MXPA00005527A - Deodorant composition - Google Patents
Deodorant compositionInfo
- Publication number
- MXPA00005527A MXPA00005527A MXPA/A/2000/005527A MXPA00005527A MXPA00005527A MX PA00005527 A MXPA00005527 A MX PA00005527A MX PA00005527 A MXPA00005527 A MX PA00005527A MX PA00005527 A MXPA00005527 A MX PA00005527A
- Authority
- MX
- Mexico
- Prior art keywords
- deodorant
- deodorant composition
- composition according
- phmb
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 66
- 239000002781 deodorant agent Substances 0.000 title claims abstract description 40
- 229920002413 Polyhexanide Polymers 0.000 claims abstract description 25
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Exidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 229960003260 Chlorhexidine Drugs 0.000 claims abstract description 14
- 210000003491 Skin Anatomy 0.000 claims abstract description 12
- 239000000969 carrier Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 9
- 239000011780 sodium chloride Substances 0.000 claims description 9
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N diguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- 230000000699 topical Effects 0.000 abstract 1
- 239000000047 product Substances 0.000 description 17
- 239000000243 solution Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000344 soap Substances 0.000 description 5
- 239000000443 aerosol Substances 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 230000001877 deodorizing Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- -1 ethanol Chemical compound 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 2
- 241001649081 Dina Species 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 210000004243 Sweat Anatomy 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003213 antiperspirant Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000249 desinfective Effects 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 229960004867 hexetidine Drugs 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000005068 transpiration Effects 0.000 description 2
- KIHBGTRZFAVZRV-UHFFFAOYSA-N 2-hydroxystearic acid Chemical compound CCCCCCCCCCCCCCCCC(O)C(O)=O KIHBGTRZFAVZRV-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N 3-Methylbutanoic acid Chemical class CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- 210000001099 Axilla Anatomy 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 108060003337 GPI Proteins 0.000 description 1
- XAPRFLSJBSXESP-UHFFFAOYSA-N Oxycinchophen Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=C(O)C=1C1=CC=CC=C1 XAPRFLSJBSXESP-UHFFFAOYSA-N 0.000 description 1
- 235000015076 Shorea robusta Nutrition 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N Stearyl alcohol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminum Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 230000001355 anti-mycobacterial Effects 0.000 description 1
- 230000000111 anti-oxidant Effects 0.000 description 1
- 230000001166 anti-perspirant Effects 0.000 description 1
- 230000000259 anti-tumor Effects 0.000 description 1
- 239000003926 antimycobacterial agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 229940058933 biguanide antimalarials Drugs 0.000 description 1
- 229940090145 biguanide blood glucose lower drugs Drugs 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 150000004287 bisbiguanides Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N butane Chemical class CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000295 complement Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000882 contact lens solution Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000875 corresponding Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001186 cumulative Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 125000001145 hydrido group Chemical group *[H] 0.000 description 1
- 230000002209 hydrophobic Effects 0.000 description 1
- 239000012051 hydrophobic carrier Substances 0.000 description 1
- 230000002147 killing Effects 0.000 description 1
- 230000002045 lasting Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 244000005706 microflora Species 0.000 description 1
- LYRFLYHAGKPMFH-UHFFFAOYSA-N octadecanamide Chemical class CCCCCCCCCCCCCCCCCC(N)=O LYRFLYHAGKPMFH-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N propane Chemical class CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001294 propane Chemical class 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002195 synergetic Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 150000003754 zirconium Chemical class 0.000 description 1
Abstract
A deodorant composition for topical application to human skin characterised in that it comprises an effective amount of polyhexamethylene biguanide and an effective amount of chlorhexidine in a cosmetically acceptable carrier.
