MXPA00005335A - Fungicide mixtures based on pyride amides and morpholine derivatives or piperidine derivatives - Google Patents

Abstract

The invention relates to fungicide mixtures containing, as active components, a) an amide compound of formula (I) A-CO-NR1R2, wherein A represents an aryl group or an aromatic or non-aromatic, 5- or 6-structured heterocyclic compound having 1 to 3 heteroatoms selected from O, N, S;whereby the aryl group or the heterocyclic compound can optionally comprise 1, 2 or 3 substituents selected independently of one another from alkyl, halogen, CHF2, CF3, alkoxyl, haloalkoxyl, alkylthio, alkyl sulfinyl and alkyl sulfonyl;R1 represents a hydrogen atom;R2 represents a phenyl group or cycloalkyl group optionally containing 1, 2 or 3 substituents selected independently of one another from alkyl, alkenyl, alkynyl, alkoxyl, alkenyloxyl, alkynyloxyl, cycloalkyl, cycloalkenyl, cycolalkyloxyl, cycloalkenyloxyl, phenyl and halogen, whereby the aliphatic and cycloaliphatic radicals can be partially or completely halogenated and/or the cycloaliphatic radicals can be substituted by 1 to 3 alkyl groups, whereby the phenyl group can contain 1 to 5 halogen atoms and/or 1 to 3 substituents selected independently of one another fromalkyl, haloalkyl, alkoxyl, haloxyl, alkylthio and haloalkylthio, and whereby the amidic phenyl group is optionally condensed with a saturated 5-structured ring which is optionally substituted by one or more alkyl groups and/or can comprise a heteroatom selected from O and S, and b) a morpholine derivative or piperidine derivative (III) selected from the group of compounds (IIa), (IIb), (IIc), (IId) and (IIe). The active components are provided in a synergistically effective quantity.

Description

FUNGICIDE MIXTURES BASED ON COMPU AND MORPHOLINE OR PIPERIDINE DERIVATIVES Description The present invention relates to fungicidal mixtures for controlling harmful fungi, as well as methods for controlling harmful fungi using these mixtures.

WO 97/08952 describes mixtures of amide compounds of the formula I A-CO-NR1R2 (I) wherein it denotes an aryl group or an aromatic or non-aromatic heterocycle with 5 or 6 members, having 1 to 3 heteroatoms selected from O, N and S; the aryl group or the heterocycle may optionally have 1, 2 or 3 substituents, each of which may be independently selected from the group consisting of alkyl, halogen, CHF 2, CF 3, alkoxy, haloalkoxy, alkylthio, alkylsulfinyl and alkylsulfonyl; R1 means a hydrogen atom; R2 means a phenyl or cycloalkyl group, optionally having 1, 2 or 3 substituents, which are selected from alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkenyl, cycloalkyloxy, cycloalkenyloxy, phenyl and halogen , whose aliphatic and cycloaliphatic radicals can be partially or completely halogenated and / or the cylcoaliphatic radicals can be substituted by 1 to 3 alkyl groups, and whose phenyl group can have from 1 to 5 halogen atoms and / or 1 to 3 substituents, are independently selected from alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio and haloalkylthio, and whose amide phenyl group can be fused with a saturated 5-membered ring, which is optionally substituted by one or more alkyl groups and / or a heteroatom selected from O, and S, and as acaricide the active substance known as Fenazaquin.

These mixtures are described as being especially effective against botrytis. nen, among others, active substances of the formulas lia, Ilb and / or lie together with other active substances from the group of oxymeteors and / or carbamates.

(H3C) 3C (lia) CH2-CH (CH3) -CH2-g (llb) [n = 10,11,12 (60-70%) or 13] Other fungicidal mixtures containing active substances of the formulas lia up to lie are known from EP-A 797386, WO 97/06681, EP- B 425857, EP-B 524496, EP-A 690792, WO 94/22308 and EP-B 645087.

The present invention has for its object to provide other mixtures especially effective for controlling harmful fungi and especially for certain indications.

Surprisingly, it has been found that this object is achieved with a mixture, which contains as active substances amide compounds of the formula I defined above and as another component of fungicidal action an active fungicide of the group of active substances of morpholine and piperidine from the formulas lia to lie. [n = 10,11,12 (60-70%) or 13] The mixtures according to the invention have synergetic action, so they are suitable for controlling harmful fungi and especially for controlling powdery mildew fungus in legumes and vines.

In the sense of the present invention, halogen means fluorine, chlorine, bromine and iodine, and especially fluorine, chlorine and bromine.

