MX9705572A - Complejos estables para el suministro de farmacos que contienen lipidos y metodos para su produccion. - Google Patents

Complejos estables para el suministro de farmacos que contienen lipidos y metodos para su produccion.

Info

Publication number
MX9705572A
MX9705572A MX9705572A MX9705572A MX9705572A MX 9705572 A MX9705572 A MX 9705572A MX 9705572 A MX9705572 A MX 9705572A MX 9705572 A MX9705572 A MX 9705572A MX 9705572 A MX9705572 A MX 9705572A
Authority
MX
Mexico
Prior art keywords
drug delivery
production
complexes
methods
lipid
Prior art date
Application number
MX9705572A
Other languages
English (en)
Other versions
MXPA97005572A (es
Inventor
Xiang Gao
Leaf Huang
Original Assignee
Univ Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh filed Critical Univ Pittsburgh
Publication of MX9705572A publication Critical patent/MX9705572A/es
Publication of MXPA97005572A publication Critical patent/MXPA97005572A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Abstract

Se describen novedosos complejos estables para la entrega de drogas, concentrados, biologicamente activos, listos para ser utilizados y que contienen lípidos, métodos para su utilizacion. La actividad biologica de los complejos producidos, es comparable a la de las formulaciones preparadas de acuerdo con el método del arte anterior basado en el mezclado conjunto; y, al ser purificados, los complejos producidos mediante el método de la presente invencion, tienen una concentracion de 50 a 500 veces la de los componentes de los complejos formados mediante el mezclado conjunto. El método descrito en la presente, permite la produccion en gran escala de sistemas entregadores de drogas y que contienen lípidos, utiles para la terapia basada en los genes, y para otras aplicaciones.
MXPA/A/1997/005572A 1995-01-23 1997-07-23 Complejos estables para el suministro de farmacosque contienen lipidos y metodos para su produccion MXPA97005572A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08376701 1995-01-23
US08/376,701 US5795587A (en) 1995-01-23 1995-01-23 Stable lipid-comprising drug delivery complexes and methods for their production

Publications (2)

Publication Number Publication Date
MX9705572A true MX9705572A (es) 1998-06-28
MXPA97005572A MXPA97005572A (es) 1998-10-30

Family

ID=

Also Published As

Publication number Publication date
AU4703796A (en) 1996-08-14
DK0814777T3 (da) 2003-03-03
DE69624801D1 (de) 2002-12-19
US20100184953A1 (en) 2010-07-22
IL116856A0 (en) 1996-07-23
AU709773B2 (en) 1999-09-09
ATE227563T1 (de) 2002-11-15
ZA96503B (en) 1996-08-07
PT814777E (pt) 2003-03-31
JP4074338B2 (ja) 2008-04-09
CA2211118A1 (en) 1996-08-01
US20130281382A1 (en) 2013-10-24
US8771728B2 (en) 2014-07-08
US20080153166A1 (en) 2008-06-26
WO1996022765A1 (en) 1996-08-01
EP0814777B1 (en) 2002-11-13
CA2211118C (en) 2009-06-30
US20120178702A1 (en) 2012-07-12
DE69624801T2 (de) 2003-04-10
US5795587A (en) 1998-08-18
EP0814777A1 (en) 1998-01-07
US7655468B2 (en) 2010-02-02
ES2186769T3 (es) 2003-05-16
JPH10512882A (ja) 1998-12-08
US7993672B2 (en) 2011-08-09
CN1177291A (zh) 1998-03-25

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