MX9301726A - GROWTH FACTOR DERIVED FROM MONOMERIC PLATELETS AND PREVENTION OF STENOSIS OR RESTENOSIS. - Google Patents

GROWTH FACTOR DERIVED FROM MONOMERIC PLATELETS AND PREVENTION OF STENOSIS OR RESTENOSIS.

Info

Publication number
MX9301726A
MX9301726A MX9301726A MX9301726A MX9301726A MX 9301726 A MX9301726 A MX 9301726A MX 9301726 A MX9301726 A MX 9301726A MX 9301726 A MX9301726 A MX 9301726A MX 9301726 A MX9301726 A MX 9301726A
Authority
MX
Mexico
Prior art keywords
pdgf
monomeric
stenosis
restenosis
platelets
Prior art date
Application number
MX9301726A
Other languages
Spanish (es)
Inventor
Michael B Cable
Thomas E Hesson
Anthony F Mannarino
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of MX9301726A publication Critical patent/MX9301726A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención proporciona métodos para inhibir la ligazón de PDGF dimérico biológicamente activo a receptores celulales. Usando estos métodos, pueden inhibirse la proliferación de las células portadoras del receptor PDGF y la estenosis o restenosis. Estos métodos emplean un PDGF e inhibir la ligaza del PDGF dimérico. Se proporcionan asi mismo métodos para producir el PDGF monomérico. La presente invención además proporciona PDGF monomérico biológicamente activo nativo.The present invention provides methods for inhibiting the binding of biologically active dimeric PDGF to cell receptors. Using these methods, the proliferation of PDGF receptor-bearing cells and stenosis or restenosis can be inhibited. These methods employ a PDGF and inhibit the binding of the dimeric PDGF. Also provided are methods for producing monomeric PDGF. The present invention further provides native biologically active monomeric PDGF.

MX9301726A 1992-03-30 1993-03-26 GROWTH FACTOR DERIVED FROM MONOMERIC PLATELETS AND PREVENTION OF STENOSIS OR RESTENOSIS. MX9301726A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86071192A 1992-03-30 1992-03-30

Publications (1)

Publication Number Publication Date
MX9301726A true MX9301726A (en) 1994-01-31

Family

ID=25333850

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301726A MX9301726A (en) 1992-03-30 1993-03-26 GROWTH FACTOR DERIVED FROM MONOMERIC PLATELETS AND PREVENTION OF STENOSIS OR RESTENOSIS.

Country Status (6)

Country Link
CN (1) CN1082921A (en)
AU (1) AU3816593A (en)
IL (1) IL105176A0 (en)
MX (1) MX9301726A (en)
WO (1) WO1993020204A1 (en)
ZA (1) ZA932179B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
US6086866A (en) * 1993-04-29 2000-07-11 Kouri; Roger Khalil Use of platelet-derived growth factor to improve collateral circulation
US5756295A (en) * 1994-12-05 1998-05-26 Takeda Chemical Industries, Ltd. DNA primer and a method for screening DNAS
CN105085652B (en) * 2014-05-16 2021-06-22 中国人民解放军军事医学科学院生物工程研究所 Platelet-derived growth factor B mutant, preparation method and application thereof
CN111303271B (en) * 2020-02-19 2022-02-01 西安交通大学医学院第一附属医院 Platelet-derived growth factor recombinant vaccine for treating pulmonary fibrosis and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE131532T1 (en) * 1986-08-13 1995-12-15 Zymogenetics Inc EXPRESSION OF BIOLOGICALLY ACTIVE PDGF ANALOGUES IN EUKARYOTIC CELLS
IL96682A0 (en) * 1989-12-15 1991-09-16 Amgen Inc Production of biologically active platelet-derived growth factor from high expression host cell systems
US5272064A (en) * 1989-12-19 1993-12-21 Amgen Inc. DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof
AU648630B2 (en) * 1990-12-21 1994-04-28 Creative Biomolecules, Inc. Biosynthetic PDGF antagonists

Also Published As

Publication number Publication date
IL105176A0 (en) 1993-07-08
CN1082921A (en) 1994-03-02
WO1993020204A1 (en) 1993-10-14
ZA932179B (en) 1994-09-26
AU3816593A (en) 1993-11-08

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