MX9603638A - Method and reagent for inhibiting the expression of disease related genes. - Google Patents
Method and reagent for inhibiting the expression of disease related genes.Info
- Publication number
- MX9603638A MX9603638A MX9603638A MX9603638A MX9603638A MX 9603638 A MX9603638 A MX 9603638A MX 9603638 A MX9603638 A MX 9603638A MX 9603638 A MX9603638 A MX 9603638A MX 9603638 A MX9603638 A MX 9603638A
- Authority
- MX
- Mexico
- Prior art keywords
- mrna
- enzymatic
- complex
- nucleic acid
- nucleic acids
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Enzymatic RNA molecules which cleave ICAM-1 mRNA, IL-5 mRNA, rel A mRNA, TNF-'alpha' mRNA, RSV mRNA or RSV genomic RNA, or CML associated mRNA, and use of these molecules for the treatment of pathological conditions related to those mRNA-levels; ribonucleosides or nucleotides modified in 2', 3' or 5', methods for their synthesis, purification and deprotection; vectors containing multiple enzymatic nucleic acids, optionally in chimeric form with tRNAs; method for introducing enzymatic nucleic acids into cells by forming a complex with a second nucleic acid, where the complex is capable of taking an R-loop base-paired structure; method for altering a mutant nucleic acid in vivo by hybridization with an oligonucleotide capable of activating dsRNA deaminase, comprising an enzymatic activity or a chemical mutagen. Further are disclosed trans-cleaving or -ligating hairpin ribozymes lacking a substrate RNA moiety, as well as hammerhead ribozymes having an interconnecting loop between base pairs in stem II.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20110994A | 1994-02-23 | 1994-02-23 | |
US08/218,934 US5639647A (en) | 1994-03-29 | 1994-03-29 | 2'-deoxy-2'alkylnucleotide containing nucleic acid |
US22279594A | 1994-04-04 | 1994-04-04 | |
US22448394A | 1994-04-07 | 1994-04-07 | |
US22804194A | 1994-04-15 | 1994-04-15 | |
US22795894A | 1994-04-15 | 1994-04-15 | |
PCT/IB1995/000156 WO1995023225A2 (en) | 1994-02-23 | 1995-02-23 | Method and reagent for inhibiting the expression of disease related genes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9603638A true MX9603638A (en) | 1997-04-30 |
Family
ID=38983879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9603638A MX9603638A (en) | 1994-02-23 | 1995-02-23 | Method and reagent for inhibiting the expression of disease related genes. |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX9603638A (en) |
-
1995
- 1995-02-23 MX MX9603638A patent/MX9603638A/en unknown
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