MXPA00004481A - Improved film-forming compositions for protecting animal skin - Google Patents

Abstract

Improved film-forming skin protectant compositions are provided which are capable of forming a long-lasting elastic barrier film when applied to skin;the compositions have particular utility as barrier teat dips, for protecting cows against mastitis, especially during their susceptible non-lactating periods. The compositions include a film-forming component (preferably a mixture of polyether polyurethane and benzoin gum) dispersed in a compatible carrier and further having a minor amount of nitrocellulose incorporated therein in order to increase the time of adherence of the compositions to skin, as compared with an otherwise identical composition without nitrocellulose. The compositions may also include a germicide (e.g., chlorhexidine diacetate), and a coloring dye. The most preferred compositions include polyether polyurethane, benzoin gum, a solvent system made up of tetrahydrafuran and a lower alcohol, and chlorhexidine diacetate.

Description

IMPROVED FILM COMPOSITIONS FOR THE PROTECTION OF ANIMAL SKIN Field of Invention The present invention concerns skin protective compositions in the form of improved films capable of forming an elastic film when applied to the skin and include a film-like component dispersed in a carrier, and wherein the compositions of the invention are improved by the condition of an amount of nitrocellulose dispersed in the carrier; Nitrocellulose is used to create a larger resistant film capable of protecting the skin (for example, the skin of the tits of bovines) for relatively long periods of time. More particularly, the preferred forms of the invention concern compositions in film form which include in them effective amounts of polyurethane polyether and benzoin gum dispersed in tetrahydrofuran solvent (THF), with a minor amount of nitrocellulose therein.

Ref: 119227 Background of the invention.

A significant problem for farmers is the incidence of mastitis in livestock. It is known that up to 40-50% of inflammatory infections are contracted in dry cows or in periods when they do not produce milk, with large percentages of these infections occurring in the first and the last two weeks of the dry period. At this time, the mammary gland is the state of transition where the immunological factors are worrying or suppressed, the milk does not flow along the gland, and the breast pressure is increased by dilating the breast, thus allowing an easy penetration of the breast. bacteria through the milk channel.

It is known to apply protective compositions to the tits of bovines, especially during or notably in the period in which milk is not produced, in order to minimize the occurrence of mastitis. The first point in such mastitis treatment is to minimize exposure to the bacteria at the ends of the teats.

U.S. Patent No. 5,192,536 discloses protective compositions containing polyurethane polyether dissolved in tetrahydrofuran. The compositions of this patent can be applied to the animal skin to form a fast-drying elastic film, which has protective qualities. Patent No. 5,688,498 further describes compositions of this general nature, but which are improved by the condition of benzoin gum (benzoin resinoid). It has been found that benzoin gum significantly increases the adhesion time of the protective compositions and renders the appropriate compositions for soaking to improve the coverage of the compositions and to facilitate use.

The pending application for U: S Patent Letter. S / N 08 / 644,009, filed on February 14, 1997, refers to the -498 patent and discloses additional compositions made to use a variety of different solvents and additional ingredients such as germicides, dyes and optional ingredients, for example fillers, perfumes, viscosity modifiers.

In addition to mastitis control, skin protective compositions also find utility as wound dressings to be applied over open wounds to protect against infection from dirt, insects or other sources of bacteria.

In order to increase the protection of the protective compositions of the skin of the past types, it is desirable that these remain intact in the skin for as long as possible. This not only provides an added measure of protection against infection, but also reduces the time and expense involved in repeating applications of the compositions again.

This is consequently a need in the art for improving skin protective compositions that maintain the ease-of-use and protection capabilities of the polyurethane polyurethane / benzoin gum compositions while giving an integrity and longevity of increased strength.

Brief description of the invention.

The present invention overcomes the problems outlined above, and provides largely improved skin protective compositions capable of forming an elastic film when applied to the skin; such compositions broadly include a film forming component dispersed in a carrier wherein the improvement of the invention comprises the addition of an amount of nitrocellulose dispersed in the carrier in an amount sufficient to increase the adherence time of the compositions to the skin, as compared to the opposite with an identical composition that does not include nitrocellulose.

