MX339142B - Combinations and modes of administration of therapeutic agents and combination therapy. - Google Patents

Combinations and modes of administration of therapeutic agents and combination therapy.

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Publication number
MX339142B
MX339142B MX2011009748A MX2011009748A MX339142B MX 339142 B MX339142 B MX 339142B MX 2011009748 A MX2011009748 A MX 2011009748A MX 2011009748 A MX2011009748 A MX 2011009748A MX 339142 B MX339142 B MX 339142B
Authority
MX
Mexico
Prior art keywords
administration
combinations
combination therapy
modes
therapeutic agents
Prior art date
Application number
MX2011009748A
Other languages
Spanish (es)
Inventor
Neil P Desai
Patrick Soon-Shiong
Original Assignee
Abraxis Bioscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36593193&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX339142(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abraxis Bioscience Llc filed Critical Abraxis Bioscience Llc
Publication of MX339142B publication Critical patent/MX339142B/en

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    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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Abstract

The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
MX2011009748A 2005-02-18 2006-02-21 Combinations and modes of administration of therapeutic agents and combination therapy. MX339142B (en)

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Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US20030133955A1 (en) * 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
KR100904931B1 (en) * 1997-06-27 2009-06-29 아브락시스 바이오사이언스, 엘엘씨 Nanoparticles and Method for the Preparation Thereof
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
KR101476067B1 (en) 2002-09-06 2014-12-23 인설트 테라페틱스, 인코퍼레이티드 Cyclodextrin-based polymers for delivering the therapeutic agents covalently bound thereto
LT1585548T (en) * 2002-12-09 2018-09-25 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
ES2368941T3 (en) 2003-01-06 2011-11-23 Angiochem Inc. ANGIOPEP-1, RELATED COMPOUNDS AND CORRESPONDING UTILIZATIONS.
US20070166388A1 (en) * 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
NZ595313A (en) * 2005-02-18 2013-03-28 Abraxis Bioscience Llc The Use Of Nanoparticles Comprising Rapamycin Or Taxane In The Treatment Of Proliferative Diseases
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
AU2006259261B2 (en) * 2005-06-16 2013-06-13 Myrexis, Inc. Pharmaceutical compositions and use thereof
PL2233156T3 (en) 2005-07-15 2013-09-30 Angiochem Inc Use of aprotinin polypeptides as carriers in pharmaceutical conjugates
DE102005039579B4 (en) * 2005-08-19 2022-06-30 Magforce Ag Method for introducing therapeutic substances into cells
KR101643416B1 (en) 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 Compositions and methods for preparation of poorly water soluble drugs with increased stability
CA2880727C (en) * 2005-08-31 2019-05-07 Neil P. Desai Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
RU2010104916A (en) * 2006-08-16 2011-08-20 Михаил В. Благосклонный (US) METHOD FOR PREVENTION AND TREATMENT OF AGE DISEASES
US20080280987A1 (en) * 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
MX2009002054A (en) * 2006-08-31 2009-05-01 Abraxis Bioscience Llc Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases.
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168661B2 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
CA2672618C (en) * 2006-12-14 2021-03-02 Abraxis Bioscience, Llc Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane
US20080176958A1 (en) 2007-01-24 2008-07-24 Insert Therapeutics, Inc. Cyclodextrin-based polymers for therapeutics delivery
AU2015271950B2 (en) * 2007-03-07 2017-09-28 Abraxis Bioscience, Llc Nanoparticle comprising rapamycin and albumin as anticancer agent
KR20150002886A (en) * 2007-03-07 2015-01-07 아브락시스 바이오사이언스, 엘엘씨 Nanoparticle comprising rapamycin and albumin as anticancer agent
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
WO2008124828A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Methods for treating vascular disruption disorders
AU2008236993A1 (en) * 2007-04-10 2008-10-16 Myrexis, Inc. Method of treating brain cancer
AU2008236994A1 (en) * 2007-04-10 2008-10-16 Myrexis, Inc. Method of treating melanoma
WO2008124824A1 (en) * 2007-04-10 2008-10-16 Myriad Genetics, Inc. Dosages and methods for the treatment of cancer
CA2720989A1 (en) * 2007-04-10 2008-10-16 Myrexis, Inc. Methods for treating cancer
EP3326630A3 (en) 2007-05-03 2018-08-29 Abraxis BioScience, LLC Methods and compositions for treating pulmonary hypertension
WO2008140751A1 (en) * 2007-05-11 2008-11-20 Champions Biotechnology, Inc. Human leiosarcoma and non small cell lung cancer lung xenograft models
US9365634B2 (en) 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
AU2008260447B2 (en) * 2007-06-01 2013-10-10 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
WO2008149230A2 (en) * 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
CA2686225A1 (en) * 2007-06-22 2008-12-31 Scidose Llc Solubilized formulation of docetaxel without tween 80
