MXPA00006928A - Underarm cosmetic compositions with lower alkyl acetate - Google Patents

Abstract

An underarm composition is provided which includes C1-C6 alkyl acetate, an underarm active selected from astringent salts and anti-microbial agents, and a carrier. The carrier may include propellant, silicone, ester and liquid paraffin. Methyl and t-butyl acetates are preferred. Acetates allow reduction in the levels of more volatile organics thereby decreasing air pollution. They also reduce formulation greasiness, are less clogging to spray nozzles, cause less metal can corrosion and reduce caking of actives through better resuspension.

Description

COSMETIC COMPOSITIONS FOR AXILLS WITH LOWER ALKYL ACETATE BACKGROUND OF THE INVENTION Field of the Invention The invention relates to armpit cosmetic compositions that include lower alkyl acetates as a vehicle for the delivery of active components.

The Related Art Alcohols and low molecular weight esters are generally incorporated into anti-inflammatory formulations or aerosol deodorizers. Ethyl alcohol provides a good suspending medium for active materials such as anti-t ru sp salt salts. An improved fragrance can also be achieved through the use of a 1 c och 1. - -From s to f o r t unadament e, high levels of alcohol accelerate the destaining, pitting and other forms of corrosion in metal cans. For this reason, commercial products are generally not formulated with alcohol in amounts greater than 10%. Volatile organic substances such as ethanol are also undesirable for environmental reasons. Government regulations aimed at air pollution require the reduction of volatile substances in cosmetic products. The formulations of ani t anstr e r and spray deodorant also often contain this emollient such as isopropyl palmitate. These esters are often greasy, staining clothes and in combination with aluminum salts clog the nozzles of the sprinkler. Substitutes are necessary for at least a portion of the alcohol and ester ingredients that are normally required for formulations of an antifreeze or spray deodorant. Aqueous deodorant formulations containing an active compound, a carboxylic resin and, in one example, ethyl acetate are described in GB-A-714551, but do not disclose aerosol formulations or problems associated with storage or dispensing. of such foundations. UA-A-5441727 describes the deodorant compositions comprising 1,3-diketone and a local carrier. Local carriers can be creams, bars, liquids for ball deodorants and liquids for sprinklers (including oils) The use of propellants in aerosol compositions is also described although the text does not describe the problems associated with the storage or distribution of aerosol formulations, or consequently how to improve one or more thereof Example III describes the use of a higher molecular weight ester, especially propylene glycol (3) myristyl ester In Examples IV and V, two examples are exemplified formulations for deodorant in the form of lotions for local administration comprising ethyl acetate, ci c 1 orne ti cona and active deodorant compounds, but no formulation is an aerosol formulation .. Accordingly, it is an object of the present invention to provide a composition antiperspirant or spray deodorant which can eliminate or minimize the ethanol ingredients and emollient ester normally formulated in such compositions. Another object of the present invention in some embodiments to provide an antiperspirant spray composition with reduced levels of volatile organic compounds. Yet another object of the present invention is to provide an anti-inflammatory composition which is less greasy, which has a dry skin feel and less obstruction in the sprinkler nozzle. Yet another object of the present invention is to provide an antiperspirant composition which reduces the agglutination of the active ingredients by improving their efficiency within the composition. It is still a further object of the present invention to provide an anti-spraying an anti-odor composition which minimizes the corrosion of its pressurized steel cans. These and other objects of the present invention will become more apparent from the consideration of the following detailed description and brief description.

BRIEF DESCRIPTION OF THE INVENTION An underarm composition is provided which includes: (i) from about 0.1 to about 80% by weight C 1 -C 6 alkyl acetate; (ii) an axillary active selected from the group consisting of astringent salts and antimicrobial agents; and (iii) from about 0.1 to about 90% of a pharmaceutically acceptable carrier comprising a propellant.

