MXPA00007274A - Concentrated polyol composition - Google Patents

Abstract

The invention concerns a concentrated polyol composition characterised in that its water content ranges from 10 to 17%, preferably between 12 and 16%, and in that it comprises:35 to 90%of hydrogenated monosaccharides including at least 30%of sorbitol;0 to 45%of hydrogenated disaccharides, said percentages being expressed in dry weight relatively to the total dry weight of the hydrogenated saccharides contained in said composition. Said concentrated polyol composition can advantageously be desugared. The invention also concerns the use of said concentrated polyol composition as dispersing medium for hydrophilic polymers, and particularly cellulose, and its use for preparing pharmaceutical or cosmetic products, such as toothpaste.

Description

• «i -» ''? i •. . COMPOSITION OF CONCENTRATED POLYOLS *. The present invention relates to a concentrated polyol composition. It also deals with its use for the dispersion of 5 hydrocolloids such as cellulose and its derivatives as well as for the repair of pharmaceutical or cosmetic products, such as toothpastes in particular. Toothpastes generally contain an abrasive, a humectant, water and a gelling agent used to confer a creamy or gel-like consistency, and to form a support for all other ingredients present in toothpastes, such as flavors, sweeteners, preservatives. The main function of the humectant is to maintain a certain humidity in the toothpaste when it is exposed to the open air in order to prevent the hardening thereof and the formation of plugs at the level of the orifice of the dentifrice tubes. The most commonly used humectants are glycerin and sorbitol in aqueous solutions, alone or in mixtures. Xylitol is sometimes used, but its obtaining procedure is more complex, it is a more expensive product. That is why, for economic reasons, it is preferred to use sorbitol, which is on the market in the form of syrups with 70% dry matter. In a general manner, it is used in the proportions of approximately 20 to 70% by weight of the toothpaste. For other On the other hand, it is desirable that the sorbitol be non-crystalline, in order to ensure a stability of! same before your. utilization. and, a stability of the toothpastes in storage. As regards gelling agents, hydrocolloids such as guar gum, guar derivatives, gum arabic, carrageenans, xanthanes, methylcellulose, carboxymethylcellulose, hydroxyethylcellulose are generally used. They are used in proportions of 0.1 to 5% by weight, depending on what is desired, a paste or a gel. Sodium carboxymethylcellulose, more commonly called CMC, is the most commonly used gelling agent in toothpastes. During the preparation of toothpastes based on non-crystallisable sorbitol syrup with 70% dry matter, the gelling agent is previously dispersed in the sorbitol syrup. This step is particularly critical since, being hydrophilic, the gelling agent has a tendency to form lumps and agglomerate. In certain cases, the water penetrates very slowly into these groups, and a complete dispersion of the gelling agent is not obtained after a considerable time. Certain manufacturers save this problem by equipping themselves with very high cut mixers, but this material is very expensive. This is not the case when glycerin is chosen as a humectant. In effect, the gelling agent is correctly dispersed in the glycerin, which is anhydrous and does not thereby cause solubilization thereof.

