MX9704780A - Secreted human fas antigen. - Google Patents

Secreted human fas antigen.

Info

Publication number
MX9704780A
MX9704780A MX9704780A MX9704780A MX9704780A MX 9704780 A MX9704780 A MX 9704780A MX 9704780 A MX9704780 A MX 9704780A MX 9704780 A MX9704780 A MX 9704780A MX 9704780 A MX9704780 A MX 9704780A
Authority
MX
Mexico
Prior art keywords
fas antigen
human fas
secreted human
disclosed
nucleic acids
Prior art date
Application number
MX9704780A
Other languages
Spanish (es)
Inventor
John D Mountz
Changdan Liu
Tong Zhou
Jianhua Cheng
Original Assignee
Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation filed Critical Uab Research Foundation
Publication of MX9704780A publication Critical patent/MX9704780A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Disclosed is a natural, soluble form of the Fas antigen polypeptide that is secreted by human cells and is the result of alternative mRNA processing in the cell. This variant of Fas is shown to be present at higher levels in patients with SLE and AILD. Also disclosed are nucleic acids encoding this unique form of the Fas antigen and methods for making and using the protein and nucleic acids, including various diagnostic embodiments such as ELISAs.
MX9704780A 1994-12-23 1995-12-22 Secreted human fas antigen. MX9704780A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37126394A 1994-12-23 1994-12-23
PCT/US1995/017083 WO1996020206A1 (en) 1994-12-23 1995-12-22 Secreted human fas antigen

Publications (1)

Publication Number Publication Date
MX9704780A true MX9704780A (en) 1998-05-31

Family

ID=23463222

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704780A MX9704780A (en) 1994-12-23 1995-12-22 Secreted human fas antigen.

Country Status (4)

Country Link
AU (1) AU705281B2 (en)
CA (1) CA2211038A1 (en)
MX (1) MX9704780A (en)
WO (1) WO1996020206A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2273852C (en) 1996-12-06 2009-09-29 Amgen Inc. Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases
US6972323B1 (en) * 1997-04-01 2005-12-06 Sankyo Company, Limited Anti-Fas antibodies
US6204055B1 (en) * 1999-04-12 2001-03-20 Isis Pharmaceuticals, Inc. Antisense inhibition of Fas mediated signaling
AU4552700A (en) * 1999-04-19 2000-11-02 Ballermann, Barbara Jutta Gene therapy
WO2001058953A2 (en) * 2000-02-11 2001-08-16 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Identification of a domain in the tumor necrosis factor receptor family that mediates pre-ligand receptor assembly and function
TWI322154B (en) 2000-03-16 2010-03-21 Amgen Inc Il-17 receptor like molecules and uses thereof
WO2008115569A1 (en) * 2007-03-21 2008-09-25 Cytologic, Inc. Method for inhibiting immune responses in mammals using muteins of fas ligand

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0510691B1 (en) * 1991-04-26 2004-11-03 Osaka Bioscience Institute DNA coding for human cell surface antigen

Also Published As

Publication number Publication date
WO1996020206A1 (en) 1996-07-04
CA2211038A1 (en) 1996-07-04
AU4691796A (en) 1996-07-19
AU705281B2 (en) 1999-05-20

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal