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Application filed by Liposome Co Inc, Braun Medical IncfiledCriticalLiposome Co Inc
Priority claimed from PCT/US1995/006480external-prioritypatent/WO1995031955A2/en
Publication of MX9605728ApublicationCriticalpatent/MX9605728A/en
Acyclic And Carbocyclic Compounds In Medicinal Compositions
(AREA)
Abstract
A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has an enclosed, sterilizable, grippable housing and can be used to mix combine fluids in reproducible and predetermined proportions. Combination is accomplished aseptically, avoiding contact between the device's operator and the fluids and the substances combined. Biologically active compounds can be combined with one or more fluids, including such aqueous liposome suspensions, using the device. A formulation preparation kit containing, in addition to the device, the fluids and compounds to be formulated is thus also provided herein; methods of using the device to prepare such formulations are further provided herein.
FORMULATION CONTAINING AT LEAST ONE LATE PROTEIN (PROTEIN L) OF ONE OR MORE PAPILOMAVIRUS AND / OR AT LEAST ONE EARLY PROTEIN (PROTEIN E) ONE OR MORE PAPILOMAVIRUS, PROCEDURE FOR THE PREPARATION OF THE FORMULATION MENTIONED AS WELL AS ITS USE MANUFACTURE OF A MEDICINAL PRODUCT