MX9708278A - Antithrombotic amidinotetrahydropyridylalanine derivatives. - Google Patents
Antithrombotic amidinotetrahydropyridylalanine derivatives.Info
- Publication number
- MX9708278A MX9708278A MX9708278A MX9708278A MX9708278A MX 9708278 A MX9708278 A MX 9708278A MX 9708278 A MX9708278 A MX 9708278A MX 9708278 A MX9708278 A MX 9708278A MX 9708278 A MX9708278 A MX 9708278A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- conr5r6
- alkoxy
- aryl
- nr5r6
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates of either entity, wherein Y is optionally monounsaturated C3-C5 alkylene optionally substituted with C1-C4 alkyl or methylene; R1 is H; C1-C4 alkyl optionally substituded with C1-C4 alkoxy, OH, NR5R6, CONR5R6, C3-C6 cycloalkyl or aryl; or C3-C6 alkenyl; R2 is H; C1-C4 alkyl optionally substituted with C1-C4 alkoxy, OH, NR5R6, CONR5R6, C3-C6 cycloalkyl or aryl; or CONR5R6; R3 and R4 are each independently selected from H; C1-C4 alkyl optionally substituded with NR5R6; C1-C4 alkoxy; halo; CONR5R6 and aryl; aryl is phenyl optionally substituted with one, two or three substituents independently selected from C1-C4 alkyl, C1-C4 alkoxy, OH, halo and CF3; R5 and R6 are each independently selected from H and C1-C4 alkyl; and m and n are each independently 1, 2 or 3; are potent and selective thrombin inhibitors useful in the treatment of, inter alia, deep vein thrombosis; reocclusion following thrombolytic therapy; chronic arterial obstruction; peripheral vascular disease; acute myocardial infarction; unstable angina; atrial fibrillation; thrombotic stroke; transient ischaemic attacks; restenosis and occlusion following angioplasty; or neurodegenerative disorders.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP1996/001459 WO1996033993A1 (en) | 1995-04-28 | 1996-04-01 | Antithrombotic amidinotetrahydropyridylalanine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9708278A true MX9708278A (en) | 1998-01-31 |
Family
ID=39165727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9708278A MX9708278A (en) | 1996-04-01 | 1996-04-01 | Antithrombotic amidinotetrahydropyridylalanine derivatives. |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX9708278A (en) |
-
1996
- 1996-04-01 MX MX9708278A patent/MX9708278A/en not_active Application Discontinuation
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