MX347181B - Method for obtaining a co-processed pharmaceutical excipient for the controlled release of active substances and product obtained with it. - Google Patents

Abstract

Described is a process for obtaining a co-processed excipient for the release of active substances that comprises the following steps: (a) locating a functional excipient in a container for the direct compression thereof in an amount ranging from 5g/L to 500 g/L; (b) adding a dispersion of nanoparticles in a content of solids that depends on the functional excipient of direct compression of: 1:1, 1:0.9, 1:0.8, 1:0.7, 1:0.6, 1:0.5, 1:0.4, 1:0.3, 1:0.2, 1:0.1; (c) adjusting to 1 Lt of constant volume with water, where said water amount will depend on the weight of the functional excipient of direct compression, and the container; (d) maintaining under constant mechanical agitation the composition for 24 hours in order to perform the assembling process by means of the polymer adsorption over the functional excipient of direct compression; (e) letting to rest the composition for a period of 24 hours; (f) decanting the solids settled in the container; (g) drying the excess of humidity at a temperature ranging from 30°C to 40°C, using any furnace drying method, using spray drying; and (h) sieving the collected powders with the purpose of homogenizing the particle size to be compressed, being sieved in meshes of 50, 60 or 70.