US8558019B2 (en) * 2007-11-08 2013-10-15 Virginia Tech Intellectual Properties, Inc. Thiolated paclitaxels for reaction with gold nanoparticles as drug delivery agents
EP2240162A4 (en) 2007-12-06 2013-10-09 Bend Res Inc NANOPARTICLES COMPRISING A NON-IONIZABLE POLYMER AND AN AMINO-FUNCTIONALIZED METHACRYLATE COPOLYMER
WO2009078755A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
EP2259844A4 (en) * 2008-03-05 2012-02-01 Vicus Therapeutics Llc COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGY THERAPIES
WO2009126401A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
JP5860698B2 (en) * 2008-04-18 2016-02-16 アンジオケム，インコーポレーテッド Pharmaceutical compositions of paclitaxel, paclitaxel analogues or paclitaxel conjugates and related methods of preparation and use
ES2774226T3 (en) 2008-05-15 2020-07-17 Celgene Corp Oral formulations of cytidine analogues and methods of use thereof
US20110086005A1 (en) * 2008-05-27 2011-04-14 Oncolytics Biotech Inc. Modulating interstitial pressure and oncolytic viral delivery and distribution
UA104147C2 (en) * 2008-09-10 2014-01-10 Новартис Аг PYROLIDINDICARBONIC ACID DERIVATIVE AND ITS APPLICATION IN THE TREATMENT OF PROLIFERATIVE DISEASES
EP2346906A4 (en) 2008-10-15 2013-04-24 Angiochem Inc Conjugates of glp-1 agonists and uses thereof
JP5705118B2 (en) 2008-10-15 2015-04-22 アンジオケム インコーポレーテッド Etoposide and doxorubicin complex for drug delivery
JP5759379B2 (en) 2008-12-05 2015-08-05 アンジオケム インコーポレーテッド Neurotensin or neurotensin analog and use thereof
US20120128732A1 (en) * 2008-12-11 2012-05-24 Vuong Trieu Combinations and modes of administration of therapeutic agents and combination therapy
WO2010069074A1 (en) 2008-12-17 2010-06-24 Universite Du Quebec A Montreal Membrane type-1 matrix metalloprotein inhibitors and uses thereof
CN102427728A (en) * 2009-03-13 2012-04-25 阿布拉科斯生物科学有限公司 Combination therapy with thiocolchicine derivatives
WO2010114770A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-agent conjugates, particles, compositions, and related methods of use
EA201171195A8 (en) * 2009-03-30 2014-08-29 Серулин Фарма Инк. CONJUGATES, PARTICLES, POLYMER-AGENT COMPOSITIONS AND METHODS OF THEIR APPLICATION
WO2010114768A1 (en) * 2009-03-30 2010-10-07 Cerulean Pharma Inc. Polymer-epothilone conjugates, particles, compositions, and related methods of use
PT2419732T (en) * 2009-04-15 2019-12-24 Abraxis Bioscience Llc Prion-free nanoparticle compositions and methods
EP2421562B1 (en) 2009-04-20 2019-03-13 Angiochem Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US10363229B2 (en) * 2009-06-05 2019-07-30 Joan McInyre Caron Methods and compositions for the treatment of cancer
RU2012103240A (en) 2009-07-02 2013-08-10 Ангиокем Инк. MULTI-DIMENSIONAL PEPTIDE CONJUGATES AND THEIR APPLICATION
US9340697B2 (en) 2009-08-14 2016-05-17 Nano-C, Inc. Solvent-based and water-based carbon nanotube inks with removable additives
CN102573832B (en) 2009-08-25 2015-07-22 阿布拉科斯生物科学有限公司 Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
JP2013505268A (en) * 2009-09-18 2013-02-14 アブラクシス バイオサイエンス リミテッド ライアビリティー カンパニー Use of the SPARC microenvironment signature in the treatment of cancer
US8541465B2 (en) * 2009-10-19 2013-09-24 Scidose, Llc Docetaxel formulations with lipoic acid and/or dihydrolipoic acid
US8912228B2 (en) 2009-10-19 2014-12-16 Scidose Llc Docetaxel formulations with lipoic acid
US20110092579A1 (en) * 2009-10-19 2011-04-21 Scidose Llc Solubilized formulation of docetaxel
US7772274B1 (en) 2009-10-19 2010-08-10 Scidose, Llc Docetaxel formulations with lipoic acid
WO2011063356A2 (en) * 2009-11-22 2011-05-26 Sirnaomics, Inc. Rare earth-doped up-conversion nanoparticles for therapeutic and diagnostic applications
MX2012008153A (en) * 2010-01-12 2012-11-06 Nestec Sa METHODS TO PREACH THE NEGATIVE TRIPLE CANCER THERAPY CANCER RESPONSE.
PL2552438T3 (en) 2010-03-26 2016-12-30 METHODS OF TREATMENT OF Hepatocellular Cancer
BR112012024590A2 (en) 2010-03-29 2016-05-31 Abraxis Bioscience Inc methods of enhancing drug release and efficacy of therapeutic agents
RU2016119999A (en) 2010-03-29 2018-11-08 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи METHODS FOR TREATING ONCOLOGICAL DISEASES
WO2011127405A1 (en) * 2010-04-08 2011-10-13 Sanford-Burnham Medical Research Institute Methods and compositions for enhanced delivery of compounds
EP2382993A1 (en) 2010-04-19 2011-11-02 KTB Tumorforschungsgesellschaft mbH Combination of drugs with protein-binding prodrugs
SG186109A1 (en) * 2010-06-02 2013-01-30 Abraxis Bioscience Llc Methods of treating bladder cancer
CN103002905A (en) * 2010-06-03 2013-03-27 阿布拉西斯生物科学有限责任公司 Use of the SPARC microenvironment signature in the treatment of cancer
JP6257324B2 (en) * 2010-06-04 2018-01-10 アブラクシス バイオサイエンス， エルエルシー How to treat pancreatic cancer
EP3056201A1 (en) * 2010-06-07 2016-08-17 Abraxis BioScience, LLC Combination therapy methods for treating proliferative diseases
KR101223484B1 (en) * 2010-10-05 2013-01-17 한국과학기술연구원 HUMAN SERUM ALBUMIN-siRNA NANO-SIZED CARRIER SYSTEM
US8884027B2 (en) 2010-10-22 2014-11-11 University Of Rochester Melampomagnolide B derivatives as antileukemic and cytotoxic agents
