MX9805074A - Staphylococcus aureus coenzyme a disulfide reductase, and inhibitors thereof useful as antimicrobial agents. - Google Patents

Staphylococcus aureus coenzyme a disulfide reductase, and inhibitors thereof useful as antimicrobial agents.

Info

Publication number
MX9805074A
MX9805074A MX9805074A MX9805074A MX9805074A MX 9805074 A MX9805074 A MX 9805074A MX 9805074 A MX9805074 A MX 9805074A MX 9805074 A MX9805074 A MX 9805074A MX 9805074 A MX9805074 A MX 9805074A
Authority
MX
Mexico
Prior art keywords
coadr
staphylococcus aureus
inhibitors
useful
antimicrobial agents
Prior art date
Application number
MX9805074A
Other languages
Spanish (es)
Inventor
Stephen B Delcardayre
Julian E Davies
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ British Columbia filed Critical Univ British Columbia
Publication of MX9805074A publication Critical patent/MX9805074A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

An isolated and purified Staphylococcus aureus Coenzyme A disulfide reductase (CoADR) is provided. Oligonucleotides encoding the CoADR, vectors and host cells containing such oligonucleotides are also provided. In addition, antibodies reactive with the CoADR are provided, as are methods of isolating the CoADR, producing recombinant CoADR, using CoADR for screening compounds for CoADR-modulating activity, and detecting S. aureus in a test sample.
MX9805074A 1995-12-22 1998-06-22 Staphylococcus aureus coenzyme a disulfide reductase, and inhibitors thereof useful as antimicrobial agents. MX9805074A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US914695P 1995-12-22 1995-12-22

Publications (1)

Publication Number Publication Date
MX9805074A true MX9805074A (en) 1998-10-31

Family

ID=21735854

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9805074A MX9805074A (en) 1995-12-22 1998-06-22 Staphylococcus aureus coenzyme a disulfide reductase, and inhibitors thereof useful as antimicrobial agents.

Country Status (5)

Country Link
EP (1) EP0868518A1 (en)
JP (1) JP2000503530A (en)
CA (1) CA2241105A1 (en)
MX (1) MX9805074A (en)
WO (1) WO1997023628A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0916729A3 (en) * 1997-07-23 1999-08-04 Smithkline Beecham Corporation Novel reductase
US6767536B1 (en) 1998-03-02 2004-07-27 Ramot At Tel Aviv University Ltd. Recombinant Staphylococcus thioredoxin reductase and inhibitors thereof useful as antimicrobial agents
WO1999045123A1 (en) * 1998-03-02 1999-09-10 Abbott Laboratories Recombinant staphylococcus thioredoxin reductase, and inhibitors thereof useful as antimicrobial agents
JP4055248B2 (en) 1998-05-25 2008-03-05 味の素株式会社 Purified human activin and method for producing the same
JP2004033214A (en) * 2002-03-13 2004-02-05 Dr Chip Biotechnology Inc Method for detecting staphylococcus aureus
US7144992B2 (en) 2004-04-01 2006-12-05 Kane Biotech Inc. Synergistic antimicrobial compositions and methods for reducing biofilm formation
JP6980375B2 (en) * 2015-12-11 2021-12-15 東洋紡株式会社 Nucleic acid amplification reagent and nucleic acid amplification method

Also Published As

Publication number Publication date
EP0868518A1 (en) 1998-10-07
JP2000503530A (en) 2000-03-28
CA2241105A1 (en) 1997-07-03
WO1997023628A1 (en) 1997-07-03

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