MX349169B - Ophthalmic pharmaceutical compositions and methods of making and using same. - Google Patents
Ophthalmic pharmaceutical compositions and methods of making and using same.Info
- Publication number
- MX349169B MX349169B MX2014009620A MX2014009620A MX349169B MX 349169 B MX349169 B MX 349169B MX 2014009620 A MX2014009620 A MX 2014009620A MX 2014009620 A MX2014009620 A MX 2014009620A MX 349169 B MX349169 B MX 349169B
- Authority
- MX
- Mexico
- Prior art keywords
- polymer
- oil
- emulsion
- making
- methods
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
A stable ophthalmic pharmaceutical composition for relief, treatment, control, alleviation, or prevention of a pathological ocular condition of the eye comprises: (a) a first polymer, a viscosity of which changes with a change in a concentration of an electrolyte, such as a salt, when added to said first polymer; (b) a second polymer that is different from the first polymer and can modify the viscosity of the first polymer; and (c) an oil. In some embodiments, the composition further comprises a non-ionic surfactant. The composition can form a stable oil-in-water emulsion on storage, but separate into an oil phase and a water phase when applied in the eye. The emulsion can comprises an ophthalmic active pharmaceutical ingredient dissolved in the oil or water phase. The emulsion can provide enhanced stability to said active pharmaceutical ingredient.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261597879P | 2012-02-13 | 2012-02-13 | |
US13/739,018 US9278132B2 (en) | 2012-02-13 | 2013-01-11 | Ophthalmic pharmaceutical compositions and methods of making and using same |
PCT/US2013/025013 WO2013122801A1 (en) | 2012-02-13 | 2013-02-07 | Ophthalmic pharmaceutical compositions and methods of making and using same |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014009620A MX2014009620A (en) | 2014-11-10 |
MX349169B true MX349169B (en) | 2017-07-17 |
Family
ID=48946121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009620A MX349169B (en) | 2012-02-13 | 2013-02-07 | Ophthalmic pharmaceutical compositions and methods of making and using same. |
Country Status (14)
Country | Link |
---|---|
US (1) | US9278132B2 (en) |
EP (1) | EP2814463B1 (en) |
JP (1) | JP5898789B2 (en) |
KR (1) | KR101760990B1 (en) |
CN (1) | CN104203215B (en) |
AR (1) | AR089962A1 (en) |
AU (1) | AU2013219822B2 (en) |
CA (1) | CA2864417C (en) |
ES (1) | ES2576113T3 (en) |
HU (1) | HUE029276T2 (en) |
MX (1) | MX349169B (en) |
PL (1) | PL2814463T3 (en) |
TW (1) | TWI535462B (en) |
WO (1) | WO2013122801A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
US10688041B2 (en) | 2012-05-03 | 2020-06-23 | Kala Pharmaceuticals, Inc. | Compositions and methods utilizing poly(vinyl alcohol) and/or other polymers that aid particle transport in mucus |
KR102310775B1 (en) | 2012-05-03 | 2021-10-07 | 칼라 파마슈티컬스, 인크. | Pharmaceutical nanoparticles showing improved mucosal transport |
US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
JP6537775B2 (en) * | 2014-03-10 | 2019-07-03 | 小林製薬株式会社 | Emulsified composition |
US10245324B2 (en) | 2014-10-31 | 2019-04-02 | Johnson & Johnson Consumer Inc. | Ophthalmic composition |
AU2017227585C1 (en) | 2016-02-29 | 2022-05-26 | Sun Pharmaceutical Industries Limited | Topical cyclosporine-containing formulations and uses thereof |
EP3231417B1 (en) * | 2016-04-15 | 2018-12-05 | Dr. Gerhard Mann Chem.-Pharm. Fabrik GmbH | Storage stable, ophthalmic compound |
CN110891555B (en) * | 2017-03-05 | 2023-12-26 | 雷斯德沃克研究及发展有限公司 | Eye drops for treating irritation caused by infection |
US10933111B2 (en) * | 2019-01-08 | 2021-03-02 | Boston Biotechnology US CORP | Treating dry eye disorders |