RU2013127625A (en) * 2010-11-18 2014-12-27 Зе Дженерал Хоспитал Корпорейшен NEW COMPOSITIONS AND APPLICATIONS OF ANTIHYPERTENSIVE MEDICINES FOR CANCER THERAPY
CA2819246C (en) * 2010-12-02 2023-04-25 Oncolytics Biotech Inc. Liquid viral formulations
US9044498B2 (en) 2010-12-02 2015-06-02 Oncolytics Biotech Inc. Lyophilized viral formulations
CA3063641A1 (en) * 2011-04-28 2012-11-01 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
ES2792062T3 (en) 2011-05-09 2020-11-06 Mayo Found Medical Education & Res Cancer treatments
MY194408A (en) 2011-10-14 2022-11-30 Genentech Inc Uses for and Article of Manufacture Including Her2 Dimerization Inhibitor Pertuzumab
BR112014010417A2 (en) 2011-11-01 2014-11-18 Celgene Corp METHODS FOR CANCER TREATMENT USING ORAL FORMULATIONS OF CITIDINE ANALOGS
WO2013085902A1 (en) 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
SMT201900502T1 (en) 2011-12-14 2019-11-13 Abraxis Bioscience Llc Use of polymeric excipients for lyophilization or freezing of particles
GB201121924D0 (en) * 2011-12-20 2012-02-01 Fahy Gurteen Labs Ltd Detection of breast cancer
EP2630971B8 (en) * 2012-02-21 2017-12-13 Vergell Medical S.A. Combinations of albumin-based drug delivery systems
US9913822B2 (en) 2012-04-04 2018-03-13 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
US20150150995A1 (en) * 2012-08-09 2015-06-04 Pono Corporation Conjugated anti-microbial compounds and conjugated anti-cancer compounds and uses thereof
AU2013313050A1 (en) * 2012-09-04 2015-03-26 Novartis Ag Method of adjuvant cancer treatment
ES2899643T3 (en) 2012-10-01 2022-03-14 Mayo Found Medical Education & Res cancer treatments
US20140094432A1 (en) 2012-10-02 2014-04-03 Cerulean Pharma Inc. Methods and systems for polymer precipitation and generation of particles
US9149455B2 (en) * 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
EA029706B1 (en) 2012-11-12 2018-05-31 Игнайта, Инк. Bendamustine alkyl esters and methods of using same
WO2014078522A1 (en) 2012-11-14 2014-05-22 Ohio State Innovation Foundation Materials and methods useful for treating glioblastoma
CN107698470A (en) 2012-11-30 2018-02-16 诺沃梅迪科斯有限公司 Substituted diaryl sulfonamide and application thereof
WO2014087230A1 (en) * 2012-12-04 2014-06-12 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of breast cancer
CN104688740A (en) * 2012-12-21 2015-06-10 百奥泰生物科技(广州)有限公司 Related maytansine derivatives and preparation method and application thereof
US20140199404A1 (en) * 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on level of a nucleoside transporter
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
US20140199405A1 (en) * 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on mutation status of k-ras
US9962452B2 (en) 2013-02-04 2018-05-08 Zhuhai Beihai Biotech Co., Ltd. Soluble complexes of drug analogs and albumin
CN109200031A (en) 2013-02-11 2019-01-15 阿布拉科斯生物科学有限公司 The method for treating melanoma
JP6349381B2 (en) * 2013-03-12 2018-06-27 アブラクシス バイオサイエンス， エルエルシー How to treat lung cancer
HUE044238T2 (en) 2013-03-13 2019-10-28 Oncoceutics Inc 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-on for use in the treatment of cancer
US9376437B2 (en) 2013-03-13 2016-06-28 Oncoceutics, Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
US20160015817A1 (en) 2013-03-13 2016-01-21 Abraxis Bioscience, Llc Methods of treatment of pediatric solid tumor
US9688679B2 (en) 2013-03-13 2017-06-27 Oncoceutics, Inc. 7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
NZ630213A (en) 2013-03-14 2017-05-26 Abraxis Bioscience Llc Methods of treating bladder cancer
WO2014165842A2 (en) * 2013-04-05 2014-10-09 Igdrasol Nanoparticle formulations in biomarker detection
KR101329646B1 (en) * 2013-05-02 2013-11-14 주식회사 지니스 Targeting-enhancing anticancer nanoparticles and preparation method the same
WO2015102680A2 (en) 2013-09-11 2015-07-09 The Board Of Trustees Of The Leland Stanford Junior University Methods and systems for beam intensity-modulation to facilitate rapid radiation therapies
WO2015042234A1 (en) * 2013-09-20 2015-03-26 Igdrasol Conditionally stable micelle compositions for cancer treatment including ovarian cancer
WO2015048467A1 (en) * 2013-09-27 2015-04-02 Cerulean Pharma Inc. Treatment of cancer
US10842969B2 (en) 2013-10-25 2020-11-24 Mercator Medsystems, Inc. Systems and methods of treating malacia by local delivery of hydrogel to augment tissue
KR20160093609A (en) * 2013-10-25 2016-08-08 머케이터 메드시스템즈, 인크. Maintenance of bronchial patency by local delivery of cytotoxic, cytostatic, or anti-neoplastic agent
KR20250006309A (en) * 2013-11-15 2025-01-10 온코슈틱스 인코포레이티드 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, salts thereof and methods of use
FI20130341A7 (en) 2013-11-19 2015-05-20 Oy Safemed Ltd Improved delivery of poorly water soluble drugs with alpha-fetoprotein stabilized with metal ions
PL3076969T3 (en) * 2013-12-06 2022-01-17 Novartis Ag Dosage regimen for an alpha-isoform selective phosphatidylinositol 3-kinase inhibitor
NO2699580T3 (en) 2014-01-24 2018-02-24
EP2924022A1 (en) * 2014-03-27 2015-09-30 INDENA S.p.A. Amorphous form of a thiocolchicine derivative
AU2015274408A1 (en) 2014-06-13 2017-01-12 Mayo Foundation For Medical Education And Research Treating lymphomas
