MX9801550A - Use of muteins of wild-type cytokines as immunogens. - Google Patents
Use of muteins of wild-type cytokines as immunogens.Info
- Publication number
- MX9801550A MX9801550A MX9801550A MX9801550A MX9801550A MX 9801550 A MX9801550 A MX 9801550A MX 9801550 A MX9801550 A MX 9801550A MX 9801550 A MX9801550 A MX 9801550A MX 9801550 A MX9801550 A MX 9801550A
- Authority
- MX
- Mexico
- Prior art keywords
- wild
- type cytokine
- muteins
- immunogens
- type
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Noise Elimination (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
These are pharmaceutical compounds used to treat or prevent diseases caused by the over-production of a specific wild-type cytokine, characterised by the fact that they contain as an active principle at least one mutant of that wild-type cytokine. In its widest scope the invention consists in the use of muteins of a specific wild-type cytokine, that are also receptor antagonists of the latter, as immunogens to elicit antibodies directed against this wild-type cytokine and capable of neutralising it in those diesases caused by its excessive production. Figure 4 shows that antibodies developed in NSE/hIL-6 transgenic mice immunised with a human interleukin 6 mutein are capable of recognising wild-type interleukin 6 and of neutralising its biological activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95RM000589A IT1277926B1 (en) | 1995-09-01 | 1995-09-01 | USE OF NATURAL CYTOKINE MUTEINS AS IMMUNOGENS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS TO TREAT OR PREVENT |
| PCT/IT1996/000164 WO1997009064A1 (en) | 1995-09-01 | 1996-08-22 | Use of muteins of wild-type cytokines as immunogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9801550A true MX9801550A (en) | 1998-05-31 |
Family
ID=11403544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9801550A MX9801550A (en) | 1995-09-01 | 1996-08-22 | Use of muteins of wild-type cytokines as immunogens. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6706261B1 (en) |
| EP (1) | EP0858345B1 (en) |
| JP (1) | JP3157837B2 (en) |
| KR (1) | KR100279539B1 (en) |
| CN (1) | CN1138562C (en) |
| AT (1) | ATE226446T1 (en) |
| AU (1) | AU703300B2 (en) |
| CA (1) | CA2229045C (en) |
| DE (1) | DE69624498T2 (en) |
| DK (1) | DK0858345T3 (en) |
| ES (1) | ES2183007T3 (en) |
| HK (1) | HK1015708A1 (en) |
| IT (1) | IT1277926B1 (en) |
| MX (1) | MX9801550A (en) |
| PT (1) | PT858345E (en) |
| RU (1) | RU2182014C2 (en) |
| WO (1) | WO1997009064A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR025984A1 (en) * | 1999-10-07 | 2002-12-26 | Maxygen Aps | SIMPLE CHAIN OLIGOMERIC POLYPEPTIDES |
| FR2812813B1 (en) * | 2000-08-09 | 2004-11-26 | Neovacs | USE OF IMMUNOGENS TO TREAT OR PREVENT WITHIN MALIGNANT TUMORS IMMUNE DISORDERS INDUCED BY EXTRACELLULAR FACTORS |
| IL161672A0 (en) * | 2004-04-29 | 2004-09-27 | Yeda Res & Dev | Compositions and methods for therapy of chemotherapy-induced neuropathy |
| FR2978964B1 (en) | 2011-08-09 | 2015-02-20 | Conservatoire Nat Arts | ANTI-IL-6 VACCINE COMPOSITION |