Since the water is added to the formulation, the gelling agent swells and disperses homogeneously to form a thick gel. »# -, * ._,, *,, - _ This is the main advantage of the glycerin opposite the orbital. * * - • - < * > However, many manufacturers seek to minimize their use of glycerin, because of its high cost and fluctuating, but also because of their weak organoleptic behavior. 5 However, as described below, a problem to be solved by toothpaste formulators that seek to privilege the use of sorbitol, in substitution of glycerin, remains. A solution has been proposed in the WO patent. 97, 48,372, which consists in spraying the polyol solutions onto the hydrocolloid particles, after drying the granules thus obtained on a fluidised bed. The polymer particles can be incorporated immediately into the preparation for toothpaste without lumping. It is not less that this complementary stage of preparation of the gelling agent complicate even more the formulation of toothpaste, and it is 15 economically unacceptable. Another solution, proposed in the patent of E. U. No. 4, 883, 537, consists of the dispersion of the hydrocolloid within the water, in the presence of a non-negligible amount of potassium carbonate. It is easy to deduce that this solution is not compatible with a use in toothpaste, due on the one hand to the important alkalinity of potassium carbonate, and on the other hand to the water supply imposed by the manufacturer. In order to remedy the agglomeration problems of the gelling agents, it can be thought that it is sufficient to reduce the amount of water of the sorbital syrups to the maximum, since it is known, on the one hand, that "when * e * was high and , lumps appeared, extremely difficult to remove and on the other hand, that when the water content of the dispersing medium was sufficiently low, there was no anticipated hydration or swelling of the gelling agent, and thus no lumps appeared. which are preferably used as humectants can present the concentration difficulties below a dry matter of the order of 80%, since, when the water contained in such syrups evaporates, they become extremely viscous. In addition, these highly viscous products have the main disadvantage of no longer being pumpable, which has made them more expensive. They are unsuitable for all industrial use, in particular with regard to the transport, storage and putting into operation of these syrups. It has been proposed in the US patents Nos. 3,651, 936, 4,728,515, 4,671, 961, 4,671, 967 to resort for the preparation of food products such as chewing gums, to concentrated compositions based on syrups of starch hydrolysates and glycerin or propylene glycol, coevaporates. In effect, glycerin and propylene glycol reduce the viscosity of starch hydrolyzing syrups and facilitate the evaporation of the water contained therein. These concentrated compositions have a relatively low amount of water, for a glycerin content of at least 25% by weight. Now, glycerin, in addition to the inconvenience of its cost, preseata-by nature urt. flavor. astringent and unpleasant that generally harms the organoleptic qualities of the final product. Likewise, in the WO patent 95,04107, it has been proposed to solubilize the polysaccharides in a mixture of sorbitol and glycerin. However, the presence of sorbitol in strong proportions leaves presage the risks of crystallization in the course of storage. In addition, the polysaccharide was present in low proportions (0.1%), this solution is not translatable for the preparation of toothpastes generally containing 1 to 5% gelling agent. The object of the invention is thus to remedy the drawbacks of the prior art and to provide a concentrated polyol composition containing sorbitol, which better responds than the existing ones to the various requirements of the practice, namely: ability to disperse the gelling agents without the formation of lumps, and without making the use of sophisticated equipment obligatory, -that presents rheological properties such that it is easy to handle and transport, -which is easy to prepare and economical, -which is usable in the pharmaceutical or cosmetic products, especially in toothpastes, which is stable therein and capable of conferring on the products to which a sufficient stability for preservation will be incorporated, especially in relation to the crystallization phenomena in the course of storage. And the Claimant has had the merit of finding, after deep investigations, that this objective could be reached of course as the concentrated polyol composition has a selected water content and a particular glucidic profile. The Claimant has indeed noticed that in a surprising and unexpected way, which appears, in the high dry matter, a new phenomenon during the dispersion of the gelling agents: in a first time, the gelling agent disperses easily as it is foreseen; a second time, it absorbs the water present. This corresponds to a very significant increase in the dry matter of the medium, with consequently a crystallization of the polyols, which is translated by a mass connection of the whole mixture. Thus, unexpectedly, and as will be exemplified elsewhere, only a precise range of water contents of the polyol composition allows in fact to conveniently disperse a gelling agent. Beyond 17% of water within said composition, the gelling agent forms lumps in the preparation, and on the 10% water side, a rapid mass take-up of the whole is observed after adding the gelling agent. Advantageously, it is advisable to place between 12 and 16% of water, in order to avoid in the best of cases the problems mentioned above. It was already known, in the patent AU 642, 177, of which the Claimant is the owner, to concentrate the syrups of maltitol and of xylitol at the proportions in water of 7 to 10%. Now, for example, high hydrogenated disaccharides of these syrups, intended for food uses, carry an important viscosity of these. On the other hand, these syrups do not contain practically sorbitol and do not necessarily respond to the economic and functional requirements of the manufacturers of pharmaceutical or cosmetic preparations, and in particular of the manufacturers of toothpastes. Other concentrated maltitol syrups are also described in patent EP 0,072,080, for the preparation of gels, placed on site in very low amounts carboxymethyl cellulose. These syrups, very rich in molecules of polymerization degree of two and more, are very viscous. It is said in effect that the viscosity is correlated with the molecular weights of the polyols contained in these syrups. Viscous xylitol compositions are also known, described in U.S. Patent 5,728,225, of which the Claimant is equally entitled. These compositions, devoid of sorbitol, have an unsuitable viscosity. The problem that is exposed accordingly, in view of concentrating sorbitol syrups, concerned with the stability and the ability to be pumped out of the resulting compositions, in which the dry matter is adapted for the satisfactory dispersibility