MX2023005081A - Anticuerpos multiespecificos para dirigirse a cd28 y pd-l1 y metodos de uso de los mismos. - Google Patents
Anticuerpos multiespecificos para dirigirse a cd28 y pd-l1 y metodos de uso de los mismos.Info
- Publication number
- MX2023005081A MX2023005081A MX2023005081A MX2023005081A MX2023005081A MX 2023005081 A MX2023005081 A MX 2023005081A MX 2023005081 A MX2023005081 A MX 2023005081A MX 2023005081 A MX2023005081 A MX 2023005081A MX 2023005081 A MX2023005081 A MX 2023005081A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- targeting
- multispecific antibodies
- antibodies
- discovering
- Prior art date
Links
- 230000008685 targeting Effects 0.000 title 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 abstract 1
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 abstract 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan en la presente anticuerpos que se unen selectivamente a CD28 y PD-L1, composiciones farmacéuticas de los mismos, así como ácidos nucleicos, y métodos de uso, y métodos para fabricar y descubrir los mismos.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063107942P | 2020-10-30 | 2020-10-30 | |
US202063123327P | 2020-12-09 | 2020-12-09 | |
US202063123329P | 2020-12-09 | 2020-12-09 | |
US202163141268P | 2021-01-25 | 2021-01-25 | |
US202163187690P | 2021-05-12 | 2021-05-12 | |
US202163187719P | 2021-05-12 | 2021-05-12 | |
US202163187699P | 2021-05-12 | 2021-05-12 | |
US202163189843P | 2021-05-18 | 2021-05-18 | |
PCT/US2021/057384 WO2022094299A2 (en) | 2020-10-30 | 2021-10-29 | Multispecific antibodies for targeting cd28 and pd-l1 and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023005081A true MX2023005081A (es) | 2023-06-15 |
Family
ID=81384468
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023005081A MX2023005081A (es) | 2020-10-30 | 2021-10-29 | Anticuerpos multiespecificos para dirigirse a cd28 y pd-l1 y metodos de uso de los mismos. |
Country Status (8)
Country | Link |
---|---|
US (1) | US20230406937A1 (es) |
EP (1) | EP4237013A2 (es) |
JP (1) | JP2023548443A (es) |
KR (1) | KR20230136913A (es) |
AU (1) | AU2021369835A1 (es) |
CA (1) | CA3196726A1 (es) |
MX (1) | MX2023005081A (es) |
WO (1) | WO2022094299A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024028386A1 (en) | 2022-08-02 | 2024-02-08 | Ose Immunotherapeutics | Multifunctional molecule directed against cd28 |
WO2024077118A2 (en) | 2022-10-06 | 2024-04-11 | Bicara Therapeutics Inc. | Multispecific proteins and related methods |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2019529499A (ja) * | 2016-09-30 | 2019-10-17 | ベイラー カレッジ オブ メディスンBaylor College Of Medicine | 組織指向性発現を用いた抗体ベースの遺伝子治療 |
US11649286B2 (en) * | 2017-06-25 | 2023-05-16 | Systimmune Inc. | Tri-specific antibodies |
PE20211696A1 (es) * | 2018-12-21 | 2021-09-01 | Hoffmann La Roche | Moleculas agonistas de union al antigeno cd28 que actuan sobre el tumor |
CA3134335A1 (en) * | 2019-03-22 | 2020-10-01 | Regeneron Pharmaceuticals, Inc. | Egfr x cd28 multispecific antibodies |
-
2021
- 2021-10-29 CA CA3196726A patent/CA3196726A1/en active Pending
- 2021-10-29 WO PCT/US2021/057384 patent/WO2022094299A2/en active Application Filing
- 2021-10-29 US US18/249,886 patent/US20230406937A1/en active Pending
- 2021-10-29 KR KR1020237017803A patent/KR20230136913A/ko unknown
- 2021-10-29 JP JP2023551651A patent/JP2023548443A/ja active Pending
- 2021-10-29 MX MX2023005081A patent/MX2023005081A/es unknown
- 2021-10-29 EP EP21887650.6A patent/EP4237013A2/en active Pending
- 2021-10-29 AU AU2021369835A patent/AU2021369835A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3196726A1 (en) | 2022-05-05 |
JP2023548443A (ja) | 2023-11-16 |
EP4237013A2 (en) | 2023-09-06 |
US20230406937A1 (en) | 2023-12-21 |
WO2022094299A2 (en) | 2022-05-05 |
AU2021369835A1 (en) | 2023-06-01 |
KR20230136913A (ko) | 2023-09-27 |
WO2022094299A3 (en) | 2022-09-29 |
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