MX363950B - Urea derivatives useful as kinase inhibitors. - Google Patents

Urea derivatives useful as kinase inhibitors.

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Publication number
MX363950B
MX363950B MX2015013945A MX2015013945A MX363950B MX 363950 B MX363950 B MX 363950B MX 2015013945 A MX2015013945 A MX 2015013945A MX 2015013945 A MX2015013945 A MX 2015013945A MX 363950 B MX363950 B MX 363950B
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
urea derivatives
derivatives useful
members
inflammatory diseases
Prior art date
Application number
MX2015013945A
Other languages
Spanish (es)
Other versions
MX2015013945A (en
Inventor
Premji Meghani
Aaron Rigby
Matthew Colin Thor Fyfe
Stephen Malcolm Thom
Thomas Matthew Baker
Gareth William Harbottle
Vedran Hasimbegovic
Colin Sambrook-Smith
Original Assignee
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201305945A external-priority patent/GB201305945D0/en
Priority claimed from GBGB1322678.2A external-priority patent/GB201322678D0/en
Priority claimed from GB201402647A external-priority patent/GB201402647D0/en
Application filed by Topivert Pharma Ltd filed Critical Topivert Pharma Ltd
Publication of MX2015013945A publication Critical patent/MX2015013945A/en
Publication of MX363950B publication Critical patent/MX363950B/en

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    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
MX2015013945A 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors. MX363950B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB201305945A GB201305945D0 (en) 2013-04-02 2013-04-02 New compounds
GBGB1322678.2A GB201322678D0 (en) 2013-12-20 2013-12-20 New compounds
GB201402647A GB201402647D0 (en) 2014-02-14 2014-02-14 New compounds
PCT/GB2014/051022 WO2014162126A1 (en) 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2015013945A MX2015013945A (en) 2015-12-11
MX363950B true MX363950B (en) 2019-04-08

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MX2015013945A MX363950B (en) 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors.
MX2015013944A MX363949B (en) 2013-04-02 2014-04-01 Kinase inhibitor.

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MX2015013944A MX363949B (en) 2013-04-02 2014-04-01 Kinase inhibitor.

Country Status (14)

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US (5) US9481648B2 (en)
EP (2) EP2981535B8 (en)
JP (2) JP6495238B2 (en)
KR (3) KR102283876B1 (en)
CN (2) CN105408315B (en)
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Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2229391B1 (en) 2007-12-19 2014-08-06 Cancer Research Technology Limited Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
WO2011092469A1 (en) 2010-02-01 2011-08-04 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
AU2012320300C1 (en) 2011-10-03 2017-06-01 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP kinase inhibitors
EP2578582A1 (en) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
US20150225373A1 (en) 2012-08-29 2015-08-13 Respivert Limited Kinase inhibitors
WO2014033449A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
WO2014033446A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
EP2925742B1 (en) 2012-11-16 2016-10-26 Respivert Limited Kinase inhibitors
EP2970190A1 (en) * 2013-03-14 2016-01-20 Respivert Limited Kinase inhibitors
EP2981534B1 (en) 2013-04-02 2017-07-19 Topivert Pharma Limited Kinase inhibitors based upon n-alkyl pyrazoles
MX363950B (en) * 2013-04-02 2019-04-08 Topivert Pharma Ltd Urea derivatives useful as kinase inhibitors.
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
CN106029651A (en) 2013-12-20 2016-10-12 瑞斯比维特有限公司 Urea derivatives useful as kinase inhibitors
MX371312B (en) 2014-02-14 2020-01-24 Respivert Ltd Pyrazolyl-ureas as kinase inhibitors.
MA40775A (en) * 2014-10-01 2017-08-08 Respivert Ltd 4- (4- (4-PHENYLUREIDO-NAPHTALÉN -1-YL) OXY-PYRIDIN-2-YL) AMINO-BENZOIC ACID USED AS A KINASE P38 INHIBITOR
AR107165A1 (en) 2015-12-23 2018-03-28 Chiesi Farm Spa QUINASE INHIBITORS
EP3440073B1 (en) * 2016-04-06 2022-06-08 Oxular Acquisitions Limited Kinase inhibitors
SG10202110259QA (en) 2017-10-05 2021-10-28 Fulcrum Therapeutics Inc Use of p38 inhibitors to reduce expression of dux4
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CN110878055B (en) * 2018-09-06 2021-02-05 中国科学院化学研究所 Method for preparing carbonyl heterocyclic compound