US10213513B2 (en) 2014-06-16 2019-02-26 Mayo Foundation For Medical Education And Research Treating myelomas
WO2015195634A1 (en) 2014-06-17 2015-12-23 Celgne Corporation Methods for treating epstein-barr virus (ebv) associated cancers using oral formulations of 5-azacytidine
US9937259B2 (en) 2014-06-27 2018-04-10 Zhuhai Beihai Biotech Co., Ltd. Abiraterone derivatives and non-covalent complexes with albumin
WO2015018380A2 (en) 2014-07-03 2015-02-12 Cspc Zhongqi Pharmaceutical Technology(Shijiazhuang)Co., Ltd. Therapeutic nanoparticles and the preparation methods thereof
US9446148B2 (en) 2014-10-06 2016-09-20 Mayo Foundation For Medical Education And Research Carrier-antibody compositions and methods of making and using the same
WO2016065283A1 (en) * 2014-10-24 2016-04-28 Bishop Alexander James Roy Methods and compositions for enhancing chemotherapy
US10201617B2 (en) 2014-10-24 2019-02-12 Zhuhai Beihai Biotech Co., Ltd. 3-substituted piperidine-2, 6-diones and non-covalent complexes with albumin
CN113149985B (en) 2015-01-30 2025-01-28 昂克希尔迪克斯有限公司 Hexahydroimidazopyridopyrimidone, its analogs and salts, and therapeutic uses thereof
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
WO2016172515A1 (en) 2015-04-23 2016-10-27 Sanford Burnham Prebys Medical Discovery Institute Targeted delivery system and methods of use therefor
CA2989400A1 (en) 2015-06-15 2016-12-22 Angiochem Inc. Ang1005 for the treatment of leptomeningeal carcinomatosis
JP6987644B2 (en) 2015-06-29 2022-01-05 アブラクシス バイオサイエンス， エルエルシー How to treat epithelioid cell tumors
TW201707725A (en) 2015-08-18 2017-03-01 美國馬友醫藥教育研究基金會 Carrier-antibody compositions and methods of making and using the same
TW201713360A (en) 2015-10-06 2017-04-16 Mayo Foundation Methods of treating cancer using compositions of antibodies and carrier proteins
US11433136B2 (en) 2015-12-18 2022-09-06 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
US11571469B2 (en) 2016-01-07 2023-02-07 Mayo Foundation For Medical Education And Research Methods of treating cancer with interferon wherein the cancer cells are HLA negative or have reduced HLA expression
US11351254B2 (en) 2016-02-12 2022-06-07 Mayo Foundation For Medical Education And Research Hematologic cancer treatments
KR20180107257A (en) 2016-02-19 2018-10-01 난트 홀딩스 아이피, 엘엘씨 METHODS OF IMMUNOGENIC MODULATION
CA3018341A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for reducing toxicity of a chemotherapeutic drug
WO2017165439A1 (en) 2016-03-21 2017-09-28 Mayo Foundation For Medical Education And Research Methods for improving the therapeutic index for a chemotherapeutic drug
SG11201807770RA (en) 2016-03-24 2018-10-30 Nantcell Inc Sequence arrangements and sequences for neoepitope presentation
US10618969B2 (en) 2016-04-06 2020-04-14 Mayo Foundation For Medical Education And Research Carrier-binding agent compositions and methods of making and using the same
AU2017273495B2 (en) 2016-06-02 2023-01-12 Innopharmax, Inc. Metronomic oral gemcitabine for cancer therapy
TW201803598A (en) 2016-06-30 2018-02-01 南特細胞公司 NANT cancer vaccine
WO2018026965A1 (en) 2016-08-02 2018-02-08 Isi Life Sciences, Inc. Compositions and methods for detecting cancer cells in a tissue sample
RU2019105550A (en) 2016-08-05 2020-09-07 Мэйо Фаундейшн Фор Медикал Эдьюкейшн Энд Рисерч Modified complexes with antibody-albumin nanoparticles for the treatment of malignant neoplasm
CN107714652B (en) * 2016-08-12 2021-03-02 四川科伦药物研究院有限公司 Tesirolimus albumin nano composition and freeze-dried preparation, preparation method and application thereof
RU2752172C2 (en) 2016-08-31 2021-07-23 Фуджифилм Корпорэйшн Antitumor agent, antitumor enhancer and antitumor kit
EP3506950A1 (en) 2016-09-01 2019-07-10 Mayo Foundation for Medical Education and Research Methods and compositions for targeting t-cell cancers
CA3035378A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Carrier-pd-l1 binding agent compositions for treating cancers
EP3509643A1 (en) 2016-09-06 2019-07-17 Mayo Foundation for Medical Education and Research Paclitaxel-albumin-binding agent compositions and methods for using and making the same
EP3509635A1 (en) 2016-09-06 2019-07-17 Vavotar Life Sciences LLC Methods of treating triple-negative breast cancer using compositions of antibodies and carrier proteins
AU2017324335A1 (en) 2016-09-06 2019-03-28 Mayo Foundation For Medical Education And Research Methods of treating PD-L1 expressing cancer
US10973773B2 (en) 2016-09-13 2021-04-13 Tiziana Life Sciences Plc Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
EP3541404A1 (en) 2016-11-21 2019-09-25 Bexion Pharmaceuticals, Inc. A combination therapy including sapc-dops for the treatment of pancreatic cancer
EP3541931A4 (en) 2016-11-21 2020-11-04 Nant Holdings IP, LLC FRACTAL COMBINATION THERAPY
WO2018115953A1 (en) * 2016-12-21 2018-06-28 Prometic Pharma Smt Limited Methods and compositions for preventing or minimizing epithelial-mesenchymal transition
US11229668B2 (en) 2017-02-07 2022-01-25 Nantcell, Inc. Maximizing T-cell memory and compositions and methods therefor
US20180235936A1 (en) * 2017-02-17 2018-08-23 University Of Notre Dame Du Lac Cancer treatment methods
CN116531511A (en) 2017-03-02 2023-08-04 豪夫迈·罗氏有限公司 Adjuvant therapy of HER2 positive breast cancer
