MX2022012957A - Metodos de uso de inhibidores de la quinasa rho para tratar la enfermedad de alzheimer. - Google Patents
Metodos de uso de inhibidores de la quinasa rho para tratar la enfermedad de alzheimer.Info
- Publication number
- MX2022012957A MX2022012957A MX2022012957A MX2022012957A MX2022012957A MX 2022012957 A MX2022012957 A MX 2022012957A MX 2022012957 A MX2022012957 A MX 2022012957A MX 2022012957 A MX2022012957 A MX 2022012957A MX 2022012957 A MX2022012957 A MX 2022012957A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- rho kinase
- preferred
- disease
- kinase inhibitors
- Prior art date
Links
- 239000003590 rho kinase inhibitor Substances 0.000 title abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- NGOGFTYYXHNFQH-UHFFFAOYSA-N fasudil Chemical compound C=1C=CC2=CN=CC=C2C=1S(=O)(=O)N1CCCNCC1 NGOGFTYYXHNFQH-UHFFFAOYSA-N 0.000 abstract 1
- 229960002435 fasudil Drugs 0.000 abstract 1
- 208000027061 mild cognitive impairment Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063014272P | 2020-04-23 | 2020-04-23 | |
| PCT/US2021/012588 WO2021216139A1 (en) | 2020-04-23 | 2021-01-08 | Methods of using rho kinase inhibitors to treat alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2022012957A true MX2022012957A (es) | 2022-11-09 |
Family
ID=78269840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2022012957A MX2022012957A (es) | 2020-04-23 | 2021-01-08 | Metodos de uso de inhibidores de la quinasa rho para tratar la enfermedad de alzheimer. |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US12329761B2 (https=) |
| EP (1) | EP4138842A4 (https=) |
| JP (2) | JP2023523706A (https=) |
| CN (1) | CN115996728A (https=) |
| CA (1) | CA3175183A1 (https=) |
| MX (1) | MX2022012957A (https=) |
| WO (1) | WO2021216139A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11642352B2 (en) * | 2020-03-25 | 2023-05-09 | Woolsey Pharmaceuticals, Inc. | Methods of treating wandering in Lewy dody dementia |
| WO2021216139A1 (en) * | 2020-04-23 | 2021-10-28 | Woolsey Pharmaceuticals, Inc | Methods of using rho kinase inhibitors to treat alzheimer's disease |
| US20240423998A1 (en) | 2021-11-29 | 2024-12-26 | Woolsey Pharmaceuticals, Inc. | Methods of treating agitation and other dementia-associated behavioral symptoms |
| CN115998736B (zh) * | 2023-03-28 | 2023-06-23 | 中国人民解放军军事科学院军事医学研究院 | Y-27632在特异性抑制幻觉作用中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117896A1 (de) | 2004-06-03 | 2005-12-15 | Schering Aktiengesellschaft | Formulierungen, die fasudil, eine matrix und einem mantel enthalten |
| WO2006094072A2 (en) | 2005-03-01 | 2006-09-08 | Functional Neuroscience Inc. | Method of treating cognitive disorders using neuromodulation |
| WO2008019395A2 (en) * | 2006-08-10 | 2008-02-14 | Translational Genomics Research Institute | Compounds for improving learning and memory |
| EP2285217A4 (en) * | 2008-05-12 | 2011-06-08 | Amnestix Inc | CONNECTIONS TO IMPROVE LEARNING AND MEMORY |
| US20120010196A1 (en) * | 2010-04-02 | 2012-01-12 | Qin Quingyu | Methods of treating neurodegenerative disorders and diseases |
| US9980972B2 (en) | 2012-03-12 | 2018-05-29 | Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin | Rho kinase inhibitors for use in treating familial amyotrophic lateral sclerosis |
| US9481864B1 (en) * | 2015-06-30 | 2016-11-01 | University Of South Florida | Conversion of non-neuronal cells into neurons |
| MX2022008513A (es) * | 2020-01-09 | 2022-08-08 | Woolsey Pharmaceuticals Inc | Metodos para tratar la deambulacion asociada con la demencia cortical. |
| US11642352B2 (en) | 2020-03-25 | 2023-05-09 | Woolsey Pharmaceuticals, Inc. | Methods of treating wandering in Lewy dody dementia |
| WO2021216139A1 (en) * | 2020-04-23 | 2021-10-28 | Woolsey Pharmaceuticals, Inc | Methods of using rho kinase inhibitors to treat alzheimer's disease |
| EP4232041A4 (en) | 2020-10-22 | 2024-09-25 | Woolsey Pharmaceuticals, Inc. | Methods of treating 4-repeat tauopathies |
| US20240423998A1 (en) * | 2021-11-29 | 2024-12-26 | Woolsey Pharmaceuticals, Inc. | Methods of treating agitation and other dementia-associated behavioral symptoms |
-
2021
- 2021-01-08 WO PCT/US2021/012588 patent/WO2021216139A1/en not_active Ceased
- 2021-01-08 JP JP2022563366A patent/JP2023523706A/ja active Pending
- 2021-01-08 US US17/996,812 patent/US12329761B2/en active Active
- 2021-01-08 MX MX2022012957A patent/MX2022012957A/es unknown
- 2021-01-08 CN CN202180043725.7A patent/CN115996728A/zh active Pending
- 2021-01-08 EP EP21793029.6A patent/EP4138842A4/en active Pending
- 2021-01-08 CA CA3175183A patent/CA3175183A1/en active Pending
-
2023
- 2023-02-28 US US18/175,605 patent/US11771704B1/en active Active
-
2025
- 2025-05-13 US US19/206,355 patent/US20250268911A1/en active Pending
- 2025-12-25 JP JP2025282162A patent/JP2026053635A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4138842A1 (en) | 2023-03-01 |
| US20250268911A1 (en) | 2025-08-28 |
| CN115996728A (zh) | 2023-04-21 |
| JP2026053635A (ja) | 2026-03-25 |
| US20230302011A1 (en) | 2023-09-28 |
| US12329761B2 (en) | 2025-06-17 |
| WO2021216139A1 (en) | 2021-10-28 |
| EP4138842A4 (en) | 2024-04-24 |
| US20230190765A1 (en) | 2023-06-22 |
| CA3175183A1 (en) | 2021-10-28 |
| JP2023523706A (ja) | 2023-06-07 |
| US11771704B1 (en) | 2023-10-03 |
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