The term "alkyl" embraces linear or branched alkyl groups. Preferably, they are linear or branched alkyl groups of 1 to 12 and especially 1 to 6 carbon atoms. Examples of alkyl groups are alkyl, such as, especially methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, n-pentyl, 1-methylbutyl, 2-methylbutyl , 3-methylbutyl, 1,2-dimethylpropyl, 1,1-dimethylpropyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1, 2-dimethylbuyl, 1,3-dimethylbutyl, 2,3-dimethylbutyl, 1,1-dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1-trimethylpropyl, 1,2,2 -trimethylpropyl, 1-ethylbutyl, 2-ethylbutyl, l-ethyl-2-methylpropyl, n-heptyl, 1-methylhexyl, 1-ethylpentyl, 2-ethylpentyl, 1-propylbutyl, octyl, decyl, dsdecyl.

Halogenoalkyl represents an alkyl group defined above, which is partially or completely halogenated with one or more halogen atoms, especially fluorine and chlorine. Preferably the difluoromethane group or the trifluoromethyl group.

The explanations given above with respect to the alkyl and haloalkyl group are analogously valid for the alkyl and haloalkyl groups in alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl and alkylsulfonyl.

The alkenyl group comprises linear and branched alkenyl groups. Preferably, they are linear or branched alkenyl groups with 3 to 12 and especially 3 to 6 carbon atoms. Examples of alkenyl groups are 2-propenyl, 2-butenyl, 3-bute-nyl, l-methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, l-methyl -2-butenyl, 2-methyl-2-butenyl, 3-methyl-2-butenyl, l-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1, 1 -dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, l-ethyl-2-propenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexe-nyl, l-methyl-2-pentenyl , 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, l-methyl-3-pentenyl, 2-methyl-3-pente-nyl, 3-methyl-3-pentenyl , 4-methyl-3-pentenyl, l-methyl-4-pente-nile, 2-methyl-4-pentenyl, 3-methyl-4-pentenyl, 4-methyl-4-pente-nyl, 1, l-dimethyl -2-butenyl, 1, l-dimethyl-3-butenyl, 1,1-dimethyl-3-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1, 3 dimethyl-2-butenyl, 1,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, -ethyl-2-butenyl, l-ethyl-3-butenyl, 2-ethyl-2-butenyl, 2-ethyl-3-bute-nyl, 1, 1,2-trimethyl-2-propeni it, l-ethyl-l-methyl-2-propenyl and l-ethyl-2-methyl-2-propenyl, especially 2-propenyl, 2-bute-nyl, 3-methyl-2-butenyl and 3-methyl-2 -pentenyl.

The alkenyl group can be partially or completely halofenode with one or more halogen atoms, especially fluoro and chloro. Preferably, it will have from 1 to 3 halogen atoms.

The alkynyl group comprises linear or branched alkynyl groups. Preferably, these are linear or branched alkynyl groups having 3 to 12 carbon atoms and especially 3 to 6 carbon atoms. Examples of alkynyl groups are 2-propynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2- methyl-3-butynyl, l-methyl-2-butynyl, 1, l-dimethyl-2-propynyl, l-ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-alkynyl, 5-hexynyl, l- methyl-2-penti-nyl, l-methyl-3-pentynyl, l-methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4-pentynyl, 3-methyl-4-pentynyl, 4-methyl-2-pentynyl, 1,2-dimethyl-2-butynyl, 1, 1-dimethyl-3-butynyl, 1,2-dimethyl-3-butynyl, 2, 2-dimethyl-3- butynyl, l-ethyl-2-butynyl, nyl. The explanations given above with respect to the alkenyl group and its halogen substituents, as well as for the alkynyl group, are analogously valid for f-alkenyloxy and alkynyloxy.

In the cycloalkyl group, it is preferably a C3-C6-cycloalkyl group, such as, for example, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl. When the cycloalkyl group is substituted, then it will preferably have 1 to 3 C-C4-alkyl radicals as substituents.

Cycloalkenyl represents, preferably a C4-C6-cycloalkenyl group, such as, for example, cyclobutenyl, cyclopentenyl or cyclohexenyl. When the cycloalkenyl group is substituted, then, it will preferably have 1 to 3 C! -C -alkyl radicals as substituents.

A cycloalkoxy group is preferably a Cs-Cg-cycloalkoxy group, such as, for example, cyclopentyloxy or cyclohexyloxy. When the cycloalkoxy group is substituted, then it will preferably have 1 to 3 Cj_-C4-alkyl radicals as substituents.

The cycloalkenyloxy group is preferably a C5-C6-cycloalkenyloxy group, such as, for example, cyclopentyloxy or cyclohexyloxy. When the cycloalkenyloxy group is substituted, then, it preferably has 1 to 3 alkyl radicals with 1 to 4 carbon atoms as substituents. jArilo preferably represents phenyl.