JP7051898B2 (en) 2017-04-24 2022-04-11 ナントセル，インコーポレイテッド Targeted neoepitope vector and method for it
US10753942B2 (en) 2017-05-15 2020-08-25 Indicator Systems International, Inc. Methods to detect remnant cancer cells
EP3654976A1 (en) 2017-07-21 2020-05-27 Varian Medical Systems, Inc. Methods of use of ultra-high dose rate radiation and therapeutic agents
KR102758037B1 (en) * 2017-08-18 2025-01-22 코테라 바이오사이언스 인코포레이티드 Polymorphic forms of TG02
JP2020536855A (en) * 2017-09-26 2020-12-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Compositions and Methods for Treating Cancer
IL274444B2 (en) 2017-11-06 2024-06-01 Rapt Therapeutics Inc Chemokine receptor modulators for treatment of epstein barr virus positive cancer
US11773187B2 (en) 2018-01-17 2023-10-03 Nantbio, Inc. Enhanced immunogenicity for GPI-anchored antigens
EP4495136A3 (en) 2018-01-26 2025-04-23 The Regents of the University of California Methods and compositions for treatment of angiogenic disorders using anti-vegf agents
SI3758708T1 (en) 2018-03-01 2025-04-30 Astrazeneca Ab Pharmaceutical compositions comprising (2s)-{(1s)-1-cyano-2-[4-(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)phenyl]ethyl}-1,4-oxazepane-2-carboxamide
RU2020134124A (en) 2018-03-20 2022-04-20 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи METHODS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS BY INTRODUCTION OF NANOPARTICLES CONTAINING mTOR AND ALBUMIN INHIBITOR
AU2019247655A1 (en) 2018-04-03 2020-10-01 Vaxess Technologies, Inc. Microneedle comprising silk fibroin applied to a dissolvable base
US11823773B2 (en) 2018-04-13 2023-11-21 Nant Holdings Ip, Llc Nant cancer vaccine strategies
EP3810091A4 (en) 2018-05-22 2022-03-02 Abraxis BioScience, LLC METHODS AND COMPOSITIONS FOR THE TREATMENT OF PULMONARY HYPERTENSION
CA3106269A1 (en) 2018-07-17 2020-01-23 Insmed Incorporated Certain (2s)-n-[(1s)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating lupus nephritis
US20220226473A1 (en) * 2018-09-30 2022-07-21 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. Nucleic acid nanocarrier drug and preparation method thereof, pharmaceutical composition and application thereof
EP3926047A4 (en) * 2018-10-16 2023-08-09 Bai Yao Zhi Da (Beijing) Nanobio Technology Co., Ltd. NUCLEIC ACID NANO-BEARING MEDICINE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
WO2020112868A1 (en) * 2018-11-30 2020-06-04 Aileron Therapeutics, Inc. Combination therapy of peptidomimetic macrocycles
RU2706347C1 (en) * 2019-07-24 2019-11-18 ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ ИМЕНИ АКАДЕМИКА А.М. ГРАНОВА" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ / ФГБУ "РНЦРХТ им. ак. А.М. Гранова" Минздрава России Method of treating operable pancreatic head adenocarcinoma
WO2021086946A1 (en) 2019-10-28 2021-05-06 Abraxis Bioscience, Llc Pharmaceutical compositions of albumin and rapamycin
BR112022010113A2 (en) 2019-11-25 2022-09-06 Univ California LONG-ACTING VEGF INHIBITORS FOR INTRAOCULAR NEOVASCULARIZATION
CN116917009A (en) 2021-02-19 2023-10-20 美国迈胜医疗系统有限公司 Rack for particle therapy system
CN114949200B (en) * 2021-02-20 2025-08-19 北京大学人民医院 Application of all-trans retinoic acid combined with low-dose rituximab in preparation of medicines for treating hormone resistance or recurrent ITP
WO2022232420A1 (en) * 2021-04-29 2022-11-03 Insmed Incorporated Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating cancer
CN119013022A (en) 2022-03-14 2024-11-22 来凯有限公司 Combination therapy for cancer
WO2023250117A2 (en) 2022-06-24 2023-12-28 Vaxess Technologies, Inc. Applicator for medicament patch
EP4577212A1 (en) * 2022-08-26 2025-07-02 Ideaya Biosciences, Inc. Methods of treating uveal melanoma
WO2024081674A1 (en) 2022-10-11 2024-04-18 Aadi Bioscience, Inc. Combination therapies for the treatment of cancer
EP4646265A1 (en) 2023-01-06 2025-11-12 Insmed Incorporated Novel, reversible dpp1 inhibitors and uses thereof
WO2024228964A1 (en) 2023-04-30 2024-11-07 Aadi Bioscience, Inc. Treatments comprising an mtor inhibitor nanoparticle composition
WO2024243413A1 (en) 2023-05-24 2024-11-28 Aadi Bioscience, Inc. Combination therapy with a mtor inhibitor and a multi-tyrosine kinase inhibitor for treating soft tissue sarcoma
KR20260021782A (en) 2023-06-23 2026-02-13 백세스 테크놀로지스, 인코포레이티드 Applicator for drug patches
WO2025034870A1 (en) 2023-08-08 2025-02-13 Aadi Bioscience, Inc. Combination of nab-sirolimus and an estrogen suppresor for use in the treatment of hormone-dependent cancers
WO2025049962A1 (en) 2023-08-31 2025-03-06 Aadi Bioscience, Inc. Combination cancer treatments with a composition comprising an mtor pathway inhibitor
WO2025129108A1 (en) 2023-12-14 2025-06-19 Aadi Bioscience, Inc. Methods of treating a cancer in an individual

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206018A (en) * 1978-11-03 1993-04-27 Ayerst, Mckenna & Harrison, Inc. Use of rapamycin in treatment of tumors
US5470571A (en) 1988-01-27 1995-11-28 The Wistar Institute Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425
FR2660556B1 (en) 1990-04-06 1994-09-16 Rhone Poulenc Sante MICROSPHERES, THEIR PREPARATION PROCESS AND THEIR USE.
