MX341474B - Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors. - Google Patents
Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors.Info
- Publication number
- MX341474B MX341474B MX2011010146A MX2011010146A MX341474B MX 341474 B MX341474 B MX 341474B MX 2011010146 A MX2011010146 A MX 2011010146A MX 2011010146 A MX2011010146 A MX 2011010146A MX 341474 B MX341474 B MX 341474B
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- substituted
- completely
- Prior art date
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Abstract
Compounds of formula (I), in which R1 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C-alkoxy, R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, 2,2-difluoroethoxy, or completely or predominantly fluorine-substituted 1-4C-alkoxy, or in which R1 and R2 together are a 1-2C-alkylenedioxy group, R3 is hydrogen or 1-4C-alkyl, R31 is hydrogen or 1-4C-alkyl, either, in a first embodiment (embodiment a) according to the present invention, R4 is -O-R41, in which R41 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, hydroxy-2-4C-alkyl, 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, and R5 is hydrogen or 1-4C-alkyl, or, in a second embodiment (embodiment b) according to the present invention, R4 is hydrogen or 1-4C-alkyl, and R5 is -O-R51, in which R51 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, hydroxy-2-4C-alkyl, 1-7C-alkylcarbonyl, or completely or predominantly fluorine-substituted 1-4C-alkyl, Har is optionally substituted by R6 and/or R7 and/or R8, and is a 5- to 10-membered monocylic or fused bicyclic unsaturated or partially saturated heteroaryl radical comprising 1 to 4 heteroatoms selected independently from the group consisting of oxygen, nitrogen and sulfur, are novel effective PDE4 inhibitors.
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EP04004973 | 2004-03-03 | ||
EP04106359 | 2004-12-07 | ||
PCT/EP2005/050931 WO2005085225A1 (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors |
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MX2011010146A MX341474B (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors. |
MXPA06009695A MXPA06009695A (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors. |
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MXPA06009695A MXPA06009695A (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors. |
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US (8) | US8003798B2 (en) |
EP (2) | EP1723135B1 (en) |
JP (2) | JP4801039B2 (en) |
KR (2) | KR101152439B1 (en) |
CN (6) | CN1922170A (en) |
AR (1) | AR049319A1 (en) |
AU (1) | AU2005219576B2 (en) |
BR (1) | BRPI0508321B1 (en) |
CA (1) | CA2557752C (en) |
CO (1) | CO5700749A2 (en) |
CY (2) | CY1114319T1 (en) |
DK (2) | DK1723135T5 (en) |
EA (2) | EA017282B1 (en) |
ES (2) | ES2505473T3 (en) |
HK (4) | HK1207635A1 (en) |
HR (2) | HRP20130828T1 (en) |
IL (2) | IL177073A (en) |
ME (1) | ME01955B (en) |
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NO (2) | NO336538B1 (en) |
NZ (1) | NZ549108A (en) |
PL (2) | PL2589599T4 (en) |
PT (2) | PT1723135E (en) |
RS (2) | RS52916B (en) |
SG (1) | SG182194A1 (en) |
SI (2) | SI2589599T1 (en) |
TW (2) | TWI372750B (en) |
WO (1) | WO2005085225A1 (en) |
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