of the gelling agents, these three criteria had never been met in the prior art. The Claimant has then shown that the criteria of • ^ .stability "and. The ability to be pumped could be complied with, of course, as the compositions of polyols, of dry matter adapted to the criterion of dispersibility, presenting a very particular glucidic profile. The invention then relates in the first place to a concentrated polyol composition, characterized in that its water content is 10 to 17%, preferably comprised between 12 to 16%, and why it comprises: -of 35 to 90% of hydrogenated monosaccharides of which at least 30% is sorbitol, -from 0 to 45% of hydrogenated disaccharides, these percentages being expressed as dry weight with respect to dry weight of the set of disaccharides contained in said composition. Preferably, this composition has a proportion of hydrogenated monosaccharides comprised between 40 and 90% of which at least 35% is sorbitol and a proportion in hydrogenated disaccharides comprised between 0 and 35%. Even more preferably, it has a content of hydrogenated monosaccharides comprised between 60 and 90% where at least 50% is sorbitol and a hydrogenated disaccharide content between 2 and 35%. The applicant has indeed shown, in the course of long research work, that by selecting this particular range of water contents, associated with this particular glucidic profile, polyol compositions according to the invention are obtained, which are perfectly suited for the easy dispersion of hydrocolloids. By "hydrogenated monosaccharide" in the sense of the present invention is meant a product selected preferably from the group comprising sorbitol, mannitol, xylitol, arabitol, iditol, ribitol and mixtures thereof. Preferably, the hydrogenated monosaccharide is selected from sorbitol, mannitol and any mixtures thereof. By "hydrogenated disaccharide" is meant a product selected preferably from the group comprising mannitol, lactitol, 1-6 mannitol glucoside, isomaltitol, cellobiitol, and any mixtures thereof. Preferably, the hydrogenated disaccharide is constituted by maltitol. The composition according to the invention can also contain other hydrogenated saccharides, such as, in particular, oligo and hydrogenated polysaccharides. In particular, the contents of 10 to 19% by weight of polysaccharides where the degree of polymerization is greater than or equal to three agree perfectly. This composition can also comprise, in addition, the hydrogenated saccharides, such as those described, traditional additives for pharmaceutical or cosmetic products, such as, for example, polishing materials, thickening agents, surfactants, fluorinated compounds, aromas. , sweeteners, dyes or bleaches, preservatives, silicones. According to an advantageous embodiment of the composition according to the invention, it has a viscosity, *, «. v. * >; * measured at 45 ° C, lower than 10,000 mPa.s, preferably lower than 5000 * mPa.s, and more preferably even between 500 and 4,500 mPa.s. Indeed, only compositions having such viscosities can generally be considered as pumpable, without any problem of overcalling at the level of industrial pumps. - With regard to the viscosity measurement, this is carried out by means of an ARES-type rheometer marketed by the company RHEOMETRIC SCTENTIFIC (EU). This rheometer is equipped with a 10 cone-plate measuring system and a thermostatic system. The solutions for testing are deposited on a movable plate with thermostat. The cut resistance of the product between the cone and ** the plate in rotation at a given temperature is measured. The results are expressed in mPa.s. 15 It is important to express viscosity every time according to the temperature at which it has been measured, since it is directly dependent. According to another variant, the composition according to the invention is presented at a temperature higher than 20 ° C, preferably comprised between 30 and 55 ° C. This characteristic allows not only to respond to the three properties sought, that is, stability , ability adapted to be pumped and ease for dispersion of gelling agents, but it is particularly advantageous also for the users and particularly the toothpaste manufacturers who make their preparations with heat. Indeed, the delivery of a hot polyol composition allows the users to free themselves from a complementary heating step. Thus, the composition according to the invention, for a temperature comprised between 30 and 55 ° C, is particularly advantageous. To prepare the composition according to the invention, a syrup can be prepared from particular polyols in the powder or liquid state or hydrogenate the particular saccharide compositions, then evaporate the water contained in the compositions thus prepared to obtain a content of water comprised between 10 and 17% in 0 weight. This evaporation step can be carried out with the aid of conventional devices, among which those marketed under the trademark "PARAVAP" by the Société APV Equipment Corporation of Tonowanda, N. Y. A composition according to the invention can be prepared which also has a very low content of reducing sugars, stable to alkalis, which will make it possible to use it particularly in toothpastes containing the basic compounds. This composition, commonly referred to as "sugar free" by the person skilled in the art, has a sugar or reducing index generally less than 1000 ppm, and preferably less than 500 ppm. According to another embodiment, the composition according to the invention can contain glyclin in low proportions, namely when much equal to 24% by weight of said composition, so as to further improve, if necessary, the fluidity of the composition. the composition. Glycerin contents of the order of 5 to d% by weight may be convenient. Accordingly, for the dispersion of hydrocolloids, particularly cellulose and its derivatives, from now on a novel, inventive and general means consisting of the selected and concentrated polyol compositions, such as those described above, is now available. These compositions can thus be easily used in the preparation of toothpastes, and in numerous pharmaceutical or cosmetic preparations such as syrups, cough gels, creams, mouth rinses. They can also be used in various chemical or agrochemical industries. The compositions according to the invention have other advantages in the industrial field which are the reduction of transport costs due to the decrease in the amount of water to be transported, the decrease in the volumes to be stored, as well as reducing the risk of contamination by microbes. The time to put in work is also reduced due to the optimization of defoaming operations together with a lower presence of water, as well as by the improvement of the dispersion time of the hydrocolloids at lower viscosity. The invention will be understood even better with the help of the following examples, which are not limiting and are only a state of certain embodiments and of certain advantageous properties of the compositions according to the invention.