DE102021212692A1 (en) | 2021-11-11 | 2023-05-11 | Ursapharm Arzneimittel Gmbh | SELF-EMULSIFYING OIL-IN-WATER MICRO- OR NANO-EMULSION AND EMULSIFYING COMPOSITION |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409205A (en) | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
US5209927A (en) | 1985-01-23 | 1993-05-11 | Alcon Laboratories, Inc. | Ophthalmic solution |
ES2084722T3 (en) | 1990-05-29 | 1996-05-16 | Boston Ocular Res | COMPOSITION FOR DRY EYE TREATMENT. |
US5474979A (en) * | 1994-05-17 | 1995-12-12 | Allergan, Inc. | Nonirritating emulsions for sensitive tissue |
ES2094688B1 (en) * | 1994-08-08 | 1997-08-01 | Cusi Lab | MANOEMULSION OF THE TYPE OF OIL IN WATER, USEFUL AS AN OPHTHALMIC VEHICLE AND PROCEDURE FOR ITS PREPARATION. |
US6114319A (en) * | 1997-05-14 | 2000-09-05 | Senju Pharmaceutical Co., Ltd. | Compositions containing difluprednate |
CN1456157A (en) | 2002-05-10 | 2003-11-19 | 刘继东 | Ophthalmic gel of L-ofloxacin |
CN1180776C (en) | 2002-12-02 | 2004-12-22 | 刘继东 | Ofloxacin eye ointment |
JP4762718B2 (en) * | 2003-11-07 | 2011-08-31 | 千寿製薬株式会社 | Prostaglandin-containing pharmaceutical composition |
US9161905B2 (en) * | 2005-01-12 | 2015-10-20 | Ocular Research Of Boston, Inc. | Dry eye treatment |
US7288520B2 (en) * | 2005-07-13 | 2007-10-30 | Allergan, Inc. | Cyclosporin compositions |
EP1985298A1 (en) | 2007-04-24 | 2008-10-29 | Azad Pharma AG | Ophtalmic oil-in-water emulsions containing prostaglandins |
HUE034213T2 (en) | 2009-06-05 | 2018-01-29 | Allergan Inc | Artificial tears and therapeutic uses |
FR2962044B1 (en) * | 2010-04-21 | 2013-02-22 | Horus Pharma | LACRYMIMETIC EMULSION |
FR2961694B1 (en) | 2010-06-29 | 2013-01-25 | Thea Lab | POLYMERIC DELIVERY SYSTEM FOR NON-VISCOUS SOLUTION BASED ON PROSTAGLANDIN WITHOUT PRESERVATIVE |
US8957048B2 (en) | 2011-10-06 | 2015-02-17 | Allergan, Inc. | Compositions for the treatment of dry eye |
-
2013
- 2013-01-11 US US13/739,018 patent/US9278132B2/en active Active
- 2013-02-07 KR KR1020147025124A patent/KR101760990B1/en active IP Right Grant
- 2013-02-07 EP EP13705675.0A patent/EP2814463B1/en active Active
- 2013-02-07 PL PL13705675.0T patent/PL2814463T3/en unknown
- 2013-02-07 AU AU2013219822A patent/AU2013219822B2/en active Active
- 2013-02-07 CA CA2864417A patent/CA2864417C/en active Active
- 2013-02-07 JP JP2014557693A patent/JP5898789B2/en active Active
- 2013-02-07 CN CN201380017182.7A patent/CN104203215B/en active Active
- 2013-02-07 MX MX2014009620A patent/MX349169B/en active IP Right Grant
- 2013-02-07 ES ES13705675.0T patent/ES2576113T3/en active Active
- 2013-02-07 WO PCT/US2013/025013 patent/WO2013122801A1/en active Application Filing
- 2013-02-07 HU HUE13705675A patent/HUE029276T2/en unknown
- 2013-02-08 TW TW102105194A patent/TWI535462B/en active
- 2013-02-08 AR ARP130100420A patent/AR089962A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUE029276T2 (en) | 2017-02-28 |
CN104203215B (en) | 2017-04-12 |
KR101760990B1 (en) | 2017-07-24 |
EP2814463B1 (en) | 2016-05-18 |
TWI535462B (en) | 2016-06-01 |
ES2576113T3 (en) | 2016-07-05 |
MX2014009620A (en) | 2014-11-10 |
AR089962A1 (en) | 2014-10-01 |
EP2814463A1 (en) | 2014-12-24 |
TW201345564A (en) | 2013-11-16 |
CA2864417A1 (en) | 2013-08-22 |
AU2013219822B2 (en) | 2016-01-14 |
JP5898789B2 (en) | 2016-04-06 |
CA2864417C (en) | 2018-10-16 |
KR20140121479A (en) | 2014-10-15 |
AU2013219822A1 (en) | 2014-08-28 |
WO2013122801A1 (en) | 2013-08-22 |
US20130210912A1 (en) | 2013-08-15 |
JP2015507010A (en) | 2015-03-05 |
CN104203215A (en) | 2014-12-10 |
PL2814463T3 (en) | 2016-11-30 |
US9278132B2 (en) | 2016-03-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |