MX363022B - Humanized rodents that express heavy chains containing vl domains. - Google Patents
Humanized rodents that express heavy chains containing vl domains.Info
- Publication number
- MX363022B MX363022B MX2014009300A MX2014009300A MX363022B MX 363022 B MX363022 B MX 363022B MX 2014009300 A MX2014009300 A MX 2014009300A MX 2014009300 A MX2014009300 A MX 2014009300A MX 363022 B MX363022 B MX 363022B
- Authority
- MX
- Mexico
- Prior art keywords
- human
- light chain
- domains
- heavy chains
- heavy chain
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity functional in a rodent (e.g., a mouse), wherein the non-human animals rearrange human immunoglobulin light chain gene segments in the context of heavy chain constant regions and express immunoglobulin-like molecules comprising human immunoglobulin light chain variable domains fused to heavy chain constant domains that are cognate with human immunoglobulin light chain variable domains fused to light chain constant domains.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261593493P | 2012-02-01 | 2012-02-01 | |
US201261677538P | 2012-07-31 | 2012-07-31 | |
PCT/US2013/024295 WO2013116609A1 (en) | 2012-02-01 | 2013-02-01 | Humanized rodents that express heavy chains containing vl domains |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014009300A MX2014009300A (en) | 2015-06-05 |
MX363022B true MX363022B (en) | 2019-03-05 |
Family
ID=54261373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009300A MX363022B (en) | 2012-02-01 | 2013-02-01 | Humanized rodents that express heavy chains containing vl domains. |
Country Status (1)
Country | Link |
---|---|
MX (1) | MX363022B (en) |
-
2013
- 2013-02-01 MX MX2014009300A patent/MX363022B/en unknown
Also Published As
Publication number | Publication date |
---|---|
MX2014009300A (en) | 2015-06-05 |
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