In preferred forms, the nitrocellulose is present at a level of about 0.2-15% by weight in the protective compositions forming a film of the invention, and more preferably about 1.5-5% by weight. Nitrocellulose is commercially available in various grades that vary in the degree of polymerization and nitration. Essentially all such commercially available nitrocellulose products are useful in the context of the present invention, however the amounts for use for respective degrees may vary.

The component forming a preferred film of the present invention is made in a mixture of polyurethane polyether and benzoin gum. The film forming component is generally preferably present at a level of about 5-50% by weight, and more preferably from about 7-25% by weight in the compositions of the invention. In more detail, the polyurethane polyether is typically used at a level of from about 5-25% by weight, more preferably from about 5-15% by weight; on the other hand, benzoin gum normally occurs at a level from about 2-20% by weight, and more preferably at a level from about 2-10% by weight. The carrier portion of the compositions is preferably a solvent for the film forming component. The most preferred solvent is a mixture of tetrahydrofuran and alcohol, with the last component being present at a level of from about 0.1-30% by weight, and more preferably at a level from about 5-25% by weight. In addition to the foregoing, a wide variety of other solvents can be used for the entire general composition is stable at room temperature and has a sufficiently rapid drying time (preferably up to about 20 minutes, and more preferably up to about 10 minutes after the application to the skin). Suitable solvents can therefore be selected from the group consisting of THF, cyclohexanone, toluene, acetone, alkylene glycols (for example propylene or ethylene glycol) and C? -C4 ether, ketones and alcohols (trimethyl ether, dimethyl ether, me t) ilet ilé ter, acetone, methyl ethyl ketone, diethyl itolone, methanol, ethanol, propanol, isopropanol or butanol).

The compositions of the invention may also have a germicidal agent dispersed in the carrier, which is normally used at a level of from about 0.01-2% by weight, and more preferably at a level from about 0.05-1% by weight. The germicidal agent can be selected from a wide variety of effective agents, such as those taken from the group consisting of straight or branched chain fatty acids (octanoic acid, nonanoic acid, decanoic acid), sodium pyridinium, polyhexamethylene, biguanide, chlorhexidine diacetate and quaternary ammonium compounds such as the alkyl dimethyl-ilbenzyl ammonium salts, dialkyl dimethyl ammonium compounds and benztonium. Combinations of such germicides can also be used, such as the germicides themselves, and in combination with the other ingredients, for compatible compositions that are physically and chemically at ambient temperatures.

The dyes can also be added to the skin protective compositions of the invention in order to improve the visualization of the barrier film in the area to be treated. Acceptable dyes include those that are soluble or dispersible in the liquid compositions of the invention. Preferred dyes provide easy viewing of the water film from a distance of at least 20 feet (6.096 meters) and can be used at relatively low concentrations. The dyes can also be used at a level from about 0.001-0.5% by weight in the compositions, and more preferably at a level from about 0.005-0.2% by weight. The dyes are normally selected from the group consisting of the red D & amp;; C 19, 43 yellow solvent, yellow fluoride naphthyl acid amide, yellow plastic TGH key, red FD &C 3, red FD &C 22, red FD &C 28, red FD &C 39, red FD &C 19, green FD &C 6, orange 5, orange 10, orange 17, red 17, red 21, red, 27, red 31, violet 2, yellow 7, and yellow 11.

In order to make the compositions of the invention more useful, they can have a desirable viscosity level to create optimal protective films. Generally, the viscosity may be at a level from about 50-2000 cPs. More preferably from about 100-1500 cPs. As previously indicated, the compositions can have a drying time at about 72 ° F (22.2 ° C) of room temperature of more than about 20 minutes and more preferably more than about 10 minutes.

The composition is used in a typical teat dipping product manner, that is, bovine tits are immersed in the liquid compositions in order to create the long-lasting protective films of the invention.

However, if desired, the compositions thereof can be applied by other means, such as by cleaning or atomizing to create elastic films that are vapor permeable, resistant to water, wind, dirt, and insects and that present a barrier to bacterium. The film protects the skin from damage or exposure during the healing process (in the case of wound treatment) or the entry of bacteria that causes mastitis when used as a teat dip.