When A means a phenyl group, it may contain one, two or three of the abovementioned substituents in arbitrary position. Preferably, these substituents will be selected, independently, from alkyl, difluoromethyl, trifluoromethyl and halogen, especially chlorine, bromine and iodine. The phenyl group very preferably has a substituent at the 2-position.

When A is a 5-membered heterocycle, it is in particular a furyl, thiazolyl, pyrazolyl, imidazolyl, oxazolyl, thienyl, triazolyl or thiadiazolyl radical or a corresponding dihydro or tetrahydro derivative. A thiazolyl or pyrazolyl radical is preferred. is a pyridyl radical or a radical of the formula: where one of the radicals X and Y means O, S or NR23, meaning R23 H or alkyl and the other radical representing X and Y CH2, S, SO, S02 or NR23. The dotted line means that a double bond is eventually present.

Most preferably, the 6-membered aromatic heterocycle is a pyridyl radical, especially a 3-pyridyl radical, or a radi-cal of the formula where X is CH2, S, SO or S02.

The heterocyclic radicals mentioned may optionally have 1, 2 or 3 of the abovementioned substituents, the substituents being preferably selected, each independently of the other, from alkyl, halogen, difluoromethyl or trifluoromethyl.

Most preferably, A means a radical of the formulas; where R3, R4, R6, R7, R8 and R9 mean, each independently of the other, hydrogen, alkyl, especially methyl, halogen, especially chloro, CHF2 or CF3. hydrogen atom.

The radical R 2 in the formula I preferably means a phenyl radi-lime. Preferably, R2 has a substituent, which is very particularly at position 2. The (or substituents) are preferably selected from alkyl, cycloalkyl, cycloalkenyl, halogen or phenyl.

The substituents of the radical R.sup.2 may in turn be replaced again. The aliphatic or aromatic substituents may be partially or completely halogenated, especially fluorinated or chlorinated. Preferably, they will have 1, 2 or 3 fluorine or chlorine atoms. When the substituent of the radical R2 is a phenyl group, then it can be substituted, preferably, by 1 to 3 halogen atoms, especially chlorine atoms, and / or by a radical, which is selected, preferably, from alkyl and alkoxy Especially preferred is the phenyl group with a halogen atom in the p-position, that is to say the especially preferred substituent of the radical R 2 is a phenyl radical substituted by halogen in p. The radical R2 can also be condensed with a five-membered ring, the ring itself being able to have from 1 to 3 alkyl substituents.

R2 represents, then, for example, indanyl, thiaindanyl and oxaindanyl. Preferred are indanyl and 2-oxaindanyl, which are linked, especially via the 4-position with the nitrogen atom.

In a preferred variant the product according to the invention contains co or amide compound a compound of formula I, wherein A has the following meanings: phenyl, pyridyl, dihydropyranyl, dihydrooxathiinyl, dihydro-oxathiinyl oxide, dihydrooxathiinyl dioxide, furyl, thiazo -lyl, pyrazolyl or sxazolyl, the groups having 1, 2 or 3 substituents, independently selected from alkyl, halogen, difluoromethyl and trifluoromethyl.

According to another preferred variant A means: pyridin-3-yl, which optionally is stabilized in the 2-position by halogen, methyl, difluoromethyl, trifluoromethyl, methoxy, methylthio, methylsulfinyl or methylsulfonyl; phenyl, which is optionally substituted in the 2-position by methyl, trifluoromethyl, chloro, bromo or iodo; 2-methyl-5,6-dihydropyran-3-yl; 2-methyl-furan-3-yl, which is optionally substituted in the 4-position and / or 5 by methyl; thiazol-5-yl, which is optionally substituted in the 2-position and / or 4 by methyl, chloro, difluoromethyl or trifluoromethyl; thiazol-4-yl, which is optionally substituted in the 2-position and / or 5 by methyl, chloro, difluoromethyl or trifluoromethyl; l-methylpyrazol-4-yl, which is optionally substituted in the 3-position and / or 5 by methyl, chloro, difluoromethyl or trifluoromethyl; or oxazol-5-yl, which, optionally, is substituted in the 2-position and / or 4 by methyl or chloro.

According to another preferred variant, the products according to the invention contain as the amide compound a compound of the formula I, wherein R 2 represents a phenyl group, which is optionally substituted by 1, 2 or 3 of the aforementioned substituents.

