICI Chemicals), sorbitan stearates (eg, SPAN 60) and sorbitan behenates, which comprise one or more of the mono-, di- and tri-ester versions of these sorbitan esters, for example, sorbitan mono-, di- and tri-palmitate, sorbitan mono-, di- and tri-stearate, sorbitan mono-, di- and tri-behenate, as well as sorbitan mono-, di- and tri-esters and tallow fatty acid mixed. Mixtures of different sorbitan esters can also be used, such as sorbitan palmitates with sorbitan stearates. Particularly preferred sorbitan esters are sorbitan stearates, usually as a mixture of mono-, di- and tri-esters (plus some tetraester) such as SPAN 60 and sorbitan stearates sold under the tradename GLYCOMUL-S by Lonza, Inc. of Fair Lawn, New Jersey. Although these sorbitan esters usually contain mixtures of mono-, di- and tri-esters, plus some tetraesters, mono- and di-esters are usually the predominant species in these mixtures. Another class of polyhydroxy fatty acid esters P1097 suitable for use in the present invention comprise certain glyceryl monoesters, preferably glyceryl monoesters and saturated C ?6-C22 fatty acids such as glyceryl monostearate, glyceryl monopalmitate and glyceryl monobehenate. Again, like sorbitan esters, glyceryl monoester mixtures will normally contain some di- and triester. However, these mixtures will predominantly contain the glyceryl monoester species to be useful in the present invention. Another class of polyhydroxy fatty acid esters suitable for use in the present invention, comprise certain esters of fatty acid and sucrose, preferably saturated C este2-C22 fatty acid esters and sucrose. Sucrose monoesters are particularly preferred and include sucrose monostearate and sucrose monolaurate. The polyhydroxy fatty acid amides suitable for use in the present invention will have the formula: O R1 If I R2- -C-N-Z wherein R1 is H, hydrocarbyl C? -C, 2 -hydroxyethyl, 2-hydroxypropyl, methoxyethyl, methoxypropyl or a mixture of P1097, preferably, C3-C4 alkyl, methoxyethyl or methoxypropyl, more preferably Cx or C2 alkyl or methoxypropyl, more preferably Ci (i.e., methyl) or methoxypropyl; and, R2 is a C5-C31 hydrocarbyl group, preferably straight chain C7-C19 alkyl or alkenyl, more preferably straight chain C9-C17 alkyl or alkenyl, most preferably straight chain C11-C17 alkyl or alkenyl or mixtures thereof; and Z is a polyhydroxyhydrocarbyl moiety having a linear hydrocarbyl chain with at least 3 hydroxyls directly attached to the chain. See U.S. Patent No. 5,174,927, issued to Honsa on December 29, 1992 and incorporated herein by reference, which discloses these polyhydroxy fatty acid amides as well as their preparation. The Z portion will preferably be derived from a reducing sugar in a reductive amination reaction; more preferably, glycityl. Suitable reducing sugars include glucose, fructose, maltose, lactose, galactose, mannose and xylose. High dextrose corn syrup, high fructose corn syrup and high maltose corn syrup may be used, as well as the individual sugars listed above. These corn syrups can produce mixtures of sugar components for the Z portion.

