MX3299E - PROCEDURE TO PREPARE 4- AMINO - PIRIDINES - Google Patents

PROCEDURE TO PREPARE 4- AMINO - PIRIDINES

Info

Publication number
MX3299E
MX3299E MX16676U MX16676U MX3299E MX 3299 E MX3299 E MX 3299E MX 16676 U MX16676 U MX 16676U MX 16676 U MX16676 U MX 16676U MX 3299 E MX3299 E MX 3299E
Authority
MX
Mexico
Prior art keywords
formula
group
atom
see gazette
represent
Prior art date
Application number
MX16676U
Other languages
Spanish (es)
Inventor
Helmut Vorbruggen
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of MX3299E publication Critical patent/MX3299E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

La presente invención se refiere a procedimiento para preparar 4-aminopiridinas de la fórmula general I; (VER GACETA) en la cual R1 y R2 que pueden ser iguales o diferentes, o un grupo alquilo con 1 a 4 átomos de carbono ó junto con el átomo de nitrógeno adyacente representan un anillo heterocíclico de 5 ó 6 miembros que puede contener como heteroátomo adicional un átomo de nitrógeno, oxígeno o azufre, en donde un cloruro de 4-piridilpiridinio o una sal del mismo se hace reaccionar con amida de ácido de la fórmula general II:(VER GACETA) en la cual R1 y R2 tienen los significados indicados arriba y Z representa un grupo de la fórmula -CO-R3, en el cual R3 representa un átomo de hidrógeno, un grupo alquilo inferior, un grupo de la fórmula: (VER GACETA) en la cual R4 y R5 cada uno representa un átomo de hidrógeno o un grupo de la fórmula: (VER GACETA) en la cual R4 y R5 tienen los significados arriba indicados: reacción que se lleva a cabo sin disolvente o en presencia de un disolvente inerte a una temperatura entre 120°C y 220°C con destilación contínua de la piridina producida.The present invention relates to a process for preparing 4-aminopyridines of the general formula I; (SEE GAZETTE) in which R1 and R2 which may be the same or different, or an alkyl group with 1 to 4 carbon atoms or together with the adjacent nitrogen atom represent a 5- or 6-membered heterocyclic ring that may contain as heteroatom additional a nitrogen, oxygen or sulfur atom, where a 4-pyridylpyridinium chloride or a salt thereof is reacted with an acid amide of the general formula II: (SEE GAZETTE) in which R1 and R2 have the indicated meanings above and Z represents a group of the formula -CO-R3, in which R3 represents a hydrogen atom, a lower alkyl group, a group of the formula: (SEE GAZETTE) in which R4 and R5 each represent an atom hydrogen or a group of the formula: (SEE GAZETTE) in which R4 and R5 have the meanings indicated above: reaction carried out without solvent or in the presence of an inert solvent at a temperature between 120 ° C and 220 ° C with continuous distillation of the pyridine produced.

MX16676U 1975-04-18 1976-04-12 PROCEDURE TO PREPARE 4- AMINO - PIRIDINES MX3299E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752517774 DE2517774C3 (en) 1975-04-18 1975-04-18 Process for the preparation of 4-aminopyridines

Publications (1)

Publication Number Publication Date
MX3299E true MX3299E (en) 1980-08-29

Family

ID=5944672

Family Applications (1)

Application Number Title Priority Date Filing Date
MX16676U MX3299E (en) 1975-04-18 1976-04-12 PROCEDURE TO PREPARE 4- AMINO - PIRIDINES

Country Status (13)

Country Link
JP (1) JPS604817B2 (en)
BE (1) BE840874A (en)
CA (1) CA1054604A (en)
CH (1) CH597189A5 (en)
DE (1) DE2517774C3 (en)
DK (1) DK142280C (en)
FR (1) FR2307802A1 (en)
GB (1) GB1548763A (en)
IE (1) IE43092B1 (en)
IT (1) IT1063241B (en)
LU (1) LU74766A1 (en)
MX (1) MX3299E (en)
NL (1) NL7604013A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390710A (en) 1981-10-19 1983-06-28 Ppg Industries, Inc. Catalyst system for manufacturing p-chlorophenyl-N-methyl carbamate
EP1422222B1 (en) * 1997-08-01 2008-12-03 Vertellus Specialties Inc. Process for preparing 4-[(di)alkylamino]pyridines
WO2024105319A1 (en) 2022-11-15 2024-05-23 Stellantis Auto Sas Motor vehicle structure with rear axle support reinforcement

Also Published As

Publication number Publication date
IE43092L (en) 1976-10-18
BE840874A (en) 1976-10-18
JPS604817B2 (en) 1985-02-06
CA1054604A (en) 1979-05-15
IE43092B1 (en) 1980-12-17
GB1548763A (en) 1979-07-18
DK142280C (en) 1981-06-29
DK142280B (en) 1980-10-06
DE2517774C3 (en) 1980-10-30
DK142276A (en) 1976-10-19
IT1063241B (en) 1985-02-11
FR2307802A1 (en) 1976-11-12
DE2517774B2 (en) 1980-02-28
LU74766A1 (en) 1976-11-11
DE2517774A1 (en) 1976-10-28
JPS51128973A (en) 1976-11-10
CH597189A5 (en) 1978-03-31
FR2307802B1 (en) 1979-05-11
NL7604013A (en) 1976-10-20

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