MX9603638A - Method and reagent for inhibiting the expression of disease related genes. - Google Patents

Method and reagent for inhibiting the expression of disease related genes.

Info

Publication number
MX9603638A
MX9603638A MX9603638A MX9603638A MX9603638A MX 9603638 A MX9603638 A MX 9603638A MX 9603638 A MX9603638 A MX 9603638A MX 9603638 A MX9603638 A MX 9603638A MX 9603638 A MX9603638 A MX 9603638A
Authority
MX
Mexico
Prior art keywords
mrna
enzymatic
complex
nucleic acid
nucleic acids
Prior art date
Application number
MX9603638A
Other languages
Spanish (es)
Inventor
Dan T Stinchcomb
Bharat Chowrira
Anthony Direnzo
Kenneth G Draper
Lech W Dudycz
Susan Grimm
Alexander Karpeisky
Kevin Kisich
Jasenka Matulic-Adamic
Original Assignee
Ribozyme Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/218,934 external-priority patent/US5639647A/en
Application filed by Ribozyme Pharm Inc filed Critical Ribozyme Pharm Inc
Priority claimed from PCT/IB1995/000156 external-priority patent/WO1995023225A2/en
Publication of MX9603638A publication Critical patent/MX9603638A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Enzymatic RNA molecules which cleave ICAM-1 mRNA, IL-5 mRNA, rel A mRNA, TNF-'alpha' mRNA, RSV mRNA or RSV genomic RNA, or CML associated mRNA, and use of these molecules for the treatment of pathological conditions related to those mRNA-levels; ribonucleosides or nucleotides modified in 2', 3' or 5', methods for their synthesis, purification and deprotection; vectors containing multiple enzymatic nucleic acids, optionally in chimeric form with tRNAs; method for introducing enzymatic nucleic acids into cells by forming a complex with a second nucleic acid, where the complex is capable of taking an R-loop base-paired structure; method for altering a mutant nucleic acid in vivo by hybridization with an oligonucleotide capable of activating dsRNA deaminase, comprising an enzymatic activity or a chemical mutagen. Further are disclosed trans-cleaving or -ligating hairpin ribozymes lacking a substrate RNA moiety, as well as hammerhead ribozymes having an interconnecting loop between base pairs in stem II.
MX9603638A 1994-02-23 1995-02-23 Method and reagent for inhibiting the expression of disease related genes. MX9603638A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US20110994A 1994-02-23 1994-02-23
US08/218,934 US5639647A (en) 1994-03-29 1994-03-29 2'-deoxy-2'alkylnucleotide containing nucleic acid
US22279594A 1994-04-04 1994-04-04
US22448394A 1994-04-07 1994-04-07
US22804194A 1994-04-15 1994-04-15
US22795894A 1994-04-15 1994-04-15
PCT/IB1995/000156 WO1995023225A2 (en) 1994-02-23 1995-02-23 Method and reagent for inhibiting the expression of disease related genes

Publications (1)

Publication Number Publication Date
MX9603638A true MX9603638A (en) 1997-04-30

Family

ID=38983879

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603638A MX9603638A (en) 1994-02-23 1995-02-23 Method and reagent for inhibiting the expression of disease related genes.

Country Status (1)

Country Link
MX (1) MX9603638A (en)

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