IL98528A0 (en) 1990-06-21 1992-07-15 Merck & Co Inc Pharmaceutical compositions containing hybrid for killing bladder cancer cells
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
KR100240308B1 (en) 1991-03-06 2000-01-15 플레믹 크리스티안 Humanized and chimeric monoclonal antibodies
US5811447A (en) 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
CA2086874E (en) * 1992-08-03 2000-01-04 Renzo Mauro Canetta Methods for administration of taxol
US6306421B1 (en) 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
FR2697752B1 (en) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Antitumor compositions containing taxane derivatives.
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6491938B2 (en) 1993-05-13 2002-12-10 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5498421A (en) * 1993-02-22 1996-03-12 Vivorx Pharmaceuticals, Inc. Composition useful for in vivo delivery of biologics and methods employing same
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US20030073642A1 (en) 1993-02-22 2003-04-17 American Bioscience, Inc. Methods and formulations for delivery of pharmacologically active agents
US5997904A (en) 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US5665382A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5665383A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5650156A (en) 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US6528067B1 (en) 1993-02-22 2003-03-04 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US20030133955A1 (en) 1993-02-22 2003-07-17 American Bioscience, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US20030068362A1 (en) 1993-02-22 2003-04-10 American Bioscience, Inc. Methods and formulations for the delivery of pharmacologically active agents
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US20070117862A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
DE69435002T2 (en) 1993-07-19 2008-03-20 Angiotech Pharmaceuticals, Inc., Vancouver Anti-angiogenic agents containing taxol and a non-biodegradable carrier and their use
US6441026B1 (en) * 1993-11-08 2002-08-27 Aventis Pharma S.A. Antitumor compositions containing taxane derivatives
AU1831395A (en) 1994-01-14 1995-08-01 Cell Therapeutics, Inc. Method for treating diseases mediated by cellular proliferation in response to pdgf, egf, fgf and vegf
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
US5662883A (en) 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US5534270A (en) 1995-02-09 1996-07-09 Nanosystems Llc Method of preparing stable drug nanoparticles
US5510118A (en) 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US5609629A (en) 1995-06-07 1997-03-11 Med Institute, Inc. Coated implantable medical device
US5744460A (en) 1996-03-07 1998-04-28 Novartis Corporation Combination for treatment of proliferative diseases
US6441025B2 (en) 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
US5977163A (en) 1996-03-12 1999-11-02 Pg-Txl Company, L. P. Water soluble paclitaxel prodrugs
US6239124B1 (en) 1996-07-30 2001-05-29 Novartis Ag Pharmaceutical compositions for the treatment of transplant rejection or autoimmune or inflammatory conditions comprising cyclosporin A and 40-0-(2-hydroxyethyl)-rapamycin
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
US20030199425A1 (en) 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
KR100904931B1 (en) 1997-06-27 2009-06-29 아브락시스 바이오사이언스, 엘엘씨 Nanoparticles and Method for the Preparation Thereof
US8853260B2 (en) 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6258084B1 (en) 1997-09-11 2001-07-10 Vnus Medical Technologies, Inc. Method for applying energy to biological tissue including the use of tumescent tissue compression
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
EP1071440B1 (en) 1998-04-16 2007-01-03 Eurovita A/S Novel synergistic compositions containing aromatic compounds and terpenoids present in alpinia galanga
WO2000006152A1 (en) * 1998-07-30 2000-02-10 Novopharm Biotech, Inc. Pharmaceutically acceptable composition comprising an aqueous solution of paclitaxel and albumin
US6682758B1 (en) 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
US6740665B1 (en) 1999-02-10 2004-05-25 Ramachandran Murali Tyrosine kinase inhibitors and methods of using the same
US6537585B1 (en) * 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
AU777528B2 (en) 1999-04-22 2004-10-21 Abraxis Bioscience, Llc Long term administration of pharmacologically active agents
HK1045646A1 (en) 1999-05-21 2002-12-06 Abraxis Bioscience, Llc Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
CA2373994A1 (en) 1999-05-24 2000-11-30 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
AU1916301A (en) 1999-11-12 2001-06-06 Children's Medical Center Corporation Methods for administration of therapeutic agents on an antiangiogenic schedule
US7740841B1 (en) 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
IT1318401B1 (en) * 2000-03-17 2003-08-25 Indena Spa N-DESACETYLTHIOCOLCHYCIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS WHICH CONTAIN.