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998052558A1 (en) 1997-05-23 1998-11-26 Bayer Corporation INHIBITION OF p38 KINASE ACTIVITY BY ARYL UREAS
JP2001521934A (en) 1997-11-03 2001-11-13 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Aromatic heterocyclic compounds as anti-inflammatory drugs
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
ATE538794T1 (en) 1999-01-13 2012-01-15 Bayer Healthcare Llc GAMMA CARBOXYARYL SUBSTITUTED DIPHENYL UREA COMPOUNDS AS P38 KINASE INHIBITORS
UA73492C2 (en) 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
US6358945B1 (en) 1999-03-12 2002-03-19 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
CA2374737C (en) 1999-07-09 2008-02-12 Boehringer Ingelheim Pharmaceuticals, Inc. Novel process for synthesis of heteroaryl-substituted urea compounds
MXPA02004594A (en) 1999-11-16 2002-10-23 Boehringer Ingelheim Pharma Urea derivatives as anti inflammatory agents.
US6492529B1 (en) 2000-01-18 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Bis pyrazole-1H-pyrazole intermediates and their synthesis
US6525046B1 (en) 2000-01-18 2003-02-25 Boehringer Ingelheim Pharmaceuticals, Inc. Aromatic heterocyclic compounds as antiinflammatory agents
CA2490819A1 (en) 2001-04-13 2002-10-24 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as anti-inflammatory agents
CA2443697A1 (en) * 2001-04-13 2002-10-24 Pier F. Cirillo 1,4-disubstituted benzo-fused compounds
WO2002092576A1 (en) 2001-05-16 2002-11-21 Boehringer Ingelheim Pharmaceuticals, Inc. Diarylurea derivatives useful as anti-inflammatory agents
CA2448626A1 (en) 2001-05-25 2002-12-05 Boehringer Ingelheim Pharmaceuticals, Inc. Carbamate and oxamide compounds as inhibitors of cytokine production
ATE360417T1 (en) 2001-07-11 2007-05-15 Boehringer Ingelheim Pharma METHOD FOR TREATING CYTOKINE-MEDIATED DISEASES
JP4636486B2 (en) 2002-02-11 2011-02-23 バイエル、ファーマシューテイカルズ、コーポレイション Arylurea with angiogenesis inhibitory activity
AU2003210969A1 (en) 2002-02-11 2003-09-04 Bayer Corporation Aryl ureas with raf kinase and angiogenesis inhibiting activity
JP4629978B2 (en) 2002-02-25 2011-02-09 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド 1,4-Disubstituted benzofused cycloalkylurea compounds useful for the treatment of cytokine-mediated diseases
TW200406374A (en) * 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
EP1549621A1 (en) * 2002-08-08 2005-07-06 Boehringer Ingelheim Pharmaceuticals Inc. Fluorinated phenyl-naphthalenyl-urea compounds as inhibitors of cytokines involved in inflammatory processes
US20050014753A1 (en) 2003-04-04 2005-01-20 Irm Llc Novel compounds and compositions as protein kinase inhibitors
WO2004113352A1 (en) 2003-06-19 2004-12-29 Amedis Pharmaceuticals Ltd. Silylated heterocyclylurea derivatives as cytokine-inhibitors
EP1644341A1 (en) 2003-06-30 2006-04-12 Boehringer Ingelheim Pharmaceuticals Inc. Process of making di-aryl urea compounds
JP2007503393A (en) 2003-08-22 2007-02-22 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド COPD and pulmonary hypertension treatment method
MXPA06002853A (en) 2003-09-11 2006-06-14 Kemia Inc Cytokine inhibitors.
WO2005044825A1 (en) 2003-10-21 2005-05-19 Amedis Pharmaceuticals Ltd. Silicon compounds and their use
JP2007515400A (en) 2003-11-28 2007-06-14 ノバルティス アクチエンゲゼルシャフト Diarylurea derivatives in the treatment of protein kinase dependent diseases
