MX9803839A - Quinoline derivatives as type iv phosphodiesterase inhibitors. - Google Patents
Quinoline derivatives as type iv phosphodiesterase inhibitors.Info
- Publication number
- MX9803839A MX9803839A MX9803839A MX9803839A MX9803839A MX 9803839 A MX9803839 A MX 9803839A MX 9803839 A MX9803839 A MX 9803839A MX 9803839 A MX9803839 A MX 9803839A MX 9803839 A MX9803839 A MX 9803839A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- benzo
- type
- phosphodiesterase inhibitors
- quinoline derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
8-(Benzo[c]thiadiazolyl, benzo[c]furazanyl, or 2-methyl-2H-benzo[d]triazolyl)-quinolines, in free or N-oxide or acid addition or ammonium salt form, are novel and found to be useful as pharmaceuticals, e.g., as PDEIV inhibitors, for example in the treatment of asthma. Novel methods of treatment using the compounds, processes for making the compounds, and pharmaceutical compositions comprising the compounds are also provided. For example, compounds of formula (1), wherein X is -O-, -S-, or -N(CH3)-, R1 is hydrogen or (C1-4)alkyl, and R2 is (C1-4)alkyl or pyridyl, in free or N-oxide or pharmaceutically acceptable acid addition or ammonium salt form.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9523267.4A GB9523267D0 (en) | 1995-11-14 | 1995-11-14 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9803839A true MX9803839A (en) | 1998-09-30 |
Family
ID=10783856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9803839A MX9803839A (en) | 1995-11-14 | 1998-05-14 | Quinoline derivatives as type iv phosphodiesterase inhibitors. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0873338A1 (en) |
| JP (1) | JPH11515000A (en) |
| KR (1) | KR19990067574A (en) |
| CN (1) | CN1202170A (en) |
| AU (1) | AU7570996A (en) |
| BR (1) | BR9611504A (en) |
| CA (1) | CA2235126A1 (en) |
| CO (1) | CO4770973A1 (en) |
| CZ (1) | CZ149498A3 (en) |
| GB (1) | GB9523267D0 (en) |
| HU (1) | HUP9903492A3 (en) |
| MX (1) | MX9803839A (en) |
| PE (1) | PE17598A1 (en) |
| PL (1) | PL326636A1 (en) |
| SK (1) | SK63998A3 (en) |
| TR (1) | TR199800851T2 (en) |
| WO (1) | WO1997018208A1 (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1212089E (en) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | ROFLUMILAST AND SALMETEROL SYNERGY COMBINATION |
| CA2447618A1 (en) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | A composition for regenerative treatment of cartilage disease |
| MXPA03010679A (en) | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Compositions for promoting healing of bone fracture. |
| CN1933839A (en) | 2004-01-23 | 2007-03-21 | 安进公司 | Compounds and methods of use |
| JP2006347936A (en) * | 2005-06-15 | 2006-12-28 | Bayer Cropscience Ag | Insecticidal benzanilides |
| CA2796826A1 (en) | 2010-05-10 | 2011-11-17 | Gilead Sciences, Inc. | Bifunctional quinoline derivatives |
| UY33373A (en) | 2010-05-10 | 2011-12-30 | Gilead Sciences Inc | ? Bifunctional pyrazolopyridine compounds, their use in therapy and compositions that comprise them ?. |
| SG11201502935VA (en) | 2012-10-16 | 2015-09-29 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of ror-gamma-t |
| BR112015008308A2 (en) | 2012-10-16 | 2017-12-05 | Janssen Pharmaceutica Nv | methylene-linked quinolinyl modulators of ror-gamma-t |
| KR20150070348A (en) | 2012-10-16 | 2015-06-24 | 얀센 파마슈티카 엔.브이. | Heteroaryl linked quinolinyl modulators of rorγt |
| JP6423423B2 (en) | 2013-10-15 | 2018-11-14 | ヤンセン ファーマシューティカ エヌ．ベー． | Rorγt alkyl-linked quinolinyl modulator |
| KR20160068956A (en) | 2013-10-15 | 2016-06-15 | 얀센 파마슈티카 엔.브이. | QUINOLINYL MODULATORS OF RORyT |
| US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
| US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
| US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
| US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
| US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
| US11427545B2 (en) * | 2018-06-24 | 2022-08-30 | Adama Agan Ltd. | Process for the preparation of Quinmerac |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
-
1995
- 1995-11-14 GB GBGB9523267.4A patent/GB9523267D0/en active Pending
-
1996
- 1996-11-12 PE PE1996000810A patent/PE17598A1/en not_active Application Discontinuation
- 1996-11-13 PL PL96326636A patent/PL326636A1/en unknown
- 1996-11-13 JP JP9515313A patent/JPH11515000A/en not_active Withdrawn
- 1996-11-13 WO PCT/EP1996/004978 patent/WO1997018208A1/en not_active Application Discontinuation
- 1996-11-13 CA CA002235126A patent/CA2235126A1/en not_active Abandoned
- 1996-11-13 EP EP96938196A patent/EP0873338A1/en not_active Withdrawn
- 1996-11-13 AU AU75709/96A patent/AU7570996A/en not_active Abandoned
- 1996-11-13 TR TR1998/00851T patent/TR199800851T2/en unknown
- 1996-11-13 KR KR1019980703597A patent/KR19990067574A/en not_active Application Discontinuation
- 1996-11-13 CN CN96198305A patent/CN1202170A/en active Pending
- 1996-11-13 CO CO96059775A patent/CO4770973A1/en unknown
- 1996-11-13 BR BR9611504A patent/BR9611504A/en not_active Application Discontinuation
- 1996-11-13 CZ CZ981494A patent/CZ149498A3/en unknown
- 1996-11-13 HU HU9903492A patent/HUP9903492A3/en unknown
- 1996-11-13 SK SK639-98A patent/SK63998A3/en unknown
-
1998
- 1998-05-14 MX MX9803839A patent/MX9803839A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9903492A3 (en) | 2000-08-28 |
| PE17598A1 (en) | 1998-04-06 |
| HUP9903492A2 (en) | 2000-07-28 |
| BR9611504A (en) | 1999-03-02 |
| JPH11515000A (en) | 1999-12-21 |
| EP0873338A1 (en) | 1998-10-28 |
| PL326636A1 (en) | 1998-10-12 |
| AU7570996A (en) | 1997-06-05 |
| WO1997018208A1 (en) | 1997-05-22 |
| GB9523267D0 (en) | 1996-01-17 |
| CZ149498A3 (en) | 1998-08-12 |
| SK63998A3 (en) | 1998-10-07 |
| CA2235126A1 (en) | 1997-05-22 |
| CO4770973A1 (en) | 1999-04-30 |
| CN1202170A (en) | 1998-12-16 |
| TR199800851T2 (en) | 1998-08-21 |
| KR19990067574A (en) | 1999-08-25 |
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