MX363022B - Humanized rodents that express heavy chains containing vl domains. - Google Patents

Humanized rodents that express heavy chains containing vl domains.

Info

Publication number
MX363022B
MX363022B MX2014009300A MX2014009300A MX363022B MX 363022 B MX363022 B MX 363022B MX 2014009300 A MX2014009300 A MX 2014009300A MX 2014009300 A MX2014009300 A MX 2014009300A MX 363022 B MX363022 B MX 363022B
Authority
MX
Mexico
Prior art keywords
human
light chain
domains
heavy chains
heavy chain
Prior art date
Application number
MX2014009300A
Other languages
Spanish (es)
Other versions
MX2014009300A (en
Inventor
J Murphy Andrew
Stevens Sean
Macdonald Lynn
Gurer Cagan
A Meagher Karolina
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Priority claimed from PCT/US2013/024295 external-priority patent/WO2013116609A1/en
Publication of MX2014009300A publication Critical patent/MX2014009300A/en
Publication of MX363022B publication Critical patent/MX363022B/en

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains.
MX2014009300A 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains. MX363022B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261593493P 2012-02-01 2012-02-01
US201261677538P 2012-07-31 2012-07-31
PCT/US2013/024295 WO2013116609A1 (en) 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains

Publications (2)

Publication Number Publication Date
MX2014009300A MX2014009300A (en) 2015-06-05
MX363022B true MX363022B (en) 2019-03-05

Family

ID=54261373

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014009300A MX363022B (en) 2012-02-01 2013-02-01 Humanized rodents that express heavy chains containing vl domains.

Country Status (1)

Country Link
MX (1) MX363022B (en)

Also Published As

Publication number Publication date
MX2014009300A (en) 2015-06-05

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