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Priority claimed from GBGB9504910.2Aexternal-prioritypatent/GB9504910D0/en
Application filed by Nycomed Imaging AsfiledCriticalNycomed Imaging As
Publication of MX9706900ApublicationCriticalpatent/MX9706900A/en
Publication of MXPA97006900ApublicationCriticalpatent/MXPA97006900A/en
C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
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Chemical & Material Sciences
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Organic Chemistry
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Organic Low-Molecular-Weight Compounds And Preparation Thereof
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Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms
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Thiazole And Isothizaole Compounds
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Abstract
The present invention relates to tribenzylcyclen compounds of formula (I) (where R is hydrogen, or a C1-12 alkyl group optionally substituted by hydroxy, alkoxy or aryl groups or R is an amphiphilic aralkyl group comprising a N, S, O or P interrupted C2-25alkylene chain, e.g. a polyalkylene oxide chain or R provides a bridge to a second tribenzylcyclen group, but with the proviso that R is other than benzyl; X is CHR1, or where R is hydrogen two X groups may each represent CO groups; and R1 is hydrogen, a C1-6alkyl group optionally substituted by hydroxy, alkoxy or carboxy groups or an aralkyl group having 1 to 6 carbons in the alkyl moiety and optionally substituted in the aryl moiety by alkyl, alkoxy, hydroxy or isothiocyanate groups). These compounds are useful in the preparation of DO3A, N-substituted-1,4,7,10-tetraazacyclododecane-N',N",N'''-tria cetic acids, and the phosphonic acid analogs.
MXPA/A/1997/006900A1995-03-101997-09-10Compounds of poliazacicloalc
MXPA97006900A
(en)
DERIVATIVES OF CYCLOPENTAN- OR CYCLOPENTEN- <font face = "Symbol"> b </font> -AMINO ACIDS AND THEIR SALTS, COMPOSITION, ACTIVE FOR S. AUREUS, CANDIDA TRANDS I.
DERIVATIVES 2-AMINO-N - [[[4- (AMINOCARBONIL) PYRIMIDIN-2-IL] AMINO] ALKYL] PYRIMIDIN-4-CARBOXAMIDE, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION
PROCEDURE FOR THE TREATMENT OF SUBSTRATES WITH AROMATIC COMPOUNDS CONTAINING SOLFO GROUPS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THEIR PREPARATION