MX2022010826A - Métodos para elaborar inmunoglobulina hipersialilada. - Google Patents

Métodos para elaborar inmunoglobulina hipersialilada.

Info

Publication number
MX2022010826A
MX2022010826A MX2022010826A MX2022010826A MX2022010826A MX 2022010826 A MX2022010826 A MX 2022010826A MX 2022010826 A MX2022010826 A MX 2022010826A MX 2022010826 A MX2022010826 A MX 2022010826A MX 2022010826 A MX2022010826 A MX 2022010826A
Authority
MX
Mexico
Prior art keywords
methods
sialylated
immunoglobulin
hyper
making
Prior art date
Application number
MX2022010826A
Other languages
English (en)
Inventor
Naveen Bhatnagar
Iii James Meador
Original Assignee
Momenta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Momenta Pharmaceuticals Inc filed Critical Momenta Pharmaceuticals Inc
Publication of MX2022010826A publication Critical patent/MX2022010826A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01038—Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase (2.4.1.38)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

En la presente descripción se describen métodos para modificar mediante galactosilación anticuerpos IgG, métodos para preparar hipersialilados (hsIgG), p. ej., usando ß1,4- galactosiltransferasa I inmovilizada (ß4GalT1), así como polipéptidos que comprenden ß1,4- galactosiltransferasa I (ß4GalT1) unidos a un soporte sólido y composiciones que los comprenden.
MX2022010826A 2020-03-05 2021-03-04 Métodos para elaborar inmunoglobulina hipersialilada. MX2022010826A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062985467P 2020-03-05 2020-03-05
US202063026805P 2020-05-19 2020-05-19
PCT/US2021/020898 WO2021178682A2 (en) 2020-03-05 2021-03-04 Methods of making hyper-sialylated immunoglobulin

Publications (1)

Publication Number Publication Date
MX2022010826A true MX2022010826A (es) 2022-12-02

Family

ID=77614440

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022010826A MX2022010826A (es) 2020-03-05 2021-03-04 Métodos para elaborar inmunoglobulina hipersialilada.

Country Status (11)

Country Link
US (1) US20230374062A1 (es)
EP (1) EP4114547A4 (es)
JP (1) JP2023516731A (es)
KR (1) KR20220150930A (es)
CN (1) CN115666751A (es)
AU (1) AU2021231997A1 (es)
BR (1) BR112022017632A2 (es)
CA (1) CA3174533A1 (es)
CO (1) CO2022014275A2 (es)
MX (1) MX2022010826A (es)
WO (1) WO2021178682A2 (es)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014179601A2 (en) * 2013-05-02 2014-11-06 Momenta Pharmaceuticals, Inc. Sialylated glycoproteins
GB201308658D0 (en) * 2013-05-14 2013-06-26 Isis Innovation Antibodies
KR102390246B1 (ko) * 2016-12-21 2022-04-22 에프. 호프만-라 로슈 아게 항체의 시험관내 글리코조작에 있어서의 효소의 재사용

Also Published As

Publication number Publication date
KR20220150930A (ko) 2022-11-11
CA3174533A1 (en) 2021-09-10
BR112022017632A2 (pt) 2022-11-08
US20230374062A1 (en) 2023-11-23
AU2021231997A1 (en) 2022-10-20
CN115666751A (zh) 2023-01-31
WO2021178682A3 (en) 2021-10-21
WO2021178682A2 (en) 2021-09-10
CO2022014275A2 (es) 2022-10-21
EP4114547A2 (en) 2023-01-11
JP2023516731A (ja) 2023-04-20
EP4114547A4 (en) 2024-03-27

Similar Documents

Publication Publication Date Title
MX2020010241A (es) Composiciones de inmunoterapia celular y usos de las mismas.
CR20200014A (es) Molécula de polipéptido con especificidad dual mejorada
AU2018258045A1 (en) Chimeric antibody/T-cell receptor constructs and uses thereof
MX2020012927A (es) Diversos dominios de enlace de antigenos, nuevas plataformas y otras mejoras para terapia celular.
CN104011080B (zh) 用于真核细胞的全长抗体展示系统及其用途
RU2014114172A (ru) Легковыделяемые биспецифические антитела с природным иммуноглобулиновым форматом
AU2003215188A1 (en) Fusion proteins of humanized g250 specific antibodies and uses thereof
NZ577828A (en) Human antibodies that bind human il-12 and methods for producing
NZ588674A (en) Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof
WO2012054654A3 (en) Anti-folate receptor alpha antibody glycoforms
NZ781138A (en) Anti-vegf protein compositions and methods for producing the same
WO2010124163A3 (en) Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies
WO2021041715A3 (en) Compositions including igg fc mutations and uses thereof
NZ583894A (en) Antibodies that bind to a non atp binding p2x7 receptor
MX2020011588A (es) Anticuerpos de alta afinidad a pd-1 y lag-3 y proteinas de union bispecificas preparadas a partir de las mismas.
MX2022011951A (es) Anticuerpos de la lectina 15 similar a la inmunoglobulina que se une a acido sialico (siglec15) y usos de los mismos.
MX2023004054A (es) Anticuerpos anti-dectina 1 y metodos de uso de los mismos.
WO2022162518A3 (en) Psma binding proteins and uses thereof
MX2023006969A (es) Moleculas de union a gucy2c y sus usos.
MX2022010826A (es) Métodos para elaborar inmunoglobulina hipersialilada.
MX2023006817A (es) Composiciones y metodos relacionados con anticuerpos activados por tumores dirigidos a psma y antigenos de celulas efectoras.
MX2022003432A (es) Metodos y composiciones que comprenden un anticuerpo monoclonal antictla4 con proteinas de celulas hospederas reducidas y estabilidad del polisorbato-80 aumentada.
ZA202305072B (en) Cd1a antibodies and uses thereof
WO2022081643A3 (en) Compositions and methods for generating recombinant antigen binding molecules from single cells
WO2023114701A3 (en) Cd28 binding antibodies and antigen binding fragments thereof