MX9605615A - Vaccine for moraxella catarrhalis. - Google Patents
Vaccine for moraxella catarrhalis.Info
- Publication number
- MX9605615A MX9605615A MX9605615A MX9605615A MX9605615A MX 9605615 A MX9605615 A MX 9605615A MX 9605615 A MX9605615 A MX 9605615A MX 9605615 A MX9605615 A MX 9605615A MX 9605615 A MX9605615 A MX 9605615A
- Authority
- MX
- Mexico
- Prior art keywords
- protein
- vaccine
- oligopeptides
- peptides
- constructing
- Prior art date
Links
- 241000588655 Moraxella catarrhalis Species 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 108010038807 Oligopeptides Proteins 0.000 abstract 5
- 102000015636 Oligopeptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 239000013598 vector Substances 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 101710116435 Outer membrane protein Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 229960001212 bacterial vaccine Drugs 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 229960004854 viral vaccine Drugs 0.000 abstract 1
- 239000013603 viral vector Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
- C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Compositions comprising outer membrane protein "E", and peptides and oligopeptides thereof, of Moraxella catarrhalis are described. Additionally, nucleotide sequences encoding the protein, peptide, or oligopeptide are disclosed, as well as recombinant vectors containing these sequences. Protein, peptide, or oligopeptide can be produced from host cell systems containing these recombinant vectors. Peptides and oligopeptides can also be chemically synthesized. Disclosed are the uses of the protein, peptides and oligopeptides as antigens for vaccine formulations, and as antigens in diagnostic immunoassays. The nucleotide sequences are useful for constructing vectors for use as vaccines, for insertions into attenuated bacteria in constructing a recombinant bacterial vaccine and for inserting into a viral vector in constructing a recombinant viral vaccine. Also described is the use of nucleotide sequences related to the gene encoding E as primers and/or probes in molecular diagnostic assays for the detection of M. catarrhalis.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/245,758 US5607846A (en) | 1994-05-17 | 1994-05-17 | Vaccine for moraxella catarrhalis |
| US08245758 | 1994-05-17 | ||
| PCT/US1995/005134 WO1995031215A1 (en) | 1994-05-17 | 1995-04-20 | VACCINE FOR $i(MORAXELLA CATARRHALIS) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9605615A true MX9605615A (en) | 1998-05-31 |
| MXPA96005615A MXPA96005615A (en) | 1998-10-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| JP4260879B2 (en) | 2009-04-30 |
| JPH10504444A (en) | 1998-05-06 |
| KR970703163A (en) | 1997-07-03 |
| DE69531241D1 (en) | 2003-08-14 |
| CA2189971C (en) | 2003-07-29 |
| ES2202361T3 (en) | 2004-04-01 |
| US5607846A (en) | 1997-03-04 |
| NZ284744A (en) | 1999-01-28 |
| KR100396408B1 (en) | 2003-11-20 |
| DE69531241T2 (en) | 2004-06-03 |
| WO1995031215A1 (en) | 1995-11-23 |
| EP0759777B1 (en) | 2003-07-09 |
| EP0759777A4 (en) | 1998-12-02 |
| CA2189971A1 (en) | 1995-11-23 |
| EP0759777A1 (en) | 1997-03-05 |
| US5948412A (en) | 1999-09-07 |
| AU2396995A (en) | 1995-12-05 |
| ATE244577T1 (en) | 2003-07-15 |
| AU709984B2 (en) | 1999-09-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ284744A (en) | Vaccine for moraxella catarrhalis | |
| EP0737085A4 (en) | VACCINE FOR -i(BRANHAMELLA CATARRHALIS) | |
| CA2230885A1 (en) | Compounds and methods for immunotherapy and diagnosis of tuberculosis | |
| MX9708438A (en) | High molecular weight major outer membrane protein of moraxella. | |
| IL133056A (en) | Polypeptide containing an immunogenic portion of an m. tuberculosis antigen, a variant thereof and pharmaceutical compositions containing same | |
| NZ334358A (en) | isolated polypeptide comprising an immunogenic portion of a M vaccine antigen, use in the treatment and diagnosis of mycobacterial infections | |
| WO1998004702A3 (en) | Proteins, in particular membrane proteins, of helicobacter pylori, their preparation and use | |
| CA2103021A1 (en) | Recombinant DNA Coding for Signal Peptide, Selective Interacting Polypeptide and Membrane Anchoring Sequence | |
| CA2272845A1 (en) | Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes | |
| EP2298793A3 (en) | Polypeptide fragments of hepatitis E virus, vaccine composition comprising said fragments and diagnostic kits | |
| SE9402089D0 (en) | Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules, diagnostic and therapeutic uses of said allergens and fragments | |
| CA2093427A1 (en) | Molecular clones of hiv-1 and uses thereof | |
| CA2135278A1 (en) | Peptide for stimulation of cytotoxic t lymphocytes specific for hepatitis c virus | |
| NZ500540A (en) | Purified proteins, fusion proteins, recombinant vector, vaccine, kit, comprising proteins from Actinobacillus pleuropneumoniae | |
| EP0294469A4 (en) | Vaccines and diagnostic assays for haemophilus influenzae. | |
| Baron et al. | Antibodies against a synthetic peptide of the poliovirus replicase protein: reaction with native, virus-encoded proteins and inhibition of virus-specific polymerase activities in vitro | |
| NZ334568A (en) | Nucleic acid and amino acid sequences relating to helicobacter pylori and vaccine compositions thereof | |
| NZ526879A (en) | Genes and proteins, and their use | |
| AU5776799A (en) | Modified hcv peptide vaccines | |
| BG105065A (en) | A vaccine-induced hepatitis b viral strain and uses thereof | |
| AU3379693A (en) | Vaccines and diagnostic assays for haemophilus influenzae | |
| ATE277182T1 (en) | THE NUCA PROTEIN OF HAEMOPHILUS INFLUENZAE AND ITS CODING GENE | |
| Murphy et al. | Vaccine for Moraxella catarrhalis | |
| Murphy Timothy et al. | VACCINE FOR MORAXELLA CATARRHALIS | |
| Murphy | Method for detecting Branhamella catarrhalis |