MX363950B - Urea derivatives useful as kinase inhibitors. - Google Patents

Urea derivatives useful as kinase inhibitors.

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Publication number
MX363950B
MX363950B MX2015013945A MX2015013945A MX363950B MX 363950 B MX363950 B MX 363950B MX 2015013945 A MX2015013945 A MX 2015013945A MX 2015013945 A MX2015013945 A MX 2015013945A MX 363950 B MX363950 B MX 363950B
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
urea derivatives
derivatives useful
members
inflammatory diseases
Prior art date
Application number
MX2015013945A
Other languages
Spanish (es)
Other versions
MX2015013945A (en
Inventor
Premji Meghani
Aaron Rigby
Matthew Colin Thor Fyfe
Stephen Malcolm Thom
Thomas Matthew Baker
Gareth William Harbottle
Vedran Hasimbegovic
Colin Sambrook-Smith
Original Assignee
Topivert Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB201305945A external-priority patent/GB201305945D0/en
Priority claimed from GBGB1322678.2A external-priority patent/GB201322678D0/en
Priority claimed from GB201402647A external-priority patent/GB201402647D0/en
Application filed by Topivert Pharma Ltd filed Critical Topivert Pharma Ltd
Publication of MX2015013945A publication Critical patent/MX2015013945A/en
Publication of MX363950B publication Critical patent/MX363950B/en

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    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract

There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
MX2015013945A 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors. MX363950B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB201305945A GB201305945D0 (en) 2013-04-02 2013-04-02 New compounds
GBGB1322678.2A GB201322678D0 (en) 2013-12-20 2013-12-20 New compounds
GB201402647A GB201402647D0 (en) 2014-02-14 2014-02-14 New compounds
PCT/GB2014/051022 WO2014162126A1 (en) 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2015013945A MX2015013945A (en) 2015-12-11
MX363950B true MX363950B (en) 2019-04-08

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MX2015013945A MX363950B (en) 2013-04-02 2014-04-01 Urea derivatives useful as kinase inhibitors.
MX2015013944A MX363949B (en) 2013-04-02 2014-04-01 Kinase inhibitor.

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MX2015013944A MX363949B (en) 2013-04-02 2014-04-01 Kinase inhibitor.

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US (5) US8927563B2 (en)
EP (2) EP2981535B8 (en)
JP (2) JP6495238B2 (en)
KR (3) KR102283876B1 (en)
CN (2) CN105408315B (en)
AU (2) AU2014246866B2 (en)
BR (2) BR112015024671A2 (en)
CA (1) CA2907663A1 (en)
DK (2) DK2981535T3 (en)
EA (2) EA027782B1 (en)
ES (2) ES2856902T3 (en)
MX (2) MX363950B (en)
TW (1) TWI641592B (en)
WO (2) WO2014162122A1 (en)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
US8198279B2 (en) 2007-12-19 2012-06-12 Institute Of Cancer Research: Royal Cancer Hospital (The) Pyrido[2,3-b]pyrazin-8-substituted compounds and their use
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