MX355439B - Proceso para preparar inhibidores de la transcriptasa inversa. - Google Patents

Proceso para preparar inhibidores de la transcriptasa inversa.

Info

Publication number
MX355439B
MX355439B MX2015007181A MX2015007181A MX355439B MX 355439 B MX355439 B MX 355439B MX 2015007181 A MX2015007181 A MX 2015007181A MX 2015007181 A MX2015007181 A MX 2015007181A MX 355439 B MX355439 B MX 355439B
Authority
MX
Mexico
Prior art keywords
reverse transcriptase
transcriptase inhibitors
making reverse
hiv
making
Prior art date
Application number
MX2015007181A
Other languages
English (en)
Other versions
MX2015007181A (es
Inventor
Ian Mangion
Tetsuji Itoh
Ingyu Jeon
Gang Qian
Benjamin D Sherry
Donald R Gauthier
Yang Cao
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2015007181A publication Critical patent/MX2015007181A/es
Publication of MX355439B publication Critical patent/MX355439B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención está dirigida a un proceso novedoso para sintetizar derivados de 3-(fenoxi sustituido)-1-[(5-oxo-4,5-dihidr o-1H-1,2,4-triazol-3-iI)metilo])-piridin-2(1H)-ona; los compuestos sintetizados por el proceso de la invención son inhibidores de la transcriptasa inversa del VIH útiles para inhibir la transcriptasa inversa, la replicación del VIH y para el tratamiento de infección por el virus de inmunodeficiencia humano en humanos.
MX2015007181A 2012-12-05 2013-12-04 Proceso para preparar inhibidores de la transcriptasa inversa. MX355439B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261733504P 2012-12-05 2012-12-05
PCT/US2013/072964 WO2014089140A1 (en) 2012-12-05 2013-12-04 Process for making reverse transcriptase inhibitors

Publications (2)

Publication Number Publication Date
MX2015007181A MX2015007181A (es) 2015-10-12
MX355439B true MX355439B (es) 2018-04-18

Family

ID=50883949

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015007181A MX355439B (es) 2012-12-05 2013-12-04 Proceso para preparar inhibidores de la transcriptasa inversa.

Country Status (7)

Country Link
US (1) US9663490B2 (es)
EP (1) EP2928472B1 (es)
CN (1) CN104994855B (es)
BR (1) BR112015012843B8 (es)
CA (1) CA2892919A1 (es)
MX (1) MX355439B (es)
WO (1) WO2014089140A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2930585A1 (en) 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Process for making reverse transcriptase inhibitors
CN104844490B (zh) * 2015-05-14 2017-06-06 常州大学 一种两步法绿色合成异硫氰酸酯的方法
TW201945346A (zh) 2018-04-10 2019-12-01 德商拜耳廠股份有限公司 2,4,5-三取代的1,2,4-三唑酮之製備方法
CN116903590A (zh) * 2023-06-06 2023-10-20 延边大学 一种含杂环结构的吡啶酮类化合物及其制备方法和用途
CN120157613A (zh) * 2023-12-15 2025-06-17 山东诚创蓝海医药科技有限公司 多拉韦林中间体及其应用和合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002053561A (ja) 1999-12-08 2002-02-19 Sumitomo Chem Co Ltd ジフルオロメチルトリアゾロン化合物、その用途およびその製造中間体
MX2009005071A (es) * 2006-11-13 2009-05-25 Novartis Ag Compuestos de pirazol y triazol sustituidos como inhibidores de ksp.
AU2008326784B2 (en) * 2007-11-20 2014-04-24 Merck Sharp & Dohme Corp. Non-nucleoside reverse transcriptase inhibitors
CN102971308B (zh) * 2010-03-30 2015-02-04 默克加拿大有限公司 非核苷类逆转录酶抑制剂

Also Published As

Publication number Publication date
EP2928472A4 (en) 2016-09-14
EP2928472A1 (en) 2015-10-14
BR112015012843A2 (pt) 2017-07-11
CN104994855B (zh) 2018-06-05
MX2015007181A (es) 2015-10-12
WO2014089140A1 (en) 2014-06-12
CA2892919A1 (en) 2014-06-12
US20150329521A1 (en) 2015-11-19
BR112015012843B8 (pt) 2023-04-25
BR112015012843B1 (pt) 2022-06-07
EP2928472B1 (en) 2018-05-02
US9663490B2 (en) 2017-05-30
CN104994855A (zh) 2015-10-21

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Legal Events

Date Code Title Description
FG Grant or registration