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Priority claimed from GB929215636Aexternal-prioritypatent/GB9215636D0/en
Priority claimed from GB939310884Aexternal-prioritypatent/GB9310884D0/en
Priority claimed from GB939314960Aexternal-prioritypatent/GB9314960D0/en
Application filed by Zeneca Ltd, Cancer Research Campaign TechofiledCriticalZeneca Ltd
Publication of MX9304449ApublicationCriticalpatent/MX9304449A/en
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents
(AREA)
Abstract
La presente invención se refiere a compuestos que se usan en la terapia de prórrogas de enzima directas al anticuerpo ( ADEPT ), a los procedimientos para su preparación, a las composiciones farmacéuticas que las contienen, y a los métodos para su uso, así como a un sistema de dos componentes que comprende 1) un conjugado de una enzima y un anticuerpo o un fragmento del anticuerpo y 2) un compuesto de la presente invención. Los compuestos son particularmente de interés como las pro-drogas para usarse en conjunción con las enzimas de la carboxípeptidasa G, particularmente la carboxipeptidasa G2 (CPG2).The present invention relates to compounds that are used in the therapy of direct enzyme extensions to the antibody (ADEPT), to the procedures for their preparation, to the pharmaceutical compositions that contain them, and to the methods for their use, as well as to a two component system comprising 1) a conjugate of an enzyme and an antibody or a fragment of the antibody and 2) a compound of the present invention. The compounds are of particular interest as pro-drugs for use in conjunction with carboxypeptidase G enzymes, particularly carboxypeptidase G2 (CPG2).
MX9304449A1992-07-231993-07-23
CHEMICAL COMPOUNDS.
MX9304449A
(en)
NEW ACIDES 9-FLUORO-7-OXO-7H-PIRIDO (1,2,3, -DE) (1,4) -BENZOXACIN-6-CARBOXILICOS AND ITS ESTERS, PROCEDURE FOR THEIR PREPARATION AND DRUGS THAT CONTAIN THEM.
DERIVATIVES OF FENIL-4-TIAZOLES SUBSTITUTED, PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND DERIVATIVES DEFENIL-4-TIAZOLES SUBSTITUTED USED IN SUCH PROCEDURE.