MX2023005055A - Proceso de purificacion de noroximorfona. - Google Patents

Proceso de purificacion de noroximorfona.

Info

Publication number
MX2023005055A
MX2023005055A MX2023005055A MX2023005055A MX2023005055A MX 2023005055 A MX2023005055 A MX 2023005055A MX 2023005055 A MX2023005055 A MX 2023005055A MX 2023005055 A MX2023005055 A MX 2023005055A MX 2023005055 A MX2023005055 A MX 2023005055A
Authority
MX
Mexico
Prior art keywords
noroxymorphone
purifying
bisulfite adduct
directed
application
Prior art date
Application number
MX2023005055A
Other languages
English (en)
Inventor
C Frederick M Huntley
Original Assignee
Rhodes Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhodes Tech filed Critical Rhodes Tech
Publication of MX2023005055A publication Critical patent/MX2023005055A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La solicitud hace referencia a un proceso de purificación de noroximorfona mediante la preparación y el aislamiento del aducto de bisulfito de noroximorfona y la regeneración de noroximorfona purificada a partir del aducto de bisulfito de noroximorfona. La solicitud también hace referencia a un compuesto representado por la Fórmula I, descrito en el presente documento, o un hidrato o zwitterión de este, y una forma cristalina de monohidrato de aducto de bisulfito de noroximorfona.
MX2023005055A 2020-11-02 2021-11-02 Proceso de purificacion de noroximorfona. MX2023005055A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063108676P 2020-11-02 2020-11-02
PCT/US2021/057737 WO2022094470A1 (en) 2020-11-02 2021-11-02 Process for purifying noroxymorphone

Publications (1)

Publication Number Publication Date
MX2023005055A true MX2023005055A (es) 2023-07-14

Family

ID=78844759

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005055A MX2023005055A (es) 2020-11-02 2021-11-02 Proceso de purificacion de noroximorfona.

Country Status (8)

Country Link
US (1) US20230399334A1 (es)
EP (1) EP4237422A1 (es)
JP (1) JP2023548356A (es)
AU (1) AU2021368196A1 (es)
CA (1) CA3196369A1 (es)
IL (1) IL302416A (es)
MX (1) MX2023005055A (es)
WO (1) WO2022094470A1 (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2854796A1 (en) * 1999-11-09 2001-05-17 Purdue Pharma Hydromorphinone and hydrocodeinone compositions and methods for their synthesis
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
CA2644095A1 (en) * 2006-03-02 2007-09-13 Mallinckrodt Inc. Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
US7671204B2 (en) * 2007-12-17 2010-03-02 Mallinckrodt Inc. N-demethylation of N-methyl morphinans
BRPI1010975B1 (pt) 2009-05-25 2021-08-24 H. Lundbeck A/S Métodos para preparar nalmefeno a partir de naltrexona em uma reação de wittig e para isolar o nalmefeno
US20110269964A1 (en) 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
AR092858A1 (es) 2012-07-16 2015-05-06 Rhodes Tech Procedimiento para una sintesis mejorada de opioide
WO2016005923A1 (en) 2014-07-09 2016-01-14 Rhodes Technologies Reduction of alpha, beta-unsaturated ketone levels in morphinan derivative compositions

Also Published As

Publication number Publication date
JP2023548356A (ja) 2023-11-16
US20230399334A1 (en) 2023-12-14
CA3196369A1 (en) 2022-05-05
IL302416A (en) 2023-06-01
AU2021368196A1 (en) 2023-06-22
WO2022094470A1 (en) 2022-05-05
EP4237422A1 (en) 2023-09-06

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