MX9706854A - Fibroblast growth factor-14 - Google Patents

Fibroblast growth factor-14

Info

Publication number
MX9706854A
MX9706854A MX9706854A MX9706854A MX9706854A MX 9706854 A MX9706854 A MX 9706854A MX 9706854 A MX9706854 A MX 9706854A MX 9706854 A MX9706854 A MX 9706854A MX 9706854 A MX9706854 A MX 9706854A
Authority
MX
Mexico
Prior art keywords
polypeptide
disclosed
prevent
polypeptides
growth factor
Prior art date
Application number
MX9706854A
Other languages
Spanish (es)
Other versions
MXPA97006854A (en
Inventor
John M Greene
Patrick J Dillon
Original Assignee
Human Genome Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1995/006730 external-priority patent/WO1996039506A1/en
Application filed by Human Genome Sciences Inc filed Critical Human Genome Sciences Inc
Publication of MX9706854A publication Critical patent/MX9706854A/en
Publication of MXPA97006854A publication Critical patent/MXPA97006854A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factors [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity

Abstract

Disclosed is a human Fibroblast growth factor-14 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing, for example as a result of burns and ulcers, to prevent neuronal damage due to/associated with stroke and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.
MXPA/A/1997/006854A 1997-09-09 Factor 14 of fibroblas growth MXPA97006854A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1995/006730 WO1996039506A1 (en) 1995-06-05 1995-06-05 Fibroblast growth factor-14

Publications (2)

Publication Number Publication Date
MX9706854A true MX9706854A (en) 1997-11-29
MXPA97006854A MXPA97006854A (en) 1998-07-03

Family

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Also Published As

Publication number Publication date
KR19980703677A (en) 1998-12-05
JP2001507561A (en) 2001-06-12

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