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
GB0423554D0 (en) 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
TW200740820A (en) 2005-07-05 2007-11-01 Takeda Pharmaceuticals Co Fused heterocyclic derivatives and use thereof
PE20070795A1 (en) 2005-10-28 2007-08-24 Lilly Co Eli PIRAZOLE-UREA-HETEROCICLIC COMPOUNDS AS KINASE INHIBITORS
US7790756B2 (en) 2006-10-11 2010-09-07 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
EA020641B1 (en) 2008-10-02 2014-12-30 Респайверт Лимитед Derivatives of n-(1-phenyl-3-alkylpyrazol-5-yl)-n'-aryl urea
GB0818033D0 (en) 2008-10-02 2008-11-05 Respivert Ltd Novel compound
NZ593104A (en) 2008-12-11 2012-11-30 Respivert Ltd P38 map kinase inhibitors
GB0905955D0 (en) 2009-04-06 2009-05-20 Respivert Ltd Novel compounds
ES2575084T3 (en) 2009-06-10 2016-06-24 Chugai Seiyaku Kabushiki Kaisha Tetracyclic compound
GB0921730D0 (en) 2009-12-11 2010-01-27 Respivert Ltd Method of treatment
GB0921731D0 (en) 2009-12-11 2010-01-27 Respivert Ltd Theraputic uses
JP5708637B2 (en) 2010-03-15 2015-04-30 宇部興産株式会社 Method for producing amide compound
GB201005589D0 (en) 2010-04-01 2010-05-19 Respivert Ltd Novel compounds
JP5787976B2 (en) 2010-04-08 2015-09-30 レスピバート・リミテツド Pyrazolyl urea as a P38 MAP kinase inhibitor
WO2011124930A1 (en) 2010-04-08 2011-10-13 Respivert Limited P38 map kinase inhibitors
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
GB201010193D0 (en) 2010-06-17 2010-07-21 Respivert Ltd Medicinal use
US8933228B2 (en) 2010-06-17 2015-01-13 Respivert, Ltd. Respiratory formulations and compounds for use therein
GB201010196D0 (en) * 2010-06-17 2010-07-21 Respivert Ltd Methods
KR20130141500A (en) * 2010-09-29 2013-12-26 크리스탈지노믹스(주) Novel aminoquinazoline compound having a protein-kinase inhibiting action
AU2012320300C1 (en) 2011-10-03 2017-06-01 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) ureas as P38 MAP kinase inhibitors
EP2578582A1 (en) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
KR101994381B1 (en) 2011-12-09 2019-06-28 키에시 파르마슈티시 엣스. 피. 에이. Kinase inhibitors
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
GB201215357D0 (en) 2012-08-29 2012-10-10 Respivert Ltd Compounds
WO2014033449A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
US20150225373A1 (en) 2012-08-29 2015-08-13 Respivert Limited Kinase inhibitors
WO2014033446A1 (en) 2012-08-29 2014-03-06 Respivert Limited Kinase inhibitors
EP2925742B1 (en) 2012-11-16 2016-10-26 Respivert Limited Kinase inhibitors
EP2970190A1 (en) * 2013-03-14 2016-01-20 Respivert Limited Kinase inhibitors
EP2981534B1 (en) 2013-04-02 2017-07-19 Topivert Pharma Limited Kinase inhibitors based upon n-alkyl pyrazoles
MX363950B (en) * 2013-04-02 2019-04-08 Topivert Pharma Ltd Urea derivatives useful as kinase inhibitors.
CN106029651A (en) 2013-12-20 2016-10-12 瑞斯比维特有限公司 Urea derivatives useful as kinase inhibitors
MX371312B (en) 2014-02-14 2020-01-24 Respivert Ltd Pyrazolyl-ureas as kinase inhibitors.
MA40775A (en) 2014-10-01 2017-08-08 Respivert Ltd 4- (4- (4-PHENYLUREIDO-NAPHTALÉN -1-YL) OXY-PYRIDIN-2-YL) AMINO-BENZOIC ACID USED AS A KINASE P38 INHIBITOR
EP3440073B1 (en) * 2016-04-06 2022-06-08 Oxular Acquisitions Limited Kinase inhibitors

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