WO2001076567A1 (en) 2000-04-10 2001-10-18 Teva Pharmaceutical Industries Ltd. Method and composition for treating cancer by administration of apoptosis-inducing chemotherapeutic agents
ITMI20001107A1 (en) * 2000-05-18 2001-11-18 Acs Dobfar Spa METHOD FOR TREATMENT OF SOLIC TUMORS BY INCORPORATING PACLITAXEL MICROPARTICLES OF ALBUMIN
IL153111A0 (en) 2000-06-30 2003-06-24 Glaxo Group Ltd Quinazoline ditosylate salt compounds
ATE526019T1 (en) 2000-07-28 2011-10-15 Sloan Kettering Inst Cancer METHOD FOR TREATING CELL PROLIFERATION DISORDERS AND VIRUS INFECTIONS
AU2001288805A1 (en) 2000-09-22 2002-04-02 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
DE60203260T2 (en) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford PHARMACEUTICAL COMBINATION CONTAINING A 4-CHINA-ZININAMINE AND PACLITAXEL, CARBOPLATIN OR VINORELBINE FOR THE TREATMENT OF CANCER
WO2002056755A2 (en) 2001-01-19 2002-07-25 Bionumerik Pharmaceuticals, Inc. Method for treating cancer
US6548531B2 (en) 2001-02-09 2003-04-15 Hoffmann-La Roche Inc. Method for cancer therapy
GB0103668D0 (en) 2001-02-15 2001-03-28 Biointeractions Ltd Methods and clinical devices for the inhibition or prevention of mammalian cell growth
WO2002069949A2 (en) 2001-03-06 2002-09-12 Prendergast Patrick T Combination therapy for reduction of toxycity of chemotherapeutic agents
EP1368034A1 (en) 2001-03-06 2003-12-10 Bristol-Myers Squibb Company Method and dosage form for treating tumors by the administration of tegafur, uracil, folinic acid, paclitaxel and carboplatin
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US7638161B2 (en) 2001-07-20 2009-12-29 Applied Materials, Inc. Method and apparatus for controlling dopant concentration during BPSG film deposition to reduce nitride consumption
US6872715B2 (en) 2001-08-06 2005-03-29 Kosan Biosciences, Inc. Benzoquinone ansamycins
US7056338B2 (en) 2003-03-28 2006-06-06 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
US20040033271A1 (en) 2001-12-03 2004-02-19 Seth Lederman Methods for contemporaneous administration of levamisole and 5-fluorouracil
US20040143004A1 (en) 2002-02-26 2004-07-22 Joseph Fargnoli Metronomic dosing of taxanes
ITMI20020681A1 (en) 2002-03-29 2003-09-29 Acs Dobfar Spa PROCEDURE FOR THE PRODUCTION OF PACLITAXEL AND ALBUMINA NANOPARTICLES
ITMI20020680A1 (en) 2002-03-29 2003-09-29 Acs Dobfar Spa IMPROVED ANTI-TUMOR COMPOSITION BASED ON PACLITAXEL AND METHOD FOR ITS OBTAINING
US20040126400A1 (en) 2002-05-03 2004-07-01 Iversen Patrick L. Delivery of therapeutic compounds via microparticles or microbubbles
US20050276812A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
US7794743B2 (en) 2002-06-21 2010-09-14 Advanced Cardiovascular Systems, Inc. Polycationic peptide coatings and methods of making the same
TWI272273B (en) 2002-07-16 2007-02-01 Sonus Pharma Inc Platinum compounds
CN1681495B (en) 2002-08-19 2010-05-12 辉瑞产品公司 Compositions for treating hyperproliferative diseases
US20040047835A1 (en) * 2002-09-06 2004-03-11 Cell Therapeutics, Inc. Combinatorial drug therapy using polymer drug conjugates
US20050158375A1 (en) * 2002-11-15 2005-07-21 Toshikiro Kimura Pharmaceutical composition containing liposomes for treating cancer
US20050095267A1 (en) 2002-12-04 2005-05-05 Todd Campbell Nanoparticle-based controlled release polymer coatings for medical implants
BR0317134A (en) * 2002-12-09 2005-11-22 American Bioscience Inc Pharmacological agent release compositions and methods
LT1585548T (en) 2002-12-09 2018-09-25 Abraxis Bioscience, Llc Compositions and methods of delivery of pharmacological agents
AU2004204778B2 (en) 2003-01-10 2008-05-22 Threshold Pharmaceuticals, Inc. Treatment of cancer with 2-deoxyglucose
MXPA05010388A (en) 2003-03-28 2006-03-08 Kosan Biosciences Inc Devices, methods, and compositions to prevent restenosis.
