MX2024012179A - Derivados de n-(3-(benzo[b]tiofeno-2-carboxamido)-fenil)-2,3-dihidrobenzo[b][1,4]dioxino-6-carboxamida y compuestos relacionados como inhibidores de la produccion de lactato/atp para el tratamiento del cancer - Google Patents

Derivados de n-(3-(benzo[b]tiofeno-2-carboxamido)-fenil)-2,3-dihidrobenzo[b][1,4]dioxino-6-carboxamida y compuestos relacionados como inhibidores de la produccion de lactato/atp para el tratamiento del cancer

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Publication number
MX2024012179A
MX2024012179A MX2024012179A MX2024012179A MX2024012179A MX 2024012179 A MX2024012179 A MX 2024012179A MX 2024012179 A MX2024012179 A MX 2024012179A MX 2024012179 A MX2024012179 A MX 2024012179A MX 2024012179 A MX2024012179 A MX 2024012179A
Authority
MX
Mexico
Prior art keywords
cancer
dioxine
dihydrobenzo
carboxamido
thiophene
Prior art date
Application number
MX2024012179A
Other languages
English (en)
Spanish (es)
Inventor
Anika Tarasewicz
Christoph Steeneck
Bartosz Leszczynski
Andreia Vieira
Stefano Sechi
George Reid
Iryna Charapitsa
Johannes Fabian
Helen Krol
Claus Kremoser
Original Assignee
Wmt Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wmt Ag filed Critical Wmt Ag
Publication of MX2024012179A publication Critical patent/MX2024012179A/es

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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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MX2024012179A 2022-04-05 2024-10-02 Derivados de n-(3-(benzo[b]tiofeno-2-carboxamido)-fenil)-2,3-dihidrobenzo[b][1,4]dioxino-6-carboxamida y compuestos relacionados como inhibidores de la produccion de lactato/atp para el tratamiento del cancer MX2024012179A (es)

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