MX9709860A - Methods and uses for apoptin. - Google Patents

Methods and uses for apoptin.

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Publication number
MX9709860A
MX9709860A MX9709860A MX9709860A MX9709860A MX 9709860 A MX9709860 A MX 9709860A MX 9709860 A MX9709860 A MX 9709860A MX 9709860 A MX9709860 A MX 9709860A MX 9709860 A MX9709860 A MX 9709860A
Authority
MX
Mexico
Prior art keywords
apoptin
apoptosis
normal cells
tumor
cells
Prior art date
Application number
MX9709860A
Other languages
Spanish (es)
Other versions
MXPA97009860A (en
Inventor
Matheus Hubertus Mari Noteborn
Original Assignee
Aesculaap Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aesculaap Bv filed Critical Aesculaap Bv
Publication of MX9709860A publication Critical patent/MX9709860A/en
Publication of MXPA97009860A publication Critical patent/MXPA97009860A/en

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention describes that apoptin fails to induce apoptosis in human normal cells. Besides, the invention describes that when normal cells are transformed, they become susceptible to the apoptin-induced apoptosis. The invention describes that apoptin induces in various human tumor cells a p53-distinct type of apoptosis, and cannot be blocked by a variety of apoptosis-inhibiting agents. The invention comprises an anti-tumor agent, which specifically kill tumor and not normal cells. It further provides the induction of cell death by means of gene therapy. Apoptin can induce apoptosis in non-human animal tumor cells. The invention also provides that in normal cells apoptin was found predominantly in the cytoplasm, while in tumor cells it was located in the nucleus. Besides, the invention comprises a diagnostic test for the determination of cell-transforming activity.
MXPA/A/1997/009860A 1995-06-07 1997-12-08 Methods and uses for apopt MXPA97009860A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60022995A 1995-06-07 1995-06-07
US484,939 1995-06-07

Publications (2)

Publication Number Publication Date
MX9709860A true MX9709860A (en) 1998-03-31
MXPA97009860A MXPA97009860A (en) 1998-10-15

Family

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Legal Events

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FG Grant or registration
MM Annulment or lapse due to non-payment of fees