P1097 The Z portion will preferably be selected from the group consisting of: CH2- (CHOH) n-CH20H, -CH (CH2OH) - [(CHOH) n-1] -CH2OH, -CH2OH-CH2- (CHOH) 2 (CHOR3 ) (CHOH) -CH2OH, wherein n is an integer from 3 to 5 and R3 is H or a cyclic or aliphatic monosaccharide. Most preferred are glycityls wherein n is 4, particularly -CH2- (CHOH) 4-CH2OH. In the above formula, R1 may be, for example, N-methyl, N-ethyl, N-propyl, N-isopropyl, N-butyl, N-2-hydroxyethyl, N-methoxypropyl or N-2-hydroxypropyl. R2 can be selected so as to provide, for example, cocamides, stearamides, oleamides, lauramides, myristamides, capricamides, palmitamides, seboamides, etc. The Z portion can be 1-deoxyglucityl, 2-deoxyfructityl, 1-deoxymaltityl, 1-deoxylactityl, 1-deoxygalactityl, 1-deoxyanityl, 1-deoxy-thiotriotyl, etc. The polyhydroxy fatty acid amides most preferably have the general formula: wherein R 1 is methyl or methoxypropyl; R2 is a Cn-C? 7 straight chain alkyl or alkenyl group, these include N-lauryl-N-methyl glucamide, N-lauryl-N-methoxypropyl glucamide, N-cocoyl-N-methyl glucamide, N-cocoyl-N -methoxypropyl glucamide, N-palmityl-N-methoxypropyl glucamide, N-tallowyl-N-methyl glucamide or N-tallowyl-N-methoxypropyl glucamide. As previously indicated, some of the immobilizing agents require an emulsifier for solubilization in the skin conditioning agent. This is particularly the case for some of the glucamides, such as N-alkyl-N-methoxypropyl glucamides having HLB values of at least about 7. Suitable emulsifiers will usually include those having HLB values below about 7. In this regard, previously described sorbitan esters, such as sorbitan stearates, having HLB values of about 4.9 or less have been found useful in the solubilization of these glucamide immobilization agents in petrolatum. Other suitable emulsifiers include steareth-2 (polyethylene glycol ethers of the stearyl alcohol which are in accordance with the formula CH3 (CH2) 17 (OCH2CH2) nOH, where n has an average value of 2), sorbitan tristearate, isosorbide laurate and glyceryl monostearate. The emulsifier can be included in an amount sufficient to solubilize the immobilizing agent in the skin conditioning agent, so that a mixture is practically obtained.

P1097 homogeneous. For example, a mixture of approximately 1: 1 of N-cocoyl-N-methyl glucamide and petrolatum that normally does not melt into a single-phase mixture will melt into a single-phase mixture with the addition of 20% a 1: 1 mixture of steareth-2 and sorbitan tristearate as an emulsifier. The amount of immobilizing agent to be included in the lotion composition will depend on a variety of factors, including the particular skin conditioning agent involved, the particular immobilizing agent involved, regardless of whether an emulsifier is required to solubilize the immobilizing agent. in the skin conditioning agent, the other components in the composition of the lotion and the like. The composition of the lotion comprises from about 5% to 60% of the immobilizing agent and, preferably, from about 10% to 40% of the immobilizing agent. 6. Other Optional Components The lotion compositions may comprise other optional components normally present in emollients, creams and lotions of this type. These optional components include viscosity modifiers, perfumes, disinfectants, active Pharmaceutical P1097, film formers, vitamins (for example, vitamin E), deodorants, opacifiers, astringents, solvents and the like. In addition, stabilizers may be added to improve the shelf life of the lotion composition, such as cellulose derivatives, antioxidant proteins and lecithin. All of these materials are well known in the art as additives to these formulations and can be used in appropriate amounts in the lotion compositions of the present invention. In addition, natural essential oils such as camphor, thymol, pine oil, menthol, eucalyptol (cineole), geraniol, lemon oil, methyl salicylate, clove and other similar materials can be used to provide the product with a medicinal aroma. In addition, some of these natural essential oils also possess antiviral and antibacterial properties. These other optional components may comprise from about 0.1% to 20% of the lotion composition.

C. Treatment of Tissue Paper with Lotion Composition When preparing lotion paper products, in accordance with the present invention, the lotion composition can be applied to at least one surface of a tissue paper web. Any one of a P1097 variety of application methods that uniformly distribute lubricating materials that have a molten or liquid consistency. Suitable methods include spraying, printing (eg, flexographic printing), coating (e.g., engraved hole coating), extrusion, or combinations of these application techniques, e.g., spraying the lotion composition on a rotating surface, such as a calendering roller, which then transfers the composition to the surface of the paper web. The lotion composition can be applied either to a surface of the tissue paper web or to both surfaces. Preferably, the lotion composition is applied to both surfaces of the paper web. The manner of applying the composition of the lotion to the tissue paper web should be such that the web is not saturated with the lotion composition. If the weave becomes saturated with the lotion composition, there is a greater potential for paper detachment to occur, thus leading to a reduction in the tensile strength of the paper. Nor is saturation of the paper web required to obtain the smoothness and benefits of the lotion-like feel of the lotion composition of the present invention. Particularly suitable application methods will apply the composition of P1097 lotion mainly to the surface or surfaces of the paper web. The saturation of the central sheet of a three-ply tissue paper would be an example of when the tissue paper may be saturated with a more liquid type lotion composition. Even if the physical properties of the leaf of a medium would probably be adversely affected, this would work even as an effective carrier of the lotion. Of course, the materials could migrate from this central sheet to the outer sheets and it would have to be avoided adversely affecting their physical properties. The lotion composition can be applied to the tissue paper web after the web has dried, i.e., a "dry web" addition method. The lotion composition is applied in an amount of from about 2 to about 40% by weight of the tissue paper web. Preferably, the lotion composition is applied in an amount from about 5 to about 25% by weight of the tissue paper web, most preferably from about 10 to about 18% by weight of the web. These relatively low levels of the lotion composition are suitable for imparting the desired softness and the benefits of the lotion-like feel to the tissue paper, although without saturating the tissue paper web to such a degree P1097 that the absorbency, wettability and, in a particular way, the resistance in an important way are affected. The amount of lotion on paper should also be optimized to obtain the effective destruction of viruses and bacteria within the paper structure. The lotion composition can also be applied non-uniformly to the surface or surfaces of the tissue paper web. By "non-uniform" it is meant that the quantity, pattern of distribution, etc. of the lotion composition may vary on the surface of the paper. For example, portions of the surface of the tissue paper web may have greater or lesser amounts of the lotion composition, including portions of the surface that do not have any of the lotion composition therein. An example of a non-uniform application is when the tissue paper structure contains different amounts and different compositions of various formulations throughout its structure or, alternatively, when some areas may not contain lotion at all, as taught in the United States No. 4,481,423, issued to Alian on November 6, 1984 and incorporated herein by reference. For example, in a double-sheet tissue paper structure, a composition of air conditioning agent can be applied to the two outer surfaces of the paper structure.

P1097 attractive skin that contains antibacterial agents, while an antiviral composition is applied to the two internal surfaces of the paper structure. Or in a three-sheet paper structure, the inner sheet may contain the antiviral lotion composition while the consumer side of the two outer sheets contains a composition of skin conditioning agent and an antibacterial agent. Additional examples include the addition of a skin conditioning agent that does not contain any antimicrobial active to the outer leaves. The skin conditioning agent can be an ingredient such as dimethicone, which would be transferred to the skin with the carving or scrubbing to form a protective layer on the skin. In addition, this composition of skin conditioning agent could lead to a superior lotion feeling than the antimicrobial composition. Or, this layer of skin conditioning agent can transfer to the skin another active agent such as a sunscreen or a skin healing additive. While this skin conditioning agent composition would be applied to the outer sheets, the antimicrobial active composition could be applied to the inner side of one or both of the outer sheets to produce antimicrobial destructive activity within the tissue paper. With the antimicrobial active P1097 On the inner side of the tissue paper and the skin conditioning agent applied on the outside, the antimicrobial killing activity would most likely be confined to the interior of the tissue paper rather than on the surface of the wearer's skin. The antimicrobial composition could also be applied to a third sheet that is sandwiched between the other two sheets containing the skin conditioning agent. These two schemes have certain advantages in that a single asset can be transferred to the skin. Furthermore, if a very high concentration of organic acid is used inside the tissue paper, the skin conditioning agent transferred to the skin could form a protective barrier against any adverse skin reactions as potentially caused by the use of the skin. an irritating acid. There are numerous permutations of these approaches. The lotion composition can be applied to the tissue paper web at some point after it has dried. For example, the lotion composition can be applied to the tissue web after it has been creped from a Yankee dryer but before calendering, that is, before it is passed through the calendering rollers. The lotion composition can also be applied to the paper web after it has passed through these calender rolls and before it is wound or wound onto a supply roll. Usually, it is preferred to apply the lotion composition to the tissue paper as it is being unwound from a supply roll and before it is wound onto smaller finished paper product rolls. The lotion composition is usually applied from a fusion thereof to the tissue paper web. Because the lotion composition melts at significantly higher temperatures than the environment, it is usually applied as a superheated coating to the tissue paper web. Typically, the lotion composition is heated to a temperature in the range of from about 35 ° to about 100 ° C, preferably from 40 ° to about 90 ° C, before it is applied to the tissue paper web. Once the molten lotion composition has been applied to the tissue paper web, it is allowed to cool and solidify to form a solidified coating or film on the surface of the paper. To allow more lotion to solidify on the tissue paper surface instead of the paper mass, fans or cooling rollers can be directed to the lotion paper to accelerate the solidification of the lotion. The lotion compositions of the present invention can be applied to tissue paper by spraying the P1097 composition in the tissue paper web or by means of gravure coating and extrusion coating methods. Embossed and extrusion coating coating methods such as those taught in U.S. Patent No. 5,246,546, issued to Ampulski on September 21, 1996 and incorporated herein by reference, are preferred. Figure 1 illustrates one of these preferred application methods that include the engraved hole coating. Referring to Figure 1, a dry tissue paper web 1 is unwound from a tissue paper feeding roll 2. (which rotates in the direction indicated by the arrow 2a) and which advances around the rotary roller 4. From the rotating roller 4, the weft 1 is advanced to the engraved offset-hole coating station 6, wherein the lotion composition it is then applied to both sides of the frame. After leaving station 6, the weft 1 becomes a weft pattern indicated by 3. The weft weave 3 is then advanced around the rotating roller 8 and then wound onto a feed roll 10 of tissue paper with lotion (which rotates in the direction indicated by arrow 10a). Station 6 comprises a pair of linked offset offset-hole presses 12 and 14. The press 12 consists of a lower engraved hole cylinder 16 and a cylinder P1097 of offset 18 higher; the press 14 similarly consists of a lower engraved hole cylinder 20 and an upper offset cylinder 22. The engraved recess cylinders 16 and 20 each have a specific engraved cell size and pattern and each has a chromed surface, while the offset cylinders 18 and 22 each have a smooth polyurethane rubber surface. The volume size of the roll cell of the engraved hole will depend on the weight of the desired coating, the line speed and the viscosity of the lotion. Both engraved and offset hole cylinders are heated to keep the lotion melted. These engraved hole and offset cylinders rotate in the directions indicated by the arrows 16a, 18a, 20a and 22a, respectively. As shown in Figure 1, the offset cylinders 18 and 22 are directly opposite and parallel to each other and provide a grip area indicated by 23 through which the weft 1 passes. Placed under the recess cylinders 16 and 20 are the supply or bridge trays 24 and 26, respectively. The hot and melted lotion composition (eg, 65 ° C) is pumped into each of these heated trays 24 and 26 to provide the deposits of the molten lotion composition, as indicated by arrows 30 and 32, respectively.