According to another preferred variant, the products according to the invention contain as the amide compound a compound of the formula I, wherein R 2 represents a phenyl group, which in the 2-position has one of the following substituents: C 3 -C 6 -alkyl, Cs-Cβ- cycloalkenyl, C5-C6-cycloalkyloxy, cycloalkenyloxy, whose groups may be substituted by 1, 2 or 3 alkyl groups with 1 to 4 carbon atoms, phenyl, which is substituted by 1 to 5 halogen atoms and / or 1 to 3 groups, independently selected from C? -C4-alkyl, C? -C4-haloalkyl, C? -C4-alkoxy, C? C4-halogen-alkoxy, C? -C4-alkylthio and C? -C4-haloalkylthio, indanyl or oxaindanyl, which, optionally, is substituted by 1, 2 or 3 alkyl groups with 1 to 4 carbon atoms.

According to another preferred variant, the products according to the invention contain, as the amide compound, a compound of the formula la, R 10 where A means (Al) (A2; (A3) (A7) (A8) X means methylene, sulfur, sulfinyl or sulfonyl (S02), 3 means methyl, difluoromethyl, trifluoromethyl, chloro, bromo or iodo, R4 means trifluoromethyl or chloro, R5 means hydrogen or methyl, R6 means methyl, difluoromethyl, trifluoromethyl or chloro, R7 means hydrogen or, methyl or chloro, R8 means methyl, difluoromethyl or trifluoromethyl, R9 means hydrogen or, methyl, difluoromethyl, trifluoromethyl or chloro, R10 means C1-C4-alkyl, C1-C-alkoxy, C1-C4-alkylthio or halogen . nen as the amide compound a compound of the formula Ib where R 4 is halogen and R 11 is phenyl, which is substituted by halogen.

Especially preferred mixtures according to the invention contain as component I compounds of the formulas Suitable amide compounds of formula I are those, of EP-A-545 099 and 589 301, which are incorporated herein by reference in their entirety.

The preparation of the amide compounds of the formula I is known, for example, from EP-A-545 099 or 589 301 or can be carried out according to analogous processes.

Also known are derivatives of morpholine or piperidine II (bundle: common name: fenpropimorf, US-A 4,202,894; Ilb: common name: fenpropidine, US-A 4,202,894; líe: common name: tridemorf, DE-A 11 64 152) , its obtaining and its action against harmful honors. portion of the amide compound of the formula I. Preferably, the amide compound and the morpholine derivative or piperidine are used in a quantitative ratio of 20: 1 to 1:20, especially 10: 1 to 1:10. .

Thanks to the basic character of the nitrogen atoms contained in them, the compounds II are capable of forming salts or adducts with inorganic or organic acids or with salts of metal ions.

Examples of inorganic acids are the halogenated hydroxides, such as, for example, hydrofluoric acid, hydrochloric acid, hydrobromic acid and hydroiodic acid, sulfuric acid, phosphoric acid and nitric acid.

Suitable organic acids are, for example, formic acid, carbonic acid and alkanoic acids, such as acetic acid, trifluoroacetic acid, trichloroacetic acid and propionic acid, as well as glycolic acid, thiocyanic acid, lactic acid, succinic acid, citric, benzoic acid, cinnamic acid, oxalic acid, alkylsulfonic acids (sulphonic acids with linear or branched alkyl radicals having 1 to 20 carbon atoms), arylsulfonic and aryldi sulphonic acids (aromatic radicals, such as phenyl and naphthyl, carrying one or two sulfonic acid groups), alkyl phosphonic acids (phosphonic acids with linear or branched alkyl radicals having 1 to 20 carbon atoms), aryl phosphonic or aryl diphosphonic acids (aromatic radicals, such as phenyl and naphthyl, which they contain one or two phosphoric acid radicals), whose alkyl or aryl radicals can carry additional substituents, such as, for example, p-toluenesulfonic acid, slicic acid, p-aminosalicyclic acid, 2-phenoxybenzoic acid, 2-acetoxybenzoic acid , etc.

As metal ions, especially the ions of the first to eighth secondary group elements, especially chromium, manganese, iron, cobalt, nickel, copper, zinc and, in addition, of the second main group, especially calcium, are especially suitable. and magnesium, from the third and fourth main group, especially aluminum, tin and lead. Metals may even be present in their corresponding valences.

Preferably, pure substances I and II are used in the preparation of the mixtures, to which other active agents against harmful fungi or against other parasites, herbicidal or growth regulating agents or fertilizers can be added.

The mixtures of the compounds I and II or the combined or separate use of the compounds I and II provide an excellent effect against a broad spectrum of phytopathogenic fungi, especially of the class of the ascomycetes, basidiomycetes, ficomycetes and deuteromycetes. In part they have systemic action, so they can also be used as foliar and soil fungicides.

They are especially important for combating a myriad of fungi in different crop plants, such as cotton, legumes (eg cucumbers, beans and cucurbits), barley, turf, oats, bananas, coffee, corn, rice, rye, soybeans, vine, barley, ornamental plants, sugar cane and countless seeds.