Description
DEODORANT COMPOSITION
DESCRIPTION OF THE INVENTION This invention relates to deodorant compositions suitable for application to human skin. In particular, it relates to the deodorant compositions comprising px > 1 i e xame t i 1 n biguanide (PHMB) or salts thereof and chlorhexidine or salts thereof. Typically, a deodorizing composition will try to significantly reduce or prevent the odor of the body, reducing either the transpiration or the number of microorganisms on the surface of the skin. The former is usually referred to as an antitumor composition and the latter as a deodorant. Compositions that reduce perspiration often comprise a metal salt, such as an aluminum or zirconium salt which blocks sweat pores. This method is very simple and nevertheless rarely a reduction in transpiration of more than 50% is obtained. Deodorants, on the other hand, reduce the number of microorganisms on the surface of the skin. It is well known that sweat has no odor until it has been degraded by the skin or the skin. Typious deodorants include ethanol and triclosan (2 ', 4, 4'-trichloro, 2-hydroxy-d-f-enyl ether) which is a well-known antibacterial agent. However, the defects of the odor obtained with such deodorants are spent quite rapidly as the microflora - it soon collects its numbers. ~~ There is, therefore, a requirement in the market- for more effective and longer lasting deodorants. PHMB is a well-known antibacterial agent and is commercially available, for example from Zeneca under the trade name Cosmocil CQ. The use of PH-MB in the deodorant compositions is described in the North American patent 4 478 821 (Gillette) which describes the PHMB's ability to reduce the bad odor of the body. Explain in column 2, line 6 to 15, the poor correlation between antibacterial activity and deodorant activity. WO 96/31189 (Unileve-r) also describes the use of PHMB for use in a propellant-driven aerosol deodorant composition. In addition EP Bl 0 180 309 (Bausch &Lomb Ine) describes the use of PHMB in disinfecting solutions for contact lenses. In EP-A2-0 174 128, ICI describes the coating of a non-woven material with a linear polymeric biguanide. C 1 o rhe-idina is also a well-established antibacterial agent and is available, for example, from ICI b-ajo the trade name Hibitane. The use of chlorhexidine or PHMB in combination with the antibacterial agent hexetidine is described - in EP Bl 0136 231 [Sal inl. This reference describes the use of either chlorohexidine or PHMB in combination with hexetidine (pi rimi di nami na) in disinfectant compositions which are particularly suitable for the sterilization of surgical instruments. Chlorhexidine or PHMB in combination with an amine oxide is exemplified in DE-A-3334555 (Johnson &Johnson Baby Products C-o) as an anti-mycobacterial mixture against gram-positive and gram-negative bacteria. A combination of chlorhexidine and PHMB is described as a preserving system for thermic solutions and particularly for contact lens solutions in WO 94/15649 for Polymer Technology Coporate. Surprisingly it has now been found that the combination of PHMB and c 1 or r oh ex i dina in a deodorant composition provides an improved deodorizing effect. The two compounds appear to act inefficiently and the deodorizing effect is larger and of longer duration than is espexaxy on the basis of the effect of each compound alone. Both substances are biguanides: the chlorhexidine being a bisbiguanide and the PHMB being a polymeric biguanide. The structural similarity between the two suggests that they exert their exterminating effect in a similar way and thus at best demonstrates a cumulative effect and in the worst of cases a complementary effect rather than a synergistic one. when they are used together Therefore, the invention provides a deodorant composition for local application to human skin which comprises in combination po 1 i hexame t i 1 enbi guani da and c 1 o r hex i dina in a cosmetically acceptable carrier.
All expressions of quantity as a percentage described in this specific CZL or n are related to percentages by weight unless declared otherwise. - - - --- The cosmetically acceptable PHMB for use in compositions according to the invention is represented in the protonated form in the following general formula: - - - - [- (CH2) 6-NH-C (= NH) -NH-C (= NH) - NH -] n - where n can have a value of up to 500 or more, but typically has a value _ of - 1-4-. In preferred embodiments of the invention, n has an average value of 10-14. The polymer is determined by a suitable final group as described in the above references, such as that of the formula - (CH2) 3-NH-C (NH) -NH-CN or (CH2) 3-NH2 _ The PHMB salt can be present in the compositions according to the invention in an amount of 0.001 to 1.0%, more preferably 0.01 to 0.5% and more preferably Q.02 to 0.35-. The clohexidine salt may be present in the compositions according to the invention in a c? txdad of 0.005 to 0.5%, of greater preference of 0.01 to 0.3% and of greater preference- from J .0L to 0.2%.