EXAM PLO 1: Dispersion test of a gelling agent. A polyol composition is prepared where the glucidic profile is as follows: -hydrogenated monosaccharides = 41.3% of which sorbitol = 38. 8% -hydrogenated diastere = 32% / dry The dry matter of this composition is 74.2% by weight. This composition is concentrated to different dry matters: 82%, 85%, 86. 7%, 91%, 92%. In a double-jacketed stainless steel bowl, heated at 45 ° C by a circulating bath, pour 200 g of the polyol composition to be tested, from a stove at 45 ° C. With stirring at 200 rpm, add 8 g. g of CMC, marketed under the name of BLANOSE® 7MXF by the company HÉRCULES. It is left in agitation for 20 minutes. Add 200 g of water and stir again 20 minutes at 200 rpm. The texture of the mixture is observed. Results: Water content of Observations the compositions ._ . 8% Presence of lumps 18% Presence of lumps 15% Bifana dispersion. No lumps. Obtaining a homogeneous gel after 40 min of agitation. 13.3% Good dispersion. No lumps. Obtaining a homogeneous gel after 40 min of agitation. 9% Quick mass intake after adding the CMC.

By analogy with the glycerin, it can be assumed that the decrease in the water content of the compositions would facilitate the dispersion of the CMC and that the more anhydrous products would be the best. However, it is nothing since a second phenomenon appears unexpectedly, that is, for water proportions lower than 10%, a correct dispersion of the CMC is observed well at first, followed almost instantaneously by a of mass of the solution. It is convenient, then, to concentrate the potassium syrups at the selected contents between 10 and 17% of water, in order to ensure a good dispersibility of the hydrocolloid.

EXAMPLE 2 Stability and viscosity of a composition according to the invention v i 5 A composition of polyesters where the material seg teres, partides. 70% has been concentrated on different dry matters. The glucidic profile of the composition is as follows: Sorbitol: 83% (percentages expressed in weight / dry weight) 5 Mannitol: 1.2% Maltitol: 4.2% On each composition obtained were performed: -a study of the stability at 45 ° C during one month - a viscosity measurement at 45 ° C; 10 The stability study consists of verifying the crystallization or not of the compositions, stored at 45 ° C for one month. The viscosities of the different compositions were measured with the aid of an ARES-type rheometer, marketed by Société RHEOMETRIC SC1ENTIFIC (EU). 15 The following results were obtained: Water content viscosity stability at 45 ° C (% by weight) at 45 ° C (mPa.s) in one month 30 45 without crystallization 19 395 without crystallization 20 18 490 without crystallization 14. 5 980 without crystallization 10 392 CRYSTAL after 15 days For all the compositions, the viscosities at 45 ° C are relatively low: for all the dry materials tested, the products are bozable (viscosity less than 10,000 mPa.s). The compositions are stable one month at 45 ° C, for water contents greater than 10%. These have a high content of sorbitol (82.4% by weight / dry weight) that favors crystallization: it is therefore an unfavorable content for the test. To increase the stability in the lower water contents, it has been thought to significantly increase the content of hydrogenated disaccharides. By way of comparison, the viscosity at different temperatures of a syrup rich in non-crystallizable maltitol marketed by the applicant under the trademark LYCASIN® 80/55, concentrated to 85% dry matter, is measured, wherein the glucidic profile is as follows: Hydrogenated monosaccharides: eight% / dry -hydrogenated diasaccharides: 55% / dry -oligo and polysaccharides: 37% / dry Temperature Viscosity (mPa.s) .30 ° C 250,000 40 ° C 70,000 50 ° C 23,000 60 ° C 8,000These data show that syrups rich in maltitol are not pumpable when concentrated to a high dry matter, except for hot ones at 60 ° C or more.