DETAILED DESCRIPTION OF THE INVENTION It has now been found that the inclusion of Ci-Cß alkyl acetate in compositions to spi r an d s or spray deodorants has a number of benefits. These include a less greasy formulation, less clogging of the sprinkler nozzles, less corrosion of the can metal, reduced agglutination of the assets, lower emission of volatiles through the reduction of ethanol content and dry skin feeling. Alkyl acetates suitable for the present invention are methyl acetate, primary acetic acid, cement oxide, sodium carbonate, sodium acetate, butyl alcohol. 1 aceto, neo-pheni-1-aceto, -hexi-1 -to-cet, and combinations thereof. More preferred are methylacetate and t -bu t i lace t a t o. Methylacetate is available from Eastman Chemical Compapy, Tennessee. The Te r-but i 1 a ce t a t o is obtained from Arco Chemical Company, Philadelphia, P e nn s and 1 van a. The amounts of alkyl acetate can reach from about 0.1 to about 80%, preferably from about 1 to about 70%, optimally from about 10 to about 60% by weight. Advantageous compositions according to the present invention have a reduced alcohol content of Cj.-C particularly ethanol, such as below 5% by weight or especially are free of such alcohols. A second essential component is that of an underarm active which may be an astringent salt or an antimicrobial agent. The astringent salts can be inorganic or organic salts of aluminum, zirconium, zinc and mixtures thereof. The salts useful as astringents or as components of astringent aluminum complexes include aluminum halides, aluminum oxyhalides, zirconyl oxyhalides, zirconyl oxyhalides, and mixtures of these material salts. Aluminum salts of this type include aluminum chloride and aluminum axihalur hydrides having the general formula Al2 (OH) xQ? -XH20 where Q is chlorine, bromine or iodine, where x is from 2 to 5 and x + y = 6 and x and y do not need to be integers; and wherein X is about 1 to 6. Various types of complexes using the above astringent salts are known in the art. For example, US Patent 3,792,068 (Luedders et al.) Discloses complexes of aluminum, zircinium and amino acids such as glycine. The complexes reported in it and similar structures are commonly known as ZAG. The ZAG complexes ordinarily have an Al: Zr ratio of approximately 1.67 to 12.5 and a Metal: Cl ratio of about 0.73 to 1.93. The preferred amino acid for preparing such ZAG-type complexes * is the glycine of the formula CH2 (NH2) COOH. Especially preferred is the spherical ZAG, with a particle size of 1 to 100 microwaves. More specifically, the following is a list of ant i t r a sp e r a t t i ng assets which may be useful for the present invention and which have approved the listing under the Federal Register of the Food and Drug Administration of the United States. They include aluminum chloride, aluminum chlorohydrate, aluminum chlorohydrex, aluminum chlorohydrex PEG, aluminum chlorohydrex PG, aluminum dihydride, aluminum dihydride, PEG aluminum, di c 1 or ohi dr ex aluminum PG, ses qui cl or aluminum ohydr ato, SES qui cl or ohi dr ex of aluminum PEG, ses qui cl or ohi dr ex of aluminum PG, sulphate of aluminum, octac 1 or oh i dra zirconio-aluminio, oc tac 1 or ohidr ex de zir conio - a lu ini or GLY, pen tac 1 or ohi dr ato de zir with io - a 1 umi ni, pen tac lo rohi dr ex de zir coni o - alumini o GLY, tet racl o hydra to de - zirc on io - a 1 umin io, tric 1 or ohi dr ato. of z i r coni o - a 1 umi ni o, t e t racl o hydr ato de z i r coni o - a lumini o GLY, and t r i c 1 rohi dr a t o de z coni o - alumini o GLY. The amounts of the astringent salt of the active can vary from about 1 to about 40%, preferably from about 5 to about 30%, optimally from about 8 to about 15% by weight of the composition.