The weight ratio of chlorhexidine: PHMB (e x p r e-s as its r e sp ective salts) is preferably selected in the range from 1: 2 to 10: 1 and especially from 1: 1 to 4: 1. Where is the composition intended for your ~ ---? used in a metal canister, such as in a conventional pressurized ---- -serosol, the salts of chlorohexy dine and PHMB are preferably free of halide. - The compositions according to the present invention advantageously contain a low molecular weight aliphatic alcohol, preferably containing up to 4 carbons and especially a monohydric alcohol such as ethanol, which can act in combination with chlorhexidine and chlorohexidine. PHMB to provide deodorance on human skin which is superior to that -provided by the constituents of the combination alone. The proportion of such alcohol in the composition is often selected within the range from 10 to 80% by weight, and in many formulations from 30 to 70% by weight. d the alcohol, and especially the ethanol at the combined weight of the PHMB and chlorhexidine salts is preferably selected in the range from 100: 1 to 40-00: 1, and in many cases from 300: 1 to 2000: 1.- _ The composition according to the invention may also comprise other materials commonly found in deodorant or antiperspirant compositions In practice, the composition of the invention usually contains at least one cosmetically acceptable vehicle in addition to the PHMB. and the chloro-exine.The cosmetically acceptable vehicle may comprise a liquid carrier as described hereinabove, and / or water and / or a hydrophobic carrier which may for example be a non-silicone oil. volatile -c vo-1á ti 1, ou n hydrocarbon liquid or an alcohol insoluble in water or aliphatic ethers or - aliphatic esters - or aromatics. The standard carrier constitutes from 10 to 80% weight / weight of the composition. The compositions of the invention may additionally contain, if s-e a ain or --- or more additional active deodorants, frequently He 0 to 5% w / w; perfumes, frequently 0 to 2% w / w; active anti-perspirant agents such as aluminum zirconium active antioxidants, frequently from 0 to 40% w / w-and when particularly present from 5 to 28% w / w; beneficial agents for the skin, including emollients, which can be provided by a number of carriers such as silicone oils or additionally for example solid silicone polymers, such additional emollients frequently. comprise from 0 to 20% weight / weight; dyes, ne neously 0 to 2% w / w; humectants, such as sorbitol or glycerol, frequently from 0 to 10% w / w; thickeners such as starches or cellulose derivatives, frequently from 0 to 5% w / w and particularly from Q to 2% w / w; gelling agents such as dibenzyl-1-sorbitol, hydroxy stearic acid, stearyl alcohol, or amide derivatives of tricalbic acids, frequently in an amount from 0 to 15% w / w and particularly from 0 to 5% w / w ~ that; suspending agents, such as clays or silicas, often in an amount of up to 5% w / w; 1-e structurants as silicone or silicone elastomers are used for the hydrous uro, for example in an amount of 0 to 15% w / w. SW; propellants such as hydrocarbons having a boiling point below 10 -, for example isomers of butane and propane, such as an amount, when 30 to 95% w / w, particularly 35 to 75% are used /weight; and other cosmetics - adjuncts conventionally employed in such compositions. Where the water and a hydrophobic material is present, the composition preferably contains an emulsion if it is stable, typically having a HLB or an average HLB of from 6 to 11, such as esters or ethers of po 1 iet ox i the to. The use of such substances and the proportions in which they are incorporated, depends on the form of the composition which may be in exo sol, bar, pellet, gel, lotion, cream, ointment, powder, suspension or soap. The invention will now be described by the following non-limiting articles. EXAMPLE 1 Formulations A, B and C summarized in Table 1 can be made by conventional methods known in the art. Formulation A is for a ball deodorant; B is for tm or aerosol; and C is for a b roader. The quantities are expressed as percentages in pe sc. Table 1
Klucel 99M (trademark) is - hydroxypropyl cellulose from Acualón. _ 1 Hydro ipropyl cellulose, ex Acualon E j emp 2 and 3 In these examples, the efficiency of deodorant combinations was measured by the Deodorant Value Test, a panel test, as described in the following. The Deodorant Value Test _ In this test the deodorant value of a deodorant composition is measured by assessing its effectiveness when applied directly to the skin. The composition is applied to the axilla (armpits) of a panel of human subjects and is subsequently treated to reduce odor. The test uses a team of 3 or 4 consultants with experience in women with odor-low-arm. These are selected with the proviso that they are capable of correctly correcting the odor intensities of a series of isovaleric acid solutions listed below. The intensities of these series of solutions form the basis of the scale of category 0/5 used to subjectively quantify the odor under the arm in the test. Scale of Cate oría de Mal Olor
New consultants are trained for their participation alongside advisors with experience in the testing of deodorant products under the arm- "Training is complete when the new assessor is able to quantify the odor under the arm in this protocol on the same basis of experienced consultants The discrimination between odor under the arm and the residual pro duct of perfume in the total axillary odor is a key part of the skill of an expert scent killer.
The panel consists of up to 50 subjects who have been selected by expert odor advisors on the basis that their body odor is not unusually weak or strong or uneven between the armpits. Panelists are denied the use of any products under their arm, and are provided with a bar of non-deodorizing home-use soap. The test is run for a period of 5 days, and includes 4 cycles of application of odor-causing p roduction. The period between the application of the product to the subjects and the assessment of the odor under the arm is 5 hours and 24 hours. - Only panelists who have not previously participated in any test of products under the arm for at least a week can take part in this test, due to the fact that product transfer effects may occur. On the first day of the test, the armpit of the panelists is washed by the advisors-s- using a soap or perfumed. A technique is used in which a wet flannel is soaked in soap for 15 seconds, the armpit is washed with flannel for 30 seconds, then "cleaned with a flannel rinse in water and dried with a towel of paper.
