MX344737B - Forms of rifaximin and uses thereof. - Google Patents

Forms of rifaximin and uses thereof.

Info

Publication number
MX344737B
MX344737B MX2012006275A MX2012006275A MX344737B MX 344737 B MX344737 B MX 344737B MX 2012006275 A MX2012006275 A MX 2012006275A MX 2012006275 A MX2012006275 A MX 2012006275A MX 344737 B MX344737 B MX 344737B
Authority
MX
Mexico
Prior art keywords
rifaximin
forms
hydrate
salt
relates
Prior art date
Application number
MX2012006275A
Other languages
Spanish (es)
Inventor
S Gushurst Karen
Yang Donglai
Roe Melanie
Schultheiss Nathan
Vlahova Petinka
S Stults Jeffrey
l houston Travis
Original Assignee
Salix Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41016698&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX344737(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Salix Pharmaceuticals Ltd filed Critical Salix Pharmaceuticals Ltd
Publication of MX344737B publication Critical patent/MX344737B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The present invention relates to Rifaximin polymorphic, salt, hydrate, and amorphous forms, to their use in medicinal preparations and to therapeutic methods using them.
MX2012006275A 2008-02-25 2009-02-25 Forms of rifaximin and uses thereof. MX344737B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3132908P 2008-02-25 2008-02-25
PCT/US2009/035192 WO2009108730A2 (en) 2008-02-25 2009-02-25 Forms of rifaximin and uses thereof

Publications (1)

Publication Number Publication Date
MX344737B true MX344737B (en) 2017-01-05

Family

ID=41016698

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010009389A MX2010009389A (en) 2008-02-25 2009-02-25 Forms of rifaximin and uses thereof.
MX2012006275A MX344737B (en) 2008-02-25 2009-02-25 Forms of rifaximin and uses thereof.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010009389A MX2010009389A (en) 2008-02-25 2009-02-25 Forms of rifaximin and uses thereof.

Country Status (21)

Country Link
US (7) US8067429B2 (en)
EP (1) EP2257557A4 (en)
JP (2) JP5706693B2 (en)
KR (1) KR101674382B1 (en)
CN (2) CN104650114A (en)
AU (1) AU2009219342B2 (en)
BR (1) BRPI0908864A2 (en)
CA (1) CA2716830C (en)
CR (2) CR11657A (en)
EA (2) EA201370208A1 (en)
GE (1) GEP20135898B (en)
IL (1) IL207730A (en)
MA (1) MA32161B1 (en)
ME (1) ME01032B (en)
MX (2) MX2010009389A (en)
MY (1) MY158257A (en)
NZ (1) NZ587099A (en)
SG (2) SG188931A1 (en)
UA (2) UA113275C2 (en)
WO (1) WO2009108730A2 (en)
ZA (2) ZA201005961B (en)