Detailed description of the invention.

The following examples illustrate the preferred film protective compositions according to the invention, and demonstrate the long-lasting nature of the elastic films using such compositions. It will be understood, however, that the examples are provided by way of illustration only, and should not be taken as a limitation on the general scope of the invention.

EXAMPLES The following compositions (Table 1) were prepared and tested for adherence to cow tits. In each case, the compositions were prepared by dissolving the polyether polyurethane / benzoin gum forming component in THF and an ethanol solvent system which is subsequently added to the nitrocellulose and other ingredients. The mixing is carried out at ambient conditions.

Table 1 In the first adhesion experiment, in the dry mid-season the cows were initially immersed with a commercially available iodine-based teat immersion (Quarter Mate sold by West Agro, Inc.) to clean the tits of the cows. The tits were submerged dried clean and submerged with the test teat protective composition of Table 1. All four tits of each cow were submerged with a different product. Adherence was evaluated every 24 hours. Positive adhesions were determined if the sealed teat still covered the orifice of the teat. The results shown below confirm that the incorporation of nitrocellulose improves the adhesion of the sealant.

Table 2 In the second experiment using cows that were completely dry, the tits of 21 cows were treated as described above. The adhesion results shown below further confirm that the composition supplemented in nitrocellulose has much better adhesion characteristics.

Table 3 In a third experiment comprising compositions A, B and E, the tits of 12 cows that do not produce milk were immersed in an iodine-based dip, dried thoroughly and then soaked in the test compositions. The four test compositions were used in a complete randomized design in and around the cows. The persistent film or protection of the end of the tit was evaluated every 12 hours. Composition A was used on two tits of each cow.

Table 4 "Retention time - When the ends of the tits are the last ones that are visualized with the test composition. 2 Complete peeling by soaking due to the milk sample needed for another experiment.

Composition E supplemented with nitrocellulose gave the best results. This was taken at the maximum (or almost to the maximum) in the 9/12 cows' and had the highest percentage of protected tits in 48, 72 and 100 hours.

Compositions F and G were prepared as previously described and compared with composition A of Table 1.

Table 5 The following Table 6 places the results of the comparison between compositions F and G of Table 5 and composition A of Table 1. TABLE 6 The compositions were tested by dipping one teat of each cow with the respective test composition. The retention time was measured at 12 hour intervals until the composition did not very effectively cover the teat duct.

The compositions in Table 7 were prepared as described above. The samples contained different ratios of polyurethane polyether, benzoin and nitrocellulose. The total solids were adjusted to give a viscosity of 298 to 334 cps. The adherence of the formulations was tested on 31 dry cows from a herd developed at the University of Guelph. The H-K products were randomly applied to the four tits of a group of cows. Samples L-0 were tested in a second group of cows. The adhesion was determined for each product in each tit. The average retention is reported in Table 7. Due to the great variation between cow and cow in adherence, the number of times the product had the highest adherence is also reported. In the H-K group, product H gave the best adhesion. In group L-0, M, N and O were similar and were better than sample L.

Table 7 Table 8 shows seven formulations that were tested for adherence in 99 cows in five flocks in Canada. The formulations were prepared as described above and containing variations in the type of nitrocellulose, type of polyurethane, and benzoin resinoid supplier. The compositions were tested in four separate groupings of four compositions as shown in Table 9. The number of times that a composition had the highest adhesion in a given cow is indicated. The control composition without nitrocellulose had the lowest number of "gains" in each of the four treatment groups. Sample Q, made with tin 5707 polyurethane polyester, gave a lower adhesion than the same composition made with Tin 5714 (sample P). Table 8 shows the combined adhesion averages for the four group of experiments. Sample U provides 1.4 days of better adhesion than control samples without nitrocellulose.

Four of the samples in Table 8, A, S, T, and U were also tested on an udder designed part of the flock developed at Iowa State University. The results are shown in Table 10. The three samples with nitrocellulose had better adhesions than the control sample without nitrocellulose.

Table 8 Table 9 Table 10 The compositions were tested by dipping one teat of each cow with the respective test composition. The retention time was measured at 12 hour intervals until the composition did not very effectively cover the teat duct.