EP1643971A2 (en) 2003-05-22 2006-04-12 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
US20050026893A1 (en) 2003-05-30 2005-02-03 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants
KR20160014775A (en) 2003-05-30 2016-02-11 제넨테크, 인크. Treatment with anti-VEGF antibodies
AR046510A1 (en) 2003-07-25 2005-12-14 Regeneron Pharma COMPOSITION OF A VEGF ANTAGONIST AND AN ANTI-PROLIFERATIVE AGENT
EP1682181A2 (en) 2003-09-23 2006-07-26 Novartis AG Combination of a vegf receptor inhibitor with a chemotherapeutic agent
AU2004283464B8 (en) 2003-10-15 2011-04-14 Syncore Biotechnology Co., Ltd Method of administering cationic liposomes comprising an active drug
US20080045559A1 (en) 2003-10-29 2008-02-21 Sonus Pharmaceuticals, Inc. Tocopherol-modified therapeutic drug compounds
KR20060110872A (en) 2003-10-29 2006-10-25 소너스파머슈티칼즈인코포레이티드 Tocopherol Degeneration Therapeutics Drug Compounds
US20050203174A1 (en) 2004-03-09 2005-09-15 Kosan Biosciences, Inc. Combination therapies using leptomycin B
WO2005090372A2 (en) 2004-03-15 2005-09-29 Sonus Pharmaceuticals, Inc. Platinum carboxylate anticancer compounds
US20060003931A1 (en) 2004-05-06 2006-01-05 Genentech, Inc. Crystal structure of the hepatocyte growth factor and methods of use
WO2005117952A2 (en) 2004-05-14 2005-12-15 Abraxis Bioscience, Inc. Treatment methods utilizing albumin-binding proteins as targets
US8420603B2 (en) 2004-05-14 2013-04-16 Abraxis Bioscience, Llc SPARC and methods of use thereof
CN1960732A (en) * 2004-06-03 2007-05-09 霍夫曼-拉罗奇有限公司 Treatment with gemcitabine and EGFR-inhibitor
BRPI0510915A (en) 2004-06-04 2007-11-13 Genentech Inc Method for treating multiple sclerosis and manufactured article
GT200500155A (en) 2004-06-16 2006-05-15 PLATINUM-RESISTANT CANCER THERAPY
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
US20070166388A1 (en) 2005-02-18 2007-07-19 Desai Neil P Combinations and modes of administration of therapeutic agents and combination therapy
CN101160321A (en) 2005-02-18 2008-04-09 阿布拉西斯生物科学公司 Q3 SPARC deletion mutants and uses thereof
NZ595313A (en) 2005-02-18 2013-03-28 Abraxis Bioscience Llc The Use Of Nanoparticles Comprising Rapamycin Or Taxane In The Treatment Of Proliferative Diseases
JP5700909B2 (en) 2005-05-04 2015-04-15 メディゲーネ アクチエンゲゼルシャフトＭｅｄｉＧｅｎｅ ＡＧ Methods for administering cationic liposome formulations containing paclitaxel
US20080221135A1 (en) 2005-05-13 2008-09-11 Bristol-Myers Squibb Company Combination therapy
KR101643416B1 (en) * 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 Compositions and methods for preparation of poorly water soluble drugs with increased stability
CA2880727C (en) 2005-08-31 2019-05-07 Neil P. Desai Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
WO2007059116A2 (en) 2005-11-14 2007-05-24 Abraxis Bioscience, Inc. Geldanamycin derivatives and pharmaceutical compositions thereof
RU2448697C2 (en) 2006-03-22 2012-04-27 Медигене Аг Treating three receptor negative breast cancer
US9037257B2 (en) * 2006-04-07 2015-05-19 Medtronic, Inc. Resonance tuning module for implantable devices and leads
SG136814A1 (en) 2006-04-12 2007-11-29 Tencube Pte Ltd System for tracking mobile equipment and associated mobile subscribersæ identity
US20080280987A1 (en) * 2006-08-31 2008-11-13 Desai Neil P Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases
US20100112077A1 (en) 2006-11-06 2010-05-06 Abraxis Bioscience, Llc Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer
CA2672618C (en) 2006-12-14 2021-03-02 Abraxis Bioscience, Llc Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane
KR20150002886A (en) 2007-03-07 2015-01-07 아브락시스 바이오사이언스, 엘엘씨 Nanoparticle comprising rapamycin and albumin as anticancer agent
EP3326630A3 (en) 2007-05-03 2018-08-29 Abraxis BioScience, LLC Methods and compositions for treating pulmonary hypertension
AU2008260447B2 (en) 2007-06-01 2013-10-10 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
WO2009009587A2 (en) 2007-07-09 2009-01-15 Board Of Regents Of The University Of Nebraska Apoptosis-modulating protein therapy for proliferative disorders and nanoparticles containing the same
WO2009126401A1 (en) * 2008-04-10 2009-10-15 Abraxis Bioscience, Llc Compositions of hydrophobic taxane derivatives and uses thereof
WO2010118365A1 (en) 2009-04-10 2010-10-14 Abraxis Bioscience, Llc Nanoparticle formulations and uses therof
US20120128732A1 (en) 2008-12-11 2012-05-24 Vuong Trieu Combinations and modes of administration of therapeutic agents and combination therapy
CN102427728A (en) 2009-03-13 2012-04-25 阿布拉科斯生物科学有限公司 Combination therapy with thiocolchicine derivatives
PT2419732T (en) 2009-04-15 2019-12-24 Abraxis Bioscience Llc Prion-free nanoparticle compositions and methods
CN102573832B (en) 2009-08-25 2015-07-22 阿布拉科斯生物科学有限公司 Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
PL2552438T3 (en) 2010-03-26 2016-12-30 METHODS OF TREATMENT OF Hepatocellular Cancer
BR112012024590A2 (en) 2010-03-29 2016-05-31 Abraxis Bioscience Inc methods of enhancing drug release and efficacy of therapeutic agents
RU2016119999A (en) 2010-03-29 2018-11-08 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи METHODS FOR TREATING ONCOLOGICAL DISEASES
EP3085387A1 (en) 2010-04-26 2016-10-26 Abraxis BioScience, LLC Sparc binding antibodies and uses thereof
SG186109A1 (en) 2010-06-02 2013-01-30 Abraxis Bioscience Llc Methods of treating bladder cancer
JP6257324B2 (en) 2010-06-04 2018-01-10 アブラクシス バイオサイエンス， エルエルシー How to treat pancreatic cancer
EP3056201A1 (en) 2010-06-07 2016-08-17 Abraxis BioScience, LLC Combination therapy methods for treating proliferative diseases
CA3063641A1 (en) 2011-04-28 2012-11-01 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
SMT201900502T1 (en) 2011-12-14 2019-11-13 Abraxis Bioscience Llc Use of polymeric excipients for lyophilization or freezing of particles
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
US20140199405A1 (en) 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on mutation status of k-ras
US20140199404A1 (en) 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on level of a nucleoside transporter

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