P1097 As the engraved hole cylinders 16 and 20 rotate in the directions indicated by the arrows 16a and 20a, within the reservoirs 30 and 32, they trap an amount of the sunken lotion composition. The excess lotion in each of the engraved recess cylinders 16 and 20 is then removed by scraper blades 34 and 36, respectively. The lotion composition remaining in the cells of the heated recess cylinder 16 and 20 is then transferred to the heated offset cylinders 18 and 22 (which rotate in the opposite direction, as indicated by arrows 18a and 22b) in the areas 38 and 40 between the respective pairs of cylinders. The lotion composition transferred to the offset cylinders 18 and 22 is then transferred simultaneously to both sides of the frame 1. The amount of lotion composition transferred to the frame 1 can be controlled: (1) by adjusting the width of the grip area 23 between the offset cylinders 18 and 22; and / or (2) adjusting the grip widths 38 and 40 between the pairs of engraved / offset hole cylinders 16/18 and 20/22. Figure 2 illustrates a preferred alternative method that includes slot extrusion coating. Referring to Figure 2, a 101 dry tissue paper web is unwound from a feeding roll P1097 102, of tissue paper (which rotates in the direction indicated by the arrow 102a) and is then advanced around the rotating roller 104. From the rotating roller 104, the frame 101 is advanced to the extrusion coating station 106 in slot, wherein the lotion composition is then applied to both sides of the screen. After leaving the station 106, the frame 101 becomes a lotion frame indicated by 103. The lotion frame 103 is then wound onto the tissue paper feed roll 110 with lotion (it is rotated in the direction indicated by the arrow 110a). The station 106 comprises a pair of extruders in separate slots 112 and 114. The extruder 112 has an elongated slot 116 and a surface 118 that contacts the weft; the extruder 114, similarly, has an elongated slot 120 and a surface 122 that contacts the weft. As shown in Figure 2, the extruders 112 and 114 are oriented so that the surface 118 is in contact with one side of the frame 101, while the surface 122 is in contact with the other side of the frame 101. The hot and melted lotion composition (for example at 65 ° C) is pumped into each of the extruders 112 and 114 and then extruded through the slots 116 and 120, respectively. As the plot 101 passes over the surface P1097 from the extruder 112 and reaches the groove 116, the molten lotion composition extruded from the groove 116 is applied to the side of the weft 101 which is in contact with the surface 118. Similarly, as the weft 101 passes over the the heated surface 122 of the extruder 114 and reaches the slot 120, the molten lotion composition extruded from the slot 120 is applied to the side of the weft 101 which is in contact with the surface 122. The amount of lotion composition transferred to the Weft 101 is controlled by: (1) the speed at which the molten lotion composition is extruded from slots 116 and 122; and / or (2) the speed at which the frame 101 travels while it is in contact with the surfaces 118 and 122.

SPECIFIC ILLUSTRATIONS OF THE PREPARATION OF THE TISSUE PAPER WITH LOTION, ACCORDING TO THE PRESENT INVENTION The following are specific illustrations of the treatment of the tissue paper with the lotion compositions according to the present invention: Example 1. A. Preparation of the composition of A. The composition of lotion A without water is prepared by first mixing the following components: propylene glycol, polyoxyethylene lauryl ether (4) (Brij 30 or P1097 equivalent) and polyoxyethylene cetyl ether (10) (Brij 56 or equivalent). This mixture is heated to 60 to 90 ° C and mixed until a clear, clear and colorless solution results. While mixing and maintaining the temperature of this solution in the range of 60 to 90 ° C, the salicylic acid is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C, until a clear, clear and colorless solution results. While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, the cetearyl alcohol is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, clear and colorless solution results. While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, the mineral oil is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, stable phase, clear and colorless solution results. The percentages by weight of these components are shown below in Table I: Table I Lotion Composition A PÍO37" Example 2 B. Preparation of lotion composition B Lotion composition B without water is prepared by first mixing the following components: propylene glycol, polyoxyethylene lauryl ether (4) (Brij 30 or equivalent) and polyoxyethylene cetyl ether (10) (Brij 56 or equivalent). This mixture is heated from 60 to 90 ° C and mixed until a clear solution results, transparent and colorless. While mixing and maintaining the temperature of this solution in the range of 60 to 90 ° C, citric acid is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, clear and colorless solution results. While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, cetearyl alcohol is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, clear and colorless solution results. While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, the mineral oil is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, stable