MX9605428A - SYNTHESIS OF 17'beta'-CYANO-3-ETHOXY-17'alpha'-HYDROXY-6-METHYLANDROSTA-3 ,5,9(11)-TRIENE. - Google Patents

SYNTHESIS OF 17'beta'-CYANO-3-ETHOXY-17'alpha'-HYDROXY-6-METHYLANDROSTA-3 ,5,9(11)-TRIENE.

Info

Publication number
MX9605428A
MX9605428A MX9605428A MX9605428A MX9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A MX 9605428 A MX9605428 A MX 9605428A
Authority
MX
Mexico
Prior art keywords
methylandrosta
triene
cyano
beta
alpha
Prior art date
Application number
MX9605428A
Other languages
Spanish (es)
Inventor
John Gregory Reid
Therese Debiak-Krook
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9605428A publication Critical patent/MX9605428A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group

Abstract

17'beta'-Cyano-3,17'alpha'-dihydroxy-6-methylandrosta-3,5,9( 11)-triene 3-ethyl ether (II) is prepared by reacting 3-hydroxy-6-methylandrosta-3,5,9(11)-trien-17-one 3- ethyl ether (I) with hydrogen cyanide at a pH of about 7 to about 11. The product is a useful intermediate in the production of pharmacologically active steroids including methylprednisolone.
MX9605428A 1994-05-09 1995-05-02 SYNTHESIS OF 17'beta'-CYANO-3-ETHOXY-17'alpha'-HYDROXY-6-METHYLANDROSTA-3 ,5,9(11)-TRIENE. MX9605428A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24003694A 1994-05-09 1994-05-09
PCT/US1995/005026 WO1995030684A1 (en) 1994-05-09 1995-05-02 SYNTHESIS OF 17β-CYANO-3-ETHOXY-17α-HYDROXY-6-METHYLANDROSTA-3,5,9(11)-TRIENE

Publications (1)

Publication Number Publication Date
MX9605428A true MX9605428A (en) 1997-12-31

Family

ID=22904843

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9605428A MX9605428A (en) 1994-05-09 1995-05-02 SYNTHESIS OF 17'beta'-CYANO-3-ETHOXY-17'alpha'-HYDROXY-6-METHYLANDROSTA-3 ,5,9(11)-TRIENE.

Country Status (9)

Country Link
EP (1) EP0759928A1 (en)
JP (1) JPH10500946A (en)
KR (1) KR970702873A (en)
CN (1) CN1147816A (en)
AU (1) AU684946B2 (en)
CA (1) CA2187522A1 (en)
HU (1) HUT75517A (en)
MX (1) MX9605428A (en)
WO (1) WO1995030684A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112898365B (en) * 2021-03-08 2023-02-28 营口德瑞化工有限公司 Synthesis method of 17 beta-cyano-17 alpha-hydroxyandrost-4-en-3-one

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2468617A1 (en) * 1979-10-26 1981-05-08 Roussel Uclaf NOVEL CHLORINATED ACETYLENIC DERIVATIVES OF ANDROST-4-ENE, THEIR PREPARATION PROCESS, AND THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
EP0153001B1 (en) * 1984-02-03 1992-03-11 The Upjohn Company Steroids having an enamide or enimide group and their preparation
DE3427486A1 (en) * 1984-07-23 1986-01-30 Schering AG, Berlin und Bergkamen, 1000 Berlin METHOD FOR PRODUCING 6 (ALPHA) METHYLSTEROIDS
DE3434448A1 (en) * 1984-09-17 1986-03-27 Schering AG, 1000 Berlin und 4709 Bergkamen METHOD FOR PRODUCING PREGNAN DERIVATIVES
DD281394A5 (en) * 1984-12-10 1990-08-08 Jenapharm Veb METHOD FOR PRODUCING STEROID C-17 ALPHA CARBONITRILES
AU607948B2 (en) * 1986-10-10 1991-03-21 Aventis Pharma S.A. 9-alpha-hydroxy steroids and process for their preparation
CA1317283C (en) * 1986-11-05 1993-05-04 Douglas Alan Livingston Steroidal 17–-silyl ethers and process to corticoids and progesterones

Also Published As

Publication number Publication date
CA2187522A1 (en) 1995-11-16
AU2362895A (en) 1995-11-29
CN1147816A (en) 1997-04-16
EP0759928A1 (en) 1997-03-05
JPH10500946A (en) 1998-01-27
HU9603110D0 (en) 1997-01-28
HUT75517A (en) 1997-05-28
KR970702873A (en) 1997-06-10
AU684946B2 (en) 1998-01-08
WO1995030684A1 (en) 1995-11-16

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