The deodorant actives according to the present invention also include different materials-from those that function as an anti-aspirant. The deodorants must be able to exterminate or prevent the growth of the microorganisms that generate the bad odor or that promote the decomposition of the corporal oils in odoriferous fatty acids. The most prominent among the antimicrobial organic materials are triclosan, trichlorban, chlorhexedine and certain fragrant oils known as deo perfumes (for example, US Pat. No. 4,278,658 to Hooper et al.). The amounts of the antimicrobial organic materials can vary from about 0.01 to about 1%, preferably about 0.1 to about 0.5% by weight. The inorganic antimicrobial materials can also serve as deodorant actives. These include zinc oxide, zinc hydroxide, zinc carbonate, zinc phenol sulphonate, magnesium oxide, magnesium hydroxide, magnesium carbonate, lactate oxide, lactate hydroxide, lactate carbonate, sodium bicarbonate. and combinations thereof.

A third essential component of the present invention is that of a carrier. The carriers can be selected from propellants, silicones, esters, liquid paraffins and combinations thereof. The amounts of the carrier can vary from about 0.1 to about 90%, preferably from about 20 to about 80%, optimally from about 30 to about 70% by weight of the composition. Typical propellants of the compositions according to the present invention are volatile organic compounds with a boiling point of -40 ° C, preferably -20 ° C and optimally not greater than 10 ° C. Suitable classes of propellants include the hydrocarbons of Ci-Cβ, di to 1 qui 1 é t es r C2-Cs, carbon dioxide and has ohidr or carbide. Among the useful hydrocarbons are propane, isopropane, butane, isobutane, isopentane, pentane and mixtures thereof. The propellants are available under the brand A31 (purely isobutane) and A45 (i s obu t ano / i s op openo) from the Phillips Petroleum Company. The most preferred one is propellant A50 which is a mixture of the product / ingredient. Another useful propellant is dimethyl ether.

The volatile silicones can be incorporated into the compositions of the present invention. They can be either polymeric or cyclic or linear. The amounts of this material can vary from about 1 to about 80%, preferably from about 15 to about 70% by weight. Commercially available from Dow Corning Corporation as DC 344, 345, 244, 246 and 245. The non-volatile silicones when used as a carrier can be selected from po 1 to 1 quil if 1 oxane, po 1 to 1 qu and 1 ar i 1 if 1 oxano, or copolymer of po 1 i erser 1 oxano, (for example dimethiconoi). Commercially they are available from Dow Corning Corp as, for example, DC 556 or the DC 200 series. The nonvolatile silicones, when present, may vary in amount from about 0.1 to about 30%, preferably from about 1 to about 15. % in weigh. Esters can also be used as a carrier. The illustrative esters are those formed from C2-C2o alkanoles and s t i e f i cted with C8-C22 alkanoic acids. Examples include isopropyl myristate, lauryl myristate, isopropyl palmitate, diisopropyl sebacate and diisopropyl adipate. Most preferred is isopropyl palmitate. The amounts of the ester can vary from about 0.5 to about 30%, preferably from 5 to 20%, optimally from about 8 to about 15% by weight. A number of optional components may also be part of the compositions according to the present invention. These include bulky agents, C? -C3 alcohols and powder fillers. Bulky or suspension agents when present may be at levels of from about 1 to about 50%, preferably from about 2 to about 8%. Clays and colloidal pyrogenic silica are the preferred materials for use as bulky or suspension agents. Colloidal silica is commercially available as Cab-O-Sil ™, a submicroscopic pyrogenic particulate silica.

The voluminous or suspending clay agents suitable for use in the compositions of the present invention are selected from the group consisting of the montmorillonite clays and the montmorillonite clays treated hydrologically or fibrously. Examples of these clays include bentonites, hectorites, and colloidal aluminum magnesium silicates. The latter are silicate complexes of α1 umini or -magne s i or colloid-l is richer in magnesium than in aluminum. Commercially they are available as Veegum ™ (R. T. Vanderbilt Co.). The preferred hydrated or preferred bodily montmorillonite clays are available under the trademark of "Bentone". These are prepared by reacting the bentonite in a cation exchange system with an amine. The different amines are reacted to obtain a range of "Bentone" clays, which may also differ in the proportions of Si02, MgO and A1204. Specific examples of Bentons within the scope of the present invention are Bentone 38, Bentone 34, Bentone 27, Bentone 14, and Bentone LT, all of which have a particle size below about 5 microns and are commercially available from Rheox, Inc. .