phase, clear and colorless solution results. The percentages by weight of these components are shown below in Table II: Table II Composition of Lotion B Example 3 C. Preparation of Lotion Composition C Lotion composition C without water is prepared by first mixing the following components: propylene glycol, polyoxyethylene (20) sorbitan monolaurate (Tween 20 or equivalent) and polyoxyethylene monostearate (4). ) of sorbitan (Tween 61 or equivalent). This mixture is heated to 60 to 90 ° C and mixed until a clear, clear and slightly clear solution results P1097 yellow While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, citric acid is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, stable phase, clear and slightly yellow solution results. The percentages by weight of these components are shown below in Table III: Table III Composition of Lotion C Example 4 D. Preparation of Lotion D composition Lotion composition D without water is prepared by first mixing petrolatum with cetearyl alcohol. This mixture is heated to 70 to 90 ° C and mixed until a clear, clear and slightly yellow solution results. While mixing and maintaining this solution temperature in the range of 70 to 90 ° C, ceteareth-10 is added. This hodgepodge is mixed and heated in the range of 70 to 90 ° C until a clear, clear and slightly yellow solution results. While mixing and maintaining this temperature of the solution in the range of 70 to 90 ° C, salicylic acid is added. This hodgepodge is mixed and heated in the range of 70 to 90 ° C until a clear, clear and slightly yellow solution results. While mixing and maintaining this temperature of the solution in the range of 70 to 90 ° C, TRICLOSAN® is added. This hodgepodge is mixed and heated in the range of 70 to 90 ° C until a clear, stable phase, clear and slightly yellow solution results. The percentages by weight of these components are shown in Table IV below: Table IV Composition of Lotion D P1097 Example 5 E. Preparation of the lotion composition? The waterless E-lotion composition is prepared by first mixing the following components: propylene glycol, polyoxyethylene lauryl ether (4) (Brij 30 or equivalent) and polyoxyethylene cetyl ether (10) (Brij 56 or equivalent). This mixture is heated to 60 to 90 ° C and mixed until a clear, clear and colorless solution results. While mixing and maintaining this solution temperature in the range of 60 to 90 ° C, the citric acid is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, clear, colorless solution results. While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, the cetearyl alcohol is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, clear and colorless solution results. While mixing and maintaining this solution temperature in the range of 60 to 90 ° C, TRICLOSAN® is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until a clear, clear and colorless solution results. While mixing and maintaining this temperature of the solution in the range of 60 to 90 ° C, the mineral oil is added. This hodgepodge is mixed and heated in the range of 60 to 90 ° C until P1097 is a clear, stable phase, transparent and colorless solution. The percentages by weight of these components are shown in Table V: Table V Composition of Lotion E B. Lotion tissue preparation by hot melt spraying Lotions A, B or C are placed separately in a Spraymatic PAM 600S hot melt spray gun (manufactured by PAM Fastening Technology, Inc.) that works at a temperature of about 70 to 90 ° C. Twelve inch by 12 inch tissue paper sheets were spray coated to the desired lotion level on each side of the substrate. Tissue papers with lotion were placed P1097 then in a convection oven at 70 ° C for 30 seconds after each side was sprayed to remove the volatile components and to ensure a more even coating of the lotion on the paper fibers. While the particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications may be made without departing from the spirit and scope of the invention. Therefore, it is intended that the appended claims cover all these changes and modifications that are within the scope of this invention.

P1097

Claims (10)

1. CLAIMS; A tissue paper having a lotion composition, wherein the lotion composition comprises: (A) at least one antimicrobial component; (B) at least one hydrophilic solvent; (C) at least one skin conditioning agent; and (D) at least one hydrophilic surfactant.
2. 2. The tissue paper according to claim 1, wherein the lotion composition is applied to at least one surface of the tissue paper in an amount ranging from about 2% to about 40% by weight of the dried tissue paper, preferably in where the lotion composition is semisolid or solid at 20 ° C and more preferably where the lotion composition is practically free of water.
3. 3. The tissue paper of claim 1, wherein the antimicrobial is selected from the group consisting of benzalkonium chloride, benzethonium chloride, chlorhexidine, polyhexamethylene biguanide hydrochloride, methylparaben, propylparaben, TRICLOCARBAN®, and OCTOPIROXI®.
