MX9503885A - Skin problems treatment with ii-cis-retinoic acid. - Google Patents

Abstract

The ??present invention discloses a distinctive, uic acid, or neotretinoin), which is usefulfor the treatment of abnormal cell differentiation or abnormal cell hyperproliferation conditions, such as psoriasis. The addition of said compound (II-Cis-Retinoic acid) to a non-irritating vehicle, is useful as a cosmetic that promotes a healthier and rejuvenated look to abnormal skin. A new method to synthesize said isomer allows to therapeutically compare it with the more commonly available isomers: 13-Cis isomer and all Trans isomer. As shown in the inventor's skin, who suffers psoriasis condition, the topical application of II-Cis-Retinoic acid to skin is much more advantageous for reducing symptoms, and substantially reduces the resulting side effects, as compared with the topical treatment using other isomers. A single application of a neotretinoin emulsion (0.001 percentby weight) to psoriasis injuries, results in a substantial improvement to the symptoms (itching, imbrication, being bleeding, look abnormal) within the following 48 hours. A continuous application results in a total remission. No irritation, erythema, nor other side effects are observed.