An additional benefit of the alkyl acetates is the activating function they can perform with respect to the clays, especially the montmor i 1 treated clays such as the Bentone ™ materials. Normally small amounts of propylene carbonate are formulated to activate the clay although for the present invention. The presence of propylene carbonate is not necessary and can be avoided. Powder fillers other than bulky agents may also be incorporated. Particularly preferred is talc, sodium bicarbonate, corn starch, modified starches and mixtures thereof. The most preferred is talcum powder. The amounts of the powder filling can vary from 0.5 to 15%, preferably from about 1 to about 10%, optimally from about 1.5 to about 5% by weight. Another optional element according to the present invention is that of a C? -C3 alcohol. The most preferred is ethanol, especially SD Alcohol 40 ™. Of course, it is also possible to use methanol or isopropanol. The amounts of the alcohol can vary from about 10 to about 70%, preferably from about 12 to about 40%, optimally from 15 to 30% by weight of the composition. In certain products it may be desirable to have an alcohol-free formulation or at least to limit the amount of alcohol to less than 10%, preferably less than 5% by weight of the composition. Minor adjunct ingredients including fragrances and anti-clogging agents may be present to keep the nozzle of the sprinkler free of solid occlusions. Although the present invention is specifically advantageous in aerosol formulations, the present invention may also be useful for other forms of spi r an t i t a r a rs that include liquids for ball deodorant and ultra dry creams. The following examples will more fully illustrate the embodiments of this invention. All parts, percentages and proportions referred to herein and in the api indications are by weight of the composition unless otherwise indicated.

EXAMPLES 1-4 A set of aerosol compositions for spraying according to the present invention are schematized in Table I.

EXAMPLES 5-11 A set of deodorant aerosol compositions suitable for the present invention are shown in Table II.

EXAMPLE 12 A series of formulations of aerosolized anionic spi rners were prepared and loaded in pressurized batches of tin-plated steel plate. These formulations were placed in storage for two weeks at 120 ° F (48.9 ° C) to evaluate the properties of corrosion. Table III details the components of these formulations as well as the corrosion results. Formulations A and D demonstrated that Methyl Acetate does not impart any destaining or corrosion to cans. Formulations B and C which include ethanol exhibit the signs of destaining principles. Methyl acetate is therefore an excellent replacement for ethanol in these formulations. The examples and description above illustrate the modalities you select <; S of the present invention. In light thereof, variations and modifications will be suggested to one skilled in the art.

Claims (8)

1. CLAIMS 1. Armpit composition comprising: (i) a suspension medium; (ii) an axillary active selected from the group consisting of astringent salts and antimicrobial agents; and (iii) from about 0.1 to about 90% of a pharmaceutically acceptable carrier, characterized in that the suspending medium comprises from about 0.1 to about 80% by weight of Ci-Cß alkyl acetate and the carrier comprises a propellant.
2. 2. Composition according to the rei indication 1, characterized in that it additionally comprises from about 0.5 to about 30% by weight of an emollient ester formed from the esterification of a C? -C20 alcohol with a Cs-C22 alkanoic acid.
3. 3. Composition according to claim 1, characterized in that it additionally comprises from about 1 to about 50% by weight of a bulky needle.
4. 4. Composition according to claim 3, characterized in that the bulky agent is a hydrophobically treated bentonite.
5. 5. Composition according to the rei indication 1, characterized in that the carrier is ci cl orne t i cona.
6. 6. Composition according to claim 1, characterized in that the astringent salt is an aluminum salt.
7. 7. Composition according to claim 1, characterized in that the alkyl acetate is selected from the group consisting of methyl acetate and t-butyl.
8. 8. Composition according to claim 1, characterized in that the propylene carbonate is absent.