4. 4. The tissue paper of claim 1, wherein the antimicrobial is selected from the group consisting of bacitracin, neomycin, polymyxin B, nystatin, and mixtures thereof. P1097 5. The tissue paper of claim 1, wherein the antimicrobial is selected from the group consisting of antivirals, antibacterials and mixtures thereof, preferably, wherein the antibacterial comprises from about 0.1% to about 6% of the composition. of lotion and is selected from the group consisting of TRICLOSAN®; povidone iodine; chloroxylenol; PCMX; ZPT; KATHON CG®; CLOFLUCARBAN; partner omadina, natural essential oils; 8-hydroxyquinoline; D-sphingosine; hexamidine; imidazolidinyl urea; hinoquitiol; eugenol; citric acid; ascorbic acid; malic acid; tartaric acid; benzoic acid; triacetin; M omomer; ethanol; butyl alcohol; isopropanol; 2-phenoxyethanol; coconut chloride amidopropyl phosphatidyl PG-dimonium; linole chloride amidopropyl phosphatidyl PG-dimonium, coconut chloride phosphatidyl PG-dimonium and mixtures thereof and wherein the antiviral is an organic acid comprising from about 1% to about 60% of the lotion composition, more preferably wherein the antibacterial is TRICLOSAN® and the organic acid is selected from the group consisting of saturated, unsaturated and aromatic Cx to C? 2 carboxylic acids possessing from 1 to 4 carboxylic acid groups and having at least one substituted hydroxyl group in the carbon alpha C2; C1 to Ci2 saturated carboxylic acids, unsaturated and aromatic having from 1 to 4 P1097 carboxylic acid groups and having at least one hydroxyl group substituted on the beta carbon C3; C 1 -C 12 saturated, unsaturated and aromatic carboxylic acids having from 1 to 4 carboxylic acid groups; saturated, unsaturated and aromatic Cx to C12 carboxylic acids, possessing from 1 to 4 carboxylic acid groups and having substituted hydroxyl groups in carbons number (s) C4 or higher; and mixtures thereof and even more preferably, wherein the organic acid is a solid at room temperature and is selected from the group consisting of citric acid, salicylic acid, tartaric acid, ascorbic acid and mixtures thereof. The tissue paper according to any of the preceding claims, wherein the tissue paper further comprises an inorganic acid selected from the group consisting of hydrochloric acid, boric acid and phosphoric acid, wherein the inorganic acid comprises from about 0.1% to 5% of the lotion composition. The tissue paper according to any of the preceding claims, wherein the hydrophilic solvent comprises from about 5% to 60% of the lotion composition, preferably wherein the hydrophilic solvent comprises from about 1 to 150 carbon atoms and wherein the carbon atoms can be straight or branched chain, saturated or unsaturated with or without ether bonds and contain from about 1 to 302 hydroxyl groups and more preferably wherein the hydrophilic solvent is selected from the group consisting of polyethylene glycols, polypropylene glycol, glycerin, propylene glycol, ethylene glycol, ethanol, isopropanol, hexylene glycol and mixtures thereof. The tissue paper according to any of the preceding claims, wherein the skin conditioning agent is substantially free of water and comprises from 0.1% to 60% of the lotion composition, preferably wherein the skin conditioning agent has a plastic or fluid consistency at 20 ° C and more preferably where the skin conditioning agent is selected from the group consisting of petroleum-based skin conditioning agents; skin conditioners of fatty acid ether; skin conditioners for fatty alcohol; polyethylene glycols; propylene glycol; glycerin; hexylene glycol; triethylene glycol; spermaceti; squalene; cholesteryl; C 2 to C 5 0 waxes, fatty alcohol ethers Ci 2 to C 28 fatty acids; acetoglycerides; ethoxylated glycerides of C12 to C28 fatty acids; fatty esters of polyhydroxy alcohols, lanolin and lanolin derivatives; silicone polyether copolymers; dimethicones having a viscosity ranging from about 20 to 12,500 centistokes at 25 ° C; amino functional polydimentylsiloxanes having a viscosity at 20 ° C from about 5 to about 2,000 centistokes and mixtures thereof 9. The tissue paper according to any of the preceding claims, wherein the lotion composition further comprises an immobilizing agent comprising from about 5% to 60% of the lotion composition and other optional components comprising from about 0.1% to about 20% of the lotion composition, wherein the other optional components are selected from the group consisting of natural essential oils, vitamin , panthenol, camphor, thymol, menthol, eucalyptol, geraniol, lemon oil, methyl salicylate, clove, alcohol and mixtures thereof, preferably, wherein the immobilizing agent has a melting point of at least about 25 ° C and more preferably wherein the immobilizing agent is selected from the group consisting of C 2 to C fatty alcohols. 22, C12 to C22 fatty acids; sorbitan stearates; sorbitan alkylates; polyoxylated mono-, di and trialkylazole sorbitan; mono-, di-, and sorbitan trialkylates; clays; waxes; polyhydroxy fatty acid esters; polyhydroxy fatty acid amides and mixtures thereof. The tissue paper according to any of the preceding claims, wherein the surfactant Hydrophilic P1097 comprises from about 0.1% to 60% of the lotion composition and has an HLB value of at least about 4 and preferably wherein the hydrophilic surfactant is non-ionic.