A separate flannel is used for each armpit of each panelist. Each panelist uses a different product in each armpit and this remains constant during the test. The technique of applying a standard product is used; for aerosols, a spray measure of 2 seconds to 6 inches from the armpit is used; For pump sprinklers, a constant number of pumps is used. The product can be applied either as a number of shocks or a known weight of the product can be applied using a balance to measure the weight loss of the product After 5 hours and 24 hours of use of the test product, the intensity of the each-axilla odor was evaluated by each assessor, each in turn assigned a marker on the scale of _Q to 5, corresponding to the strength of the bad odor under the arm.After the 5-hour assessment, the panelists undertake their Standard activities for the rest of the day After 24 hours of the test, the panelists are first evaluated for odor under the arm, and then they are washed and the products are repaired.The prototype is repeated for 4 days after On the last day of the test, the panelists were evaluated but no washing was done and no additional product was applied.The malodor markers of -5 and 24 hours of use period were they treat separately. s of day 4 of all expert scent advisors are averaged to give a result for each test product during the week, "and these are then averaged to give a team marker.The results were analyzed using a SAS routine based on Vari i arrei analysis to which ton- on account the facto is leading to variability, eg, subject, day, preference iz quierdo de re ch o The analysis also gives the difference in the bad odor score needed to make a statistically-significant result at the level of P = 0.05. for a test composition is the difference in the score between the test composition and a placebo.This test for the determination of the deodorant value of a deodorant composition for use according to the invention is based ere X "a1 On the proof invented by Whitehouse and Carter as published in "Th e proceedings of the S cence Section of the Toilet Goods Association", No. 48, December 1967 on pages 31-37 under the - title of "Evaluation o f Deodorant Toilet "Bars - The test described in that publication has been - however, generally modified in three main ways: first, the product is applied directly to the armpit rather than the form of a soap bar wash, in the second, a scale of 0 to 5 was used instead of 0 to 10 and, thirdly, the odor intensity classification was performed at 5 hours and 24 hours instead of only 2 hours after treatment. This test is referenced here as the Deodorant Test Value. In Example 2, a comparison was made between the deodorant efficiency of ethanolic solutions of D-digluconate de-c? Orohexidine respectively, (CHDG); E-Cosmocil CQ; and ~ F - a mixture of half the concentration of each. The solutions were thickened with 0.25% w / w Klusel 99M (hydroxypropyl cellulose). The compositions were applied using a bead deodorant. The results of Example 2 are summarized in Table 2 below.
Table 2 Active Deodorant Mean Marker of Bad Odor after 24 hours
D 0.204% CHDG 2.04 E 0.50% Cosmocil CQ (20% 1.88 active) F 0.102% CHDG + 1.58 0.25%, Cosmocil CQ (20% active) D i ference 0.15 significant (95%) From Table 2, it can be seen that the combination according to the invention F, for example the combination of CHDG and PHMB in ethanol was more effective for a statistically significant rate of any of the comparative compositions D and E, especially C-HDG or PHMB in ethanol ^ - In Example 3, non-thickened aerosol alcohol formulations were prepared containing the concentrations of CHDG and PHMB shown in Table 3 below.
Table 3 ^ Active Deodorant Marker- Means of Bad Odor- after 24 hours
G 0.04% CHDG 1.73 H 0.10% Cosmocil CQ (20% 1.88 active) _ I 0.02% CHDG + 1.52 0.05% Cosmocil CQ (20% active) Difference 0.15 significant (95%) From Table 3 you can see that the combination according to the invention I, for example, the combination of CHDG and PHMB in ethanol was more effective for a statistically significant range of any of the comparative compositions G and H, especially CHDG or PHMB in ethanol.
Claims (9)
1. Deodorant composition for local application to human skin characterized in that it comprises a combination of an effective amount of po 1 ihexame 111 in biguanide and an effective amount of chlorhexidine in an acceptable ammonium carrier comprising a monohydric alcohol of Cl through C4 .
2. Disintegrating composition according to claim 1, characterized in that the po 1 rhexame t i 1 e-n biguanide is in the f-crma of a cosmetically acceptable salt.
3. Deodorant composition according to claim 1 or 2, characterized in that the c 1 or r hexate di n a is in the form of a cosmetically acceptable salt.
4. Deodorant composition according to any preceding claim characterized in that the p or 1 i h e x ame 111 in biguanide comprises 0.001 to 1.0% by weight of the composition.
5. Deodorant composition according to any preceding claim characterized in that the chlorohexidine comprises from 0.005 to 0.5 by weight of the composition.
6. Deodorant composition according to any preceding claim - characterized in that chlorhexidine and polyhexamethylene biguanide are in a weight ratio of 1: 1 to 4: 1.
7. Deodorant composition according to any preceding claim characterized in that the carrier comprises ethanol.
8. Deodorant composition according to claim 7, characterized in that the "ethanol is present in a weight ratio to the combined weight of chlorhexidine and p or 1 i h e xame 111 in biguanide in the range of 100: 1 to 4000: 1
9. Cosmetic method for preventing or reducing malodor by local application to human skin of a deodorant composition according to any preceding claim. -
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9726132.5 | 1997-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA00005527A true MXPA00005527A (en) | 2001-07-03 |
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