It can be seen in this manner, that the compositions of the invention provide a significant degree of protective film over a substantial period of unequal time in prior compositions of this character. It will be further apparent that a wide variety of specific ingredients can be used in the formulations of the invention and at various novel uses. The following Table 11 shows the approximate spectrum and preferred ranges for the essential and preferred ingredients used in the formulations, and also shows the important critical properties.

Table 11 'Brookfield Viscosity @ 24 ° C (60 rpm, axis # 3) It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is that which is clear from the present description of the invention.

Having described the invention as above, the content of the following is claimed as property.

Claims (29)

Claims

1. A skin protective composition that forms a film capable of forming an elastic film when applied to the skin including a film forming component dispersed in a carrier, the improvement characterized in that it comprises an amount of nitrocellulose dispersed in the carrier in a amount to increase the time of adherence of the composition to the skin, as compared to the opposite with an identical composition without nitrocellulose.

2. The composition according to claim 1, characterized in that the nitrocellulose is present at a level from about 0.2-15% by weight in the composition.

3. The composition according to claim 2, characterized in that the level is from about 1-10% by weight.

4. The composition according to claim 1, characterized in that the component comprises a mixture of polyurethane polyether and benzoin gum.

5. The composition according to claim 4, characterized in that the polyurethane polyether is present at a level of about 5-25% by weight in the composition.

6. The composition according to claim 5, characterized in that the level is from about 5-15% by weight.

7. The composition according to claim 4, characterized in that the benzoin gum is present at a level of about 2-20% by weight in the composition.

8. The composition according to claim 7, characterized in that the level is from about 2-10% by weight.

9. The composition according to claim 1, characterized in that the carrier is a solvent for the component that forms a film.

10. The composition according to claim 9, characterized in that the solvent is selected from the group consisting of THF, cyclohexane, toluene, C? -C4 ethers, ketones and alcohols, alkylene glycols and mixtures thereof.

11. The composition according to claim 1, characterized in that it includes a germicidal agent dispersed in the carrier.

12. The composition according to claim 11, characterized in that the germicidal agent is present at a level of about 0.01-2% by weight in the composition.

13. The composition according to claim 12, characterized in that the level is from about 0.05-1% by weight.

14. The composition according to claim 11, characterized in that the germicidal agent is selected from the group consisting of straight or branched chain fatty acids, polyhexamethylene biguanide, chlorhexidine diacetate, quaternary ammonium compounds and mixtures thereof.

15. The composition according to claim 14, characterized in that the germicidal agent comprises chlorhexidine diacetate.

16. The composition according to claim 1, characterized in that it includes a dye dispersed in the carrier.

17. The composition according to claim 16, characterized in that the dye is selected from the group consisting of the red, orange and yellow dyes and mixtures thereof.

18. The composition according to claim 16, characterized in that the dye is present at a level from about 0.001-0.5% by weight in the composition.

19. The composition according to claim 18, characterized in that the level is from about 0.005-0.2% by weight.

20. The composition according to claim 1, characterized in that the carrier comprises respectively quantities of THF and an alcohol of C? -C4.

21. The composition according to claim 2, characterized in that the alcohol is present at a level of about 0.1-30% by weight, with the THF making the balance of the composition.

22. The composition according to claim 21, characterized in that the level is from about 5-20% by weight.

23. The composition according to claim 21, characterized in that the alcohol is ethanol.

24. The composition according to claim 1, characterized in that the composition has a viscosity from about 50-2000 cPs.

25. The composition according to claim 24, characterized in that the viscosity is present from about 100-1500 cPs.

26. The composition according to claim 1, characterized in that it has a skin drying time of about 72 ° F (22.2 ° C) of room temperature of more than about 20 minutes.

27. The composition according to claim 26, characterized in that the time is up to 10 months.

28. A method to protect the tits of bovines, characterized in that it comprises the step of applying to the tits the composition of claim 1, and allowing the applied composition to dry on it and form a protective, elastic teat film.

29. The method according to claim 28, characterized in that the tits are the tits of cows that do not produce milk.