MX9704937A - Mercaptoketones and mercaptoalcohols and a process for their preparation. - Google Patents
Mercaptoketones and mercaptoalcohols and a process for their preparation.Info
- Publication number
- MX9704937A MX9704937A MX9704937A MX9704937A MX9704937A MX 9704937 A MX9704937 A MX 9704937A MX 9704937 A MX9704937 A MX 9704937A MX 9704937 A MX9704937 A MX 9704937A MX 9704937 A MX9704937 A MX 9704937A
- Authority
- MX
- Mexico
- Prior art keywords
- mmp
- alkoxy
- aryl
- hydroxy
- halogen
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
This invention relates to matrix metalloproteinase (MMP) inhibiting compounds of the formula: (see formula) where R1 is C1-C12 alkyl, straight or branched and optionally substituted by halogen, hydroxy, C1-C6 alkoxy, amino, carboxyl, C1-C5 alkoxycarbonyl, carboxamide, nitrile, mono- or di-(C1-C6)alkylamino, thio, C1-C6 alkylthio, aryl, -Oaryl or -OCH2aryl where aryl is optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, carboxy, halogen, cyano, nitro, carboxamido, or hydroxy; and C1-C6 alkanesulfonyloxy. R2 is (-OH or (-OH and R6 is H or R2 and R6 together are carbonyl; the chemical intermediates; and processes for the preparation of these compounds and the intermediates thereto. Matrix metalloproteinases (MMP) are a family of zinc-containing calcium dependent proteinases, including stromelysins, collagenases, and gelatinases. These MMP enzymes are capable of degrading the proteinaceous components of connective tissue and appear to be involved in tissue remodeling, i.e., wound healing and connective tissue turnover. Unexpectedly, the mercaptoalcohols with the S-configuration at the hidroxyl-bearing carbon have been found to be at least 4 times more potent than the analogous (R)-alcohols both in vitro and in vivo in inhibiting the MMP enzyme.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX9704937A MX9704937A (en) | 1997-06-30 | 1997-06-30 | Mercaptoketones and mercaptoalcohols and a process for their preparation. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US677994 | 1996-07-10 | ||
MX9704937A MX9704937A (en) | 1997-06-30 | 1997-06-30 | Mercaptoketones and mercaptoalcohols and a process for their preparation. |
Publications (2)
Publication Number | Publication Date |
---|---|
MXPA97004937A MXPA97004937A (en) | 1998-01-01 |
MX9704937A true MX9704937A (en) | 1998-01-31 |
Family
ID=39165578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9704937A MX9704937A (en) | 1997-06-30 | 1997-06-30 | Mercaptoketones and mercaptoalcohols and a process for their preparation. |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX9704937A (en) |
-
1997
- 1997-06-30 MX MX9704937A patent/MX9704937A/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2003024448A3 (en) | Inhibitors of histone deacetylase | |
WO2001081312A3 (en) | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore | |
MXPA04006048A (en) | Amide derivatives as gk activators. | |
FI20050461A (en) | Antipsychotic use | |
ES2167733T3 (en) | BIFENYLSULFONAMIDE MATRIX METALOPROTEINASE INHIBITORS. | |
BR0313969A (en) | Oxytocin Inhibitors | |
DE60219614D1 (en) | 3, 7 THIAPROSTANSÄUREDERIVATE AS A MEANS FOR THE REDUCTION OF THE AUGENINNENDRUCKES | |
AU2002356991A1 (en) | Amino acid derivatives useful for the treatment of alzheimer's disease | |
AU2001273997A1 (en) | N-(2-pyrimidinyl)(thio)phosphoric triamides, method for producing the same, and the use thereof as agents for regulating or inhibiting enzymatic urea hydrolysis | |
IL138688A0 (en) | Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme | |
MX9704937A (en) | Mercaptoketones and mercaptoalcohols and a process for their preparation. | |
PL317349A1 (en) | Organic compounds | |
IL121125A0 (en) | Mercaptoketones and mercaptoalcohols and their preparation | |
AU3729397A (en) | Butyric acid matrix metalloproteinase inhibitors | |
WO2004048368A3 (en) | Heteroarylsulfonylmethyl hydroxamic acids and amides and their use as protease inhibitors | |
MXPA04004743A (en) | Neurotensin active 2,3-diaryl-pyrazolidine derivatives. | |
AU2003216965A1 (en) | Compounds, particularly of urea derivatives or ester derivatives of haloacetamidobenzoic acid and use thereof for the treatment of parasitic diseases |