| WO2015024148A1 (en) * | 2013-08-23 | 2015-02-26 | 中国科学院微生物研究所 | Vaccine from cell factor mutant of heterogeneous animal |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677654B1 (en) | 1991-06-17 | 1995-11-17 | Pasteur Merieux Serums Vacc | COMPOUNDS WITH AN IMMUNOGENIC ANTI-CYTOKIN EFFECT, AN ANTIYTOSTATIC IMMUNOGENIC EFFECT OR AN ANTI-HIV INFECTION VACCINE EFFECT. |
| US5338833A (en) * | 1992-07-23 | 1994-08-16 | The University Of North Carolina At Chapel Hill | Carboxy terminal IL-6 muteins |
| IT1263022B (en) * | 1992-11-06 | 1996-07-23 | Angeletti P Ist Richerche Bio | INTERLEUCHINA-6 MUTANT WITH IMPROVED BIOLOGICAL ACTIVITY COMPARED TO WILD INTERLEUCHINA-6. |
| IT1261787B (en) * | 1993-06-23 | 1996-06-03 | Angeletti P Ist Richerche Bio | METHODOLOGY FOR THE SELECTION OF SUPERAGONISTS, ANTAGONISTS AND SUPER-ANTAGONISTS OF HORMONES OF WHICH RECEPTOR COMPLEX IS PART OF GP 130. |
| WO1997010338A1 (en) | 1995-09-12 | 1997-03-20 | Chiron Corporation | Improved interleukin-6 receptor antagonist |
-
1995
- 1995-09-01 IT IT95RM000589A patent/IT1277926B1/en active IP Right Grant
-
1996
- 1996-08-22 AT AT96930345T patent/ATE226446T1/en not_active IP Right Cessation
- 1996-08-22 EP EP96930345A patent/EP0858345B1/en not_active Expired - Lifetime
- 1996-08-22 AU AU69428/96A patent/AU703300B2/en not_active Ceased
- 1996-08-22 RU RU98105679/14A patent/RU2182014C2/en not_active IP Right Cessation
- 1996-08-22 MX MX9801550A patent/MX9801550A/en not_active IP Right Cessation
- 1996-08-22 DK DK96930345T patent/DK0858345T3/en active
- 1996-08-22 CA CA002229045A patent/CA2229045C/en not_active Expired - Fee Related
- 1996-08-22 JP JP51104897A patent/JP3157837B2/en not_active Expired - Fee Related
- 1996-08-22 PT PT96930345T patent/PT858345E/en unknown
- 1996-08-22 ES ES96930345T patent/ES2183007T3/en not_active Expired - Lifetime
- 1996-08-22 CN CNB961972955A patent/CN1138562C/en not_active Expired - Fee Related
- 1996-08-22 DE DE69624498T patent/DE69624498T2/en not_active Expired - Fee Related
- 1996-08-22 KR KR1019980701561A patent/KR100279539B1/en not_active IP Right Cessation
- 1996-08-22 WO PCT/IT1996/000164 patent/WO1997009064A1/en active IP Right Grant
-
1999
- 1999-03-09 HK HK99100962A patent/HK1015708A1/en not_active IP Right Cessation
-
2000
- 2000-04-27 US US09/559,950 patent/US6706261B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997009064A1 (en) | 1997-03-13 |
| AU703300B2 (en) | 1999-03-25 |
| DE69624498T2 (en) | 2003-06-18 |
| EP0858345B1 (en) | 2002-10-23 |
| CN1138562C (en) | 2004-02-18 |
| CA2229045A1 (en) | 1997-03-13 |
| JPH10511111A (en) | 1998-10-27 |
| KR100279539B1 (en) | 2001-02-01 |
| EP0858345A1 (en) | 1998-08-19 |
| PT858345E (en) | 2003-02-28 |
| ITRM950589A0 (en) | 1995-09-01 |
| CA2229045C (en) | 2005-10-25 |
| DK0858345T3 (en) | 2003-02-24 |
| RU2182014C2 (en) | 2002-05-10 |
| DE69624498D1 (en) | 2002-11-28 |
| IT1277926B1 (en) | 1997-11-12 |
| ITRM950589A1 (en) | 1997-03-01 |
| KR19990044321A (en) | 1999-06-25 |
| ES2183007T3 (en) | 2003-03-16 |
| ATE226446T1 (en) | 2002-11-15 |
| US6706261B1 (en) | 2004-03-16 |
| AU6942896A (en) | 1997-03-27 |
| CN1198098A (en) | 1998-11-04 |
| HK1015708A1 (en) | 1999-10-22 |
| JP3157837B2 (en) | 2001-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |