MX9800281A - Novel heterocyclic compounds for the treatment of pain and use thereof. - Google Patents

Novel heterocyclic compounds for the treatment of pain and use thereof.

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Publication number
MX9800281A
MX9800281A MX9800281A MX9800281A MX9800281A MX 9800281 A MX9800281 A MX 9800281A MX 9800281 A MX9800281 A MX 9800281A MX 9800281 A MX9800281 A MX 9800281A MX 9800281 A MX9800281 A MX 9800281A
Authority
MX
Mexico
Prior art keywords
alkyl
pain
treatment
independently
heterocyclic compounds
Prior art date
Application number
MX9800281A
Other languages
Spanish (es)
Other versions
MXPA98000281A (en
Inventor
John Dimaio
Dilip M Dixit
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA1996/000467 external-priority patent/WO1997003978A1/en
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of MX9800281A publication Critical patent/MX9800281A/en
Publication of MXPA98000281A publication Critical patent/MXPA98000281A/en

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Abstract

Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl, or halogen; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. For the treatment of pain and pharmaceutically acceptable compositions comprising those compounds. The compounds of this invention act as agonists at the opiate receptor.
MXPA/A/1998/000281A 1995-07-14 1998-01-09 New heterociclic compounds for the treatment of pains and use of mis MXPA98000281A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB95144176 1995-07-14
GB95144176 1995-07-14
PCT/CA1996/000467 WO1997003978A1 (en) 1995-07-14 1996-07-12 Novel heterocyclic compounds for the treatment of pain and use thereof

Publications (2)

Publication Number Publication Date
MX9800281A true MX9800281A (en) 1998-07-31
MXPA98000281A MXPA98000281A (en) 1998-11-09

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