EX EMPLO 3:,. . . A composition according to the invention is prepared by concentrating at 14.5% water a sorbitol syrup having the same glucidic spectrum as in Example 2, initially at 30% water. The viscosity, the stability of the composition and the dispersibility of the CMC in the composition at 45 ° C are measured, according to the techniques described above. Viscosity of composition: 980 mPa.s Stability at 45 ° C in one month: no crystallization. Dispersion of the CMC: no lumps. Thickening important after adding the CMC. The composition according to the invention, tested here comprising 84.2 wt.% / Dry of hydrogenated monosaccharides, 4.2 wt.% / Dry of hydrogenated disaccharides, and 14.5 wt.% Of water is thus stable, pumpable and allows a dispersion of the CMC what does not allow neither: - a sorbitol syrup of the prior art, not concentrated, - a sorbitol syrup of the same glucidic spectrum, but concentrated at a water concentration greater than 17% or less than 10%, - a syrup of polyols with a water content of between 10 and 17%, but with a different glucidic profile, namely containing more than 35% of hydrogenated disaccharides and / or less than 30% of sorbitol. Only the compositions specifically selected by the applicant fully meet the requirements of industrial practice. In addition, they can be delivered at 45 ° C and used directly at a temperature for the manufacturers of pharmaceutical or cosmetic products interested in this heat utilization of the compositions.

EXAMPLE 4 A polyol composition according to the invention is prepared, where the glucidic profile is the following: sorbitol: 63.2% mannitol: 3.8% hydrogenated disaccharides: 22.3% hydrogenated polysaccharides- 10.5% (DP3 and +) is added to the composition 6% by weight of glycerin. Matter and composition are presented at 90%. The stability of the composition, the dispersibility of the CMC in this composition is evaluated in accordance with the previous examples. This composition is not crystal-clear. It allows a good dispersion of the CMC. The viscosities at different temperatures are measured according to the preceding method described and show the pumpability of the composition from 45 ° C 40 ° C to 14,400 mPa. s 45 ° C 9,560 mPa.s 50 ° C 4,720 mPa? S * • 60 ° C 1, 760 mPa.s EXAMPLE 5: preparation of toothpastes A toothpaste A is prepared based on a sorbitol syrup according to the invention, with 85% dry matter, which is compared with a toothpaste B prepared with a sorbitol syrup of the prior art . Formula: A B. sorbitol syrup at 70% MS 64% sorbitol syrup at 85.8% MS 52.2% Abrasive silica Tixosit 73 14% 14% Silica thickener Tixosil 43 9% 9% Texapon at 30% MS 4.16% 4. 16% CMC: Blanose 7 MXF 0.7% 0.7% Sodium saccharinate 0.2% 0.2% Sodium monofluorophosphate 0.76% 0.76% Scent of Silesian mint 0.8% 0.8% Green coloring (1% solution) 1% one% Meti! Paraben 0.18% 0.18% Propyl Paraben 0.02% 0.02% Water 16. 98% 5.18% Protocol: Paste A: water is heated to 65 ° C in a container, and lubricant saGarinate and the monofluorophosphate. An A1 solution is obtained. - In a vacuum mixer, equipped with a simple shovel the bottom of the tank, GUEDU brand, type 4.5NO, (marketed by the company GUEDU 21 140 SEMUR in AUXOIS), the sorbitol syrup according to the invention is introduced with stirring at 470 rpm. The CMC is incorporated and mixed for five minutes. An A2 solution is obtained. The solution A1 is then introduced into A2, mixed for 5 minutes, then left to rest for 30 minutes, allowing the mixture to cool. The dye and aroma are added immediately, mixed for 5 minutes under vacuum. The portion of silicas is added, mix 10 minutes under vacuum. The second portion of silicas is added, 10 minutes are mixed under vacuum. The Texapon is finally added, then mixed for 2 minutes 30 seconds under vacuum. Paste B: the water is heated to 50 ° C in a container, and saccharinate and monofluorophosphate are solubilized, an A1 solution is obtained. The sorbitol syrup is heated according to the prior art at 80 ° C and the parabens are solubilized. "The solution is cooled to 50 ° C and the CMC is added very slowly with very strong stirring in a Polytron homogenizer (marketed by the Swiss company K1NEMATJCA) regulated at 12,000 rpm.An B2 solution is obtained. B2, mix for 5 minutes, then introduce this solution into a GUEDU mixer, and let it stand for 30 minutes.The protocol of adding the aroma and the silicas below is the same as for the paste A. Results: the paste made With the composition according to the invention it is all a satisfactory fact.It seems brighter than that made with the standard syrup.The Helipath viscosity 24 hours after manufacture is 450,000 cps at 20 ° C. The refractive index is similar for the two pastes: A = 1 .4462 B = 1 .4457 It is necessary to note, furthermore, that the use of the composition according to the invention allows to advantageously dispose of a larger quantity of free water p for the dissolution of the assets. . In the same way, a toothpaste is prepared in which the formula does not differ except for the silicas that are replaced by calcium carbonate. The sorbitol syrup of the prior art is a sorbitol syrup stable to the alkaline agents, marketed by the Applicant under the trademark NEOSORB® 70 / 70SB. This syrup is concentrated at 85.8% dry matter according to the invention.

The formula of the pasta is as follows: A B NEOSORB® 70 / 70SB at 70% MS 35.7% - at 85.8% MS 29.10% Calcium carbonate 45% 45% Texapon at 30% MS 5.66% 5.66% Btanose 7MXF 1.15% 1.15% Sodium saccharinate 0.2% 0.2% Sodium monofluorophosphate 0.8% 0.8% Mint scent Silesia 1% 1% Methyl paraben 0.18% 0.18% Propyl paraben 0.02% 0.02% Aaua 16. 89% 10. 29% The protocol is identified with that of the previous pastes. The results are also very satisfactory. The viscosity Hipaipath of the paste according to the invention after manufacture is 340,000 cps at 42 ° C, and 600,000 cps at 20 ° C after 12 hours of manufacture. In the same way, the amount of free water available increases when the composition according to the invention is used.

EXAMPLE 6: stability study at 45 ° C. The color stability, of composition, of a composition according to the invention stored at 45 ° C. was studied.

- • For this purpose, a sorbitol syrup, stable to heat and alkalis, marketed by the Complainant under the trademark NEOSORB® 70 / 70SB, which is 85% dry matter at the end, is prepared. This syrup is stored for four months in a heated container, at a temperature of approximately 45 ° C. During this storage, no evolution was observed visually: there was no appearance of crystals, there was no yellowing.

The samples of this syrup were subjected to 15 days, one month, two months and four months of storage for comparative analysis. The results are the following: - The composition according to the invention did not evolve during the four months of storage at 45 ° C, it seemed very stable at this temperature. It is therefore perfectly considered to store and deliver this composition at this temperature

Claims (7)

1. REVIVAL DICATIONS 1. A concentrated polyol composition, characterized in that its water content is 10 to 17%, preferably comprised between 12 and 16%, and because it comprises: -from 35 to 90% of hydrogenated monosaccharides of which at least 30% is sorbitol -from 0 to 45% of hydrogenated disaccharides, these percentages being expressed as dry weight with respect to the dry weight of all the hydrogenated saccharides contained in said composition.
2. 2. The composition according to claim 1, characterized in that its content in hydrogenated monosaccharides is comprised between 40 and 90%, of which at least 35% is sorbitol, and its content of hydrogenated disaccharides is between 0 and 35. %.
3. 3. The composition according to claim 1 characterized in that its content in hydrogenated monosaccharides is between 60 and 90%, of which at least 50% is sorbitol, and its content of hydrogenated disaccharides is between 2 and 35 %.
4. 4. The composition according to any of claims 1 to 3, characterized in that it has a content of reducing sugars of less than 500 ppm on dry.
5. 5. The composition according to any of claims 1 to 4, characterized in that it occurs at a temperature higher than 20 ° C, preferably comprised between 30 and 55 ° C.
6. 6. The composition according to any of claims 1 to 5, characterized in that it further comprises from 10 to 19% by weight of hydrogenated polysaccharides of polymerization degree greater than or equal to 3. The composition according to any of claims 1 to 6, characterized in that it also comprises giicerin, in an amount less than or equal to 24% by weight with respect to the weight of said composition. 9. The use of a composition according to any of claims 1 to 7 for the preparation of pharmaceutical or cosmetic products. The use of a composition according to one or other of claims 1 to 7 for the preparation of a toothpaste.