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US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
ITMI20032144A1 (en) 2003-11-07 2005-05-08 Alfa Wassermann Spa REFLEXIMINE POLIMORPHIC FORMS, PROCESSES TO OBTAIN THEM AND
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
ES2522895T3 (en) 2005-03-03 2014-11-19 Alfa Wassermann S.P.A. New polymorphic forms of rifaximin, procedures for their production and use in medicinal preparations
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
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US7928115B2 (en) * 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
PL2350096T3 (en) 2008-10-02 2020-06-29 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
US9018684B2 (en) 2009-11-23 2015-04-28 California Institute Of Technology Chemical sensing and/or measuring devices and methods
IT1397107B1 (en) * 2009-12-28 2012-12-28 Lavagna NEW METHOD FOR THE PREPARATION OF ANTIBIOTICS IN THE STATE AMORPHOUS AND PRODUCTS OBTAINED BY USING THIS METHOD.
EP2401282B2 (en) † 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
IT1399141B1 (en) * 2010-04-02 2013-04-05 Secci METHOD FOR THE PREPARATION OF RIFAXIMINA IN THE AMORPHOUS STATE.
IT1398550B1 (en) * 2010-03-05 2013-03-01 Alfa Wassermann Spa RIFAXIMINA COMPREHENSIVE FORMULATIONS USEFUL TO OBTAIN A PROLONGED EFFECT IN TIME
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WO2012035544A2 (en) * 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
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WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITMI20110890A1 (en) * 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A POLYMORPHO OF RIFAXIMINA AND PROCESS FOR ITS PREPARATION
ITMI20110983A1 (en) * 2011-05-30 2012-12-01 A M S A Anonima Materie Sint & Affini S P A RIFAXIMINA AMORPHOUS AND PROCESS FOR ITS PREPARATION
WO2013027227A1 (en) * 2011-07-20 2013-02-28 Ind-Swift Laboratories Limited Novel polymorphic form i of rifaximin
ITBO20110461A1 (en) 2011-07-29 2013-01-30 Alfa Wassermann Spa PHARMACEUTICAL COMPOSITIONS INCLUDING RIFAXIMINA, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF VAGINAL INFECTIONS.
US20130184302A1 (en) * 2011-11-02 2013-07-18 Enoch Bortey Methods for treating irritable bowel syndrome (ibs) and infections
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WO2013185211A1 (en) * 2012-06-13 2013-12-19 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
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EP2401282B2 (en) * 2009-12-28 2017-01-04 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
NZ603590A (en) 2010-06-03 2015-08-28 Salix Pharmaceuticals Ltd New forms of rifaximin and uses thereof
WO2011156897A2 (en) 2010-06-16 2011-12-22 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
AU2012214239B2 (en) 2011-02-11 2016-06-30 Salix Pharmaceuticals, Ltd. Forms of Rifaximin and uses thereof

Also Published As

Publication number Publication date
CR20150401A (en) 2015-11-19
WO2009108730A2 (en) 2009-09-03
US9700545B2 (en) 2017-07-11
US8067429B2 (en) 2011-11-29
MA32161B1 (en) 2011-03-01
EP2257557A4 (en) 2011-06-29
MY158257A (en) 2016-09-30
AU2009219342A1 (en) 2009-09-03
JP5706693B2 (en) 2015-04-22
CN102015725B (en) 2014-10-22
MX2010009389A (en) 2010-11-22
SG10201607926VA (en) 2016-11-29
GEP20135898B (en) 2013-08-12
US20100239664A1 (en) 2010-09-23
EP2257557A2 (en) 2010-12-08
US20150299199A1 (en) 2015-10-22
CR11657A (en) 2010-11-22
KR20100127797A (en) 2010-12-06
EA021176B1 (en) 2015-04-30
JP2011513243A (en) 2011-04-28
IL207730A (en) 2016-04-21
UA113275C2 (en) 2017-01-10
NZ587099A (en) 2012-08-31
US20130066079A1 (en) 2013-03-14
US20160317507A1 (en) 2016-11-03
CA2716830C (en) 2019-01-08
JP2015129168A (en) 2015-07-16
US20110105550A1 (en) 2011-05-05
US20120076857A1 (en) 2012-03-29
EA201001372A1 (en) 2011-04-29
CA2716830A1 (en) 2009-09-03
US8754098B2 (en) 2014-06-17
ZA201005961B (en) 2018-11-28
AU2009219342B2 (en) 2014-10-30
US20140011828A1 (en) 2014-01-09
US9359357B2 (en) 2016-06-07
KR101674382B1 (en) 2016-11-09
CN102015725A (en) 2011-04-13
ZA201308527B (en) 2014-07-30
IL207730A0 (en) 2010-12-30
US9181274B2 (en) 2015-11-10
BRPI0908864A2 (en) 2018-09-18
ME01032B (en) 2012-10-20
WO2009108730A3 (en) 2009-12-30
UA101829C2 (en) 2013-05-13
SG188931A1 (en) 2013-04-30
CN104650114A (en) 2015-05-27
EA201370208A1 (en) 2014-06-30

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