They are especially suitable for combating the following phytopathogenic fungi: Erysiphe graminis (powdery mildew) in cereals, Erysiphe cichoracearum and Sphaerotheca fuliginea in cucurbitáces, Podosphaera leucotricha in apples, Uncinula necator in the vine, Puccinia species in cereals, Rhizoctonia species in cotton, rice and grass, Ustilago species in cereals and sugar cane, Venturia inaequalis in apples, Helminthos-porium species in cereals, Septoria nodorum in wheat, Botrytis ciñera (gray rot) in strawberries, legumes, ornamental plants and vine, Cercospora arachidicola in peanuts, Pseudocercosporella herpotrichoides in wheat and barley, Pyricularia oryzae in rice, Phytophthora infestans in potatoes and tomatoes, Pseudope-ronospora species in cucurbitas and hops, Plasmopara viticulture in the vine, Alternate species in legumes and fruits, as well as species of Fusarium and Verticillium.

In addition, they are suitable for the protection of materials (eg protection of wood), for example, against Paecilomyces vario-tii.

The mixtures according to the invention are most preferably used to col powdery mildew in vine and vegetable crops, as well as ornamental plants.

The compounds I and II can be applied simultaneously together or separately or successively; in the separate application, generally, the order in which the compounds are applied has no effect on the success of the treatment. they vary, especially in areas of agricultural cultivation, according to the desired effect of 0.01 to 8 kg / ha, preferably 0.1 to 5 kg / ha, especially of 0.2 to 3.0 kg / ha.

The application rates of compounds I vary from 0.01 to 2.5 kg / ha, preferably 0.05 to 2.5 kg / ha, especially 0.1 to 1.0 kg / ha.

The application rates of compounds II vary, correspondingly, from 0.01 to 10 kg / ha, preferably 0.05 to 5 kg / ha, especially 0.05 to 2.0 kg / ha.

In the treatment of the seeds, the mixtures are applied in amounts of 0.001 to 250 g / kg of seeds, preferably 0.01 to 100 g / kg, especially 0.01 to 50 g / kg.

Whenever the plants are to combat phytopathogenic fungi, the separate or combined application of compounds I and II or mixtures from compounds I and II is carried out by spraying or spraying the seeds, plants or the soils before or after the planting of the plants, or before or after the emergence of the plants.

The synergistic fungicidal mixtures of the invention or compounds I and II can be used in the form of directly pulverisable solutions, powders and suspensions or in the form of aqueous, oleic or other highly concentrated suspensions, dispersions, emulsions, oil dispersions. , spraying agents, spraying agents, directly sprayable granules, spraying, spraying, spraying or spraying. The forms of application depend entirely on the respective application purposes; in all cases, the finest possible distribution of the mixtures of the invention should be ensured.

The formulations are prepared in known manner, eg by mixing the active substance with solvents and / or support substances, if desired, using emulsifiers and dispersants, being precise, that in the case of using water as a diluent, they can be used also other organic solvents as auxiliary solvents. Suitable acyl substances are essentially: solvents, such as aromatics (eg xylenes), chlorinated aromatics (eg chlorobenzenes), paraffins (eg petroleum fractions), alcohols (eg methanol, butanol), ketones (eg cyclohexanone), amines (eg ethanolamine, dimethylformamide) and water; carrier substances, such as natural stone pellets (eg kaolins, clays, talcum) and emulsifying stone powders, such as nonionic and anionic emulsifiers (eg polyoxyethylene fatty alcohol, alkyl sulfonates and aryl) and dispersants, such as sulphite residual liquors and methylcellulose.

Suitable surface-active substances are the alkaline earth metal and ammonium salts of lignin sulphonic acid, naphthalamine acid, phenolsulfonic acid, dibutyl naphthalene sulphonic acid, fatty acids, alkyl and alkylaryl sulphonates, alkyl sulfates, lauryl ether sulphates and alcohol sulfates. fatty acids, and the salts of sulphonated hexa, hepta and octadecanols, sulphonated naphthalene condensates and naphthalene derivatives with formaldehyde, condensates of naphthalene or of naphthalene sulfonic acid with phenol and formaldehyde, polyoxyethylene-noctilphenol ethers, ethoxylated isooctylphenol, octylphenol, nonylphenol, alkylphenol polyglycol ether, tributylphenyl polyglycol ether, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol condensates, ethylene oxide, ethoxylated castor oil, polyoxyethylene alkyl ether, polyoxypropylene ethoxylated, polyglycol ether-ketal of lauryl alcohol, sorbitol ester, lignin sulphide residual liquors cas and methylcellulose.

The powders, spraying and spreading agents can be obtained by mixing or co-grinding the compounds I or II or the mixture from the compounds I and II with a solid support.

Granules, eg coated granules, impregnated granules and homogeneous granules can be prepared by joining active substances with solid supports.

Suitable solid fillers or carriers are, for example, mineral earths, such as silica gel, siliceous acids, silicates, aleo, kaolin, attaclay, limestone, chalk, bolus, loess, dolomite, diatomaceous earth, magnesium sulfate and sulphate. calcium, magnesium oxide, ground plastics, fertilizers, such as eg ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas and vegetable products, such as cereal flours, bark powders of trees, wood and nut shell, cellulose powder and other solid supports.

The formulations generally contain between 0.1 and 95% by weight, preferably between 0.5 to 90% by weight, of one of the compounds I or II or of the mixture of the compounds I or II. The active substances are used here in a purity of 90% up to 100%, preferably 95% up to 100% (according to HPLC spectrum). corresponding, treating the harmful fungi, their living space or the plants, seeds, soils, areas, materials or enclosures to be kept free of them, with an active fungicidal amount of the compounds I and II in the separate application.

The application can be made before or after infection by harmful fungi.

Examples of formulations of this type, which contain the active substances, are: I. a solution from 90 parts by weight of the active substances and 10 parts by weight of N-methylpyrrolidone, suitable for use in the form of tiny drops; II. a mixture from 20 parts by weight of the active substances, 80 parts by weight of xylene, 10 parts by weight of the addition product of 8 to 10 moles of ethylene oxide to 1 mole of oleic acid N-monoethanolamide, 5 parts by weight of calcium salt of dodecylbenzenesulfonic acid, 5 parts by weight of the addition product of 40 moles of ethylene oxide to 1 moles of castor oil; by distributing the solution finely in water a dispersion is obtained; III. an aqueous dispersion from 20 parts by weight of the active substances, 40 parts by weight of cyclohexanone, 30 parts by weight of isobutanol, 20 parts by weight of the addition product of 40 moles of ethylene oxide to 1 mole of oil of castor IV. an aqueous dispersion from 20 parts by weight of the active substances, 25 parts by weight of cyclohexanol, 65 parts by weight of a mineral acid fraction from the boiling point of 210 to 280 ° C and 10 parts by weight of the product of addition of 40 moles of ethylene oxide to 1 mole of castor oil; V. a milled mixture in a hammer mill from 80 parts by weight of the active substances, 3 parts by weight of the sodium salt of diisobutylnaphthalene-1-sulphonic acid, 10 parts by weight of the sodium salt of a lignin sulphonic acid of a sulphite residual liquor and 7 parts by weight of powdery silicagel; by distributing the mixture finely in water, a spray mixture is obtained; SAW. an intimate mixture from 3 parts by weight of the active substances and 97 parts by weight of finely divided kaolin; this spraying agent contains 3% by weight of active substance; active, 92 parts by weight of powdery silicagel and 8 parts by weight of paraffin oil applied on the surface of this silica gel; this preparation gives an active substance with good adhesion; VIII. a stable aqueous dispersion from 40 parts by weight of the active substances, 10 parts by weight of the sodium salt of a condensate of phenolsulfonic acid, urea-formaldehyde, 2 parts by weight of silica gel and 48 parts by weight of water, which can be be further diluted; IX. a stable olefin dispersion from 20 parts by weight of the active substances, 2 parts by weight of the calcium salt of dodecylbenzenesulfonic acid, 8 parts by weight of the fatty alcohol polyglycol ether, 20 parts by weight of the sodium salt of an acid condensate phenylsulphonic-urea-formaldehyde and 88 parts by weight of a paraffinic mineral oil.

Application example The synergistic effect of the mixtures according to the invention can be demonstrated by the following tests: The active substances, used separately or together, are formulated as a 10% emulsion in a mixture from 63% by weight of cyclohexanone and 27% by weight of an emulsifier, and are diluted in water to the desired concentration.

The evaluation is carried out, determining the area of the leaves in-festedas in percent. These percentage values are converted into degrees of action. The degree of action (W) is determined by means of the formula of Abbot in the following way: W = (1 - a) -100 / ß a is equivalent to the fungal infection of the plants treated in% and ß is equivalent to the fungal infection of the untreated (control) plants in%.

Given a degree of action equal to O, the infestation of the treated plants is equivalent to that of the untreated control plants; in the case of a 100% action grade, the treated plants do not show any infestation. vas are determined by means of Colby's formula [R.S. Colby, weeds 1_5, 20-22 (1967)] and compared with the observed degrees of action.

Colby's formula: E = x + y - x-y / 100 E means the expected degree of action, translated in% of the untreated control, when using the mixture from the active substances A and B in the concentrations a and b; x is the degree of action, translated in% of the untreated control, by using the active substance A in the concentration a; and it is the degree of action, translated in% of the untreated control, by using the active substance B in the concentration b.

Application example 1 - Healing efficiency against Puccinia retinitis in wheat (brown wheat rust) The leaves of wheat seedlings of the "Kanzler" variety grown in pots are sprayed with spores of the brown rust (Puccinia re-condita). The pots are then placed for 24 hours in a chamber with high humidity (90 to 95%) and 20 to 22 ° C. During this time the spores germinate and the germ tubes penetrate the tissue of the leaf. The infected plates are sprayed the next day with an aqueous preparation of active substance, which is composed of a stock solution from 10% active substance, 63% cyclohexanone and 27% emulsifier. Once the powdered layer has been dried, the test plants are grown for 7 days in the greenhouse at temperatures between 20 and 22 ° C and 65 to 70% relative humidity of the air. Then the expulsion of the fungus development in the leaves is evaluated.

The following components are used as compounds of formula I: 1. 1 The results can be derived from the following tables 1 and 2.

Table 1 Table 2 From the results of the test it is clear that the degree of action observed is with all the mixing ratios higher than the 5 degree of action precalculated according to the Colby formula.

Application example 2 - Efficiency against wheat powdery mildew 0 Leaves of wheat seedlings of the "Kanzler" variety grown in pots are sprayed until they drip with an aqueous preparation of active substance, prepared from a stock solution composed of 10% active substance, 63% cyclohexanone and 27% of emulsifier and sprayed 24 hours after drying layer 5 sprayed with spores of wheat powdery mildew (Erysiphe graminis forma specialis tritici). The test plates are then placed in the greenhouse at a temperature of between 20 and 24 ° C and 60 to 90% relative humidity. After 7 days, the extent of powdery mildew on the surface of the leaf is visually determined.

The results can be derived from the following tables 3 and 4.

Table 3 *) calculated according to the formula of Colby From the results of the test it is clear that the degree of action observed is with all the mixing ratios higher than the degree of action calculated according to Colby's formula.

Claims (2)

Claims

1. Fungicidal mixtures containing as active components a) an amide compound of the formula I A-CO-NR! R2 I where A means an aryl group or an aromatic or non-aromatic heterocycle with 5 or 6 members, having 1 to 3 heteroatoms selected from O, N and S; The aryl group or the heterocycle may optionally have 1, 2 or 3 substituents, each of which may be independently selected from the group consisting of alkyl, halogen, CHF, CF3, alkoxy, haloalkoxy, alkylthio, alkylsulfinyl and alkylsulfonyl; Ri means a hydrogen atom; R2 means a phenyl or cycloalkyl group, optionally having 1, 2 or 3 substituents, which are selected from alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkenyl, cycloalkyloxy, cycloalkenyloxy, phenyl and halogen, aliphatic and cycloaliphatic radicals can be partially or completely halogenated and / or the cylcoaliphatic radicals can be substituted by 1 to 3 alkyl groups, and whose phenyl group can have from 1 to 5 halogen atoms and / or 1 to 3 substituents, which are selected independently from alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio and haloalkylthio, and whose amidic phenyl group can be fused with a saturated 5-membered ring, which is optionally substituted by one or more alkyl groups and / or a heteroatom selected from between O, and S, Y b) a morpholine derivative or piperidine II selected from the group of compounds Lia, Ilb, and Lie (H3C) 3C (lia) Lf (H3C) 3C (llb) [n = 10, 11, 12 (60-70%) or 13] in an active synergistic amount. Fungicidal mixture according to claim 1, wherein in the formula I the radical A means one of the following groups: phenyl, pyridyl, dihydropyranyl, dihydrooxathiinyl, dihydrooxathiinyl oxide, dihydrooxathiinyl dioxide, furyl, thiazolyl, pyrazolyl or oxazolyl, which groups may have 1, 2 or 3 substituents independently selected from alkyl, halogen, difluoromethyl and trifluoromethyl. Fungicidal mixture according to claim 1, wherein in the formula I the radical A means one of the following groups: pyridin-3-yl, which is optionally substituted at the 2-position by halogen, methyl, difluoromethyl, trifluoromethyl, methoxy, methylthio, methylsulfinyl or methylsulfonyl; phenyl, which is optionally substituted in the 2-position by methyl, trifluoromethyl, chloro, bromo or iodo;

2-methyl-5,6-dihydropyran-3-yl; 2-methyl-5,6-dihydro-l, 4-oxatiin-3-yl or the 4-oxide or 4,4-dioxide thereof; 2-methyl-furan-3-yl, which is optionally substituted in the 4-position and / or 5 by methyl; 2 and / or 4 by methyl, chloro, difluoromethyl or trifluoromethyl; thiazol-4-yl, which is optionally substituted in the 2-position and / or 5 by methyl, chloro, difluoromethyl or trifluoromethyl; l-methylpyrazol-4-yl, which is optionally substituted in the 3-position and / or 5 by methyl, chloro, difluoromethyl or trifluoromethyl; or oxazol-5-yl, which is optionally substituted in the 2-position and / or 4 by methyl or chloro. Fungicidal mixture according to one of the preceding claims, which contains a compound of the formula I, wherein R 2 represents a phenyl group, which is optionally substituted by 1, 2 or 3 of the substituents indicated in claim 1. Fungicidal mixture according to claim 4, wherein R2 means a phenyl group, which has in the 2-position one of the following substituents: C3-C6-alkyl, C5-C6-cycloalkenyl, C5-C6-cycloalkyloxy, cycloalkenyloxy, whose groups may be substituted by 1, 2 or 3 alkyl groups with 1 to 4 carbon atoms, phenyl, which may be substituted by 1 to 5 halogen atoms and / or 1 to 3 groups, independently selected from C? -C4-alkyl, C C4-haloalkyl, C? -C4-alkoxy, C? -C4-haloalkoxy, C? -C4-alkylthio and C? -C4-haloalkyl-thio, or where R2 means indanyl or oxaindanyl, which is optionally substituted by 1? , 2 or 3 alkyl groups with 1 to 4 carbon atoms. Fungicidal mixture according to one of claims 1 to 5, which contains an amide compound of the formula as follows: where A means (Al) (A2) (A3) (A7) (AS; X denotes methylene, sulfur, sulfinyl or sulfonyl (S02), R3 means methyl, difluoromethyl, trifluoromethyl, chloro, bromo or iodo, R4 means trifluoromethyl or chloro, R5 means hydrogen or methyl, R6 means methyl, difluoromethyl , trifluoromethyl or chloro, R7 signifies hydrogen, methyl or chloro, R8 signifies methyl, difluoromethyl or trifluoromethyl, R9 signifies hydrogen, methyl, difluoromethyl, trifluoromethyl or chloro, Ri ° signifies C? -C4-alkyl, C? -4 -alkoxy, C? -C4-alkylthio or halogen. contain as compounds of amide a compound of the following formula Ib: where R 4 is halogen and R 1 is phenyl, which is substituted by halogen. Fungicidal mixture according to claim 1, which contain as compound of amide a compound of the following formulas: Fungicidal mixture according to one of the preceding claims, which is conditioned in two parts, the first containing the amide compound I in a solid or liquid support and the second part one or more of the compounds of the formulas lia to lie on a solid support or liquid. Process for controlling harmful fungi, characterized in that the fungi, their living space or the materials, plants, seeds, soils, areas or enclosures to be kept free from infestation by the fungi are treated with a fungicide mixture according to one of the claims 1 to 9, being able or several of them to be included in the formulas until simultaneously, namely, jointly or separately, or successively. SUMMARY OF THE INVENTION Fungicidal mixtures containing as active components a) an amide compound of the formula I A-CO-NR! R2 (i) where A denotes an aryl group or an aromatic or non-aromatic heterocycle with 5 or 6 members, having 1 to 3 heteroatoms selected from O, N and S; the aryl group or the heterocycle may optionally have 1, 2 or 3 substituents, each of which may be independently selected from the group consisting of alkyl, halogen, CHF 2, CF 3, alkoxy, haloalkoxy, alkylthio, alkylsulfinyl and alkylsulfonyl; R1 means a hydrogen atom; R2 means a phenyl or cycloalkyl group, optionally having 1, 2 or 3 substituents, which are selected from alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, cycloalkyl, cycloalkenyl, cycloalkyloxy, cycloalkenyloxy, phenyl and halogen, whose aliphatic and cycloaliphatic radicals can be partially or completely halogenated and / or the cylcoaliphatic radicals can be substituted by 1 to 3 alkyl groups, and whose phenyl group can have from 1 to 5 halogen atoms and / or 1 to 3 substituents , which are independently selected from alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio and haloalkylthio, and whose amide phenyl group can be fused with a saturated 5-membered ring, which is optionally substituted by one or more alkyl groups and / or a heteroatom selected from O, and S, and b) a morpholine derivative or piperidine II selected from the group of the compounds lia, Ilb, lid and lie (H3C) 3C (lia) (H3C) 3C (llb) [n = 10,11,12 (60-70%) or 13] 15 in an active synergistic amount. twenty 25 30 35 40 Four. Five