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Application filed by Us Gov Representado Por El, Secretario Del EjercitofiledCriticalUs Gov Representado Por El
Publication of MX9707310ApublicationCriticalpatent/MX9707310A/en
Publication of MXPA97007310ApublicationCriticalpatent/MXPA97007310A/en
A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
A61K9/00—Medicinal preparations characterised by special physical form
A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
Abstract
Novel burst-free, sustained release biocompatible and biodegradable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer as a blend of uncapped (free carboxyl end group) and end-capped forms ranging in ratios from 100/0 to 1/99.
MXPA/A/1997/007310A1996-01-241997-09-24Novidae microspheres of poly- (lactida / glicolide) of release sustained without estallamie
MXPA97007310A
(en)